{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:09:28Z","timestamp":1791266968716,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH64824"],"award-info":[{"award-number":["MH64824"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.biopsych.2010.08.034","type":"journal-article","created":{"date-parts":[[2010,10,30]],"date-time":"2010-10-30T04:20:59Z","timestamp":1288412459000},"page":"1156-1162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Parent-of-Origin of the Extra X Chromosome May Differentially Affect Psychopathology in Klinefelter Syndrome"],"prefix":"10.1016","volume":"68","author":[{"given":"Hilgo","family":"Bruining","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"van Rijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Swaab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Giltay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Kates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martien J.H.","family":"Kas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"van Engeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"de Sonneville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2010.08.034_bib1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/1098-2779(2000)6:2<107::AID-MRDD4>3.0.CO;2-2","article-title":"Neurobehavioral phenotype of Klinefelter syndrome","volume":"6","author":"Geschwind","year":"2000","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"10.1016\/j.biopsych.2010.08.034_bib2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0140-6736(04)16678-6","article-title":"Klinefelter's syndrome","volume":"364","author":"Lanfranco","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.biopsych.2010.08.034_bib3","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1210\/jc.2002-021491","article-title":"Prenatal and postnatal prevalence of Klinefelter syndrome: A national registry study","volume":"88","author":"Bojesen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.biopsych.2010.08.034_bib4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.ejhg.5201956","article-title":"Is the prevalence of Klinefelter syndrome increasing?","volume":"16","author":"Morris","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.biopsych.2010.08.034_bib5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF01213097","article-title":"Chromosome abnormalities found among 34,910 newborn children: Results from a 13-year incidence study in Arhus, Denmark","volume":"87","author":"Nielsen","year":"1991","journal-title":"Hum Genet"},{"key":"10.1016\/j.biopsych.2010.08.034_bib6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/1096-8628(20010101)98:1<25::AID-AJMG1015>3.0.CO;2-X","article-title":"Evidence of skewed X-chromosome inactivation in 47,XXY and 48,XXYY Klinefelter patients","volume":"98","author":"Iitsuka","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2010.08.034_bib7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1399-0004.2006.00635.x","article-title":"Is there an influence of X-chromosomal imprinting on the phenotype in Klinefelter syndrome?","volume":"70","author":"Stemkens","year":"2006","journal-title":"Clin Genet"},{"key":"10.1016\/j.biopsych.2010.08.034_bib8","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/molehr\/gaq019","article-title":"Novel genetic aspects of Klinefelter's syndrome","volume":"16","author":"Tuttelmann","year":"2010","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.biopsych.2010.08.034_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1469-1809.1988.tb01084.x","article-title":"Klinefelter's syndrome: an analysis of the origin of the additional sex chromosome using molecular probes","volume":"52","author":"Jacobs","year":"1988","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.biopsych.2010.08.034_bib10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/humupd\/dmg028","article-title":"Aberrant recombination and the origin of Klinefelter syndrome","volume":"9","author":"Thomas","year":"2003","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.biopsych.2010.08.034_bib11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrn2754","article-title":"Sex differences in molecular neuroscience: from fruit flies to humans","volume":"11","author":"Jazin","year":"2010","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2010.08.034_bib12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.brainres.2006.08.053","article-title":"High expression of the mammalian X chromosome in brain","volume":"1126","author":"Nguyen","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.biopsych.2010.08.034_bib13","doi-asserted-by":"crossref","first-page":"R27","DOI":"10.1093\/hmg\/ddi112","article-title":"X-linked genes and mental functioning","volume":"14","author":"Skuse","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2010.08.034_bib14","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/ddrr.83","article-title":"The cognitive phenotype in Klinefelter syndrome: A review of the literature including genetic and hormonal factors","volume":"15","author":"Boada","year":"2009","journal-title":"Dev Disabil Resour Rev"},{"key":"10.1016\/j.biopsych.2010.08.034_bib15","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/ddrr.76","article-title":"Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY","volume":"15","author":"Visootsak","year":"2009","journal-title":"Dev Disabil Resour Rev"},{"key":"10.1016\/j.biopsych.2010.08.034_bib16","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1210\/jc.2005-0697","article-title":"Morbidity in Klinefelter syndrome: A Danish register study based on hospital discharge diagnoses","volume":"91","author":"Bojesen","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.biopsych.2010.08.034_bib17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.schres.2007.03.015","article-title":"Psychiatric morbidity and X-chromosomal origin in a Klinefelter