{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:57:56Z","timestamp":1791068276054,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.biopsych.2013.11.023","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T13:05:34Z","timestamp":1386248734000},"page":"823-831","source":"Crossref","is-referenced-by-count":56,"title":["Selective Overexpression of Dopamine D3 Receptors in the Striatum Disrupts Motivation but not Cognition"],"prefix":"10.1016","volume":"76","author":[{"given":"Eleanor H.","family":"Simpson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Winiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik K.","family":"Biezonski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iram","family":"Haq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Kandel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kellendonk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2013.11.023_bib1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.neuron.2010.02.014","article-title":"A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia","volume":"65","author":"Simpson","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2013.11.023_bib2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1001\/archgenpsychiatry.2012.169","article-title":"The nature of dopamine dysfunction in schizophrenia and what this means for treatment","volume":"69","author":"Howes","year":"2012","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2013.11.023_bib3","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1126\/science.1145194","article-title":"Antipsychotic drugs: Direct correlation between clinical potency and presynaptic action on dopamine neurons","volume":"188","author":"Seeman","year":"1975","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2013.11.023_bib4","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.3854","article-title":"Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs","volume":"192","author":"Creese","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2013.11.023_bib5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0165-0173(99)00043-0","article-title":"Possible implications of the dopamine D(3) receptor in schizophrenia and in antipsychotic drug actions","volume":"31","author":"Schwartz","year":"2000","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.biopsych.2013.11.023_bib6","series-title":"Neuropharmacology: The Fifth Generation of Progress.","article-title":"Neurochemical and neuropharmacological imaging in schizophrenia","author":"Weinberger","year":"2001"},{"key":"10.1016\/j.biopsych.2013.11.023_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0165-6147(91)90480-G","article-title":"Cloning of a \u2018D3\u2019 receptor subtype expands dopamine receptor family","volume":"12","author":"Sibley","year":"1991","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.biopsych.2013.11.023_bib8","series-title":"The Dopamine Receptors, 2nd ed","first-page":"101","article-title":"Dopamine receptor subtype-selective drugs: D2-like receptors","author":"Prante","year":"2010"},{"key":"10.1016\/j.biopsych.2013.11.023_bib9","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/syn.21535","article-title":"Affinity and selectivity of [(1)(1)C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo","volume":"66","author":"Gallezot","year":"2012","journal-title":"Synapse"},{"key":"10.1016\/j.biopsych.2013.11.023_bib10","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neuroimage.2010.06.044","article-title":"Imaging dopamine receptors in humans with [11C]-(+)-PHNO: Dissection of D3 signal and anatomy","volume":"54","author":"Tziortzi","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2013.11.023_bib11","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.biopsych.2010.04.038","article-title":"Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist","volume":"68","author":"Searle","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.11.023_bib12","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/npp.2008.199","article-title":"The dopamine D2 receptors in high-affinity state and D3 receptors in schizophrenia: A clinical [11C]-(+)-PHNO PET study","volume":"34","author":"Graff-Guerrero","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2013.11.023_bib13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0014-2999(93)90839-A","article-title":"In vitro binding of a novel dopamine D3 receptor ligand: [125I]trans-7-OH-PIPAT-A","volume":"235","author":"Kung","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.biopsych.2013.11.023_bib14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1001\/archpsyc.1997.01830150047009","article-title":"Mesolimbic dopamine D3 receptors and use of antipsychotics in patients with schizophrenia. A postmortem study","volume":"54","author":"Gurevich","year":"1997","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2013.11.023_bib15","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.neuron.2006.01.023","article-title":"Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning","volume":"49","author":"Kellendonk","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2013.11.023_bib16","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1126\/science.274.5293.1678","article-title":"Control of memory formation through regulated expression of a CaMKII transgene","volume":"274","author":"Mayford","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2013.11.023_bib17","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/BF00267823","article-title":"A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: