{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:07:09Z","timestamp":1791234429925,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.biopsych.2012.05.008","type":"journal-article","created":{"date-parts":[[2012,6,9]],"date-time":"2012-06-09T02:29:14Z","timestamp":1339208954000},"page":"671-676","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":133,"title":["Three Dyslexia Susceptibility Genes, DYX1C1, DCDC2, and KIAA0319, Affect Temporo-Parietal White Matter Structure"],"prefix":"10.1016","volume":"72","author":[{"given":"Fahimeh","family":"Darki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Peyrard-Janvid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Matsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Kere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torkel","family":"Klingberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2012.05.008_bib1","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1001\/jama.1990.03450080084036","article-title":"Prevalence of reading disability in boys and girls","volume":"264","author":"Shaywitz","year":"1990","journal-title":"JAMA"},{"key":"10.1016\/j.biopsych.2012.05.008_bib2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1056\/NEJM199801293380507","article-title":"Dyslexia","volume":"338","author":"Shaywitz","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biopsych.2012.05.008_bib3","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ana.410180210","article-title":"Developmental dyslexia: Four consecutive patients with cortical anomalies","volume":"18","author":"Galaburda","year":"1985","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopsych.2012.05.008_bib4","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/ana.410280602","article-title":"Developmental dyslexia in women: Neuropathological findings in three patients","volume":"28","author":"Humphreys","year":"1990","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopsych.2012.05.008_bib5","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1126\/science.1057179","article-title":"Dyslexia: Cultural diversity and biological unity","volume":"291","author":"Paulesu","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2012.05.008_bib6","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.neuroimage.2011.02.040","article-title":"Meta-analyzing brain dysfunctions in dyslexic children and adults","volume":"53","author":"Richlan","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2012.05.008_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0006-3223(02)01365-3","article-title":"Disruption of posterior brain systems for reading in children with developmental dyslexia","volume":"52","author":"Shaywitz","year":"2002","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.05.008_bib8","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1093\/brain\/awh579","article-title":"Brain abnormalities underlying altered activation in dyslexia: A voxel based morphometry study","volume":"128","author":"Silani","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2012.05.008_bib9","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0896-6273(00)80911-3","article-title":"Microstructure of temporo-parietal white matter as a basis for reading ability: Evidence from diffusion tensor magnetic resonance imaging","volume":"25","author":"Klingberg","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2012.05.008_bib10","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.neuroimage.2004.12.053","article-title":"Imaging brain connectivity in children with diverse reading ability","volume":"25","author":"Beaulieu","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2012.05.008_bib11","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0010-9452(08)70272-7","article-title":"Special issue children's reading performance is correlated with white matter structure measured by diffusion tensor imaging","volume":"41","author":"Deutsch","year":"2005","journal-title":"Cortex"},{"key":"10.1016\/j.biopsych.2012.05.008_bib12","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1016\/j.neuropsychologia.2006.01.011","article-title":"Left lateralized white matter microstructure accounts for individual differences in reading ability and disability","volume":"44","author":"Niogi","year":"2006","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.biopsych.2012.05.008_bib13","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1086\/429131","article-title":"Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia","volume":"76","author":"Cope","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2012.05.008_bib14","doi-asserted-by":"crossref","first-page":"17053","DOI":"10.1073\/pnas.0508591102","article-title":"DCDC2 is associated with reading disability and modulates neuronal development in the brain","volume":"102","author":"Meng","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2012.05.008_bib15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1086\/498992","article-title":"Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia","volume":"78","author":"Schumacher","year":"2006","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2012.05.008_bib16","doi-asserted-by":"crossref","first-page":"11553","DOI":"10.1073\/pnas.1833911100","article-title":"A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain","volume":"100","author":"Taipale","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2012.05.008_bib17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/YPG.0b013e32832080e1","article-title":"Further evidence for DYX1C1 as a susceptibility factor for dyslexia","volume":"19","author":"Dahdouh","year":"2009","journal-title":"Psychiatr Genet"},{"key":"10.1016\/j.biopsych.2012.05.008_bib18","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1093\/hmg\/ddp215","article-title":"Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia","volume":"18","author":"Massinen","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2012.05.008_bib19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/sj.mp.4001596","article-title":"No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia","volume":"10","author":"Cope","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.05.008_bib20","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/sj.ejhg.5201356","article-title":"A family-based association study does not support DYX1C1 on 15q21. 