{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:21:04Z","timestamp":1791102064234,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"crossref","award":["R01MH087583"],"award-info":[{"award-number":["R01MH087583"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.biopsych.2011.11.028","type":"journal-article","created":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T19:59:01Z","timestamp":1327694341000},"page":"642-651","source":"Crossref","is-referenced-by-count":75,"title":["Extracellular Signal-Regulated Kinase 2 Signaling in the Hippocampal Dentate Gyrus Mediates the Antidepressant Effects of Testosterone"],"prefix":"10.1016","volume":"71","author":[{"given":"Nicole","family":"Carrier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Kabbaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2011.11.028_bib1","first-page":"1","article-title":"Sex differences in psychiatric disorders: Origins and developmental influences","volume":"5","author":"Earls","year":"1987","journal-title":"Psychiatr Dev"},{"key":"10.1016\/j.biopsych.2011.11.028_bib2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00406-002-0381-6","article-title":"Gender differences in depression","volume":"252","author":"Angst","year":"2002","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.biopsych.2011.11.028_bib3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1080\/0954026021000045976","article-title":"The influence of age and sex on the prevalence of depressive conditions: Report from the National Survey of Psychiatric Morbidity","volume":"15","author":"Bebbington","year":"2003","journal-title":"Int Rev Psychiatry"},{"key":"10.1016\/j.biopsych.2011.11.028_bib4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0165-0327(02)00426-3","article-title":"Epidemiology of women and depression","volume":"74","author":"Kessler","year":"2003","journal-title":"J Affect Disord"},{"key":"10.1016\/j.biopsych.2011.11.028_bib5","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1037\/1064-1297.15.6.529","article-title":"Testosterone supplementation for depressed men: current research and suggested treatment guidelines","volume":"15","author":"Kanayama","year":"2007","journal-title":"Exp Clin Psychopharmacol"},{"key":"10.1016\/j.biopsych.2011.11.028_bib6","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.psyneuen.2006.06.005","article-title":"Calculated bioavailable testosterone levels and depression in middle-aged men","volume":"31","author":"McIntyre","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.biopsych.2011.11.028_bib7","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1001\/jama.1989.03420170069032","article-title":"Testosterone replacement with transdermal therapeutic systems","volume":"261","author":"Cunningham","year":"1989","journal-title":"JAMA"},{"key":"10.1016\/j.biopsych.2011.11.028_bib8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1046\/j.1464-410X.2003.04016.x","article-title":"A novel testosterone gel formulation normalizes androgen levels in hypogonadal men, with improvements in body composition and sexual function","volume":"91","author":"McNicholas","year":"2003","journal-title":"BJU Int"},{"key":"10.1016\/j.biopsych.2011.11.028_bib9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1080\/tam.5.3.170.176","article-title":"Diagnosis of hypogonadism in the aging male","volume":"5","author":"Vermeulen","year":"2002","journal-title":"Aging Male"},{"key":"10.1016\/j.biopsych.2011.11.028_bib10","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.physbeh.2009.02.022","article-title":"Depression-like behavior of aged male and female mice is ameliorated with administration of testosterone or its metabolites","volume":"97","author":"Frye","year":"2009","journal-title":"Physiol Behav"},{"key":"10.1016\/j.biopsych.2011.11.028_bib11","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.yhbeh.2009.07.011","article-title":"Gonadal hormones modulate the display of conditioned defeat in male Syrian hamsters","volume":"56","author":"Solomon","year":"2009","journal-title":"Horm Behav"},{"key":"10.1016\/j.biopsych.2011.11.028_bib12","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2011.11.028_bib13","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000","article-title":"Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus","volume":"20","author":"Malberg","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2011.11.028_bib14","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1523\/JNEUROSCI.0237-07.2007","article-title":"Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates","volume":"27","author":"Perera","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2011.11.028_bib15","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0006-3223(00)00228-6","article-title":"Increased neurogenesis in a model of electroconvulsive therapy","volume":"47","author":"Madsen","year":"2000","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2011.11.028_bib16","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.1073\/pnas.96.23.13427","article-title":"Running enhances neurogenesis, learning, and long-term potentiation in mice","volume":"96","author":"van Praag","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2011.11.028_bib17","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2011.11.028_bib18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/hipo.20156","article-title":"Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment","volume":"16","author":"Warner-Schmidt","year":"2006","journal-title":"Hippocampus"},{"key":"10.1016\/j.biopsych.2011.11.028_bib19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0165-0327(00)00352-9","article-title":"Stress, hypercortisolism and corticosteroid receptors in depression: Implications for therapy","volume":"62","author":"Holsboer","year":"2001","journal-title":"J Affect Disord"},{"key":"10.1016\/j.biopsych.2011.11.028_bib20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1749-6632.1997.tb52357.x","article-title":"Regulation of 5-HT receptors and the hypothalamic-pituitary-adrenal axis","volume":"836","author":"Lopez","year":"1997","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.biopsych.2011.11.028_bib21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.psyneuen.2010.03.007","article-title":"The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?","volume":"36","author":"Anacker","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.biopsych.2011.11.028_bib22","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1093\/emboj\/19.20.5406","article-title":"Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation","volume":"19","author":"Migliaccio","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.biopsych.2011.11.028_bib23","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.nbd.2008.05.003","article-title":"Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress","volume":"31","author":"Qi","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.biopsych.2011.11.028_bib24","doi-asserted-by":"crossref","first-page":"7311","DOI":"10.1523\/JNEUROSCI.23-19-07311.2003","article-title":"The