{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:13:45Z","timestamp":1789928025572,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.biopsych.2009.09.008","type":"journal-article","created":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T09:11:24Z","timestamp":1257066684000},"page":"672-678","source":"Crossref","is-referenced-by-count":85,"title":["A Computational Model for Cerebral Cortical Dysfunction in Autism Spectrum Disorders"],"prefix":"10.1016","volume":"67","author":[{"given":"Shashaank","family":"Vattikuti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carson C.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2009.09.008_bib1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1034\/j.1601-183X.2003.00037.x","article-title":"Model of autism: Increased ratio of excitation\/inhibition in key neural systems","volume":"2","author":"Rubenstein","year":"2003","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.biopsych.2009.09.008_bib2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1023\/A:1010715619091","article-title":"Suppressed GABAergic inhibition as a common factor in suspected etiologies of autism","volume":"31","author":"Hussman","year":"2001","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.biopsych.2009.09.008_bib3","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1177\/1073858403253552","article-title":"Disruption in the inhibitory architecture of the cell minicolumn: Implications for autism","volume":"9","author":"Casanova","year":"2003","journal-title":"Neuroscientist"},{"key":"10.1016\/j.biopsych.2009.09.008_bib4","series-title":"Capute and Accardo's Neurodevelopmental Disablities in Infancy and Childhood","author":"Accardo","year":"2008"},{"key":"10.1016\/j.biopsych.2009.09.008_bib5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1192\/bjp.176.4.357","article-title":"Catatonia in autistic spectrum disorders","volume":"176","author":"Wing","year":"2000","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.biopsych.2009.09.008_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10803-008-0646-7","article-title":"GABA(A) receptor downregulation in brains of subjects with autism","volume":"39","author":"Fatemi","year":"2009","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.biopsych.2009.09.008_bib7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nrg2346","article-title":"Advances in autism genetics: On the threshold of a new neurobiology","volume":"9","author":"Abrahams","year":"2008","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.biopsych.2009.09.008_bib8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1101\/sqb.2007.72.020","article-title":"The possible interplay of synaptic and clock genes in autism spectrum disorders","volume":"72","author":"Bourgeron","year":"2007","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"10.1016\/j.biopsych.2009.09.008_bib9","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1152\/jn.90752.2008","article-title":"Imbalance of neocortical excitation and inhibition and altered up states reflect network hyperexcitability in the mouse model of fragile x syndrome","volume":"100","author":"Gibson","year":"2008","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.biopsych.2009.09.008_bib10","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1093\/cercor\/bhn159","article-title":"Downregulation of tonic GABAergic inhibition in a mouse model of fragile x syndrome","volume":"19","author":"Curia","year":"2009","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2009.09.008_bib11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00401-006-0085-5","article-title":"Minicolumnar abnormalities in autism","volume":"112","author":"Casanova","year":"2006","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.biopsych.2009.09.008_bib12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1017\/S0022215100105286","article-title":"Oculomotor findings in autistic children","volume":"102","author":"Rosenhall","year":"1988","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.biopsych.2009.09.008_bib13","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1136\/jnnp.2003.022491","article-title":"Oculomotor abnormalities parallel cerebellar histopathology in autism","volume":"75","author":"Takarae","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2009.09.008_bib14","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1093\/brain\/awh307","article-title":"Pursuit eye movement deficits in autism","volume":"127","author":"Takarae","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2009.09.008_bib15","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.biopsych.2006.02.030","article-title":"Maturation of executive function in autism","volume":"61","author":"Luna","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.09.008_bib16","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1093\/brain\/115.5.1387","article-title":"Saccadic dysmetria in a patient with a right frontoparietal lesion","volume":"115","author":"Duhamel","year":"1992","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2009.09.008_bib17","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1196\/annals.1325.018","article-title":"Role of the posterior parietal cortex in the initiation of saccades and vergence: Right\/left functional asymmetry","volume":"1039","author":"Kapoula","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.biopsych.2009.09.008_bib18","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1152\/jn.1991.66.3.1109","article-title":"Saccade related activity in the lateral intraparietal area","volume":"66","author":"Barash","year":"1991","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.biopsych.2009.09.008_bib19","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1152\/jn.1996.76.3.1457","article-title":"Motor intention activity in the macaque's lateral intraparietal area","volume":"76","author":"Bracewell","year":"1996","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.biopsych.2009.09.008_bib20","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1152\/jn.2000.83.3.1550","article-title":"Inactivation of parietal and prefrontal cortex reveals interdependence of neural activity during memory-guided saccades","volume":"83","author":"Chafee","year":"2000","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.biopsych.2009.09.008_bib21","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s00221-001-0954-z","article-title":"Ocular fixation and visual activity in the monkey lateral intraparietal area","volume":"142","author":"Ben Hamed","year":"2002","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.biopsych.2009.09.008_bib22","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.tics.2008.09.003","article-title":"Trans-saccadic perception","volume":"12","author":"Melcher","year":"2008","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.biopsych.2009.09.008_bib23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1152\/jn.00400.2007","article-title":"Direction