{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:59:58Z","timestamp":1789736398419,"version":"4.0.1"},"reference-count":95,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.biopsych.2013.06.010","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T17:22:42Z","timestamp":1374772962000},"page":"316-323","source":"Crossref","is-referenced-by-count":165,"title":["Immune System Disturbances in Schizophrenia"],"prefix":"10.1016","volume":"75","author":[{"given":"Szatm\u00e1r","family":"Horv\u00e1th","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1roly","family":"Mirnics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2013.06.010_bib1","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/dneu.22044","article-title":"Immune system gene dysregulation in autism and schizophrenia","volume":"72","author":"Michel","year":"2012","journal-title":"Dev Neurobiol"},{"key":"10.1016\/j.biopsych.2013.06.010_bib2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pneurobio.2010.09.003","article-title":"The environment and susceptibility to schizophrenia","volume":"93","author":"Brown","year":"2010","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.biopsych.2013.06.010_bib3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1176\/appi.ajp.2009.09030361","article-title":"Prenatal infection and schizophrenia: A review of epidemiologic and translational studies","volume":"167","author":"Brown","year":"2010","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib4","first-page":"31","article-title":"COX-2 inhibitors as antidepressants and antipsychotics: Clinical evidence","volume":"11","author":"Muller","year":"2010","journal-title":"Curr Opin Investig Drugs"},{"key":"10.1016\/j.biopsych.2013.06.010_bib5","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.2174\/138920112800784826","article-title":"Immunological treatment options for schizophrenia","volume":"13","author":"Muller","year":"2012","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.biopsych.2013.06.010_bib6","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nature08186","article-title":"Common variants conferring risk of schizophrenia","volume":"460","author":"Stefansson","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2013.06.010_bib7","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/schbul\/sbs087","article-title":"Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure","volume":"38","author":"Bamne","year":"2012","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.biopsych.2013.06.010_bib8","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.biopsych.2011.02.034","article-title":"Common sequence variants in the major histocompatibility complex region associate with cerebral ventricular size in schizophrenia","volume":"70","author":"Agartz","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib9","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/ng.940","article-title":"Genome-wide association study identifies five new schizophrenia loci","volume":"43","author":"Consortium SPG-WAS","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2013.06.010_bib10","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1136\/jmedgenet-2011-100397","article-title":"A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia","volume":"49","author":"Jia","year":"2011","journal-title":"J Med Genet"},{"key":"10.1016\/j.biopsych.2013.06.010_bib11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0920-9964(00)00111-0","article-title":"Transmission disequilibrium analysis of HLA class II DRB1, DQA1, DQB1 and DPB1 polymorphisms in schizophrenia using family trios from a Han Chinese population","volume":"49","author":"Li","year":"2001","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2013.06.010_bib12","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.biopsych.2006.12.021","article-title":"Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia","volume":"62","author":"Arion","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib13","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.nbd.2009.12.013","article-title":"Infragranular gene expression disturbances in the prefrontal cortex in schizophrenia: Signature of altered neural development?","volume":"37","author":"Arion","year":"2009","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.biopsych.2013.06.010_bib14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1471-244X-7-46","article-title":"Inflammation-related genes up-regulated in schizophrenia brains","volume":"7","author":"Saetre","year":"2007","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib15","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/mp.2012.110","article-title":"Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia","volume":"18","author":"Fillman","year":"2012","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib16","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.biopsych.2011.04.013","article-title":"Meta-analysis of cytokine alterations in schizophrenia: Clinical status and antipsychotic effects","volume":"70","author":"Miller","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/mp.2009.117","article-title":"Identification of blood biomarkers for psychosis using convergent functional genomics","volume":"16","author":"Kurian","year":"2009","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1586\/ern.09.144","article-title":"The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder","volume":"10","author":"Drexhage","year":"2009","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.biopsych.2013.06.010_bib19","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.biopsych.2008.10.018","article-title":"The interaction of nuclear factor-kappa B and cytokines is associated with schizophrenia","volume":"65","author":"Song","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1001\/2013.jamapsychiatry.86","article-title":"Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: Specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis","volume":"70","author":"Steiner","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib21","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1741-7015-11-74","article-title":"Aspirin: A review of its neurobiological properties and therapeutic potential for mental illness","volume":"11","author":"Berk","year":"2013","journal-title":"BMC Med"},{"key":"10.1016\/j.biopsych.2013.06.010_bib22","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.schres.2010.04.015","article-title":"Celecoxib treatment in an early stage of schizophrenia: Results of a randomized, double-blind, placebo-controlled trial of celecoxib augmentation of amisulpride treatment","volume":"121","author":"Muller","year":"2010","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2013.06.010_bib23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.pnpbp.2008.12.006","article-title":"Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice","volume":"33","author":"Sugino","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib24","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1017\/S1461145710001410","article-title":"Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: Evidence from human peripheral studies and CNS studies","volume":"14","author":"Dean","year":"2010","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2013.06.010_bib25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1523\/JNEUROSCI.23-01-00297.2003","article-title":"Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring","volume":"23","author":"Shi","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2013.06.010_bib26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neures.2006.06.002","article-title":"Recent progress in animal modeling of immune inflammatory processes in schizophrenia: implication of specific cytokines","volume":"56","author":"Nawa","year":"2006","journal-title":"Neurosci Res"},{"key":"10.1016\/j.biopsych.2013.06.010_bib27","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/978-1-61779-458-2_28","article-title":"Experimental schizophrenia models in rodents established with inflammatory agents and cytokines","volume":"829","author":"Nawa","year":"2012","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.biopsych.2013.06.010_bib28","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1176\/appi.ajp.162.4.767","article-title":"Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring","volume":"162","author":"Brown","year":"2005","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib29","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","article-title":"Maternal immune activation alters fetal brain development through interleukin-6","volume":"27","author":"Smith","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2013.06.010_bib30","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.bbi.2010.03.005","article-title":"Effects of prenatal infection on brain development and behavior: A review of findings from animal models","volume":"24","author":"Boksa","year":"2010","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2013.06.010_bib31","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1523\/JNEUROSCI.4230-10.2011","article-title":"Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT(2)A and mGlu(2) receptors in the adult offspring","volume":"31","author":"Moreno","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2013.06.010_bib32","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1126\/science.1228261","article-title":"Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice","volume":"339","author":"Giovanoli","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2013.06.010_bib33","doi-asserted-by":"crossref","first-page":"7654","DOI":"10.1523\/JNEUROSCI.0091-13.2013","article-title":"Maternal immune activation during gestation interacts with Disc1 point mutation to exacerbate schizophrenia-related behaviors in mice","volume":"33","author":"Lipina","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2013.06.010_bib34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.biopsych.2010.07.017","article-title":"Analyzing schizophrenia by DNA microarrays","volume":"69","author":"Horvath","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib35","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.biopsych.2006.02.003","article-title":"Critical appraisal of DNA microarrays in psychiatric genomics","volume":"60","author":"Mirnics","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib36","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nm0509-488","article-title":"Breaking the gene barrier in schizophrenia","volume":"15","author":"Horvath","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2013.06.010_bib37","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0166-2236(00)01862-2","article-title":"Analysis of complex brain disorders with gene expression microarrays: Schizophrenia as a disease of the synapse","volume":"24","author":"Mirnics","year":"2001","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.biopsych.2013.06.010_bib38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0896-6273(00)00085-4","article-title":"Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex","volume":"28","author":"Mirnics","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2013.06.010_bib39","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ijdevneu.2011.02.013","article-title":"Synaptic changes in the brain of subjects with schizophrenia","volume":"29","author":"Faludi","year":"2011","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.biopsych.2013.06.010_bib40","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1176\/appi.ajp.2007.07081223","article-title":"Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia","volume":"165","author":"Hashimoto","year":"2008","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib41","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/sj.mp.4002011","article-title":"Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia","volume":"13","author":"Hashimoto","year":"2008","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib42","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1523\/JNEUROSCI.22-07-02718.2002","article-title":"Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia","volume":"22","author":"Middleton","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2013.06.010_bib43","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/07853890801923753","article-title":"Mitochondrial involvement in psychiatric disorders","volume":"40","author":"Shao","year":"2008","journal-title":"Ann Med"},{"key":"10.1016\/j.biopsych.2013.06.010_bib44","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/hmg\/ddi022","article-title":"Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis","volume":"14","author":"Iwamoto","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2013.06.010_bib45","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ajmg.b.30481","article-title":"Towards understanding the schizophrenia code: An expanded convergent functional genomics approach","volume":"144B","author":"Le-Niculescu","year":"2007","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.biopsych.2013.06.010_bib46","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.1073\/pnas.081071198","article-title":"Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia","volume":"98","author":"Hakak","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2013.06.010_bib47","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1001\/archgenpsychiatry.2012.704","article-title":"A system-level transcriptomic analysis of schizophrenia using postmortem brain tissue samples","volume":"69","author":"Roussos","year":"2012","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib48","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jneuroim.2011.08.007","article-title":"Role of alpha7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-alpha (TNF-alpha) as revealed by subtype selective