{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:22:27Z","timestamp":1791267747486,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.biopsych.2012.11.007","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T17:58:20Z","timestamp":1356631100000},"page":"48-54","source":"Crossref","is-referenced-by-count":296,"title":["A Treatment-Resistant Default Mode Subnetwork in Major Depression"],"prefix":"10.1016","volume":"74","author":[{"given":"Baojuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl J.","family":"Friston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Li","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2012.11.007_bib1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/archpsyc.62.6.617","article-title":"Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.biopsych.2011.05.018","article-title":"Disrupted brain connectivity networks in drug-naive, first-episode major depressive disorder","volume":"70","author":"Zhang","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jad.2011.03.049","article-title":"Gray matter abnormalities in major depressive disorder: A meta-analysis of voxel based morphometry studies","volume":"138","author":"Bora","year":"2012","journal-title":"J Affect Disord"},{"key":"10.1016\/j.biopsych.2012.11.007_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pnpbp.2011.09.014","article-title":"Voxelwise meta-analysis of gray matter reduction in major depressive disorder","volume":"36","author":"Du","year":"2012","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0924-977X(02)00102-5","article-title":"Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism","volume":"12","author":"Drevets","year":"2002","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2012.11.007_bib6","first-page":"199","article-title":"Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depression","volume":"33","author":"Wagner","year":"2008","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.biopsych.2012.11.007_bib7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ejrad.2010.04.006","article-title":"Cerebral and cerebellar gray matter reduction in first-episode patients with major depressive disorder: A voxel-based morphometry study","volume":"80","author":"Peng","year":"2011","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.biopsych.2012.11.007_bib8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.biopsycho.2011.08.007","article-title":"Amygdala hyperactivation and prefrontal hypoactivation in subjects with cognitive vulnerability to depression","volume":"88","author":"Zhong","year":"2011","journal-title":"Biol Psychol"},{"key":"10.1016\/j.biopsych.2012.11.007_bib9","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jpsychires.2010.09.007","article-title":"Neural correlates of emotional processing in depression: Changes with cognitive behavioral therapy and predictors of treatment response","volume":"45","author":"Ritchey","year":"2011","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.biopsych.2012.11.007_bib10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jad.2011.04.006","article-title":"Demonstration of decreased gray matter concentration in the midbrain encompassing the dorsal raphe nucleus and the limbic subcortical regions in major depressive disorder: An optimized voxel-based morphometry study","volume":"133","author":"Lee","year":"2011","journal-title":"J Affect Disord"},{"key":"10.1016\/j.biopsych.2012.11.007_bib11","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3109\/15622975.2010.545145","article-title":"Reduced negative BOLD responses in the default-mode network and increased self-focus in depression","volume":"12","author":"Grimm","year":"2011","journal-title":"World J Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jad.2009.11.003","article-title":"Self-referential processing and the prefrontal cortex over the course of depression: A pilot study","volume":"124","author":"Lemogne","year":"2010","journal-title":"J Affect Disord"},{"key":"10.1016\/j.biopsych.2012.11.007_bib13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2174\/1874440001105010014","article-title":"Brain activation during autobiographical memory retrieval with special reference to default mode network","volume":"5","author":"Ino","year":"2011","journal-title":"Open Neuroimag J"},{"key":"10.1016\/j.biopsych.2012.11.007_bib14","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1162\/jocn.2009.21282","article-title":"Patterns of brain activity supporting autobiographical memory, prospection, and theory of mind, and their relationship to the default mode network","volume":"22","author":"Spreng","year":"2010","journal-title":"J Cogn Neurosci"},{"key":"10.1016\/j.biopsych.2012.11.007_bib15","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.brat.2007.12.007","article-title":"Field perspective deficit for positive memories characterizes autobiographical memory in euthymic depressed patients","volume":"46","author":"Bergouignan","year":"2008","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.biopsych.2012.11.007_bib16","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1002\/hbm.20693","article-title":"Increased self-focus in major depressive disorder is related to neural abnormalities in subcortical-cortical midline structures","volume":"30","author":"Grimm","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.biopsych.2012.11.007_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2007.02.012","article-title":"Psychopathology and pathophysiology of the self in depression-neuropsychiatric hypothesis","volume":"104","author":"Northoff","year":"2007","journal-title":"J Affect Disord"},{"key":"10.1016\/j.biopsych.2012.11.007_bib18","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1037\/0021-843X.109.3.504","article-title":"The role of rumination in depressive disorders and mixed anxiety\/depressive symptoms","volume":"109","author":"Nolen-Hoeksema","year":"2000","journal-title":"J