{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:47:52Z","timestamp":1759693672932,"version":"3.44.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.biopsych.2014.01.022","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T12:36:57Z","timestamp":1391517417000},"page":"e15-e17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Blood Mononuclear Cell Proteome Suggests Integrin and Ras Signaling as Critical Pathways for Antidepressant Treatment Response"],"prefix":"10.1016","volume":"76","author":[{"given":"Daniel","family":"Martins-de-Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Maccarrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Ising","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Kloiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Lucae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Holsboer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph W.","family":"Turck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2014.01.022_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1017\/S0033291798007429","article-title":"Subclinical symptoms in mood disorders: Pathophysiological and therapeutic implications","volume":"29","author":"Fava","year":"1999","journal-title":"Psychol Med"},{"key":"10.1016\/j.biopsych.2014.01.022_bib2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.pharmthera.2006.07.002","article-title":"Differentiating antidepressants of the future: Efficacy and safety","volume":"113","author":"Rosenzweig-Lipson","year":"2007","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.biopsych.2014.01.022_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/321071","article-title":"Biomarkers for psychiatric disorders: Where are we standing?","volume":"35","author":"Martins-de-Souza","year":"2013","journal-title":"Dis Markers"},{"key":"10.1016\/j.biopsych.2014.01.022_bib4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1155\/2013\/984845","article-title":"Biomarkers predicting antidepressant treatment response: How can we advance the field?","volume":"35","author":"Labermaier","year":"2013","journal-title":"Dis Markers"},{"key":"10.1016\/j.biopsych.2014.01.022_bib5","first-page":"3","article-title":"Is clinical proteomics heading towards to \u201cbench to bedside\u201d?","volume":"1","author":"Oliveira","year":"2013","journal-title":"Transl Proteomics"},{"key":"10.1016\/j.biopsych.2014.01.022_bib6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jpsychires.2008.05.002","article-title":"Clinical characteristics and treatment outcome in a representative sample of depressed inpatients\u2014findings from the Munich Antidepressant Response Signature (MARS) project","volume":"43","author":"Hennings","year":"2009","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.biopsych.2014.01.022_bib7","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/pmic.201200377","article-title":"Proteome profiling of peripheral mononuclear cells from human blood","volume":"13","author":"Maccarrone","year":"2013","journal-title":"Proteomics"},{"key":"10.1016\/j.biopsych.2014.01.022_bib8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10930-009-9227-7","article-title":"Shotgun mass spectrometry workflow combining IEF and LC-MALDI-TOF\/TOF","volume":"29","author":"Maccarrone","year":"2010","journal-title":"Protein J"},{"key":"10.1016\/j.biopsych.2014.01.022_bib9","first-page":"561","article-title":"Is the word \u2018biomarker\u2019 being properly used by proteomics research in neuroscience?","volume":"260","author":"Martins-de-Souza","year":"2010"},{"key":"10.1016\/j.biopsych.2014.01.022_bib10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neures.2011.02.006","article-title":"Stabilising influence: Integrins in regulation of synaptic plasticity","volume":"70","author":"McGeachie","year":"2011","journal-title":"Neurosci Res"},{"key":"10.1016\/j.biopsych.2014.01.022_bib11","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1111\/j.1460-9568.2012.08163.x","article-title":"Beta3 integrin is dispensable for conditioned fear and hebbian forms of plasticity in the hippocampus","volume":"36","author":"McGeachie","year":"2012","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2014.01.022_bib12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/aur.180","article-title":"Absence of preference for social novelty and increased grooming in integrin beta3 knockout mice: Initial studies and future directions","volume":"4","author":"Carter","year":"2011","journal-title":"Autism Res"},{"key":"10.1016\/j.biopsych.2014.01.022_bib13","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.neuron.2008.04.011","article-title":"Activity-dependent regulation of synaptic AMPA receptor composition and abundance by beta3 integrins","volume":"58","author":"Cingolani","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2014.01.022_bib14","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1172\/JCI33374","article-title":"Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans","volume":"118","author":"Carneiro","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.biopsych.2014.01.022_bib15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF02742438","article-title":"Ubiquitin-mediated proteolysis in learning and