role of the extracellular signal-regulated kinase signaling pathway in mood modulation","volume":"23","author":"Einat","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2011.11.028_bib25","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbr.2006.08.035","article-title":"The depressive-like behaviors are correlated with decreased phosphorylation of mitogen-activated protein kinases in rat brain following chronic forced swim stress","volume":"175","author":"Qi","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.biopsych.2011.11.028_bib26","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/dneu.20457","article-title":"Testosterone and dihydrotestosterone, but not estradiol, enhance survival of new hippocampal neurons in adult male rats","volume":"67","author":"Spritzer","year":"2007","journal-title":"Dev Neurobiol"},{"key":"10.1016\/j.biopsych.2011.11.028_bib27","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1021\/bi952723e","article-title":"Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate","volume":"35","author":"Robinson","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.biopsych.2011.11.028_bib28","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0306-4522(96)00645-8","article-title":"Introduction of the glutamate receptor subunit 1 into motor neurons in vitro and in vivo using a recombinant herpes simplex virus","volume":"79","author":"Neve","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2011.11.028_bib29","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cell.2007.09.018","article-title":"Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions","volume":"131","author":"Krishnan","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2011.11.028_bib30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nn1812","article-title":"IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates","volume":"10","author":"Russo","year":"2007","journal-title":"Nature Neurosci"},{"key":"10.1016\/j.biopsych.2011.11.028_bib31","doi-asserted-by":"crossref","first-page":"7652","DOI":"10.1523\/JNEUROSCI.0951-10.2010","article-title":"Extracellular signal-regulated kinase-2 within the ventral tegmental area regulates responses to stress","volume":"30","author":"Iniguez","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2011.11.028_bib32","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.biopsych.2011.11.028_bib33","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1126\/science.282.5397.2272","article-title":"Regulation of cocaine reward by CREB","volume":"282","author":"Carlezon","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2011.11.028_bib34","doi-asserted-by":"crossref","first-page":"11435","DOI":"10.1073\/pnas.172091899","article-title":"CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli","volume":"99","author":"Barrot","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2011.11.028_bib35","doi-asserted-by":"crossref","unstructured":"Hollis F, Duclot F, Gunjan A, Kabbaj M Individual differences in the effect of social defeat on anhedonia and histone acetylation in the rat hippocampus. Horm Behav 59:331\u2013337.","DOI":"10.1016\/j.yhbeh.2010.09.005"},{"key":"10.1016\/j.biopsych.2011.11.028_bib36","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00008877-199711000-00010","article-title":"The forced swimming test as a model for core and component behavioral effects of antidepressant drugs","volume":"8","author":"Lucki","year":"1997","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.biopsych.2011.11.028_bib37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1699-0463.1988.tb05320.x","article-title":"Some new, simple and efficient stereological methods and their use in pathological research and diagnosis","volume":"96","author":"Gundersen","year":"1988","journal-title":"APMIS"},{"key":"10.1016\/j.biopsych.2011.11.028_bib38","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0306-4522(98)00341-8","article-title":"Gonadectomy in adult life increases tyrosine hydroxylase immunoreactivity in the prefrontal cortex and decreases open field activity in male rats","volume":"89","author":"Adler","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2011.11.028_bib39","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1037\/h0077264","article-title":"Androgenic control of food intake and body weight in male rats","volume":"90","author":"Gentry","year":"1976","journal-title":"J Comp Physiol Psychol"},{"key":"10.1016\/j.biopsych.2011.11.028_bib40","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.physbeh.2010.08.010","article-title":"Testosterone decrease does not play a major role in the suppression of hippocampal cell proliferation following social defeat stress in rats","volume":"101","author":"Buwalda","year":"2010","journal-title":"Physiol Behav"},{"key":"10.1016\/j.biopsych.2011.11.028_bib41","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0006-3223(03)00527-4","article-title":"Reduced cell proliferation in the dentate gyrus is not correlated with the development of learned helplessness","volume":"54","author":"Vollmayr","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2011.11.028_bib42","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/sj.mp.4001791","article-title":"Neural stem cell proliferation is decreased in schizophrenia, but not in depression","volume":"11","author":"Reif","year":"2006","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2011.11.028_bib43","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/mp.2008.119","article-title":"The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling","volume":"14","author":"Bessa","year":"2009","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2011.11.028_bib44","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/sj.npp.1301399","article-title":"Behavioral effects of chronic fluoxetine in BALB\/cJ mice do not require adult hippocampal neurogenesis or the serotonin 1A receptor","volume":"33","author":"Holick","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2011.11.028_bib45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/sj.mp.4002104","article-title":"Chronic fluoxetine treatment alters behavior, but