agonists","volume":"239","author":"Li","year":"2011","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.biopsych.2013.06.010_bib49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/1389203711314010005","article-title":"Neurotransmitters and microglial-mediated neuroinflammation","volume":"14","author":"Lee","year":"2013","journal-title":"Curr Protein Pept Sci"},{"key":"10.1016\/j.biopsych.2013.06.010_bib50","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nri2971","article-title":"Illuminating viral infections in the nervous system","volume":"11","author":"McGavern","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.biopsych.2013.06.010_bib51","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.schres.2005.03.020","article-title":"Variations in differential gene expression patterns across multiple brain regions in schizophrenia","volume":"77","author":"Katsel","year":"2005","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2013.06.010_bib52","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.2741\/2275","article-title":"SERPINA3 (aka alpha-1-antichymotrypsin)","volume":"12","author":"Baker","year":"2007","journal-title":"Front Biosci"},{"key":"10.1016\/j.biopsych.2013.06.010_bib53","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neulet.2013.02.034","article-title":"Sequencing of hippocampal and cerebellar transcriptomes provides new insights into the complexity of gene regulation in the human brain","volume":"541","author":"Twine","year":"2013","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.biopsych.2013.06.010_bib54","doi-asserted-by":"crossref","first-page":"13126","DOI":"10.1074\/jbc.M601194200","article-title":"Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes","volume":"281","author":"Gopalan","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2013.06.010_bib55","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1074\/jbc.M510935200","article-title":"Astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes requires activator protein-1","volume":"281","author":"Gopalan","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2013.06.010_bib56","doi-asserted-by":"crossref","first-page":"43168","DOI":"10.1074\/jbc.M505598200","article-title":"The murine orthologue of human antichymotrypsin: A structural paradigm for clade A3 serpins","volume":"280","author":"Horvath","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2013.06.010_bib57","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1093\/hmg\/dds006","article-title":"Genetic and epigenetic mechanisms collaborate to control SERPINA3 expression and its association with placental diseases","volume":"21","author":"Chelbi","year":"2013","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2013.06.010_bib58","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1161\/01.HYP.0000250831.52876.cb","article-title":"Expressional and epigenetic alterations of placental serine protease inhibitors: SERPINA3 is a potential marker of preeclampsia","volume":"49","author":"Chelbi","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.biopsych.2013.06.010_bib59","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/imm.12038","article-title":"Recent advances in understanding viral evasion of type I interferon","volume":"138","author":"Taylor","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.biopsych.2013.06.010_bib60","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nri3344","article-title":"The broad-spectrum antiviral functions of IFIT and IFITM proteins","volume":"13","author":"Diamond","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.biopsych.2013.06.010_bib61","doi-asserted-by":"crossref","first-page":"e1002337","DOI":"10.1371\/journal.ppat.1002337","article-title":"IFITM3 inhibits influenza A virus infection by preventing cytosolic entry","volume":"7","author":"Feeley","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.biopsych.2013.06.010_bib62","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.cell.2009.12.017","article-title":"The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus","volume":"139","author":"Brass","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2013.06.010_bib63","doi-asserted-by":"crossref","first-page":"e1002909","DOI":"10.1371\/journal.ppat.1002909","article-title":"Ifitm3 limits the severity of acute influenza in mice","volume":"8","author":"Bailey","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.biopsych.2013.06.010_bib64","first-page":"T32","article-title":"Elevated transcript levels for viral restriction factors in cortical endothelial cells in schizophrenia","volume":"38","author":"Volk","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2013.06.010_bib65","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.schres.2009.12.002","article-title":"The chitinase 3-like 1 gene and schizophrenia: Evidence from a multi-center case-control study and meta-analysis","volume":"116","author":"Ohi","year":"2010","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2013.06.010_bib66","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.biopsych.2007.12.012","article-title":"Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: Genetic association and a potential functional mechanism","volume":"64","author":"Yang","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib67","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.neulet.2012.02.039","article-title":"A promoter variant in the chitinase 3-like 1 gene is associated with serum YKL-40 level and personality trait","volume":"513","author":"Yamamori","year":"2012","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.biopsych.2013.06.010_bib68","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1755-8794-3-18","article-title":"Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities","volume":"3","author":"Medina","year":"2010","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.biopsych.2013.06.010_bib69","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.cellsig.2012.01.018","article-title":"The macrophage response towards LPS and its control through the p38(MAPK)-STAT3 axis","volume":"24","author":"Bode","year":"2012","journal-title":"Cell Signal"},{"key":"10.1016\/j.biopsych.2013.06.010_bib70","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10735-006-9075-0","article-title":"YKL-40 protein expression in normal adult human tissues\u2014an immunohistochemical study","volume":"38","author":"Ringsholt","year":"2007","journal-title":"J Mol Histol"},{"key":"10.1016\/j.biopsych.2013.06.010_bib71","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1349-7006.2005.00026.x","article-title":"Regulation of YKL-40 expression during genotoxic or microenvironmental stress in human glioblastoma cells","volume":"96","author":"Junker","year":"2005","journal-title":"Cancer Sci"},{"key":"10.1016\/j.biopsych.2013.06.010_bib72","first-page":"827","article-title":"Astrocytes in Alzheimer\u2019s disease gray matter express alpha 1-antichymotrypsin