sample","volume":"93","author":"Boks","year":"2007","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2010.08.034_bib18","doi-asserted-by":"crossref","first-page":"e865","DOI":"10.1542\/peds.2008-1954","article-title":"Psychiatric characteristics in a self-selected sample of boys with Klinefelter syndrome","volume":"123","author":"Bruining","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.biopsych.2010.08.034_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/ajmg.b.30163","article-title":"Klinefelter's syndrome (XXY) as a genetic model for psychotic disorders","volume":"135B","author":"DeLisi","year":"2005","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.biopsych.2010.08.034_bib20","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/schbul\/20.3.495","article-title":"Schizophrenia and sex chromosome anomalies","volume":"20","author":"DeLisi","year":"1994","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.biopsych.2010.08.034_bib21","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1192\/bjp.bp.105.008961","article-title":"Klinefelter's syndrome (karyotype 47,XXY) and schizophrenia-spectrum pathology","volume":"189","author":"van Rijn","year":"2006","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.biopsych.2010.08.034_bib22","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1007\/s10803-008-0542-1","article-title":"Social behavior and autism traits in a sex chromosomal disorder: Klinefelter (47XXY) syndrome","volume":"38","author":"van Rijn","year":"2008","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.biopsych.2010.08.034_bib23","doi-asserted-by":"crossref","first-page":"R138","DOI":"10.1093\/hmg\/ddl213","article-title":"Epigenetics of autism spectrum disorders","volume":"15","author":"Schanen","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2010.08.034_bib24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00041444-200512000-00006","article-title":"Autism spectrum disorders in Prader-Willi and Angelman syndromes: A systematic review","volume":"15","author":"Veltman","year":"2005","journal-title":"Psychiatr Genet"},{"key":"10.1016\/j.biopsych.2010.08.034_bib25","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/j.1420-9101.2006.01091.x","article-title":"Imbalanced genomic imprinting in brain development: an evolutionary basis for the aetiology of autism","volume":"19","author":"Badcock","year":"2006","journal-title":"J Evol Biol"},{"key":"10.1016\/j.biopsych.2010.08.034_bib26","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1469-185X.2008.00050.x","article-title":"Genomic imprinting in the development and evolution of psychotic spectrum conditions","volume":"83","author":"Crespi","year":"2008","journal-title":"Biol Rev Camb Philos Soc"},{"key":"10.1016\/j.biopsych.2010.08.034_bib27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1017\/S0140525X08004214","article-title":"Psychosis and autism as diametrical disorders of the social brain","volume":"31","author":"Crespi","year":"2008","journal-title":"Behav Brain Sci"},{"key":"10.1016\/j.biopsych.2010.08.034_bib28","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/42706","article-title":"Evidence from Turner's syndrome of an imprinted X-linked locus affecting cognitive function","volume":"387","author":"Skuse","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2010.08.034_bib29","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/ajmg.a.32232","article-title":"Cognitive and motor development during childhood in boys with Klinefelter syndrome","volume":"146A","author":"Ross","year":"2008","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.biopsych.2010.08.034_bib30","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jpeds.2007.10.019","article-title":"Effect of ascertainment and genetic features on the phenotype of Klinefelter syndrome","volume":"152","author":"Zeger","year":"2008","journal-title":"J Pediatr"},{"key":"10.1016\/j.biopsych.2010.08.034_bib31","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.1210\/jc.2005-0432","article-title":"Androgen receptor CAGn repeat length influences phenotype of 47 Klinefelter: XXY syndrome","volume":"90","author":"Zinn","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.biopsych.2010.08.034_bib32","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1002\/ajmg.a.32012","article-title":"Comparing phenotypes in patients with idiopathic autism to patients with velocardiofacial syndrome (22q11 DS) with and without autism","volume":"143A","author":"Kates","year":"2007","journal-title":"Am J Med Genet A"},{"issue":"suppl 20","key":"10.1016\/j.biopsych.2010.08.034_bib33","first-page":"22","article-title":"The mini-international neuropsychiatric interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.biopsych.2010.08.034_bib34","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/BF02172145","article-title":"Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders","volume":"24","author":"Lord","year":"1994","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.biopsych.2010.08.034_bib35","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1176\/ajp.2006.163.12.2148","article-title":"5-HTTLPR genotype-specific phenotype in children and adolescents with autism","volume":"163","author":"Brune","year":"2006","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2010.08.034_bib36","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/schbul\/17.4.555","article-title":"The SPQ: A scale for the assessment of schizotypal personality based on DSM-III-R criteria","volume":"17","author":"Raine","year":"1991","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.biopsych.2010.08.034_bib37","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/oxfordjournals.schbul.a033478","article-title":"The multidimensionality of self-report schizotypy in a psychiatric population: An analysis using multidimensional Rasch