memory","volume":"20","author":"Chain","year":"1999","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.biopsych.2014.01.022_bib16","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jad.2011.04.020","article-title":"Possible association between ubiquitin-specific peptidase 46 gene and major depressive disorders in the Japanese population","volume":"133","author":"Fukuo","year":"2011","journal-title":"J Affect Disord"},{"key":"10.1016\/j.biopsych.2014.01.022_bib17","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.cellsig.2011.12.027","article-title":"RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation","volume":"24","author":"Matthys","year":"2012","journal-title":"Cell Signal"},{"key":"10.1016\/j.biopsych.2014.01.022_bib18","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1523\/JNEUROSCI.6458-11.2012","article-title":"MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation","volume":"32","author":"Mouri","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2014.01.022_bib19","first-page":"2500","article-title":"Sculpting the endomembrane system in deep time: High resolution phylogenetics of Rab GTPases","volume":"125","author":"Elias","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biopsych.2014.01.022_bib20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/mrd.1080420419","article-title":"Ras-related proteins in signal transduction and growth control","volume":"42","author":"McCormick","year":"1995","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.biopsych.2014.01.022_bib21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nm.3090","article-title":"Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression","volume":"19","author":"Golden","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2014.01.022_bib22","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.2174\/138161209788168001","article-title":"Monoaminergic neurotransmission: The history of the discovery of antidepressants from 1950s until today","volume":"15","author":"Lopez-Munoz","year":"2009","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.biopsych.2014.01.022_bib23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/2045125312445469","article-title":"The drugs don\u2019t work? Antidepressants and the current and future pharmacological management of depression","volume":"2","author":"Penn","year":"2012","journal-title":"Ther Adv Psychopharmacol"},{"key":"10.1016\/j.biopsych.2014.01.022_bib24","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1016\/j.febslet.2011.09.010","article-title":"Glucocorticoid suppresses BDNF-stimulated MAPK\/ERK pathway via inhibiting interaction of Shp2 with TrkB","volume":"585","author":"Kumamaru","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1016\/j.biopsych.2014.01.022_bib25","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1176\/appi.ajp.2012.12081053","article-title":"New insights into BDNF signaling: Relevance to major depression and antidepressant action","volume":"169","author":"Kerman","year":"2012","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2014.01.022_bib26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1017\/S1092852913000059","article-title":"Second messenger\/signal transduction pathways in major mood disorders: Moving from membrane to mechanism of action, part I: Major depressive disorder","volume":"18","author":"Niciu","year":"2013","journal-title":"CNS Spectr"},{"key":"10.1016\/j.biopsych.2014.01.022_bib27","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/nm.2219","article-title":"A negative regulator of MAP kinase causes depressive behavior","volume":"16","author":"Duric","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2014.01.022_bib28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neuroscience.2012.11.061","article-title":"Acute antidepressant treatment differently modulates ERK\/MAPK activation in neurons and astrocytes of the adult mouse prefrontal cortex","volume":"232","author":"Di Benedetto","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2014.01.022_bib29","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/nm1110-1187","article-title":"Keep the \u2018phospho\u2019 on MAPK, be happy","volume":"16","author":"Akbarian","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2014.01.022_bib30","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.ejcb.2010.05.002","article-title":"Dexamethasone enhances the norepinephrine-induced ERK\/MAPK intracellular pathway possibly via dysregulation of the alpha2-adrenergic receptor: implications for antidepressant drug mechanism of action","volume":"89","author":"Yaniv","year":"2010","journal-title":"Eur J Cell Biol"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322314000869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322314000869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T14:58:13Z","timestamp":1757775493000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322314000869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0006322314000869"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2014.01.022","relation":{},"ISSN":["0006-3223"],"issn-type":[{"type":"print","value":"0006-3223"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blood Mononuclear Cell Proteome Suggests Integrin and Ras Signaling as Critical Pathways for Antidepressant Treatment Response","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2014.01.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}