{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:47:48Z","timestamp":1786985268301,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Institutes of Health, National Institute of Neurological Disorders and Stroke","award":["NS40068"],"award-info":[{"award-number":["NS40068"]}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.biopsych.2011.07.030","type":"journal-article","created":{"date-parts":[[2011,9,10]],"date-time":"2011-09-10T12:23:39Z","timestamp":1315657419000},"page":"822-828","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"title":["Striatal Volume Contributes to the Prediction of Onset of Huntington Disease in Incident Cases"],"prefix":"10.1016","volume":"71","author":[{"given":"Elizabeth H.","family":"Aylward","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy C.","family":"Nopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald K.","family":"Pierson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane S.","family":"Paulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2011.07.030_bib1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2011.07.030_bib2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington's disease: From molecular pathogenesis to clinical treatment","volume":"10","author":"Ross","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.biopsych.2011.07.030_bib3","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1001\/archneur.1996.00550120105023","article-title":"Basal ganglia volume and proximity to onset in presymptomatic Huntington disease","volume":"53","author":"Aylward","year":"1996","journal-title":"Arch Neurol"},{"key":"10.1016\/j.biopsych.2011.07.030_bib4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainresbull.2010.04.003","article-title":"Striatal and white matter predictors of estimated diagnosis for Huntington disease","volume":"82","author":"Paulsen","year":"2010","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.biopsych.2011.07.030_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ng0893-387","article-title":"Trinucleotide repeat length instability and age of onset in Huntington's disease","volume":"4","author":"Duyao","year":"1993","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2011.07.030_bib6","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/hmg\/2.10.1547","article-title":"Correlation between the onset age of Huntington's disease and length of the trinucleotide repeat in IT-15","volume":"2","author":"Stine","year":"1993","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2011.07.030_bib7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1399-0004.2004.00241.x","article-title":"A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length","volume":"65","author":"Langbehn","year":"2004","journal-title":"Clin Genet"},{"key":"10.1016\/j.biopsych.2011.07.030_bib8","first-page":"593","article-title":"Anticipation and instability of IT-15 (CAG)n repeats in parent-offspring pairs with Huntington disease","volume":"57","author":"Ranen","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2011.07.030_bib9","first-page":"1202","article-title":"The likelihood of being affected with Huntington disease by a particular age, for a specific CAG size","volume":"60","author":"Brinkman","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2011.07.030_bib10","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1001\/archneur.63.6.883","article-title":"Preparing for preventive clinical trials: The Predict-HD study","volume":"63","author":"Paulsen","year":"2006","journal-title":"Arch Neurol"},{"key":"10.1016\/j.biopsych.2011.07.030_bib11","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"Unified Huntington's Disease Rating Scale: Reliability and consistency","volume":"11","year":"1996","journal-title":"Mov Disord"},{"key":"10.1016\/j.biopsych.2011.07.030_bib12","series-title":"A Physician's Guide to the Management of Huntington's Disease","author":"Rosenblatt","year":"1999"},{"key":"10.1016\/j.biopsych.2011.07.030_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neuroimage.2010.06.047","article-title":"Fully automated analysis using BRAINS: AutoWorkup","volume":"54","author":"Pierson","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2011.07.030_bib14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0895-6111(02)00011-3","article-title":"Structural MR image processing using the BRAINS2 toolbox","volume":"26","author":"Magnotta","year":"2002","journal-title":"Comput Med Imaging Graph"},{"key":"10.1016\/j.biopsych.2011.07.030_bib15","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neuroimage.2007.05.063","article-title":"Registration and machine learning-based automated segmentation of subcortical and cerebellar brain structures","volume":"39","author":"Powell","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2011.07.030_bib16","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/jnnp.51.10.1259","article-title":"Neuropsychological and neuroradiological correlates in Huntington's disease","volume":"51","author":"Starkstein","year":"1988","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2011.07.030_bib17","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/brain\/117.4.859","article-title":"The behavioural and motor consequences of focal lesions of the basal ganglia in man","volume":"117","author":"Bhatia","year":"1994","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2011.07.030_bib18","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1212\/01.WNL.0000065888.88988.6E","article-title":"Evidence for more widespread cerebral pathology in early HD: An MRI-based morphometric analysis","volume":"60","author":"Rosas","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2011.07.030_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/ana.410310113","article-title":"Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease","volume":"31","author":"Harris","year":"1992","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopsych.2011.07.030_bib20","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/brain\/122.9.1667","article-title":"Reduced basal ganglia blood flow and volume in pre-symptomatic, gene-tested persons at-risk for Huntington's disease","volume":"122","author":"Harris","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2011.07.030_bib21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/jnnp.2010.208264","article-title":"Longitudinal change in regional brain volumes in pre-HDHuntington disease","volume":"82","author":"Aylward","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2011.07.030_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00415-009-0086-0","article-title":"Diffusion-weighted versus volumetric imaging of the striatum in early symptomatic Huntington disease","volume":"256","author":"Vandenberghe","year":"2009","journal-title":"J Neurol"},{"key":"10.1016\/j.biopsych.2011.07.030_bib23","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1212\/WNL.48.2.394","article-title":"Longitudinal change in basal ganglia volume in patients with Huntington's disease","volume":"48","author":"Aylward","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2011.07.030_bib24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1212\/01.WNL.0000132965.14653.D1","article-title":"Onset and rate of striatal atrophy in preclinical Huntington disease","volume":"63","author":"Aylward","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2011.07.030_bib25","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1093\/brain\/awm217","article-title":"Thalamic metabolism and symptom onset in preclinical Huntington's disease","volume":"130","author":"Feigin","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2011.07.030_bib26","first-page":"215","article-title":"Brain white-matter volume loss and glucose hypometabolism precede the clnical symptoms of Huntington's disease","volume":"47","author":"Ciarmiello","year":"2006","journal-title":"J Nucl Med"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322311007773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322311007773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T14:56:46Z","timestamp":1757775406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322311007773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0006322311007773"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2011.07.030","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Striatal Volume Contributes to the Prediction of Onset of Huntington Disease in Incident Cases","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2011.07.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}