not adult hippocampal neurogenesis, in BALB\/cJ mice","volume":"13","author":"Huang","year":"2008","journal-title":"Mol Psychiatry"},{"issue":"1 suppl","key":"10.1016\/j.biopsych.2011.11.028_bib46","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/01.psy.0000163456.22154.d2","article-title":"Hypercortisolemia and depression","volume":"67","author":"Gillespie","year":"2005","journal-title":"Psychosom Med"},{"key":"10.1016\/j.biopsych.2011.11.028_bib47","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1006\/nbdi.2000.0350","article-title":"Stress hormones: good and bad","volume":"7","author":"Sapolsky","year":"2000","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.biopsych.2011.11.028_bib48","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0006-3223(00)01088-X","article-title":"Glucocorticoid receptors in major depression: Relevance to pathophysiology and treatment","volume":"49","author":"Pariante","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2011.11.028_bib49","first-page":"185","article-title":"Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression","volume":"29","author":"Barden","year":"2004","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.biopsych.2011.11.028_bib50","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1152\/physrev.00041.2006","article-title":"Physiology and neurobiology of stress and adaptation: Central role of the brain","volume":"87","author":"McEwen","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.biopsych.2011.11.028_bib51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1385\/NMM:5:1:011","article-title":"Role of neurotrophic factors in the etiology and treatment of mood disorders","volume":"5","author":"Duman","year":"2004","journal-title":"Neuromol Med"},{"key":"10.1016\/j.biopsych.2011.11.028_bib52","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archpsyc.1997.01830190015002","article-title":"A molecular and cellular theory of depression","volume":"54","author":"Duman","year":"1997","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2011.11.028_bib53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","article-title":"Neurobiology of depression","volume":"34","author":"Nestler","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2011.11.028_bib54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature10130","article-title":"NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses","volume":"475","author":"Autry","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2011.11.028_bib55","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1021\/cr000241p","article-title":"MAP kinases","volume":"101","author":"Chen","year":"2001","journal-title":"Chem Rev"},{"key":"10.1016\/j.biopsych.2011.11.028_bib56","doi-asserted-by":"crossref","first-page":"8177","DOI":"10.1523\/JNEUROSCI.20-21-08177.2000","article-title":"Activation of ERK\/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning","volume":"20","author":"Schafe","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2011.11.028_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1471-4159.2001.00054.x","article-title":"The neuronal MAP kinase cascade: A biochemical signal integration system subserving synaptic plasticity and memory","volume":"76","author":"Sweatt","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopsych.2011.11.028_bib58","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1210\/en.2006-1465","article-title":"Testosterone activates mitogen-activated protein kinase via Src kinase and the epidermal growth factor receptor in sertoli cells","volume":"148","author":"Cheng","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopsych.2011.11.028_bib59","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/87865","article-title":"The cellular neurobiology of depression","volume":"7","author":"Manji","year":"2001","journal-title":"Nature Med"},{"key":"10.1016\/j.biopsych.2011.11.028_bib60","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neuroscience.2004.08.048","article-title":"Ultrastructural evidence that androgen receptors are located at extranuclear sites in the rat hippocampal formation","volume":"130","author":"Tabori","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2011.11.028_bib61","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1210\/en.2010-0607","article-title":"Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain","volume":"152","author":"Konkle","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopsych.2011.11.028_bib62","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/(SICI)1096-9861(19971201)388:4<603::AID-CNE8>3.0.CO;2-6","article-title":"Distribution and hormone regulation of estrogen receptor immunoreactive cells in the hippocampus of male and female rats","volume":"388","author":"Weiland","year":"1997","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.biopsych.2011.11.028_bib63","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1210\/rp.57.1.357","article-title":"Estrogen actions throughout the brain","volume":"57","author":"McEwen","year":"2002","journal-title":"Recent Prog Horm Res"},{"key":"10.1016\/j.biopsych.2011.11.028_bib64","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2826.2008.01809.x","article-title":"Different forms of oestrogen rapidly upregulate cell proliferation in the dentate gyrus of adult female rats","volume":"21","author":"Barha","year":"2009","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.biopsych.2011.11.028_bib65","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.brainresrev.2007.05.008","article-title":"Gonadal hormone modulation of neurogenesis in the dentate gyrus of adult male and female rodents","volume":"57","author":"Galea","year":"2008","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.biopsych.2011.11.028_bib66","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.neuroscience.2007.10.071","article-title":"Repeated estradiol administration alters different aspects of neurogenesis and cell death in the hippocampus of female, but not male, rats","volume":"152","author":"Barker","year":"2008","journal-title":"Neuroscience"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322311012017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322311012017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T20:19:16Z","timestamp":1561234756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322311012017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":66,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0006322311012017"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2011.11.028","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}