{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:59:04Z","timestamp":1791104344124,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.biopsych.2012.01.002","type":"journal-article","created":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T11:01:50Z","timestamp":1329476510000},"page":"890-897","source":"Crossref","is-referenced-by-count":32,"title":["Common and Differential Pathophysiological Features Accompany Comparable Cognitive Impairments in Medication-Free Patients with Schizophrenia and in Healthy Aging Subjects"],"prefix":"10.1016","volume":"71","author":[{"given":"Jean-Claude","family":"Dreher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Kohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Apud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Weinberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Faith","family":"Berman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2012.01.002_bib1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/npp.2009.111","article-title":"Executive function, neural circuitry, and genetic mechanisms in schizophrenia","volume":"35","author":"Eisenberg","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2012.01.002_bib2","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1001\/archpsyc.62.10.1071","article-title":"Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia","volume":"62","author":"Cannon","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2012.01.002_bib3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.schres.2008.12.025","article-title":"Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia","volume":"108","author":"Karlsgodt","year":"2009","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2012.01.002_bib4","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1176\/appi.ajp.162.3.475","article-title":"Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis","volume":"162","author":"MacDonald","year":"2005","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2012.01.002_bib5","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1098\/rstb.1996.0135","article-title":"Prefrontal function in schizophrenia: Confounds and controversies","volume":"351","author":"Weinberger","year":"1996","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.biopsych.2012.01.002_bib6","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.biopsych.2008.07.029","article-title":"Impairment of working memory maintenance and response in schizophrenia: Functional magnetic resonance imaging evidence","volume":"64","author":"Driesen","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.01.002_bib7","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1001\/archgenpsychiatry.2009.91","article-title":"Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia","volume":"66","author":"Minzenberg","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2012.01.002_bib8","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1093\/cercor\/10.11.1078","article-title":"Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited","volume":"10","author":"Callicott","year":"2000","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2012.01.002_bib9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0006-3223(00)00227-4","article-title":"Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance","volume":"48","author":"Manoach","year":"2000","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.01.002_bib10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/hbm.20138","article-title":"Beyond hypofrontality: A quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia","volume":"25","author":"Glahn","year":"2005","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.biopsych.2012.01.002_bib11","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1176\/appi.ajp.160.12.2209","article-title":"Complexity of prefrontal cortical dysfunction in schizophrenia: More than up or down","volume":"160","author":"Callicott","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2012.01.002_bib12","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0920-9964(02)00294-3","article-title":"Prefrontal cortex dysfunction during working memory performance in schizophrenia: Reconciling discrepant findings","volume":"60","author":"Manoach","year":"2003","journal-title":"Schizophr Res"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2012.01.002_bib13","doi-asserted-by":"crossref","first-page":"i171","DOI":"10.1093\/cercor\/bhm069","article-title":"Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophrenia","volume":"17","author":"Tan","year":"2007","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2012.01.002_bib14","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1176\/ajp.2006.163.11.1969","article-title":"Dysfunctional prefrontal regional specialization and compensation in schizophrenia","volume":"163","author":"Tan","year":"2006","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2012.01.002_bib15","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1093\/brain\/awf188","article-title":"Excessive recruitment of neural systems subserving logical reasoning in schizophrenia","volume":"125","author":"Ramsey","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2012.01.002_bib16","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1093\/brain\/awm147","article-title":"Ageing and early-stage Parkinson's disease affect separable neural mechanisms of mesolimbic reward processing","volume":"130","author":"Schott","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2012.01.002_bib17","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1176\/appi.ajp.2007.07020365","article-title":"Prefrontal function and activation in bipolar disorder and schizophrenia","volume":"165","author":"McIntosh","year":"2008","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2012.01.002_bib18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0079-6123(06)57004-9","article-title":"Altered brain activity in healthy seniors: What does it mean?","volume":"157","author":"Persson","year":"2006","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.biopsych.2012.01.002_bib19","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/1078","article-title":"The missing link: A failure of fronto-hippocampal integration in schizophrenia","volume":"1","author":"Fletcher","year":"1998","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2012.01.002_bib20","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/1137","article-title":"Impaired recruitment of the hippocampus during conscious recollection in schizophrenia [see comments]","volume":"1","author":"Heckers","year":"1998","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2012.01.002_bib21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1037\/0882-7974.17.1.85","article-title":"Hemispheric asymmetry reduction in older adults: The HAROLD model","volume":"17","author":"Cabeza","year":"2002","journal-title":"Psychol Aging"},{"key":"10.1016\/j.biopsych.2012.01.002_bib22","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1073\/pnas.0809141106","article-title":"Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia","volume":"106","author":"Whitfield-Gabrieli","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2012.01.002_bib23","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/archpsyc.62.4.379","article-title":"Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia","volume":"62","author":"Meyer-Lindenberg","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2012.01.002_bib24","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1017\/S0033291708003565","article-title":"Failure