{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:14:39Z","timestamp":1792664079339,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.biopsych.2009.04.005","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T16:47:13Z","timestamp":1243615633000},"page":"554-561","source":"Crossref","is-referenced-by-count":98,"title":["Striatal Overexpression of \u0394JunD Resets L-DOPA-Induced Dyskinesia in a Primate Model of Parkinson Disease"],"prefix":"10.1016","volume":"66","author":[{"given":"Olivier","family":"Berton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Guigoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard H.","family":"Bioulac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Incarnation","family":"Aubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian E.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph J.","family":"DiLeone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Nestler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Bezard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2009.04.005_bib1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1471-4159.2008.05417.x","article-title":"Striatal histone modifications in models of levodopa-induced dyskinesia","volume":"106","author":"Nicholas","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopsych.2009.04.005_bib2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.nbd.2004.07.005","article-title":"Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia","volume":"17","author":"Konradi","year":"2004","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.biopsych.2009.04.005_bib3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00726-001-0116-4","article-title":"Transcription factors involved in the pathogenesis of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease","volume":"23","author":"Cenci","year":"2002","journal-title":"Amino Acids"},{"key":"10.1016\/j.biopsych.2009.04.005_bib4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1460-9568.1996.tb01220.x","article-title":"Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of deltaFosB-like protein(s) in both the rodent and primate striatum","volume":"8","author":"Doucet","year":"1996","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2009.04.005_bib5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0169-328X(97)00253-2","article-title":"Behavioural sensitization in 6-hydroxydopamine-lesioned rats is related to compositional changes of the AP-1 transcription factor: Evidence for induction of FosB- and JunD-related proteins","volume":"52","author":"Vallone","year":"1997","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.biopsych.2009.04.005_bib6","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/0896-6273(94)90061-2","article-title":"Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments","volume":"13","author":"Hope","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2009.04.005_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biopsych.2005.05.044","article-title":"ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice","volume":"59","author":"Pavon","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.04.005_bib8","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1046\/j.0953-816x.2001.01743.x","article-title":"Persistent changes in striatal gene expression induced by long-term L-DOPA treatment in a rat model of Parkinson's disease","volume":"14","author":"Westin","year":"2001","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2009.04.005_bib9","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1523\/JNEUROSCI.2949-06.2007","article-title":"High-frequency stimulation of the subthalamic nucleus potentiates L-DOPA-induced neurochemical changes in the striatum in a rat model of Parkinson's disease","volume":"27","author":"Oueslati","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.04.005_bib10","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1523\/JNEUROSCI.17-13-04933.1997","article-title":"Chronic Fos-related antigens: Stable variants of deltaFosB induced in brain by chronic treatments","volume":"17","author":"Chen","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.04.005_bib11","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0026-895X(25)10546-4","article-title":"Regulation of delta FosB and FosB-like proteins by electroconvulsive seizure and cocaine treatments","volume":"48","author":"Chen","year":"1995","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.biopsych.2009.04.005_bib12","doi-asserted-by":"crossref","first-page":"9930","DOI":"10.1523\/JNEUROSCI.21-24-09930.2001","article-title":"cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum","volume":"21","author":"Andersson","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.04.005_bib13","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1046\/j.1460-9568.2003.02469.x","article-title":"Time course of striatal DeltaFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatment","volume":"17","author":"Andersson","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2009.04.005_bib14","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.molbrainres.2004.05.014","article-title":"DeltaFosB: A molecular switch for long-term adaptation in the brain","volume":"132","author":"McClung","year":"2004","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.biopsych.2009.04.005_bib15","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/nbdi.1999.0259","article-title":"Striatal fosB expression is causally linked with L-DOPA-induced abnormal involuntary movements and the associated upregulation of striatal prodynorphin mRNA in a rat model of Parkinson's disease","volume":"6","author":"Andersson","year":"1999","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.biopsych.2009.04.005_bib16","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s11596-006-0514-7","article-title":"Effect of antisense FosB and CREB on the expression of prodynorphin gene in rats with levodopa-induced dyskinesias","volume":"26","author":"Chen","year":"2006","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"10.1016\/j.biopsych.2009.04.005_bib17","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0006-3223(01)01234-3","article-title":"Elevated levels of DeltaFosB and RGS9 in striatum in Parkinson's disease","volume":"50","author":"Tekumalla","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.04.005_bib18","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1523\/JNEUROSCI.21-17-06853.2001","article-title":"Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive MPTP-lesioned macaque model of Parkinson's