{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:43:16Z","timestamp":1793299396233,"version":"4.5.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24MHO79510"],"award-info":[{"award-number":["K24MHO79510"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AG026275"],"award-info":[{"award-number":["P01AG026275"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AG03991"],"award-info":[{"award-number":["P01AG03991"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30NS048056"],"award-info":[{"award-number":["P30NS048056"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30NS06833"],"award-info":[{"award-number":["P30NS06833"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50AG05681"],"award-info":[{"award-number":["P50AG05681"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.biopsych.2009.08.024","type":"journal-article","created":{"date-parts":[[2009,10,15]],"date-time":"2009-10-15T04:17:23Z","timestamp":1255580243000},"page":"584-587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":549,"title":["Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly"],"prefix":"10.1016","volume":"67","author":[{"given":"Yvette I.","family":"Sheline","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus E.","family":"Raichle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham Z.","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Head","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Mintun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2009.08.024_bib1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1073\/pnas.98.2.676","article-title":"A default mode of brain function","volume":"98","author":"Raichle","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2009.08.024_bib2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1212\/01.wnl.0000228230.26044.a4","article-title":"[11C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease","volume":"67","author":"Mintun","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2009.08.024_bib3","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1073\/pnas.0308627101","article-title":"Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI","volume":"101","author":"Greicius","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2009.08.024_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000100","article-title":"Network analysis of intrinsic functional brain connectivity in Alzheimer's disease","volume":"4","author":"Supekar","year":"2008","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.biopsych.2009.08.024_bib5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbr.2008.08.012","article-title":"Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer's disease","volume":"197","author":"Zhang","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.biopsych.2009.08.024_bib6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X","article-title":"Tangles and plaques in nondemented aging and \u201cpreclinical\u201d Alzheimer's disease","volume":"45","author":"Price","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopsych.2009.08.024_bib7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0072-9752(07)01223-7","article-title":"Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer's disease","volume":"89","author":"Selkoe","year":"2008","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.biopsych.2009.08.024_bib8","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1212\/WNL.59.7.1034","article-title":"Rates of progression in mild cognitive impairment and early Alzheimer's disease","volume":"59","author":"Storandt","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2009.08.024_bib9","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1001\/archneur.65.11.1467","article-title":"Alzheimer disease and cognitive reserve: Variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake","volume":"65","author":"Roe","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.biopsych.2009.08.024_bib10","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1152\/jn.00048.2006","article-title":"Coherent spontaneous activity identifies a hippocampal-parietal memory network","volume":"96","author":"Vincent","year":"2006","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.biopsych.2009.08.024_bib11","doi-asserted-by":"crossref","first-page":"10046","DOI":"10.1073\/pnas.0604187103","article-title":"Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems","volume":"103","author":"Fox","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2009.08.024_bib12","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.neuroimage.2005.06.058","article-title":"A Population-Average, Landmark- and Surface-based (PALS) atlas of the human cerebral cortex","volume":"28","author":"Van Essen","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2009.08.024_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuron.2009.07.003","article-title":"Amyloid deposition is associated with impaired default network function in older persons without dementia","volume":"63","author":"Sperling","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2009.08.024_bib14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/cne.10883","article-title":"Macaque monkey retrosplenial cortex","volume":"466","author":"Kobayashi","year":"2003","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.biopsych.2009.08.024_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain's default network: Anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.biopsych.2009.08.024_bib16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2009.08.024_bib17","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X","article-title":"Tangles and plaques in nondemented aging and \u201cpreclinical\u201d Alzheimer's disease","volume":"45","author":"Price","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopsych.2009.08.024_bib18","unstructured":"Morris J, Roe C, Xiong C, Fagan A, Goate A, Holtzman D, Mintun M. (in press): APOE predicts A\u03b2 but not tau Alzheimer's pathology in cognitively normal aging. Ann Neurol."}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322309010324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322309010324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T14:54:09Z","timestamp":1757775249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322309010324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0006322309010324"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2009.08.024","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717952740.793458218","asserted-by":"object"}]},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2009.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}