to deactivate in the prefrontal cortex in schizophrenia: Dysfunction of the default mode network?","volume":"38","author":"Pomarol-Clotet","year":"2008","journal-title":"Psychol Med"},{"key":"10.1016\/j.biopsych.2012.01.002_bib25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0926-6410(02)00052-6","article-title":"Brain imaging of human memory systems: Between-systems similarities and within-system differences","volume":"13","author":"Nyberg","year":"2002","journal-title":"Brain Res Cogn Brain Res"},{"key":"10.1016\/j.biopsych.2012.01.002_bib26","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1523\/JNEUROSCI.23-09-03869.2003","article-title":"Functional dissociation among components of remembering: Control, perceived oldness, and content","volume":"23","author":"Wheeler","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2012.01.002_bib27","doi-asserted-by":"crossref","first-page":"e3227","DOI":"10.1371\/journal.pone.0003227","article-title":"Damage to the fronto-polar cortex is associated with impaired multitasking","volume":"3","author":"Dreher","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2012.01.002_bib28","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1001\/archgenpsychiatry.2009.10","article-title":"Organization of cognitive control within the lateral prefrontal cortex in schizophrenia","volume":"66","author":"Barbalat","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2012.01.002_bib29","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0006-3223(02)01674-8","article-title":"Working memory and prefrontal cortex dysfunction: specificity to schizophrenia compared with major depression","volume":"53","author":"Barch","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.01.002_bib30","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1093\/cercor\/bhg082","article-title":"Interindividual differences in functional interactions among prefrontal, parietal and parahippocampal regions during working memory","volume":"13","author":"Glabus","year":"2003","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2012.01.002_bib31","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0006-3223(01)01252-5","article-title":"Prefrontal neurons and the genetics of schizophrenia","volume":"50","author":"Weinberger","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.01.002_bib32","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1192\/bjp.162.2.183","article-title":"Is the mechanism of prefrontal hypofunction in depression the same as in schizophrenia?","volume":"162","author":"Berman","year":"1993","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.biopsych.2012.01.002_bib33","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1162\/089892900561814","article-title":"Age differences in the frontal lateralization of verbal and spatial working memory revealed by PET","volume":"12","author":"Reuter-Lorenz","year":"2000","journal-title":"J Cogn Neurosci"},{"key":"10.1016\/j.biopsych.2012.01.002_bib34","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev.psych.59.103006.093656","article-title":"The adaptive brain: Aging and neurocognitive scaffolding","volume":"60","author":"Park","year":"2009","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.biopsych.2012.01.002_bib35","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/brain\/122.5.963","article-title":"Context-dependent, neural system-specific neurophysiological concomitants of ageing: Mapping PET correlates during cognitive activation","volume":"122","author":"Esposito","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2012.01.002_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2000.tb06716.x","article-title":"Anatomical organization of the parahippocampal-hippocampal network","volume":"911","author":"Witter","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.biopsych.2012.01.002_bib37","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1073\/pnas.0308627101","article-title":"Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI","volume":"101","author":"Greicius","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2012.01.002_bib38","doi-asserted-by":"crossref","first-page":"14504","DOI":"10.1073\/pnas.2235925100","article-title":"Functional deactivations: change with age and dementia of the Alzheimer type","volume":"100","author":"Lustig","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2012.01.002_bib39","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1162\/jocn.2007.19.6.1021","article-title":"Age differences in deactivation: A link to cognitive control?","volume":"19","author":"Persson","year":"2007","journal-title":"J Cogn Neurosci"},{"key":"10.1016\/j.biopsych.2012.01.002_bib40","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1176\/appi.ajp.158.11.1809","article-title":"Evidence for abnormal cortical functional connectivity during working memory in schizophrenia","volume":"158","author":"Meyer-Lindenberg","year":"2001","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2012.01.002_bib41","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/cercor\/bhg133","article-title":"Task-independent and task-specific age effects on brain activity during working memory, visual attention and episodic retrieval","volume":"14","author":"Cabeza","year":"2004","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2012.01.002_bib42","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrn3085","article-title":"A pathophysiological framework of hippocampal dysfunction in ageing and disease","volume":"12","author":"Small","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2012.01.002_bib43","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.neubiorev.2006.06.005","article-title":"The correlative triad among aging, dopamine, and cognition: Current status and future prospects","volume":"30","author":"Backman","year":"2006","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.biopsych.2012.01.002_bib44","doi-asserted-by":"crossref","first-page":"9235","DOI":"10.1073\/pnas.93.17.9235","article-title":"Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects","volume":"93","author":"Laruelle","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2012.01.002_bib45","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuron.2005.05.002","article-title":"The hippocampal-VTA loop: Controlling the entry of information into long-term memory","volume":"46","author":"Lisman","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2012.01.002_bib46","doi-asserted-by":"crossref","first-page":"15106","DOI":"10.1073\/pnas.0802127105","article-title":"Age-related changes in midbrain dopaminergic regulation of the human reward system","volume":"105","author":"Dreher","year":"2008","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000632231200008X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000632231200008X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T22:11:15Z","timestamp":1561327875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000632231200008X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S000632231200008X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2012.01.002","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}