selectivity of neurons in the macaque lateral intraparietal area","volume":"101","author":"Fanini","year":"2009","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.biopsych.2009.09.008_bib24","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1162\/089976601750264974","article-title":"Stationary bumps in networks of spiking neurons","volume":"13","author":"Laing","year":"2001","journal-title":"Neural Comput"},{"key":"10.1016\/j.biopsych.2009.09.008_bib25","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/cercor\/10.9.910","article-title":"Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical networked model","volume":"10","author":"Compte","year":"2000","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2009.09.008_bib26","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.1055\/s-2006-931501","article-title":"Toward a prefrontal microcircuit model of cognitive deficits in schizophrenia","volume":"39","author":"Wang","year":"2006","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.biopsych.2009.09.008_bib27","doi-asserted-by":"crossref","first-page":"i16","DOI":"10.1093\/cercor\/bhm103","article-title":"Cannabinoid-mediated disinhibition and working memory: Dynamical interplay of multiple feedback mechanisms in a continuous attractor model of prefrontal cortex","volume":"17","author":"Carter","year":"2007","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2009.09.008_bib28","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.1073\/pnas.0901894106","article-title":"Mechanism for top-down control of working memory capacity","volume":"106","author":"Edin","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2009.09.008_bib29","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.neuron.2007.10.017","article-title":"Mapping the matrix: The ways of neocortex","volume":"56","author":"Douglas","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2009.09.008_bib30","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1152\/jn.1995.74.6.2744","article-title":"Acute activation and inactivation of macaque frontal eye field with GABA-related drugs","volume":"74","author":"Dias","year":"1995","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.biopsych.2009.09.008_bib31","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1137\/060654347","article-title":"Existence and wandering of bumps in a spiking neural network model","volume":"5","author":"Chow","year":"2006","journal-title":"SIAM Journal on Applied Dynamical Systems"},{"key":"10.1016\/j.biopsych.2009.09.008_bib32","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.biopsych.2009.01.008","article-title":"Lateralized response timing deficits in autism","volume":"66","author":"D'Cruz","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.09.008_bib33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.pscychresns.2007.03.008","article-title":"Atypical involvement of frontostriatal systems during sensorimotor control in autism","volume":"156","author":"Takarae","year":"2007","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.biopsych.2009.09.008_bib34","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1469-7610.2008.02051.x","article-title":"Visual orienting in the early broader autism phenotype: Disengagement and facilitation","volume":"50","author":"Elsabbagh","year":"2009","journal-title":"J Child Psychol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.09.008_bib35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF02244431","article-title":"Pharmacology of saccadic eye movements in man: 1","volume":"105","author":"Ball","year":"1991","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2009.09.008_bib36","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.bandc.2008.08.026","article-title":"Pharmacological treatment effects on eye movement control","volume":"68","author":"Reilly","year":"2008","journal-title":"Brain Cogn"},{"key":"10.1016\/j.biopsych.2009.09.008_bib37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1023\/A:1011204814320","article-title":"Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition","volume":"11","author":"Brunel","year":"2000","journal-title":"J Comput Neurosci"},{"key":"10.1016\/j.biopsych.2009.09.008_bib38","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1176\/jnp.2007.19.4.406","article-title":"Review of adjunctive glutamate antagonist therapy in the treatment of catatonic syndromes","volume":"19","author":"Carroll","year":"2007","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.1016\/j.biopsych.2009.09.008_bib39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0074-7742(05)72014-6","article-title":"Catatonia in autistic spectrum disorders: A medical treatment algorithm","volume":"72","author":"Fink","year":"2006","journal-title":"Int Rev Neurobiol"},{"key":"10.1016\/j.biopsych.2009.09.008_bib40","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1136\/jnnp.67.4.445","article-title":"Decreased density of GABA-A receptors in the left sensorimotor cortex in akinetic catatonia: Investigation of in vivo benzodiazepine receptor binding","volume":"67","author":"Northoff","year":"1999","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2009.09.008_bib41","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0006-3223(00)01004-0","article-title":"Atypical patterns of cerebral motor activation in autism: A functional magnetic resonance study","volume":"49","author":"Muller","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.09.008_bib42","doi-asserted-by":"crossref","first-page":"8275","DOI":"10.1073\/pnas.0600674103","article-title":"Failing to deactivate: Resting functional abnormalities in autism","volume":"103","author":"Kennedy","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2009.09.008_bib43","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1212\/WNL.52.5.917","article-title":"Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism","volume":"52","author":"Minshew","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2009.09.008_bib44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.psychres.2005.07.005","article-title":"Oculomotor studies of cerebellar function in autism","volume":"137","author":"Nowinski","year":"2005","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.biopsych.2009.09.008_bib45","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1750-3639.2007.00100.x","article-title":"The neuropathology of autism","volume":"17","author":"Casanova","year":"2007","journal-title":"Brain Pathol"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322309010877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322309010877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T14:48:11Z","timestamp":1558622891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322309010877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0006322309010877"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2009.09.008","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}