In situ hybridization using digoxigenin-labelled cRNA probes","volume":"100","author":"Schaeren-Wiemers","year":"1993","journal-title":"Histochemistry"},{"key":"10.1016\/j.biopsych.2013.11.023_bib18","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/j.1471-4159.2009.06515.x","article-title":"Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: Implications for MDMA neurotoxicity","volume":"112","author":"Biezonski","year":"2010","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopsych.2013.11.023_bib19","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.biopsych.2011.01.012","article-title":"Pharmacologic rescue of motivational deficit in an animal model of the negative symptoms of schizophrenia","volume":"69","author":"Simpson","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.11.023_bib20","first-page":"1372","article-title":"Processing of gene expression data generated by quantitative real-time RT-PCR","volume":"32","author":"Muller","year":"2002","journal-title":"Biotechniques"},{"key":"10.1016\/j.biopsych.2013.11.023_bib21","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1523\/JNEUROSCI.5406-05.2006","article-title":"Impaired bidirectional synaptic plasticity and procedural memory formation in striatum-specific cAMP response element-binding protein-deficient mice","volume":"26","author":"Pittenger","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2013.11.023_bib22","doi-asserted-by":"crossref","first-page":"16027","DOI":"10.1073\/pnas.0807746105","article-title":"Transient and selective overexpression of D2 receptors in the striatum causes persistent deficits in conditional associative learning","volume":"105","author":"Bach","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2013.11.023_bib23","doi-asserted-by":"crossref","first-page":"7731","DOI":"10.1523\/JNEUROSCI.1736-07.2007","article-title":"Transient overexpression of striatal D2 receptors impairs operant motivation and interval timing","volume":"27","author":"Drew","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2013.11.023_bib24","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1523\/JNEUROSCI.6056-11.2012","article-title":"Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels","volume":"32","author":"Cazorla","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2013.11.023_bib25","doi-asserted-by":"crossref","first-page":"10178","DOI":"10.1073\/pnas.89.21.10178","article-title":"Dopamine receptor subtypes colocalize in rat striatonigral neurons","volume":"89","author":"Surmeier","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2013.11.023_bib26","doi-asserted-by":"crossref","first-page":"6579","DOI":"10.1523\/JNEUROSCI.16-20-06579.1996","article-title":"Coordinated expression of dopamine receptors in neostriatal medium spiny neurons","volume":"16","author":"Surmeier","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2013.11.023_bib27","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1176\/ajp.156.9.1358","article-title":"Memory impairment in schizophrenia: A meta-analysis","volume":"156","author":"Aleman","year":"1999","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2013.11.023_bib28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11065-005-6254-9","article-title":"A meta-analysis of cognitive deficits in adults with a diagnosis of schizophrenia","volume":"15","author":"Fioravanti","year":"2005","journal-title":"Neuropsychol Rev"},{"key":"10.1016\/j.biopsych.2013.11.023_bib29","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.schres.2011.11.014","article-title":"Spatial memory deficits in a virtual reality eight-arm radial maze in schizophrenia","volume":"135","author":"Spieker","year":"2012","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2013.11.023_bib30","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1176\/jnp.6.4.348","article-title":"Working memory dysfunction in schizophrenia","volume":"6","author":"Goldman-Rakic","year":"1994","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.1016\/j.biopsych.2013.11.023_bib31","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1037\/0021-843X.114.4.599","article-title":"Working memory impairments in schizophrenia: A meta-analysis","volume":"114","author":"Lee","year":"2005","journal-title":"J Abnorm Psychol"},{"key":"10.1016\/j.biopsych.2013.11.023_bib32","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1001\/archpsyc.1992.01820120063009","article-title":"Schizophrenics show spatial working memory deficits","volume":"49","author":"Park","year":"1992","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2013.11.023_bib33","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0006-3223(00)00930-6","article-title":"Effects of contextual processing on visual conditional associative learning in schizophrenia","volume":"48","author":"Gold","year":"2000","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2013.11.023_bib34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000118337","article-title":"Conditional associative learning in drug-free schizophrenic patients","volume":"17","author":"Kemali","year":"1987","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.biopsych.2013.11.023_bib35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0920-9964(98)00117-0","article-title":"Episodic memory and learning in patients with chronic