{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:24:03Z","timestamp":1790137443723,"version":"4.0.1"},"reference-count":57,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.biopsych.2014.11.017","type":"journal-article","created":{"date-parts":[[2014,11,29]],"date-time":"2014-11-29T08:53:51Z","timestamp":1417251231000},"page":"912-920","source":"Crossref","is-referenced-by-count":31,"title":["Effects of Prior Cocaine Versus Morphine or Heroin Self-Administration on Extinction Learning Driven by Overexpectation Versus Omission of Reward"],"prefix":"10.1016","volume":"77","author":[{"given":"Federica","family":"Lucantonio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarita","family":"Kambhampati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Z.","family":"Haney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Atalayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil E.","family":"Rowland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavin","family":"Shaham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Schoenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2014.11.017_bib1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1046\/j.1360-0443.2002.00014.x","article-title":"Applying extinction research and theory to cue-exposure addiction treatments","volume":"97","author":"Conklin","year":"2002","journal-title":"Addiction"},{"key":"10.1016\/j.biopsych.2014.11.017_bib2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0740-5472(98)00004-X","article-title":"Cue reactivity and effects of cue exposure in abstinent posttreatment drug users","volume":"16","author":"Franken","year":"1999","journal-title":"J Subst Abuse Treat"},{"key":"10.1016\/j.biopsych.2014.11.017_bib3","first-page":"207","article-title":"Psychotherapy for cocaine dependence","volume":"166","author":"O\u2019Brien","year":"1992","journal-title":"Ciba Found Symp"},{"key":"10.1016\/j.biopsych.2014.11.017_bib4","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/archpsyc.1973.01750350005001","article-title":"Dynamics of drug dependence. Implications of a conditioning theory for research and treatment","volume":"28","author":"Wikler","year":"1973","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2014.11.017_bib5","series-title":"Conditioned Reflexes","author":"Pavlov","year":"1927"},{"key":"10.1016\/j.biopsych.2014.11.017_bib6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.nlm.2013.08.012","article-title":"Behavioral and neurobiological mechanisms of extinction in Pavlovian and instrumental learning","volume":"108C","author":"Todd","year":"2014","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.biopsych.2014.11.017_bib7","series-title":"Classical Conditioning II: Current Research and Theory","first-page":"64","article-title":"A theory of Pavlovian conditioning: Variations in the effectiveness of reinforcement and nonreinforcement","author":"Rescorla","year":"1972"},{"key":"10.1016\/j.biopsych.2014.11.017_bib8","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1101\/lm.534807","article-title":"Withdrawal from cocaine self-administration produces long-lasting deficits in orbitofrontal-dependent reversal learning in rats","volume":"14","author":"Calu","year":"2007","journal-title":"Learn Mem"},{"key":"10.1016\/j.biopsych.2014.11.017_bib9","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00213-013-3222-6","article-title":"Disruption of model-based behavior and learning by cocaine self-administration in rats","volume":"229","author":"Wied","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2014.11.017_bib10","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nn.3014","article-title":"The impact of orbitofrontal dysfunction on cocaine addiction","volume":"15","author":"Lucantonio","year":"2012","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib11","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1196\/annals.1401.022","article-title":"The orbital prefrontal cortex and drug addiction in laboratory animals and humans","volume":"1121","author":"Everitt","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib12","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0893-133X(01)00355-4","article-title":"Impairments of reversal learning and response perseveration after repeated, intermittent cocaine administrations to monkeys","volume":"26","author":"Jentsch","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2014.11.017_bib13","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1111\/j.1460-9568.2004.03274.x","article-title":"Cocaine-experienced rats exhibit learning deficits in a task sensitive to orbitofrontal cortex lesions","volume":"19","author":"Schoenbaum","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib14","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1196\/annals.1401.024","article-title":"The orbitofrontal cortex, impulsivity, and addiction: Probing orbitofrontal dysfunction at the neural, neurochemical, and molecular level","volume":"1121","author":"Winstanley","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib15","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1523\/JNEUROSCI.4305-05.2006","article-title":"Amphetamine exposure enhances habit formation","volume":"26","author":"Nelson","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib16","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0028-3932(00)00136-6","article-title":"Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers","volume":"39","author":"Bechara","year":"2001","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.biopsych.2014.11.017_bib17","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0893-133X(98)00091-8","article-title":"Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: Evidence for monoaminergic mechanisms","volume":"20","author":"Rogers","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2014.11.017_bib18","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1093\/cercor\/bhh216","article-title":"Cocaine makes actions insensitive to outcomes but not extinction: Implications