{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:59:05Z","timestamp":1792709945820,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.biopsych.2012.03.029","type":"journal-article","created":{"date-parts":[[2012,4,21]],"date-time":"2012-04-21T20:36:54Z","timestamp":1335040614000},"page":"555-561","source":"Crossref","is-referenced-by-count":165,"title":["Synaptic Potentiation Is Critical for Rapid Antidepressant Response to Ketamine in Treatment-Resistant Major Depression"],"prefix":"10.1016","volume":"72","author":[{"given":"Brian R.","family":"Cornwell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Salvadore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Furey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig A.","family":"Marquardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy E.","family":"Brutsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Grillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Carlos A.","family":"Zarate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2012.03.029_bib1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrd2462","article-title":"Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders","volume":"7","author":"Sanacora","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.biopsych.2012.03.029_bib2","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.biopsych.2010.06.016","article-title":"Magnetic resonance spectroscopy studies of glutamate-related abnormalities in mood disorders","volume":"68","author":"Y\u00fcksel","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib3","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/mp.2010.44","article-title":"Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression","volume":"16","author":"Bernard","year":"2011","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib4","doi-asserted-by":"crossref","first-page":"15653","DOI":"10.1073\/pnas.0507901102","article-title":"Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression","volume":"102","author":"Choudary","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2012.03.029_bib5","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","article-title":"A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression","volume":"63","author":"Zarate","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib6","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1001\/archgenpsychiatry.2010.90","article-title":"A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression","volume":"67","author":"DiazGranados","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2011.12.010","article-title":"Replication of ketamine's antidepressant efficacy in bipolar depression: A randomized controlled add-on trial","author":"Zarate","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.biopsych.2007.05.028","article-title":"Cellular mechanisms underlying the antidepressant effects of ketamine: Role of \u03b1a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors","volume":"63","author":"Maeng","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature10130","article-title":"NMDA receptor blockage at rest triggers rapid behavioural antidepressant response","volume":"475","author":"Autry","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2012.03.029_bib10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbr.2011.05.035","article-title":"Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression","volume":"224","author":"Koike","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.biopsych.2012.03.029_bib11","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2012.03.029_bib12","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/sj.npp.1301178","article-title":"The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: Relationship to clinical effects in mood disorders","volume":"32","author":"Du","year":"2007","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2012.03.029_bib13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tins.2011.11.004","article-title":"Signaling pathways underlying the pathophysiology and treatment of depression: Novel mechanisms for rapid-acting agents","volume":"35","author":"Duman","year":"2012","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.biopsych.2012.03.029_bib14","article-title":"Brain-derived neurotropic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex","author":"Liu","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib15","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.4088\/JCP.08m04659","article-title":"Brain-derived neurotrophic factor and initial antidepressant response to an N-Methyl-D-Aspartate antagonist","volume":"70","author":"Machado-Viera","year":"2009","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib16","doi-asserted-by":"crossref","first-page":"11496","DOI":"10.1523\/JNEUROSCI.2213-07.2007","article-title":"NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons","volume":"27","author":"Homayoun","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2012.03.029_bib17","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1523\/JNEUROSCI.17-08-02921.1997","article-title":"Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade","volume":"17","author":"Moghaddam","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2012.03.029_bib18","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0166-2236(02)02270-1","article-title":"Regulation of AMPA receptors during synaptic plasticity","volume":"11","author":"Song","year":"2002","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.biopsych.2012.03.029_bib19","article-title":"A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior","author":"Carlen","year":"2011","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib20","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1162\/jocn.2009.21305","article-title":"Ketamine modulates theta and gamma oscillations","volume":"22","author":"Lazarawicz","year":"2009","journal-title":"J Cogn Neurosci"},{"key":"10.1016\/j.biopsych.2012.03.029_bib21","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.clinph.2006.05.011","article-title":"Increase in high frequency EEG activity explains the poor performance of EEG spectral entropy monitor during S-ketamine anesthesia","volume":"117","author":"Maksimow","year":"2006","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.biopsych.2012.03.029_bib22","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nature07991","article-title":"Parvalbumin neurons and gamma rhythms enhance cortical circuit performance","volume":"459","author":"Sohal","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2012.03.029_bib23","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/npp.2010.183","article-title":"NMDA receptor hypofunction phase couples independent \u03b3-oscillations in the rat visual cortex","volume":"36","author":"Anver","year":"2011","journal-title":"Neuropychopharmacol"},{"key":"10.1016\/j.biopsych.2012.03.029_bib24","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/npp.2009.168","article-title":"Gamma and delta neural oscillations and association with clinical symptoms under subanesthetic ketamine","volume":"35","author":"Hong","year":"2010","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2012.03.029_bib25","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.biopsych.2007.10.006","article-title":"N-methyl D-aspartate receptor antagonists ketamine and MK-801 induce wake-related aberrant \u03b3 oscillations in the rat neocortex","volume":"63","author":"Pinault","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/neuro.09.033.2009","article-title":"The functional consequences of cortical circuit abnormalities on gamma oscillations in schizophrenia: Insights from computational modeling","volume":"3","author":"Spencer","year":"2009","journal-title":"Front Hum Neurosci"},{"key":"10.1016\/j.biopsych.2012.03.029_bib27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nrn2774","article-title":"Abnormal neural oscillations and synchrony in schizophrenia","volume":"11","author":"Ulhaas","year":"2010","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2012.03.029_bib28","doi-asserted-by":"crossref","first-page":"8684","DOI":"10.1016\/j.brainresbull.2005.11.003","article-title":"A direct demonstration of cortical LTP