schizophrenia","volume":"35","author":"Rushe","year":"1999","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2013.11.023_bib36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1369-1600.2006.00011.x","article-title":"Will the last person who uses the term \u2018reward\u2019 please turn out the lights? Comments on processes related to reinforcement, learning, motivation and effort","volume":"11","author":"Salamone","year":"2006","journal-title":"Addict Biol"},{"key":"10.1016\/j.biopsych.2013.11.023_bib37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0091-3057(98)00112-9","article-title":"Effects of dopamine antagonists and accumbens dopamine depletions on time-constrained progressive-ratio performance","volume":"61","author":"Aberman","year":"1998","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.biopsych.2013.11.023_bib38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0091-3057(94)90460-X","article-title":"Nucleus accumbens dopamine depletions in rats affect relative response allocation in a novel cost\/benefit procedure","volume":"49","author":"Cousins","year":"1994","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.biopsych.2013.11.023_bib39","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00213-001-0994-x","article-title":"Dopamine antagonists alter response allocation but do not suppress appetite for food in rats: Contrast between the effects of SKF 83566, raclopride, and fenfluramine on a concurrent choice task","volume":"160","author":"Salamone","year":"2002","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2013.11.023_bib40","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.lfs.2010.03.018","article-title":"Decreased binding of [11C]NNC112 and [11C]SCH23390 in patients with chronic schizophrenia","volume":"86","author":"Kosaka","year":"2010","journal-title":"Life Sci"},{"key":"10.1016\/j.biopsych.2013.11.023_bib41","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1177\/0269881111409265","article-title":"Increased prefrontal cortical D(1) receptors in drug naive patients with schizophrenia: A PET study with [(1)(1)C]NNC112","volume":"26","author":"Abi-Dargham","year":"2012","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.biopsych.2013.11.023_bib42","doi-asserted-by":"crossref","first-page":"11043","DOI":"10.1523\/JNEUROSCI.1682-10.2010","article-title":"Role of aberrant striatal dopamine D1 receptor\/cAMP\/protein kinase A\/DARPP32 signaling in the paradoxical calming effect of amphetamine","volume":"30","author":"Napolitano","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2013.11.023_bib43","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0304-3940(90)90279-I","article-title":"Lack of effect of chronic dopamine receptor blockade on D2 dopamine receptor mRNA level","volume":"111","author":"van Tol","year":"1990","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.biopsych.2013.11.023_bib44","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0006-8993(91)91456-B","article-title":"Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: Comparison with dopamine D2 receptor mRNA","volume":"564","author":"Bouthenet","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.biopsych.2013.11.023_bib45","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35075076","article-title":"BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization","volume":"411","author":"Guillin","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2013.11.023_bib46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2174\/187152706784111551","article-title":"The dopamine D3 receptor: A therapeutic target for the treatment of neuropsychiatric disorders","volume":"5","author":"Sokoloff","year":"2006","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.biopsych.2013.11.023_bib47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1124\/mol.107.043885","article-title":"Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization","volume":"74","author":"Fiorentini","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.biopsych.2013.11.023_bib48","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00213-006-0578-x","article-title":"The debate over dopamine\u2019s role in reward: The case for incentive salience","volume":"191","author":"Berridge","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2013.11.023_bib49","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature09588","article-title":"A selective role for dopamine in stimulus-reward learning","volume":"469","author":"Flagel","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2013.11.023_bib50","unstructured":"Adham N, Gyertyan I, Kiss B, Pasztor G, Gupta S, Szombathelyi Z, et al. (2007): Antidepressant activity of RGH-188, a potential antipsychotic with D3\/D2 antagonist\/partial agonist properties in a chronic mild stress-induced anhedonia model. Presented at the Society for Neuroscience Annual Meeting, November 12\u201317, San Diego, California. San Diego, CA: Society for Neuroscience."}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322313010561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322313010561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T18:39:09Z","timestamp":1688841549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322313010561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0006322313010561"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2013.11.023","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}