for altered orbitofrontal-amygdalar function","volume":"15","author":"Schoenbaum","year":"2005","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2014.11.017_bib19","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1037\/0735-7044.121.3.543","article-title":"Cocaine exposure causes long-term increases in impulsive choice","volume":"121","author":"Simon","year":"2007","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib20","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1037\/a0020458","article-title":"Self-administered cocaine causes long-lasting increases in impulsive choice in a delay discounting task","volume":"124","author":"Mendez","year":"2010","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1523\/JNEUROSCI.4080-06.2007","article-title":"Previous cocaine exposure makes rats hypersensitive to both delay and reward magnitude","volume":"27","author":"Roesch","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib22","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/nn.3763","article-title":"Orbitofrontal activation restores insight lost after cocaine use","volume":"17","author":"Lucantonio","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3758\/BF03199227","article-title":"Overexpectation in appetitive Pavlovian and instrumental conditioning","volume":"26","author":"Lattal","year":"1998","journal-title":"Animal Learn Behav"},{"key":"10.1016\/j.biopsych.2014.11.017_bib24","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1111\/j.1460-9568.2006.05128.x","article-title":"Abnormal associative encoding in orbitofrontal neurons in cocaine-experienced rats during decision-making","volume":"24","author":"Stalnaker","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.neuron.2009.03.005","article-title":"The orbitofrontal cortex and ventral tegmental area are necessary for learning from unexpected outcomes","volume":"62","author":"Takahashi","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2014.11.017_bib26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.neuron.2013.08.008","article-title":"Neural estimates of imagined outcomes in the orbitofrontal cortex drive behavior and learning","volume":"80","author":"Takahashi","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2014.11.017_bib27","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1523\/JNEUROSCI.0054-10.2010","article-title":"Inactivation of the central but not the basolateral nucleus of the amygdala disrupts learning in response to over-expectation of reward","volume":"30","author":"Haney","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib28","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1523\/JNEUROSCI.5499-10.2011","article-title":"Ventral striatum and orbitofrontal cortex are both required for model-based, but not model-free, reinforcement learning","volume":"31","author":"McDannald","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib29","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrn3104","article-title":"Opiate versus psychostimulant addiction: The differences do matter","volume":"12","author":"Badiani","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib30","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1523\/JNEUROSCI.22-09-03321.2002","article-title":"Neural systems underlying opiate addiction","volume":"22","author":"De Vries","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib31","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0893-133X(99)00133-5","article-title":"Persistent increase in the motivation to take heroin in rats with a history of drug escalation","volume":"22","author":"Ahmed","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2014.11.017_bib32","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.282.5387.298","article-title":"Transition from moderate to excessive drug intake: Change in hedonic set point","volume":"282","author":"Ahmed","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2014.11.017_bib33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.conb.2010.01.009","article-title":"How do you (estimate you will) like them apples? Integration as a defining trait of orbitofrontal function","volume":"20","author":"Schoenbaum","year":"2010","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.biopsych.2014.11.017_bib34","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.pbb.2008.12.007","article-title":"DeltaFosB induction in orbitofrontal cortex potentiates locomotor sensitization despite attenuating the cognitive dysfunction caused by cocaine","volume":"93","author":"Winstanley","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.biopsych.2014.11.017_bib35","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/cercor\/bhn094","article-title":"Increased impulsivity during withdrawal from cocaine self-administration: Role for DeltaFosB in the orbitofrontal cortex","volume":"19","author":"Winstanley","year":"2009","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2014.11.017_bib36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00213-009-1579-3","article-title":"Effects of self-administered cocaine in adolescent and adult male rats on orbitofrontal cortex-related neurocognitive functioning","volume":"206","author":"Harvey","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2014.11.017_bib37","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1097\/00001756-200108080-00060","article-title":"Addiction changes orbitofrontal gyrus function: Involvement in response inhibition","volume":"12","author":"Goldstein","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.biopsych.2014.11.017_bib38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1176\/ajp.156.1.11","article-title":"Limbic activation during cue-induced cocaine