{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:45:42Z","timestamp":1791405942204,"version":"4.3.3"},"reference-count":38,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.biopsych.2011.11.031","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T03:50:33Z","timestamp":1327895433000},"page":"829-835","source":"Crossref","is-referenced-by-count":60,"title":["Increased Cerebrospinal Fluid Levels of Double-Stranded RNA-Dependant Protein Kinase in Alzheimer's Disease"],"prefix":"10.1016","volume":"71","author":[{"given":"Fran\u00e7ois","family":"Mouton-Liger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Paquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Dumurgier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Lapalus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Laplanche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Hugon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2011.11.031_bib1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S1474-4422(10)70159-9","article-title":"The diagnosis of young-onset dementia","volume":"9","author":"Rossor","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.biopsych.2011.11.031_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-009-0532-1","article-title":"Classification and basic pathology of Alzheimer disease","volume":"118","author":"Duyckaerts","year":"2009","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.biopsych.2011.11.031_bib3","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1001\/archneur.58.12.1985","article-title":"Current concepts in mild cognitive impairment","volume":"58","author":"Petersen","year":"2001","journal-title":"Arch Neurol"},{"key":"10.1016\/j.biopsych.2011.11.031_bib4","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2011.11.031_bib5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/ana.22359","article-title":"Apomorphine and Alzheimer A\u03b2: Roles for regulated \u03b1 cleavage, autophagy, and antioxidation?","volume":"69","author":"Steele","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopsych.2011.11.031_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrneurol.2010.4","article-title":"Cerebrospinal fluid and plasma biomarkers in Alzheimer disease","volume":"6","author":"Blennow","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.biopsych.2011.11.031_bib7","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S1474-4422(10)70223-4","article-title":"Revising the definition of Alzheimer's disease: A new lexicon","volume":"9","author":"Dubois","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.biopsych.2011.11.031_bib8","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S1474-4422(07)70178-3","article-title":"Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria","volume":"6","author":"Dubois","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.biopsych.2011.11.031_bib9","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.biopsych.2011.11.031_bib10","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/archneurol.2008.596","article-title":"Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain","volume":"66","author":"Tapiola","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1016\/j.biopsych.2011.11.031_bib11","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.biopsych.2009.01.027","article-title":"Beta amyloid in Alzheimer's disease: Increased deposition in brain is reflected in reduced concentration in cerebrospinal fluid","volume":"65","author":"Grimmer","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2011.11.031_bib12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.nbd.2010.07.007","article-title":"Inverse association between CSF Abeta 42 levels and years of education in mild form of Alzheimer's disease: The cognitive reserve theory","volume":"40","author":"Dumurgier","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.biopsych.2011.11.031_bib13","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1212\/WNL.0b013e3181bc010c","article-title":"Relationships between biomarkers in aging and dementia","volume":"73","author":"Jagust","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2011.11.031_bib14","doi-asserted-by":"crossref","first-page":"6112","DOI":"10.1038\/sj.onc.1203127","article-title":"PKR: A sentinel kinase for cellular stress","volume":"18","author":"Williams","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.biopsych.2011.11.031_bib15","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.biochi.2007.03.001","article-title":"The dsRNA protein kinase PKR: virus and cell control","volume":"89","author":"Garcia","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.biopsych.2011.11.031_bib16","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2011.11.031_bib17","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.cell.2010.01.001","article-title":"Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis","volume":"140","author":"Nakamura","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2011.11.031_bib18","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1097\/00001756-200212200-00011","article-title":"Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease","volume":"13","author":"Chang","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.biopsych.2011.11.031_bib19","article-title":"The PKR activator PACT is induced by A\u03b2: Involvement in Alzheimer's disease","author":"Paquet","year":"2011","journal-title":"Brain Pathol"},{"key":"10.1016\/j.biopsych.2011.11.031_bib20","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1046\/j.1471-4159.2002.01237.x","article-title":"Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration","volume":"83","author":"Chang","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopsych.2011.11.031_bib21","doi-asserted-by":"crossref","first-page":"49819","DOI":"10.1074\/jbc.M306503200","article-title":"Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine\/threonine protein kinase in beta-amyloid peptide neurotoxicity","volume":"278","author":"Suen","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2011.11.031_bib22","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.neuroscience.2006.01.047","article-title":"Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease","volume":"139","author":"Page","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2011.11.031_bib23","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/sj.emboj.7600049","article-title":"An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease","volume":"23","author":"Onuki","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.biopsych.2011.11.031_bib24","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0969-9961(03)00086-X","article-title":"Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice","volume":"14","author":"Peel","year":"2003","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.biopsych.2011.11.031_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1750-3639.2010.00437.x","article-title":"Modulation of tau phosphorylation by the kinase PKR: Implications in Alzheimer's disease","volume":"21","author":"Bose","year":"2011","journal-title":"Brain Pathol"},{"key":"10.1016\/j.biopsych.2011.11.031_bib26","doi-asserted-by":"crossref","first-page":"e21456","DOI":"10.1371\/journal.pone.0021456","article-title":"Activation of PKR causes amyloid ss-peptide accumulation via de-repression of BACE1 expression","volume":"6","author":"Ill-Raga","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2011.11.031_bib27","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2011.11.031_bib28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/NEN.0b013e318196cd7c","article-title":"Neuronal phosphorylated RNA-dependent protein kinase in Creutzfeldt-Jakob disease","volume":"68","author":"Paquet","year":"2009","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.biopsych.2011.11.031_bib29","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.biopsych.2011.11.031_bib30","doi-asserted-by":"crossref","first-page":"12451","DOI":"10.1073\/pnas.93.22.12451","article-title":"An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells","volume":"93","author":"Yeung","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2011.11.031_bib31","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(10)61349-9","article-title":"Alzheimer's disease","volume":"377","author":"Ballard","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.biopsych.2011.11.031_bib32","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer's disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biopsych.2011.11.031_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/alzrt24","article-title":"Inflammation in Alzheimer's disease: Relevance to pathogenesis and therapy","volume":"2","author":"Zotova","year":"2010","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.biopsych.2011.11.031_bib34","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.neuroscience.2010.06.016","article-title":"Activation of eukaryotic initiation factor-2 alpha-kinases in okadaic acid-treated neurons","volume":"169","author":"Kim","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2011.11.031_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuint.2004.07.005","article-title":"Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease","volume":"46","author":"Bando","year":"2005","journal-title":"Neurochem Int"},{"key":"10.1016\/j.biopsych.2011.11.031_bib36","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1093\/hmg\/10.15.1531","article-title":"Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue","volume":"10","author":"Peel","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2011.11.031_bib37","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000095562","article-title":"Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease","volume":"22","author":"Paccalin","year":"2006","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.biopsych.2011.11.031_bib38","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1586\/ern.09.92","article-title":"Could PKR inhibition modulate human neurodegeneration?","volume":"9","author":"Hugon","year":"2009","journal-title":"Expert Rev Neurother"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322311012121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322311012121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T15:22:47Z","timestamp":1543245767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322311012121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0006322311012121"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2011.11.031","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}