Abnorm Psychol"},{"key":"10.1016\/j.biopsych.2012.11.007_bib19","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1073\/pnas.0812686106","article-title":"The default mode network and self-referential processes in depression","volume":"106","author":"Sheline","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2012.11.007_bib20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.biopsych.2006.09.020","article-title":"Resting-state functional connectivity in major depression: Abnormally increased contributions from subgenual cingulate cortex and thalamus","volume":"62","author":"Greicius","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib21","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1440-1819.2009.02030.x","article-title":"Resting state default-mode network connectivity in early depression using a seed region-of-interest analysis: Decreased connectivity with caudate nucleus","volume":"63","author":"Bluhm","year":"2009","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.biopsych.2012.11.007_bib22","doi-asserted-by":"crossref","first-page":"11020","DOI":"10.1073\/pnas.1000446107","article-title":"Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus","volume":"107","author":"Sheline","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2012.11.007_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/npp.2008.81","article-title":"Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects","volume":"34","author":"Grimm","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2012.11.007_bib24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.pscychresns.2008.03.012","article-title":"Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression","volume":"171","author":"Anand","year":"2009","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.biopsych.2012.11.007_bib25","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/mp.2010.46","article-title":"Investigating neural primacy in major depressive disorder: Multivariate Granger causality analysis of resting-state fMRI time-series data","volume":"16","author":"Hamilton","year":"2011","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib26","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.biopsych.2011.10.035","article-title":"Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients","volume":"71","author":"Zhu","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib27","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.biopsych.2011.02.003","article-title":"Default-mode and task-positive network activity in major depressive disorder: Implications for adaptive and maladaptive rumination","volume":"70","author":"Hamilton","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pscychresns.2011.04.003","article-title":"Default-mode network connectivity and white matter burden in late-life depression","volume":"194","author":"Wu","year":"2011","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.biopsych.2012.11.007_bib29","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1177\/0269881112450779","article-title":"Functional neuroanatomy of emotion processing in major depressive disorder is altered after successful antidepressant therapy","volume":"26","author":"Rosenblau","year":"2012","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.biopsych.2012.11.007_bib30","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0006-3223(01)01263-X","article-title":"Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: An fMRI study","volume":"50","author":"Sheline","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib31","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jad.2008.04.027","article-title":"Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression","volume":"112","author":"Fales","year":"2009","journal-title":"J Affect Disord"},{"key":"10.1016\/j.biopsych.2012.11.007_bib32","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/archpsyc.1992.01820100026006","article-title":"Course of depressive symptoms over follow-up. Findings from the National Institute of Mental Health Treatment of Depression Collaborative Research Program","volume":"49","author":"Shea","year":"1992","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib33","first-page":"469","article-title":"NIMH\/NIH Consensus Development Conference statement. Mood disorders: Pharmacologic prevention of recurrences","author":"Consensus Development Panel","year":"1985","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib34","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.biopsych.2011.03.009","article-title":"Mood-linked responses in medial prefrontal cortex predict relapse in patients with recurrent unipolar depression","volume":"70","author":"Farb","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib35","doi-asserted-by":"crossref","first-page":"625","DOI":"10.4088\/JCP.11m06865","article-title":"Brain-volume increase with sustained remission in patients with treatment-resistant unipolar depression","volume":"73","author":"Phillips","year":"2012","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1001\/archgenpsychiatry.2011.139","article-title":"Reduced medial prefrontal responses to social interaction images in remitted depression","volume":"69","author":"Elliott","year":"2012","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib37","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.neuroimage.2012.03.089","article-title":"Neural correlates of emotion regulation deficits in remitted depression: The influence of regulation strategy, habitual regulation use, and emotional valence","volume":"61","author":"Kanske","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2012.11.007_bib38","doi-asserted-by":"crossref","first-page":"625","DOI":"10.4088\/JCP.11m06865","article-title":"Brain-volume increase with sustained remission in patients with treatment-resistant unipolar