in humans: A combined TMS\/EEG study","volume":"69","author":"Esser","year":"2006","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.biopsych.2012.03.029_bib29","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/nn1758","article-title":"Arm immobilization causes cortical plastic changes and locally decreases sleep slow wave activity","volume":"9","author":"Huber","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2012.03.029_bib30","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1994"},{"key":"10.1016\/j.biopsych.2012.03.029_bib31","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib32","series-title":"Structured Clinical Interview for DSM-IV-TR Axis I Disorders\u2014Patient Edition","author":"First","year":"2002"},{"key":"10.1016\/j.biopsych.2012.03.029_bib33","first-page":"10","article-title":"The definition and meaning of treatment-resistant depression","volume":"62","author":"Sackeim","year":"2001","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib34","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1038\/npp.2011.338","article-title":"Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs. add-on riluzole: Results from a 4-week, double-blind, placebo-controlled study","volume":"37","author":"Ibrahim","year":"2012","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2012.03.029_bib35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1176\/appi.ajp.161.1.171","article-title":"An open-label trial of riluzole in patients with treatment-resistant major depression","volume":"161","author":"Zarate","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib36","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1046\/j.1460-9568.2000.00242.x","article-title":"Riluzole inhibits the persistent sodium current in mammalian CNS neurons","volume":"12","author":"Urbani","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2012.03.029_bib37","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/j.1552-4604.1997.tb05630.x","article-title":"Single- and multiple-dose pharmacokinetics of riluzole in white subjects","volume":"37","author":"Le Liboux","year":"1997","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.biopsych.2012.03.029_bib38","doi-asserted-by":"crossref","first-page":"790","DOI":"10.2466\/pr0.1962.10.3.799","article-title":"The brief psychiatric rating scale","volume":"10","author":"Overall","year":"1962","journal-title":"Psychol Rep"},{"key":"10.1016\/j.biopsych.2012.03.029_bib39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1023\/A:1024465317902","article-title":"Measurement of dissociative states with the clinician-administered dissociative states scale (CADSS)","volume":"11","author":"Bremner","year":"1998","journal-title":"J Trauma Stress"},{"key":"10.1016\/j.biopsych.2012.03.029_bib40","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1109\/78.492555","article-title":"Localization of the complex spectrum: The S transform","volume":"44","author":"Stockwell","year":"1996","journal-title":"IEEEE Trans Signal Process"},{"key":"10.1016\/j.biopsych.2012.03.029_bib41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1006\/meth.2001.1238","article-title":"Signal processing in magnetoencephalography","volume":"25","author":"Vrba","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.biopsych.2012.03.029_bib42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.brainres.2008.09.068","article-title":"Evoked amygdala responses to negative faces revealed by adaptive MEG beamformers","volume":"1244","author":"Cornwell","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.biopsych.2012.03.029_bib43","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.biopsych.2008.08.014","article-title":"Increased anterior cingulate cortical activity in response to fearful faces: A neurophysiological biomarker that predicts rapid antidepressant response to ketamine","volume":"65","author":"Salvadore","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib44","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1109\/10.930901","article-title":"Reconstructing spatio-temporal activities of neural sources using an MEG vector beamformer technique","volume":"48","author":"Sekihara","year":"2001","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.1016\/j.biopsych.2012.03.029_bib45","first-page":"109","article-title":"Localization of event-related activity by SAM(erf)","volume":"2004","author":"Robinson","year":"2004","journal-title":"Neurol Clin Neurophysiol"},{"key":"10.1016\/j.biopsych.2012.03.029_bib46","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cbmr.1996.0014","article-title":"AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages","volume":"29","author":"Cox","year":"1996","journal-title":"Comput Biomed Res"},{"key":"10.1016\/j.biopsych.2012.03.029_bib47","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1006\/nimg.2001.1037","article-title":"Thresholding of statistical maps in functional neuroimaging using false discovery rates","volume":"15","author":"Genovese","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2012.03.029_bib48","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1002\/hbm.20746","article-title":"Magnetoencephalographic gamma power reduction in patients with schizophrenia during resting condition","volume":"30","author":"Rutter","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.biopsych.2012.03.029_bib49","first-page":"819","article-title":"Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine","volume":"34","author":"Salvadore","year":"2010","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2012.03.029_bib50","first-page":"1","article-title":"An investigation of amino-acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression","volume":"1","author":"Salvadore","year":"2011","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2012.03.029_bib51","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0893-133X(98)00067-0","article-title":"Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis","volume":"20","author":"Newcomer","year":"1999","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2012.03.029_bib52","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1176\/appi.ajp.162.2.394","article-title":"Effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: A 4-T proton MRS study","volume":"162","author":"Rowland","year":"2005","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib53","doi-asserted-by":"crossref","DOI":"10.1038\/mp.2011.171","article-title":"Ketamine effects on brain GABA and glutamate levels with 1H-MRS: Relationship to ketamine-induced psychopathology","author":"Stone","year":"2012","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.03.029_bib54","article-title":"Lack of effect of ketamine on cortical glutamate and glutamine in healthy volunteers: A proton magnetic resonance spectroscopy study","author":"Taylor","year":"2011","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.biopsych.2012.03.029_bib55","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pscychresns.2010.10.009","article-title":"The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [1H]-MRS","volume":"191","author":"Valentine","year":"2011","journal-title":"Psychiatry Res: Neuroimage"},{"key":"10.1016\/j.biopsych.2012.03.029_bib56","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.neuron.2007.01.031","article-title":"Recruitment of parvalbumin-positive interneurons determines hippocampal function and associative behavior","volume":"53","author":"Fuchs","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2012.03.029_bib57","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/JCP.0b013e31818a6cea","article-title":"An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder","volume":"28","author":"Preskorn","year":"2008","journal-title":"J Clin Psychopharmacol"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322312003071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322312003071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T17:38:09Z","timestamp":1561657089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322312003071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0006322312003071"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2012.03.029","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}