disease","volume":"21","author":"Bezard","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.04.005_bib19","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nm875","article-title":"Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function","volume":"9","author":"Bezard","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2009.04.005_bib20","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/332649a0","article-title":"The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast","volume":"332","author":"Struhl","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2009.04.005_bib21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ana.20296","article-title":"Increased D1 dopamine receptor signalling in levodopa-induced dyskinesia","volume":"57","author":"Aubert","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopsych.2009.04.005_bib22","doi-asserted-by":"crossref","first-page":"14338","DOI":"10.1523\/JNEUROSCI.4223-07.2007","article-title":"RGS9-2 negatively modulates L-3,4-dihydroxyphenylalanine-induced dyskinesia in experimental Parkinson's disease","volume":"27","author":"Gold","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.04.005_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1460-9568.2005.04196.x","article-title":"Levodopa-induced dyskinesia in MPTP-treated macaque is not dependent of the extent and pattern of the nigrostrial lesion","volume":"22","author":"Guigoni","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2009.04.005_bib24","doi-asserted-by":"crossref","first-page":"8653","DOI":"10.1523\/JNEUROSCI.2582-06.2006","article-title":"Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: A call for a reappraisal of the functional organization of the basal ganglia","volume":"26","author":"Nadjar","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.04.005_bib25","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1523\/JNEUROSCI.5059-04.2005","article-title":"Involvement of sensorimotor, limbic, and associative basal ganglia domains in levodopa-induced dyskinesia","volume":"25","author":"Guigoni","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.04.005_bib26","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.biopsych.2006.06.038","article-title":"Enhanced preproenkephalin-B-derived opioid transmission in striatum and subthalamic nucleus converges upon globus pallidus internalis in L-dopa-induced dyskinesia","volume":"61","author":"Aubert","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.04.005_bib27","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/306611a0","article-title":"Isolation and structural organization of the human preproenkephalin B gene","volume":"306","author":"Horikawa","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2009.04.005_bib28","doi-asserted-by":"crossref","first-page":"14301","DOI":"10.1016\/S0021-9258(18)89893-3","article-title":"Rat brain preproenkephalin mRNA","volume":"259","author":"Yoshikawa","year":"1984","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2009.04.005_bib29","series-title":"Advances in Neurology","first-page":"35","article-title":"Stereotaxic technique for stimulation and recording in nonanaesthetized monkeys: Application to the determination of connections between caudate nucleus and substantia nigra","author":"Feger","year":"1975"},{"key":"10.1016\/j.biopsych.2009.04.005_bib30","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/brain\/124.3.546","article-title":"Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alteration of pallidal neurons in the MPTP-treated monkey","volume":"124","author":"Boraud","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2009.04.005_bib31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0361-9230(96)00161-X","article-title":"A stereotaxic atlas of the basal ganglia in macaques","volume":"41","author":"Fran\u00e7ois","year":"1996","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.biopsych.2009.04.005_bib32","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neuron.2007.06.033","article-title":"Induction of deltaFosB in the periaqueductal gray by stress promotes active coping responses","volume":"55","author":"Berton","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2009.04.005_bib33","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1038\/nm964","article-title":"Local gene knockdown in the brain using viral-mediated RNA interference","volume":"9","author":"Hommel","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2009.04.005_bib34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/hum.2006.178","article-title":"Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain","volume":"18","author":"Taymans","year":"2007","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.biopsych.2009.04.005_bib35","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1523\/JNEUROSCI.18-17-06952.1998","article-title":"Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures","volume":"18","author":"Hiroi","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.04.005_bib36","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nn1636","article-title":"An essential role for DeltaFosB in the nucleus accumbens in morphine action","volume":"9","author":"Zachariou","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2009.04.005_bib37","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/S0140-6736(07)60982-9","article-title":"Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: An open label, phase I trial","volume":"369","author":"Kaplitt","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.biopsych.2009.04.005_bib38","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.neuroscience.2006.09.001","article-title":"Expression pattern of JunD after acute or chronic L-DOPA treatment: Comparison with deltaFosB","volume":"144","author":"Valastro","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2009.04.005_bib39","first-page":"1013","article-title":"Dominant-negative mutants of cJun inhibit AP-1 activity through multiple mechanisms and with different potencies","volume":"7","author":"Brown","year":"1996","journal-title":"Cell Growth Differ"},{"key":"10.1016\/j.biopsych.2009.04.005_bib40","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0006-8993(03)02230-3","article-title":"Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine","volume":"970","author":"Peakman","year":"2003","journal-title":"Brain Res"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322309004478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322309004478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T19:44:59Z","timestamp":1739130299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322309004478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0006322309004478"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2009.04.005","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}