{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:22:10Z","timestamp":1791519730415,"version":"4.3.4"},"reference-count":59,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.biopsych.2009.06.008","type":"journal-article","created":{"date-parts":[[2009,7,30]],"date-time":"2009-07-30T14:32:12Z","timestamp":1248964332000},"page":"871-878","source":"Crossref","is-referenced-by-count":47,"title":["Prospective Association Between C-Reactive Protein and Fatigue in the Coronary Artery Risk Development in Young Adults Study"],"prefix":"10.1016","volume":"66","author":[{"given":"Hyong Jin","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa E.","family":"Seeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julienne E.","family":"Bower","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina I.","family":"Kiefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Irwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2009.06.008_bib1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/fampra\/2.1.48","article-title":"Fatigue of unknown aetiology\u2014A review","volume":"2","author":"Valdini","year":"1985","journal-title":"Fam Pract"},{"key":"10.1016\/j.biopsych.2009.06.008_bib2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/bmj.308.6931.763","article-title":"Population based study of fatigue and psychological distress","volume":"308","author":"Pawlikowska","year":"1994","journal-title":"BMJ"},{"key":"10.1016\/j.biopsych.2009.06.008_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0037-1963(00)90063-5","article-title":"Impact of fatigue on quality of life in oncology patients","volume":"37","author":"Curt","year":"2000","journal-title":"Semin Hematol"},{"key":"10.1016\/j.biopsych.2009.06.008_bib4","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1177\/135245850100700511","article-title":"Quality of life in multiple sclerosis: The impact of depression, fatigue and disability","volume":"7","author":"Amato","year":"2001","journal-title":"Mult Scler"},{"key":"10.1016\/j.biopsych.2009.06.008_bib5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/00005053-199706000-00001","article-title":"The quality of life of persons with chronic fatigue syndrome","volume":"185","author":"Anderson","year":"1997","journal-title":"J Nerv Ment Dis"},{"key":"10.1016\/j.biopsych.2009.06.008_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.jom.0000249782.60321.2a","article-title":"Fatigue in the US workforce: Prevalence and implications for lost productive work time","volume":"49","author":"Ricci","year":"2007","journal-title":"J Occup Environ Med"},{"key":"10.1016\/j.biopsych.2009.06.008_bib7","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1001\/jama.290.18.2443","article-title":"Lost productive time and cost due to common pain conditions in the US workforce","volume":"290","author":"Stewart","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.biopsych.2009.06.008_bib8","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1001\/jama.289.23.3135","article-title":"Cost of lost productive work time among US workers with depression","volume":"289","author":"Stewart","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.biopsych.2009.06.008_bib9","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1365-2362.2007.01851.x","article-title":"Increased voluntary exercise in mice deficient for tumour necrosis factor-alpha and lymphotoxin-alpha","volume":"37","author":"Netea","year":"2007","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.biopsych.2009.06.008_bib10","doi-asserted-by":"crossref","first-page":"R1109","DOI":"10.1152\/ajpregu.90302.2008","article-title":"Exacerbated fatigue and motor deficits in interleukin-10-deficient mice after peripheral immune stimulation","volume":"295","author":"Krzyszton","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.biopsych.2009.06.008_bib11","first-page":"1573","article-title":"Acute effects of recombinant human interleukin-6 on endocrine and central nervous sleep functions in healthy men","volume":"83","author":"Spath-Schwalbe","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.biopsych.2009.06.008_bib12","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0893-133X(01)00407-9","article-title":"Neurobehavioral effects of interferon-alpha in cancer patients: Phenomenology and paroxetine responsiveness of symptom dimensions","volume":"26","author":"Capuron","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2009.06.008_bib13","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1038\/sj.npp.1301362","article-title":"Basal ganglia hypermetabolism and symptoms of fatigue during interferon-alpha therapy","volume":"32","author":"Capuron","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2009.06.008_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1136\/bmj.321.7255.199","article-title":"Low grade inflammation and coronary heart disease: Prospective study and updated meta-analyses","volume":"321","author":"Danesh","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.biopsych.2009.06.008_bib15","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/1043-4666(91)90497-2","article-title":"Altered cytokine release in peripheral blood mononuclear cell cultures from patients with the chronic fatigue syndrome","volume":"3","author":"Chao","year":"1991","journal-title":"Cytokines"},{"key":"10.1016\/j.biopsych.2009.06.008_bib16","first-page":"372","article-title":"Markers of inflammation and immune activation in chronic fatigue and chronic fatigue syndrome","volume":"24","author":"Buchwald","year":"1997","journal-title":"J Rheumatol"},{"key":"10.1016\/j.biopsych.2009.06.008_bib17","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1023\/A:1027314713231","article-title":"Interleukin-1\u03b2, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome","volume":"17","author":"Cannon","year":"1997","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.biopsych.2009.06.008_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0022-3956(96)00063-5","article-title":"Cytokine production by adherent and non-adherent mononuclear cells in chronic fatigue