craving","volume":"156","author":"Childress","year":"1999","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2014.11.017_bib39","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0006-3223(01)01269-0","article-title":"Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients","volume":"51","author":"Franklin","year":"2002","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2014.11.017_bib40","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1176\/ajp.155.1.124","article-title":"Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving","volume":"155","author":"Maas","year":"1998","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2014.11.017_bib41","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s002130050871","article-title":"Short-term treatment with citicoline (CDP-choline) attenuates some measures of craving in cocaine-dependent subjects: a preliminary report","volume":"142","author":"Renshaw","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2014.11.017_bib42","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1176\/ajp.156.1.11","article-title":"Orbitofrontal cortex supports behavior and learning using inferred but not cached values","volume":"338","author":"Jones","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2014.11.017_bib43","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0006-8993(83)90913-7","article-title":"Morphine-induced activation of A10 dopamine neurons in the rat","volume":"277","author":"Gysling","year":"1983","journal-title":"Brain Res"},{"key":"10.1016\/j.biopsych.2014.11.017_bib44","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1176\/ajp.155.1.124","article-title":"Opioids excite dopamine neurons by hyperpolarization of local interneurons","volume":"12","author":"Johnson","year":"1992","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib45","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0028-3908(73)90120-2","article-title":"Uptake of (3H)-catecholamines by homogenates of rat corpus striatum and cerebral cortex: Effects of amphetamine analogues","volume":"12","author":"Harris","year":"1973","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopsych.2014.11.017_bib46","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0376-8716(02)00110-2","article-title":"Prefrontal cortical volume reduction associated with frontal cortex function deficit in 6-week abstinent crack-cocaine dependent men","volume":"68","author":"Fein","year":"2002","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.biopsych.2014.11.017_bib47","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00213-005-0198-x","article-title":"Prefrontal and temporal gray matter density decreases in opiate dependence","volume":"184","author":"Lyoo","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2014.11.017_bib48","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1176\/ajp.148.5.621","article-title":"Changes in brain glucose metabolism in cocaine dependence and withdrawal","volume":"148","author":"Volkow","year":"1991","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2014.11.017_bib49","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1001\/archpsyc.1990.01810180067010","article-title":"Cocaine-induced reduction of glucose utilization in human brain. A study using positron emission tomography and [fluorine 18]-fluorodeoxyglucose","volume":"47","author":"London","year":"1990","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2014.11.017_bib50","first-page":"47","article-title":"Metabolic studies of drugs of abuse","volume":"105","author":"Volkow","year":"1990","journal-title":"NIDA Res Monogr"},{"key":"10.1016\/j.biopsych.2014.11.017_bib51","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/syn.890110303","article-title":"Long-term frontal brain metabolic changes in cocaine abusers","volume":"11","author":"Volkow","year":"1992","journal-title":"Synapse"},{"key":"10.1016\/j.biopsych.2014.11.017_bib52","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1176\/ajp.148.5.621","article-title":"Opposite effects of amphetamine self-administration experience on dendritic spines in the medial and orbital prefrontal cortex","volume":"15","author":"Crombag","year":"2005","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2014.11.017_bib53","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/syn.10146","article-title":"Widespread but regionally specific effects of experimenter- versus self-administered morphine on dendritic spines in the nucleus accumbens, hippocampus, and neocortex of adult rats","volume":"46","author":"Robinson","year":"2002","journal-title":"Synapse"},{"key":"10.1016\/j.biopsych.2014.11.017_bib54","doi-asserted-by":"crossref","first-page":"11600","DOI":"10.1523\/JNEUROSCI.1914-12.2012","article-title":"Role of orbitofrontal cortex neuronal ensembles in the expression of incubation of heroin craving","volume":"32","author":"Fanous","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib55","doi-asserted-by":"crossref","first-page":"6600","DOI":"10.1523\/JNEUROSCI.1924-04.2004","article-title":"Differential involvement of orbitofrontal cortex subregions in conditioned cue-induced and cocaine-primed reinstatement of cocaine seeking in rats","volume":"24","author":"Fuchs","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2014.11.017_bib56","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/S0028-3932(99)00158-X","article-title":"Drug abusers show impaired performance in a laboratory test of decision making","volume":"38","author":"Grant","year":"2000","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.biopsych.2014.11.017_bib57","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00213-007-1051-1","article-title":"Chronic cocaine but not chronic amphetamine use is associated with perseverative responding in humans","volume":"197","author":"Ersche","year":"2008","journal-title":"Psychopharmacology (Berl)"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322314009111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322314009111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T19:18:54Z","timestamp":1566069534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322314009111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0006322314009111"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2014.11.017","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}