{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:31:01Z","timestamp":1791354661568,"version":"4.3.1"},"reference-count":65,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA008227"],"award-info":[{"award-number":["DA008227"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.biopsych.2009.08.041","type":"journal-article","created":{"date-parts":[[2009,11,16]],"date-time":"2009-11-16T04:21:58Z","timestamp":1258345318000},"page":"761-769","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Brain Region Specific Actions of Regulator of G Protein Signaling 4 Oppose Morphine Reward and Dependence but Promote Analgesia"],"prefix":"10.1016","volume":"67","author":[{"given":"Ming-Hi","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willam","family":"Renthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Ring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zia","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassi","family":"Psifogeorgou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Howland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari","family":"Birnbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Neve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Nestler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venetia","family":"Zachariou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2009.08.041_bib1","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1074\/jbc.272.7.3871","article-title":"RGS proteins and signaling by heterotrimeric G proteins","volume":"272","author":"Dohlman","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2009.08.041_bib2","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1074\/jbc.273.3.1269","article-title":"Mammalian RGS proteins: Barbarians at the gates","volume":"273","author":"Berman","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2009.08.041_bib3","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1124\/pr.54.3.527","article-title":"Cellular regulation of RGS proteins: Modulators and integrators of G protein signaling","volume":"54","author":"Hollinger","year":"2002","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.biopsych.2009.08.041_bib4","first-page":"300","article-title":"Regulators of G protein signaling and neuropsychiatric disorders","volume":"86","author":"Terzi","year":"2009","journal-title":"Prog Mol Biol Translational Scienc"},{"key":"10.1016\/j.biopsych.2009.08.041_bib5","doi-asserted-by":"crossref","first-page":"8024","DOI":"10.1523\/JNEUROSCI.17-20-08024.1997","article-title":"Regulators of G-protein signaling (RGS) proteins: Region-specific expression of nine subtypes in rat brain","volume":"17","author":"Gold","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.08.041_bib6","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/35000601","article-title":"Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1","volume":"403","author":"Chen","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2009.08.041_bib7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature02170","article-title":"Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation","volume":"427","author":"Nishiguchi","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2009.08.041_bib8","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0896-6273(03)00321-0","article-title":"RGS9 modulates dopamine signaling in the basal ganglia","volume":"38","author":"Rahman","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2009.08.041_bib9","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1523\/JNEUROSCI.5112-06.2007","article-title":"Allelic variation in RGS4 impacts functional and structural connectivity in the human brain","volume":"27","author":"Buckholtz","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.08.041_bib10","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0006-3223(01)01234-3","article-title":"Elevated levels of \u0394FosB and RGS9 in striatum in Parkinson's disease","volume":"50","author":"Tekumalla","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.08.041_bib11","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1046\/j.1460-9568.2003.02529.x","article-title":"Regulation of RGS proteins by chronic morphine in rat locus coeruleus","volume":"17","author":"Gold","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2009.08.041_bib12","doi-asserted-by":"crossref","first-page":"13656","DOI":"10.1073\/pnas.2232594100","article-title":"Essential role for RGS9 in opiate action","volume":"100","author":"Zachariou","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2009.08.041_bib13","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.biopsych.2006.04.028","article-title":"Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4)","volume":"60","author":"Levitt","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.08.041_bib14","doi-asserted-by":"crossref","first-page":"34687","DOI":"10.1074\/jbc.273.52.34687","article-title":"The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling","volume":"273","author":"Zeng","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2009.08.041_bib15","doi-asserted-by":"crossref","first-page":"22931","DOI":"10.1074\/jbc.M001605200","article-title":"RGS4 is arginylated and degraded by the N-end rule pathway in vitro","volume":"275","author":"Davydov","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2009.08.041_bib16","doi-asserted-by":"crossref","first-page":"15030","DOI":"10.1073\/pnas.0507533102","article-title":"RGS4 and RGS5 proteins are in vivo substrates of the N-end rule pathway","volume":"102","author":"Lee","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2009.08.041_bib17","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/sj.mp.4000866","article-title":"Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia","volume":"6","author":"Mirnics","year":"2001","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.08.041_bib18","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/syn.20265","article-title":"Regional alterations in RGS4 protein in schizophrenia","volume":"59","author":"Erdely","year":"2006","journal-title":"Synapse"},{"key":"10.1016\/j.biopsych.2009.08.041_bib19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.schres.2006.09.003","article-title":"Altered expression of regulator of G-protein signalling 4 (RGS4) mRNA in the superior temporal gyrus in schizophrenia","volume":"89","author":"Bowden","year":"2007","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2009.08.041_bib20","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.biopsych.2008.10.026","article-title":"Expression of RGS4 Splice variants in dorsolateral prefrontal cortex of Schizophrenic and bipolar disorder patients","volume":"65","author":"Ding","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.08.041_bib21","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1124\/mol.106.032490","article-title":"RGS4 modulates