syndrome","volume":"31","author":"Gupta","year":"1997","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.biopsych.2009.06.008_bib19","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1023\/A:1020558917955","article-title":"Acute phase responses and cytokine secretion in chronic fatigue syndrome","volume":"19","author":"Cannon","year":"1999","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.biopsych.2009.06.008_bib20","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1023\/A:1020595709352","article-title":"TNF-a and chronic fatigue syndrome","volume":"19","author":"Moss","year":"1999","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.biopsych.2009.06.008_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1023\/A:1020510718013","article-title":"Immunological response in chronic fatigue syndrome following a graded exercise test to exhaustion","volume":"19","author":"LaManca","year":"1999","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.biopsych.2009.06.008_bib22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1128\/CDLI.6.1.6-13.1999","article-title":"Changes in immune parameters seen in Gulf War veterans but not in civilians with chronic fatigue syndrome","volume":"6","author":"Zhang","year":"1999","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.biopsych.2009.06.008_bib23","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1046\/j.1365-2249.2003.02149.x","article-title":"Normal production of inflammatory cytokines in chronic fatigue and fibromyalgia syndromes determined by intracellular cytokine staining in short-term cultured blood mononuclear cells","volume":"132","author":"Kashipaz","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.biopsych.2009.06.008_bib24","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1086\/520990","article-title":"Postinfective fatigue syndrome is not associated with altered cytokine production","volume":"45","author":"Vollmer-Conna","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.biopsych.2009.06.008_bib25","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.bbi.2007.04.007","article-title":"Longitudinal analysis of pro- and anti-inflammatory cytokine production in severely fatigued adolescents","volume":"21","author":"ter Wolbeek","year":"2007","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2009.06.008_bib26","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1212\/WNL.57.4.676","article-title":"Fatigue is not associated with raised inflammatory markers in multiple sclerosis","volume":"57","author":"Giovannoni","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2009.06.008_bib27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1191\/1352458504ms991oa","article-title":"Cytokine mRNA expression in patients with multiple sclerosis and fatigue","volume":"10","author":"Flachenecker","year":"2004","journal-title":"Mult Scler"},{"key":"10.1016\/j.biopsych.2009.06.008_bib28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/jnnp.2005.065805","article-title":"Fatigue in multiple sclerosis: An example of cytokine mediated sickness behaviour?","volume":"77","author":"Heesen","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2009.06.008_bib29","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0895-4356(88)90080-7","article-title":"CARDIA: Study design, recruitment, and some characteristics of the examined subjects","volume":"41","author":"Friedman","year":"1988","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.biopsych.2009.06.008_bib30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00005650-199603000-00003","article-title":"A 12-Item Short-Form Health Survey: Construction of scales and preliminary tests of reliability and validity","volume":"34","author":"Ware","year":"1996","journal-title":"Med Care"},{"key":"10.1016\/j.biopsych.2009.06.008_bib31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/oxfordjournals.pubmed.a024606","article-title":"A shorter form health survey: Can the SF-12 replicate results from the SF-36 in longitudinal studies?","volume":"19","author":"Jenkinson","year":"1997","journal-title":"J Pub Health"},{"key":"10.1016\/j.biopsych.2009.06.008_bib32","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/rheumatology\/37.8.862","article-title":"Comparison of the MOS short form-12 (SF12) health status questionnaire with the SF36 in patients with rheumatoid arthritis","volume":"37","author":"Hurst","year":"1998","journal-title":"Rheumatology"},{"key":"10.1016\/j.biopsych.2009.06.008_bib33","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/00002030-200202150-00015","article-title":"Assessing the utility of five domains in SF-12 health status questionnaire in an AIDS clinical trial","volume":"16","author":"Han","year":"2002","journal-title":"AIDS"},{"key":"10.1016\/j.biopsych.2009.06.008_bib34","series-title":"Statistical Methods for Categorical Data Analysis","author":"Powers","year":"2000"},{"key":"10.1016\/j.biopsych.2009.06.008_bib35","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/ije\/dyh372","article-title":"Cohort Profile: The Whitehall II study","volume":"34","author":"Marmot","year":"2005","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.biopsych.2009.06.008_bib36","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/jnci\/djh060","article-title":"Quality of life at the end of primary treatment of breast cancer: First results from the moving beyond cancer randomized trial","volume":"96","author":"Ganz","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.biopsych.2009.06.008_bib37","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1023\/A:1008842517972","article-title":"Measurement of fatigue in cancer patients: Development and validation of the Fatigue Symptom Inventory","volume":"7","author":"Hann","year":"1998","journal-title":"Qual Life Res"},{"key":"10.1016\/j.biopsych.2009.06.008_bib38","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/01.CIR.0000052939.59093.45","article-title":"Markers of inflammation and cardiovascular disease: Application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association","volume":"107","author":"Pearson","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.biopsych.2009.06.008_bib39","doi-asserted-by":"crossref","first-page":"703","DOI":"10.2105\/AJPH.2004.055889","article-title":"Physical