models","volume":"26","author":"Vollema","year":"2000","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.biopsych.2010.08.034_bib38","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/oxfordjournals.schbul.a006946","article-title":"Neurocognitive correlates of schizotypy in first degree relatives of schizophrenia patients","volume":"28","author":"Vollema","year":"2002","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.biopsych.2010.08.034_bib39","series-title":"Applied Multivariate Statistics for the Social Sciences","author":"Stevens","year":"1986"},{"key":"10.1016\/j.biopsych.2010.08.034_bib40","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature03479","article-title":"X-inactivation profile reveals extensive variability in X-linked gene expression in females","volume":"434","author":"Carrel","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2010.08.034_bib41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/bies.20341","article-title":"X-linked imprinting: effects on brain and behaviour","volume":"28","author":"Davies","year":"2006","journal-title":"Bioessays"},{"key":"10.1016\/j.biopsych.2010.08.034_bib42","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1210\/jc.2005-1596","article-title":"The structural brain correlates of cognitive deficits in adults with Klinefelter's syndrome","volume":"91","author":"Itti","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.biopsych.2010.08.034_bib43","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/ajmg.b.30454","article-title":"Dysregulation of X-linked gene expression in Klinefelter's syndrome and association with verbal cognition","volume":"144B","author":"Vawter","year":"2007","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.biopsych.2010.08.034_bib44","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1752-4571.2008.00017.x","article-title":"Turner syndrome and the evolution of human sexual dimorphism","volume":"1","author":"Crespi","year":"2008","journal-title":"Evol Appl"},{"key":"10.1016\/j.biopsych.2010.08.034_bib45","first-page":"339","article-title":"Confirmatory factor analysis of schizotypal personality traits in university students [in Turkish]","volume":"20","author":"Bora","year":"2009","journal-title":"Turk Psikiyatri Derg"},{"key":"10.1016\/j.biopsych.2010.08.034_bib46","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/NMD.0b013e318162aa79","article-title":"Schizotypy in adolescence: the role of gender and age","volume":"196","author":"Fonseca-Pedrero","year":"2008","journal-title":"J Nerv Ment Dis"},{"key":"10.1016\/j.biopsych.2010.08.034_bib47","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/256640a0","article-title":"Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse","volume":"256","author":"Takagi","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2010.08.034_bib48","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/262580a0","article-title":"Non-random inactivation of X chromosome in the rat yolk sac","volume":"262","author":"Wake","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2010.08.034_bib49","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/ng900","article-title":"Aberrant patterns of X chromosome inactivation in bovine clones","volume":"31","author":"Xue","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2010.08.034_bib50","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/ng0105-3a","article-title":"Explaining the X-linkage bias of placentally expressed genes","volume":"37","author":"Moore","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2010.08.034_bib51","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1017\/S0016672300031736","article-title":"Parental imprinting on the mouse X chromosome: Effects on the early development of X0, XXY and XXX embryos","volume":"62","author":"Tada","year":"1993","journal-title":"Genet Res"},{"key":"10.1016\/j.biopsych.2010.08.034_bib52","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1053\/plac.2002.0889","article-title":"X-inactivation patterns in human embryonic and extra-embryonic tissues","volume":"24","author":"Zeng","year":"2003","journal-title":"Placenta"},{"key":"10.1016\/j.biopsych.2010.08.034_bib53","doi-asserted-by":"crossref","first-page":"e10947","DOI":"10.1371\/journal.pone.0010947","article-title":"Random X inactivation and extensive mosaicism in human placenta","volume":"5","author":"Moreira de Mello","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.biopsych.2010.08.034_bib54","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1192\/bjp.bp.108.054387","article-title":"Early-life origins of schizotypal traits in adulthood","volume":"195","author":"Lahti","year":"2009","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.biopsych.2010.08.034_bib55","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.1190830","article-title":"High-resolution analysis of parent-of-origin allelic expression in the mouse brain","volume":"329","author":"Gregg","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2010.08.034_bib56","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.1190831","article-title":"Sex-specific parent-of-origin allelic expression in the mouse brain","volume":"329","author":"Gregg","year":"2010","journal-title":"Science"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322310009479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322310009479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T14:55:01Z","timestamp":1757775301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322310009479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":56,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0006322310009479"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2010.08.034","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Parent-of-Origin of the Extra X Chromosome May Differentially Affect Psychopathology in Klinefelter Syndrome","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2010.08.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}