3 as a candidate gene in developmental dyslexia","volume":"13","author":"Marino","year":"2005","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.biopsych.2012.05.008_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00439-005-0017-9","article-title":"TDT-association analysis of EKN1 and dyslexia in a Colorado twin cohort","volume":"118","author":"Meng","year":"2005","journal-title":"Hum Genet"},{"key":"10.1016\/j.biopsych.2012.05.008_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10519-010-9441-2","article-title":"An examination of candidate gene SNPs for dyslexia in an Indian sample","volume":"41","author":"Venkatesh","year":"2011","journal-title":"Behav Genet"},{"key":"10.1016\/j.biopsych.2012.05.008_bib23","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1093\/hmg\/ddl089","article-title":"The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration","volume":"15","author":"Paracchini","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2012.05.008_bib24","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.neuroscience.2006.08.022","article-title":"DYX1C1 functions in neuronal migration in developing neocortex","volume":"143","author":"Wang","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2012.05.008_bib25","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/mp.2009.120","article-title":"Dyslexia and DYX1C1: Deficits in reading and spelling associated with a missense mutation","volume":"15","author":"Bates","year":"2009","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.05.008_bib26","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ejhg.2009.237","article-title":"Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample","volume":"18","author":"Lind","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.biopsych.2012.05.008_bib27","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1601-183X.2010.00651.x","article-title":"Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population","volume":"10","author":"Paracchini","year":"2011","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.biopsych.2012.05.008_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.biopsych.2011.02.005","article-title":"DCDC2, KIAA0319 and CMIP are associated with reading-related traits","volume":"70","author":"Scerri","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.05.008_bib29","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1523\/JNEUROSCI.5996-10.2012","article-title":"Genetic variants of FOXP2 and KIAA0319\/TTRAP\/THEM2 locus are associated with altered brain activation in distinct language-related regions","volume":"32","author":"Pinel","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2012.05.008_bib30","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.biopsych.2011.02.027","article-title":"Influence of the COMT genotype on working memory and brain activity changes during development","volume":"70","author":"Dumontheil","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.05.008_bib31","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.biopsych.2010.07.036","article-title":"The SNAP25 gene is linked to working memory capacity and maturation of the posterior cingulate cortex during childhood","volume":"68","author":"S\u00f6derqvist","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.05.008_bib32","series-title":"The Woodcock Reading Mastery Test\u2014Revised","author":"Woodcock","year":"1987"},{"key":"10.1016\/j.biopsych.2012.05.008_bib33","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.neuroimage.2004.01.041","article-title":"Nonstationary cluster-size inference with random field and permutation methods","volume":"22","author":"Hayasaka","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2012.05.008_bib34","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/mrdd.10080","article-title":"The development of reading impairment: A cognitive neuroscience model","volume":"9","author":"McCandliss","year":"2003","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"10.1016\/j.biopsych.2012.05.008_bib35","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1001\/archneur.1997.00550170042013","article-title":"A positron emission tomographic study of impaired word recognition and phonological processing in dyslexic men","volume":"54","author":"Rumsey","year":"1997","journal-title":"Arch Neurol"},{"key":"10.1016\/j.biopsych.2012.05.008_bib36","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nn1065","article-title":"Development of neural mechanisms for reading","volume":"6","author":"Turkeltaub","year":"2003","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2012.05.008_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/nature08461","article-title":"An anatomical signature for literacy","volume":"461","author":"Carreiras","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2012.05.008_bib38","article-title":"Neural plasticity after pre-linguistic injury to the arcuate and superior longitudinal fasciculi [published online ahead of print September 2]","author":"Yeatman","year":"2011","journal-title":"Cortex"},{"key":"10.1016\/j.biopsych.2012.05.008_bib39","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1177\/002221940103400606","article-title":"Event-related potentials and consonant differentiation in newborns with familial risk for dyslexia","volume":"34","author":"Guttorm","year":"2001","journal-title":"J Learn Disabil"},{"key":"10.1016\/j.biopsych.2012.05.008_bib40","doi-asserted-by":"crossref","first-page":"e20580","DOI":"10.1371\/journal.pone.0020580","article-title":"Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons","volume":"6","author":"Massinen","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.biopsych.2012.05.008_bib41","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1093\/cercor\/bhp154","article-title":"The effect of variation in expression of the candidate dyslexia susceptibility gene homolog Kiaa0319 on neuronal migration and dendritic morphology in the rat","volume":"20","author":"Peschansky","year":"2010","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2012.05.008_bib42","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.nbd.2009.06.019","article-title":"Progress towards a cellular neurobiology of reading disability","volume":"38","author":"Gabel","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.biopsych.2012.05.008_bib43","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ijdevneu.2012.01.009","article-title":"Neocortical disruption and behavioral impairments in rats following in utero RNAi of candidate dyslexia risk gene Kiaa0319","volume":"30","author":"Szalkowski","year":"2012","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.biopsych.2012.05.008_bib44","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1093\/cercor\/bhl162","article-title":"Disruption of neuronal migration by RNAi of Dyx1c1 results in neocortical and hippocampal malformations","volume":"17","author":"Rosen","year":"2007","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2012.05.008_bib45","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.biopsych.2007.03.007","article-title":"A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability","volume":"62","author":"Luciano","year":"2007","journal-title":"Biol Psychiatry"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322312004453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322312004453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:59:37Z","timestamp":1762099177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322312004453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0006322312004453"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2012.05.008","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Three Dyslexia Susceptibility Genes, DYX1C1, DCDC2, and KIAA0319, Affect Temporo-Parietal White Matter Structure","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2012.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}