mRNA","volume":"135","author":"Pasternack","year":"1989","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biopsych.2013.06.010_bib73","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bbr.2008.12.016","article-title":"Immune involvement in schizophrenia and autism: Etiology, pathology and animal models","volume":"204","author":"Patterson","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.biopsych.2013.06.010_bib74","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/dneu.22045","article-title":"Placental regulation of maternal-fetal interactions and brain development","volume":"72","author":"Hsiao","year":"2012","journal-title":"Dev Neurobiol"},{"key":"10.1016\/j.biopsych.2013.06.010_bib75","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/ana.23648","article-title":"The blood-brain barrier in health and disease","volume":"72","author":"Daneman","year":"2013","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopsych.2013.06.010_bib76","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1038\/tp.2012.24","article-title":"Effects of maternal immune activation on gene expression patterns in the fetal brain","volume":"2","author":"Garbett","year":"2012","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib77","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.jpsychires.2010.04.014","article-title":"Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia","volume":"44","author":"Martins-de-Souza","year":"2010","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.biopsych.2013.06.010_bib78","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jpsychires.2010.03.003","article-title":"Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia","volume":"44","author":"Martins-de-Souza","year":"2010","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.biopsych.2013.06.010_bib79","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.biopsych.2010.09.022","article-title":"Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology","volume":"68","author":"Abazyan","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib80","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/nn1764","article-title":"Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12\/CXCR4 signaling","volume":"9","author":"Borrell","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2013.06.010_bib81","doi-asserted-by":"crossref","first-page":"15718","DOI":"10.1073\/pnas.95.26.15718","article-title":"A decrease of reelin expression as a putative vulnerability factor in schizophrenia","volume":"95","author":"Impagnatiello","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2013.06.010_bib82","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/sj.mp.4000520","article-title":"Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice","volume":"4","author":"Fatemi","year":"1999","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib83","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1749-8104-7-2","article-title":"Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith\/hith mice","volume":"7","author":"Zarbalis","year":"2012","journal-title":"Neural Dev"},{"key":"10.1016\/j.biopsych.2013.06.010_bib84","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4049\/jimmunol.0802258","article-title":"IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis","volume":"183","author":"McCandless","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.biopsych.2013.06.010_bib85","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3109\/15622975.2011.583941","article-title":"Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity","volume":"13","author":"Steiner","year":"2011","journal-title":"World J Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib86","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1440-1819.2010.02094.x","article-title":"Cytokine hypothesis of schizophrenia pathogenesis: Evidence from human studies and animal models","volume":"64","author":"Watanabe","year":"2010","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.biopsych.2013.06.010_bib87","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/glia.22461","article-title":"Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice","volume":"61","author":"Ibi","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.biopsych.2013.06.010_bib88","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1001\/archpsyc.55.3.215","article-title":"Neuronal and glial somal size in the prefrontal cortex: A postmortem morphometric study of schizophrenia and Huntington disease","volume":"55","author":"Rajkowska","year":"1998","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib89","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/syn.20329","article-title":"Lamina-specific abnormalities of AMPA receptor trafficking and signaling molecule transcripts in the prefrontal cortex in schizophrenia","volume":"60","author":"Beneyto","year":"2006","journal-title":"Synapse"},{"key":"10.1016\/j.biopsych.2013.06.010_bib90","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/sj.mp.4001954","article-title":"Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection","volume":"12","author":"Ruzicka","year":"2007","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib91","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1001\/archpsyc.1995.03950160008002","article-title":"Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics","volume":"52","author":"Akbarian","year":"1995","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib92","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S0006-3223(02)01360-4","article-title":"Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins","volume":"52","author":"Beasley","year":"2002","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.06.010_bib93","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1038\/npp.2011.102","article-title":"Selective pyramidal cell reduction of GABA(A) receptor alpha1 subunit messenger RNA expression in schizophrenia","volume":"36","author":"Glausier","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2013.06.010_bib94","doi-asserted-by":"crossref","unstructured":"Wu JQ, Wang X, Beveridge NJ, Tooney PA, Scott RJ, Carr VJ, et al. (2012): Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia. PLoS One 7:e36351.","DOI":"10.1371\/journal.pone.0036351"},{"key":"10.1016\/j.biopsych.2013.06.010_bib95","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.nbd.2008.01.012","article-title":"Immune transcriptome alterations in the temporal cortex of subjects with autism","volume":"30","author":"Garbett","year":"2008","journal-title":"Neurobiol Dis"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322313005817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322313005817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T13:56:28Z","timestamp":1563544588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322313005817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":95,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0006322313005817"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2013.06.010","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]}}}