serotonin signaling in prefrontal cortex and links to serotonin dysfunction in a rat model of schizophrenia","volume":"71","author":"Gu","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.biopsych.2009.08.041_bib22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.biopsych.2007.04.018","article-title":"Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia","volume":"63","author":"Campbell","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.08.041_bib23","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/nn1700","article-title":"RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion","volume":"9","author":"Ding","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2009.08.041_bib24","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1046\/j.1471-4159.2003.01610.x","article-title":"Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: Clues for RGS2 and RGS4 functions","volume":"84","author":"Taymans","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopsych.2009.08.041_bib25","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1111\/j.0953-816X.2004.03336.x","article-title":"Dopamine receptor mediated regulation of RGS2 and RGS4 mRNA differentially depends on ascending dopamine projections and time","volume":"19","author":"Taymans","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2009.08.041_bib26","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1523\/JNEUROSCI.19-10-03674.1999","article-title":"Region-specific regulation of RGS4 (regulator of G protein signalling type 4) in brain by stress and glucocorticoids: In vivo and in vitro studies","volume":"19","author":"Ni","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.08.041_bib27","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1006\/nbdi.2002.0518","article-title":"Abused drugs modulate RGS4 mRNA levels in rat brain: Comparison between acute drug treatment and a drug challenge after chronic treatment","volume":"10","author":"Bishop","year":"2002","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.biopsych.2009.08.041_bib28","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1111\/j.1471-4159.2006.03669.x","article-title":"Acute amphetamine downregulates RGS4 mRNA and protein expression in rat forebrain: Distinct roles of D1 and D2 dopamine receptors","volume":"96","author":"Schwendt","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopsych.2009.08.041_bib29","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1523\/JNEUROSCI.2840-04.2005","article-title":"D2 dopamine receptors colocalize regulator of G protein signalling 9\u20132 via the RGS9 DEP domain, and RGS9 knockout mice develop dyskinesias associated with dopamine pathways","volume":"23","author":"Kovoor","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.08.041_bib30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1124\/mi.5.1.7","article-title":"Regulators of G protein signaling and drugs of abuse","volume":"5","author":"Traynor","year":"2005","journal-title":"Mol Interv"},{"key":"10.1016\/j.biopsych.2009.08.041_bib31","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1471-4159.2007.04812.x","article-title":"RGS9-2 is a negative modulator of mu opioid receptor function","volume":"103","author":"Psifogeorgou","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopsych.2009.08.041_bib32","doi-asserted-by":"crossref","first-page":"14338","DOI":"10.1523\/JNEUROSCI.4223-07.2007","article-title":"RGS9-2 negatively modulates L-3,4-dihydroxyphenylalanine-induced dyskinesia in experimental Parkinson's disease","volume":"52","author":"Gold","year":"2007","journal-title":"J Neurosci"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2009.08.041_bib33","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuropharm.2004.06.016","article-title":"Secrets of the opium poppy revealed","volume":"47","author":"Evans","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopsych.2009.08.041_bib34","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.conb.2004.05.005","article-title":"Mu opioid receptor: A gateway to drug addiction","volume":"14","author":"Contet","year":"2004","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.biopsych.2009.08.041_bib35","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0896-6273(00)80557-7","article-title":"Neuroscience of addiction","volume":"21","author":"Koob","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2009.08.041_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1749-6632.2001.tb03557.x","article-title":"Drug addictions","volume":"937","author":"Kreek","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.biopsych.2009.08.041_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/35053570","article-title":"Molecular basis of long-term plasticity underlying addiction","volume":"2","author":"Nestler","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2009.08.041_bib38","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1126\/science.1120972","article-title":"Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress","volume":"311","author":"Berton","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2009.08.041_bib39","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1038\/nm964","article-title":"Local gene knockdown in the brain using viral-mediated RNA interference","volume":"12","author":"Hommel","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2009.08.041_bib40","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nn1636","article-title":"An essential role for DeltaFosB in the nucleus accumbens in morphine action","volume":"9","author":"Zachariou","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2009.08.041_bib41","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.neuron.2007.09.032","article-title":"Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli","volume":"56","author":"Renthal","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2009.08.041_bib42","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neuron.2008.02.006","article-title":"Multiple actions of spinophilin modulate mu opioid receptor function","volume":"58","author":"Charlton","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2009.08.041_bib43","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.1523\/JNEUROSCI.4701-05.2006","article-title":"Role of cAMP response element-binding protein in the rat locus coeruleus: Regulation of neuronal activity and opiate withdrawal behaviors","volume":"26","author":"Han","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.08.041_bib44","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0006-8993(95)00545-2","article-title":"Long-term glutamate desensitization in locus coeruleus neurons and its role in opiate withdrawal","volume":"14","author":"Kogan","year":"1995","journal-title":"Brain Res"},{"key":"10.1016\/j.biopsych.2009.08.041_bib45","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0306-4522(96)00485-X","article-title":"Carbon