activity in young adults and incident hypertension over 15 years of follow-up: The CARDIA Study","volume":"97","author":"Parker","year":"2007","journal-title":"Am J Pub Health"},{"key":"10.1016\/j.biopsych.2009.06.008_bib40","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/(SICI)1097-0258(20000430)19:8<1059::AID-SIM412>3.0.CO;2-0","article-title":"Prognostic modelling with logistic regression analysis: A comparison of selection and estimation methods in small data sets","volume":"19","author":"Steyerberg","year":"2000","journal-title":"Stat Med"},{"key":"10.1016\/j.biopsych.2009.06.008_bib41","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1037\/1082-989X.7.1.83","article-title":"A comparison of methods to test mediation and other intervening variable effects","volume":"7","author":"MacKinnon","year":"2002","journal-title":"Psychol Methods"},{"key":"10.1016\/j.biopsych.2009.06.008_bib42","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1097\/00006842-200207000-00010","article-title":"Fatigue and proinflammatory cytokine activity in breast cancer survivors","volume":"64","author":"Bower","year":"2002","journal-title":"Psychosom Med"},{"key":"10.1016\/j.biopsych.2009.06.008_bib43","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1158\/1078-0432.CCR-05-2398","article-title":"Inflammatory biomarkers for persistent fatigue in breast cancer survivors","volume":"12","author":"Collado-Hidalgo","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.biopsych.2009.06.008_bib44","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1200\/JCO.2007.10.7805","article-title":"Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer","volume":"26","author":"Miller","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.biopsych.2009.06.008_bib45","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bbi.2006.11.004","article-title":"The association between fatigue and inflammatory marker levels in cancer patients: A quantitative review","volume":"21","author":"Schubert","year":"2007","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2009.06.008_bib46","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/109980040200300407","article-title":"Predictors of fatigue in healthy young adults: Moderating effects of cigarette smoking and gender","volume":"3","author":"Corwin","year":"2002","journal-title":"Biol Res Nurs"},{"key":"10.1016\/j.biopsych.2009.06.008_bib47","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0889-1591(02)00021-1","article-title":"Stress and the inflammatory response: A review of neurogenic inflammation","volume":"16","author":"Black","year":"2002","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2009.06.008_bib48","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: When the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2009.06.008_bib49","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.biopsych.2005.03.033","article-title":"Anterior cingulate activation and error processing during interferon-alpha treatment","volume":"58","author":"Capuron","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.06.008_bib50","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1176\/appi.ajp.160.7.1342","article-title":"Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy","volume":"160","author":"Capuron","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2009.06.008_bib51","article-title":"Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment","author":"Bull","year":"2008","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.06.008_bib52","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1086\/431366","article-title":"Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels","volume":"77","author":"Carlson","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2009.06.008_bib53","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.biopsych.2006.03.016","article-title":"Relationship of early life stress and psychological functioning to adult C-reactive protein in the Coronary Artery Risk Development in Young Adults Study","volume":"60","author":"Taylor","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.06.008_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2008.05.009","article-title":"Cytokine gene polymorphisms and fatigue in breast cancer survivors: Early findings","author":"Collado-Hidalgo","year":"2008","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2009.06.008_bib55","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbi.2005.12.002","article-title":"Aerobic exercise, but not flexibility\/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults","volume":"20","author":"Kohut","year":"2006","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2009.06.008_bib56","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1210\/jc.2003-031310","article-title":"Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women","volume":"89","author":"You","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.biopsych.2009.06.008_bib57","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","article-title":"C-reactive protein: A critical update","volume":"111","author":"Pepys","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.biopsych.2009.06.008_bib58","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/PSY.0b013e3181907c1b","article-title":"Associations of depression with C-reactive protein, IL-1, and IL-6: A Meta-analysis","volume":"71","author":"Howren","year":"2009","journal-title":"Psychosom Med"},{"key":"10.1016\/j.biopsych.2009.06.008_bib59","series-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322309007616?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322309007616?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T03:06:24Z","timestamp":1590030384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322309007616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":59,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0006322309007616"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2009.06.008","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}