depression","volume":"73","author":"Phillips","year":"2012","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib39","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/hbm.20581","article-title":"Modulation of temporally coherent brain networks estimated using ICA at rest and during cognitive tasks","volume":"29","author":"Calhoun","year":"2008","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.biopsych.2012.11.007_bib40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.clinph.2009.11.015","article-title":"Independent component approach to the analysis of EEG recordings at early stages of depressive disorders","volume":"121","author":"Grin-Yatsenko","year":"2010","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.biopsych.2012.11.007_bib41","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.biopsych.2011.10.035","article-title":"Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients","volume":"71","author":"Zhu","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib42","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1073\/pnas.95.3.803","article-title":"Spatially independent activity patterns in functional MRI data during the stroop color-naming task","volume":"95","author":"McKeown","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2012.11.007_bib43","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/hbm.20463","article-title":"Temporal lobe and \"default\" hemodynamic brain modes discriminate between schizophrenia and bipolar disorder","volume":"29","author":"Calhoun","year":"2008","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.biopsych.2012.11.007_bib44","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1073\/pnas.0800376105","article-title":"The maturing architecture of the brain's default network","volume":"105","author":"Fair","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2012.11.007_bib45","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1093\/cercor\/bhm207","article-title":"Reduced resting-state brain activity in the \"default network\" in normal aging","volume":"18","author":"Damoiseaux","year":"2008","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2012.11.007_bib46","doi-asserted-by":"crossref","first-page":"13848","DOI":"10.1073\/pnas.0601417103","article-title":"Consistent resting-state networks across healthy subjects","volume":"103","author":"Damoiseaux","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2012.11.007_bib47","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/hbm.20531","article-title":"Functional connectivity of default mode network components: Correlation, anticorrelation, and causality","volume":"30","author":"Uddin","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.biopsych.2012.11.007_bib48","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1523\/JNEUROSCI.3335-10.2011","article-title":"Episodic memory retrieval, parietal cortex, and the default mode network: Functional and topographic analyses","volume":"31","author":"Sestieri","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2012.11.007_bib49","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1097\/JGP.0b013e318227f4f9","article-title":"The default mode network in late-life anxious depression","volume":"19","author":"Andreescu","year":"2011","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib50","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3109\/15622975.2010.545145","article-title":"Reduced negative BOLD responses in the default-mode network and increased self-focus in depression","volume":"12","author":"Grimm","year":"2011","journal-title":"World J Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib51","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jad.2010.11.034","article-title":"Medial prefrontal cortex and the self in major depression","volume":"136","author":"Lemogne","year":"2012","journal-title":"J Affect Disord"},{"key":"10.1016\/j.biopsych.2012.11.007_bib52","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.neuroimage.2011.05.051","article-title":"Antidepressant medications reduce subcortical-cortical resting-state functional connectivity in healthy volunteers","volume":"57","author":"McCabe","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2012.11.007_bib53","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1001\/archgenpsychiatry.2009.156","article-title":"Brain monoamine oxidase A binding in major depressive disorder: relationship to selective serotonin reuptake inhibitor treatment, recovery, and recurrence","volume":"66","author":"Meyer","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib54","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1001\/archpsyc.61.1.34","article-title":"Modulation of cortical-limbic pathways in major depression: Treatment-specific effects of cognitive behavior therapy","volume":"61","author":"Goldapple","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib55","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.biopsych.2006.03.024","article-title":"Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression","volume":"60","author":"Schaefer","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2012.11.007_bib56","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.biopsych.2008.03.022","article-title":"Ventromedial prefrontal cortex processing during emotional evaluation in late-life depression: A longitudinal functional magnetic resonance imaging study","volume":"64","author":"Brassen","year":"2008","journal-title":"Biol Psychiatry"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322312009870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322312009870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T13:01:51Z","timestamp":1562504511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322312009870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0006322312009870"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2012.11.007","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}