{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:45:45Z","timestamp":1791027945191,"version":"4.1.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.biopsych.2009.06.025","type":"journal-article","created":{"date-parts":[[2009,8,27]],"date-time":"2009-08-27T04:20:18Z","timestamp":1251346818000},"page":"e15-e17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Bithalamical Deep Brain Stimulation in Tourette Syndrome Is Associated with Reduction in Dopaminergic Transmission"],"prefix":"10.1016","volume":"66","author":[{"given":"Ingo","family":"Vernaleken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Lenartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mardjan","family":"Raptis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Huff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hildegard","family":"Janouschek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Neuner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang M.","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Gr\u00fcnder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Sturm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2009.06.025_bib1","first-page":"1","article-title":"From psychosurgery to neuromodulation: Deep brain stimulation for intractable Tourette syndrome","volume":"11","author":"Neuner","year":"2008","journal-title":"World J Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.06.025_bib2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.nurt.2008.01.009","article-title":"Deep brain stimulation in Tourette's syndrome","volume":"5","author":"Ackermans","year":"2008","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.biopsych.2009.06.025_bib3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00006123-200208000-00044","article-title":"Deep brain stimulation for psychiatric disorders","volume":"51","year":"2002","journal-title":"Neurosurgery"},{"key":"10.1016\/j.biopsych.2009.06.025_bib4","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S0140-6736(98)05964-9","article-title":"Stereotactic treatment of Gilles de la Tourette syndrome by high frequency stimulation of thalamus","volume":"353","author":"Vandewalle","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.biopsych.2009.06.025_bib5","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0887-8994(01)00262-4","article-title":"Basal ganglia dysfunction in Tourette's syndrome: A new hypothesis","volume":"25","author":"Mink","year":"2001","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.biopsych.2009.06.025_bib6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1136\/jnnp.2006.104067","article-title":"Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: The surgery and stimulation","volume":"79","author":"Servello","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2009.06.025_bib7","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.3171\/jns.2003.99.6.1094","article-title":"Chronic bilateral thalamic stimulation: A new therapeutic approach in intractable Tourette syndrome","volume":"99","author":"Visser-Vandewalle","year":"2003","journal-title":"J Neurosurg"},{"key":"10.1016\/j.biopsych.2009.06.025_bib8","first-page":"964","article-title":"Parametric mapping of binding in human brain of D2 receptor ligands of different affinities","volume":"46","author":"Siessmeier","year":"2005","journal-title":"J Nucl Med"},{"key":"10.1016\/j.biopsych.2009.06.025_bib9","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/JCP.0b013e31818ba2f6","article-title":"Striatal and extrastriatal D2\/D3-receptor-binding properties of ziprasidone: A positron emission tomography study with [18F]Fallypride and [11C]raclopride (D2\/D3-receptor occupancy of ziprasidone)","volume":"28","author":"Vernaleken","year":"2008","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.biopsych.2009.06.025_bib10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/syn.20506","article-title":"Small effect of dopamine release and no effect of dopamine depletion on [18F]fallypride binding in healthy humans","volume":"62","author":"Cropley","year":"2008","journal-title":"Synapse"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322309008348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322309008348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:58:10Z","timestamp":1762099090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322309008348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0006322309008348"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2009.06.025","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bithalamical Deep Brain Stimulation in Tourette Syndrome Is Associated with Reduction in Dopaminergic Transmission","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2009.06.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}