dioxide regulates the tonic activity of locus coeruleus neurons by modulating a proton- and polyamine-sensitive inward rectifier potassium current","volume":"77","author":"Pineda","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2009.08.041_bib46","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1152\/physrev.2001.81.1.299","article-title":"Cellular and synaptic adaptations mediating opioid dependence","volume":"81","author":"Williams","year":"2001","journal-title":"Physiol Rev"},{"key":"10.1016\/j.biopsych.2009.08.041_bib47","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0006-8993(97)00682-3","article-title":"Local opiate withdrawal in locus coeruleus in vivo","volume":"765","author":"Aston-Jones","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.biopsych.2009.08.041_bib48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.278.5335.58","article-title":"Molecular and cellular basis of addiction","volume":"278","author":"Nestler","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2009.08.041_bib49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF02431544","article-title":"Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal","volume":"96","author":"Taylor","year":"1998","journal-title":"Psychopharmocology (Berl)"},{"key":"10.1016\/j.biopsych.2009.08.041_bib50","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-2999(92)90261-2","article-title":"Elevated basal firing rates and enhanced responses to 8-Br-cAMP in locus coeruleus neurons in brain slices from opiate-dependent rats","volume":"211","author":"Kogan","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.biopsych.2009.08.041_bib51","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0006-8993(93)91364-X","article-title":"Destruction of the locus coeruleus decreases physical signs of opiate withdrawal","volume":"605","author":"Maldonado","year":"1993","journal-title":"Brain Res"},{"key":"10.1016\/j.biopsych.2009.08.041_bib52","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cellsig.2005.07.003","article-title":"Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- and delta-opioid receptors regulate opioid receptor signaling","volume":"18","author":"Georgoussi","year":"2006","journal-title":"Cell Signal"},{"key":"10.1016\/j.biopsych.2009.08.041_bib53","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.1523\/JNEUROSCI.0062-05.2005","article-title":"Regulation of gene expression by chronic morphine and morphine withdrawal in the locus coeruleus and ventral tegmental area","volume":"25","author":"McClung","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.08.041_bib54","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.biopsych.2007.11.021","article-title":"Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: Behavioral, electrophysiological, and molecular studies","volume":"63","author":"Zachariou","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.08.041_bib55","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0022-3565(25)22179-6","article-title":"Acute and chronic opiate-regulation of adenylate cyclase in brain: Specific effects in locus coeruleus","volume":"246","author":"Duman","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.biopsych.2009.08.041_bib56","doi-asserted-by":"crossref","first-page":"7890","DOI":"10.1523\/JNEUROSCI.17-20-07890.1997","article-title":"CREB in the locus coeruleus: Biochemical, physiological, and behavioral evidence for a role in opiate dependence","volume":"17","author":"Lane-Ladd","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2009.08.041_bib57","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1126\/science.1962211","article-title":"Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits","volume":"254","author":"Tang","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2009.08.041_bib58","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1128\/MCB.25.10.4221-4228.2005","article-title":"Generation and characterization of RGS4 mutant mice","volume":"25","author":"Grillet","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.biopsych.2009.08.041_bib59","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1074\/jbc.274.6.3549","article-title":"RGS proteins determine signaling specificity of Gq-coupled receptors","volume":"274","author":"Xu","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2009.08.041_bib60","doi-asserted-by":"crossref","first-page":"6159","DOI":"10.1073\/pnas.94.12.6159","article-title":"Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells","volume":"94","author":"Huang","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2009.08.041_bib61","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1126\/science.1118890","article-title":"Snapshot of activated G proteins at the membrane: The Galphaq-GRK2-Gbetagamma complex","volume":"310","author":"Tesmer","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2009.08.041_bib62","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1046\/j.1471-4159.1998.70052203.x","article-title":"Differential coupling of mu, delta and kappa opioid receptors to Ga16 mediated coupling of phospholipase C","volume":"70","author":"Lee","year":"1998","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopsych.2009.08.041_bib63","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0169-328X(02)00656-3","article-title":"The mu opioid agonist DAMGO, stimulates cAMP production in SK-N\u2013SH cells through a PLC-PKC-Ca++ pathway","volume":"110","author":"Rubovitch","year":"2003","journal-title":"Mol Brain Res"},{"key":"10.1016\/j.biopsych.2009.08.041_bib64","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejphar.2007.03.005","article-title":"Regulator of G protein signaling proteins differentially modulate signaling of mu and delta opioid receptors","volume":"565","author":"Xie","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.biopsych.2009.08.041_bib65","doi-asserted-by":"crossref","first-page":"E587","DOI":"10.1208\/aapsj070360","article-title":"Mu opioid receptor regulation and opiate responsiveness","volume":"7","author":"Raehal","year":"2005","journal-title":"AAPS J"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000632230901155X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000632230901155X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:58:30Z","timestamp":1762099110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000632230901155X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":65,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S000632230901155X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2009.08.041","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain Region Specific Actions of Regulator of G Protein Signaling 4 Oppose Morphine Reward and Dependence but Promote Analgesia","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2009.08.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}