{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T07:29:21Z","timestamp":1770017361314,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Tourette's Syndrome Association"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.biopsych.2009.09.034","type":"journal-article","created":{"date-parts":[[2009,12,16]],"date-time":"2009-12-16T10:11:57Z","timestamp":1260958317000},"page":"679-683","source":"Crossref","is-referenced-by-count":37,"title":["Children with Tourette's Syndrome May Suffer Immunoglobulin A Dysgammaglobulinemia: Preliminary Report"],"prefix":"10.1016","volume":"67","author":[{"given":"Ivana","family":"Kawikova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart P.X.","family":"Grady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Tobiasova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristo","family":"Vojdani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliya","family":"Katsovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Richmand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred L.M.","family":"Bothwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Leckman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2009.09.034_bib1","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/sj.mp.4001542","article-title":"PANDAS: Current status and directions for research","volume":"9","author":"Snider","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.09.034_bib2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/adc.2003.031880","article-title":"Anti-basal ganglia antibodies: A possible diagnostic utility in idiopathic movement disorders?","volume":"89","author":"Church","year":"2004","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.biopsych.2009.09.034_bib3","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm892","article-title":"Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea","volume":"9","author":"Kirvan","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2009.09.034_bib4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jneuroim.2005.10.014","article-title":"Neuronal surface glycolytic enzymes are autoantigen targets in post-streptococcal autoimmune CNS disease","volume":"172","author":"Dale","year":"2006","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.biopsych.2009.09.034_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jneuroim.2006.08.007","article-title":"Identification of pyruvate kinase as an antigen associated with Tourette's syndrome","volume":"181","author":"Kansy","year":"2006","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.biopsych.2009.09.034_bib6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jneuroim.2006.06.017","article-title":"Antibody-mediated neuronal cell signaling in behavior and movement disorders","volume":"179","author":"Kirvan","year":"2006","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.biopsych.2009.09.034_bib7","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.biopsych.2004.12.004","article-title":"Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette's syndrome","volume":"57","author":"Leckman","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.09.034_bib8","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/j.1468-1331.2008.02159.x","article-title":"Immunophenotyping in Tourette's syndrome\u2014A pilot study","volume":"15","author":"Moller","year":"2008","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.biopsych.2009.09.034_bib9","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/ajmg.b.30550","article-title":"A subgroup of Tourette's patients overexpress specific natural killer cell genes in blood: A preliminary report","volume":"144B","author":"Lit","year":"2007","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.biopsych.2009.09.034_bib10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.biopsych.2006.06.012","article-title":"Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with Tourette's syndrome: A preliminary study","volume":"61","author":"Kawikova","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.09.034_bib11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1542\/peds.2004-2058","article-title":"Association between streptococcal infection and obsessive-compulsive disorder, Tourette's syndrome, and tic disorder","volume":"116","author":"Mell","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.biopsych.2009.09.034_bib12","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1097\/CHI.0b013e3181825a3d","article-title":"Neuropsychiatric disorders associated with streptococcal infection: A Case-control study among privately insured children","volume":"47","author":"Leslie","year":"2008","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.biopsych.2009.09.034_bib13","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1177\/08830738060210080501","article-title":"Neuroimaging of Tourette's syndrome","volume":"21","author":"Frey","year":"2006","journal-title":"J Child Neurol"},{"key":"10.1016\/j.biopsych.2009.09.034_bib14","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0165-5728(02)00180-7","article-title":"Antibodies to neuron-specific antigens in children with autism: Possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A","volume":"129","author":"Vojdani","year":"2002","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.biopsych.2009.09.034_bib15","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1176\/ajp.155.2.264","article-title":"Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: Clinical description of the first 50 cases","volume":"155","author":"Swedo","year":"1998","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2009.09.034_bib16","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/path.1877","article-title":"The function of immunoglobulin A in immunity","volume":"208","author":"Woof","year":"2006","journal-title":"J Pathol"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2009.09.034_bib17","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1007\/s10875-007-9163-2","article-title":"Autoimmunity in IgA deficiency: Revisiting the role of IgA as a silent housekeeper","volume":"28","author":"Jacob","year":"2008","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.biopsych.2009.09.034_bib18","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1073\/pnas.84.8.2449","article-title":"IgA antibody-producing cells in peripheral blood after antigen ingestion: Evidence for a common mucosal immune system in humans","volume":"84","author":"Czerkinsky","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2009.09.034_bib19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/BF00918659","article-title":"Immunoglobulin levels in saliva in individuals with selective IgA deficiency: Compensatory IgM secretion and its correlation with HLA and susceptibility to infections","volume":"9","author":"Norhagen","year":"1989","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.biopsych.2009.09.034_bib20","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1097\/00004583-199712000-00006","article-title":"Immunology of TS\/OCD","volume":"36","author":"Hansen","year":"1997","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.biopsych.2009.09.034_bib21","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1182\/blood.V83.5.1278.1278","article-title":"Human serum IgA downregulates the release of inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6) in human monocytes","volume":"83","author":"Wolf","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.biopsych.2009.09.034_bib22","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.4049\/jimmunol.152.4.2051","article-title":"Superantigen modulation of experimental allergic encephalomyelitis: Activation of anergy determines outcome","volume":"152","author":"Racke","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.biopsych.2009.09.034_bib23","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1084\/jem.170.3.1039","article-title":"Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes","volume":"170","author":"Coffman","year":"1989","journal-title":"J Exp Med"},{"key":"10.1016\/j.biopsych.2009.09.034_bib24","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.1169152","article-title":"Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches","volume":"323","author":"Tsuji","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2009.09.034_bib25","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1176\/appi.ajp.158.4.605","article-title":"Elevated D8\/17 expression on B lymphocytes, a marker of rheumatic fever, measured with flow cytometry in tic disorder patients","volume":"158","author":"Hoekstra","year":"2001","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2009.09.034_bib26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.psychres.2004.04.009","article-title":"Mycoplasma pneumoniae infection and Tourette's syndrome","volume":"129","author":"Muller","year":"2004","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.biopsych.2009.09.034_bib27","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s10803-007-0400-6","article-title":"Are there enhanced MBP autoantibodies in autism?","volume":"38","author":"Libbey","year":"2008","journal-title":"J Autism Dev Disord"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322309012347?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322309012347?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T22:33:37Z","timestamp":1685226817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322309012347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0006322309012347"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2009.09.034","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}