{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:03:46Z","timestamp":1791198226824,"version":"4.1.0"},"reference-count":89,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.biopsych.2015.02.018","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:53:06Z","timestamp":1424739186000},"page":"463-473","source":"Crossref","is-referenced-by-count":140,"title":["Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model"],"prefix":"10.1016","volume":"78","author":[{"given":"Daniele","family":"Caprioli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Venniro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Zeric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweta","family":"Adhikary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajtarun","family":"Madangopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan J.","family":"Marchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Lucantonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Schoenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Bossert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavin","family":"Shaham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2015.02.018_bib1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/08897070802218554","article-title":"Pharmacotherapy of methamphetamine addiction: An update","volume":"29","author":"Elkashef","year":"2008","journal-title":"Subst Abuse"},{"key":"10.1016\/j.biopsych.2015.02.018_bib2","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1360-0443.2004.00707.x","article-title":"A multi-site comparison of psychosocial approaches for the treatment of methamphetamine dependence","volume":"99","author":"Rawson","year":"2004","journal-title":"Addiction"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2015.02.018_bib3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1360-0443.2006.01774.x","article-title":"Contingency management: An evidence-based component of methamphetamine use disorder treatments","volume":"102","author":"Roll","year":"2007","journal-title":"Addiction"},{"key":"10.1016\/j.biopsych.2015.02.018_bib4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1749-6632.1992.tb25984.x","article-title":"Classical conditioning in drug-dependent humans","volume":"654","author":"O\u05f3Brien","year":"1992","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.biopsych.2015.02.018_bib5","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013): Diagnostic and Statistical Manual of Mental Disorders, 5th ed: DSM-5. American Psychiatric Publishing.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"10.1016\/j.biopsych.2015.02.018_bib6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1001\/archpsyc.1986.01800020013003","article-title":"Abstinence symptomatology and psychiatric diagnosis in cocaine abusers. Clinical observations","volume":"43","author":"Gawin","year":"1986","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2015.02.018_bib7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/35084134","article-title":"Incubation of cocaine craving after withdrawal","volume":"412","author":"Grimm","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2015.02.018_bib8","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1523\/JNEUROSCI.20-02-00798.2000","article-title":"Fos protein expression and cocaine-seeking behavior in rats after exposure to a cocaine self-administration environment","volume":"20","author":"Neisewander","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2015.02.018_bib9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s002130100748","article-title":"Time-dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in rats","volume":"156","author":"Shalev","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2015.02.018_bib10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.euroneuro.2003.10.005","article-title":"Time-dependent changes in alcohol-seeking behaviour during abstinence","volume":"14","author":"Bienkowski","year":"2004","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2015.02.018_bib11","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1460-9568.2010.07114.x","article-title":"Incubation of nicotine seeking is associated with enhanced protein kinase A-regulated signaling of dopamine- and cAMP-regulated phosphoprotein of 32 kDa in the insular cortex","volume":"31","author":"Abdolahi","year":"2010","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2015.02.018_bib12","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.biopsych.2004.02.032","article-title":"The anxiogenic drug yohimbine reinstates methamphetamine seeking in a rat model of drug relapse","volume":"55","author":"Shepard","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2015.02.018_bib13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00213-004-1860-4","article-title":"Cocaine seeking over extended withdrawal periods in rats: Different time courses of responding induced by cocaine cues versus cocaine priming over the first 6 months","volume":"176","author":"Lu","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2015.02.018_bib14","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.biopsych.2010.07.014","article-title":"Incubation of cue-induced cigarette craving during abstinence in human smokers","volume":"69","author":"Bedi","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2015.02.018_bib15","doi-asserted-by":"crossref","first-page":"e68791","DOI":"10.1371\/journal.pone.0068791","article-title":"Effects of length of abstinence on decision-making and craving in methamphetamine abusers","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2015.02.018_bib16","article-title":"Incubation of alcohol craving during abstinence in patients with alcohol dependence [published online ahead of print April 2]","author":"Li","year":"2014","journal-title":"Addict Biol."},{"key":"10.1016\/j.biopsych.2015.02.018_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00213-006-0529-6","article-title":"Toward a model of drug relapse: An assessment of the validity of the reinstatement procedure","volume":"189","author":"Epstein","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2015.02.018_bib18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00213-003-1441-y","article-title":"The validity of the reinstatement model of craving and relapse to drug use","volume":"168","author":"Katz","year":"2003","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2015.02.018_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1037\/1064-1297.4.1.55","article-title":"Models of relapse and relapse prevention: A commentary","volume":"4","author":"Marlatt","year":"1996","journal-title":"Exp Clin Psychopharmacol"},{"key":"10.1016\/j.biopsych.2015.02.018_bib20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00213-003-1470-6","article-title":"The reinstatement model and relapse prevention: A clinical perspective","volume":"168","author":"Epstein","year":"2003","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2015.02.018_bib21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00213-002-1193-0","article-title":"Reinstatement of punishment-suppressed opioid self-administration in rats: An alternative model of relapse to drug abuse","volume":"168","author":"Panlilio","year":"2003","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2015.02.018_bib22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00213-007-0827-7","article-title":"A conflict rat model of cue-induced relapse to cocaine seeking","volume":"194","author":"Cooper","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2015.02.018_bib23","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.biopsych.2008.12.008","article-title":"High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinence","volume":"65","author":"Economidou","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2015.02.018_bib24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00213-014-3648-5","article-title":"Differential vulnerability to the punishment of cocaine related behaviours: Effects of locus of punishment, cocaine taking history and alternative reinforcer availability","volume":"232","author":"Pelloux","year":"2015","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2015.02.018_bib25","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.biopsych.2012.07.007","article-title":"Context-induced relapse to alcohol seeking after punishment in a rat model","volume":"73","author":"Marchant","year":"2013","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2015.02.018_bib26","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1038\/npp.2014.50","article-title":"Incubation of methamphetamine and palatable food craving after punishment-induced abstinence","volume":"39","author":"Krasnova","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2015.02.018_bib27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00213-013-3120-y","article-title":"The reinstatement model of drug relapse: Recent neurobiological findings, emerging research topics, and translational research","volume":"229","author":"Bossert","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2015.02.018_bib28","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.conb.2013.01.003","article-title":"Recent developments in animal models of drug relapse","volume":"23","author":"Marchant","year":"2013","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.biopsych.2015.02.018_bib29","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.neubiorev.2010.04.005","article-title":"Validation crisis in animal models of drug addiction: Beyond non-disordered drug use toward drug addiction","volume":"35","author":"Ahmed","year":"2010","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.biopsych.2015.02.018_bib30","first-page":"281768","article-title":"Preclinical determinants of drug choice under concurrent schedules of drug self-administration","volume":"2012","author":"Banks","year":"2012","journal-title":"Adv Pharmacol Sci"},{"key":"10.1016\/j.biopsych.2015.02.018_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0376-8716(02)00023-6","article-title":"Abstinence reinforcement maintenance contingency and one-year follow-up","volume":"67","author":"Preston","year":"2002","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.biopsych.2015.02.018_bib32","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev.psych.55.090902.142033","article-title":"Clinical implications of reinforcement as a determinant of substance use disorders","volume":"55","author":"Higgins","year":"2004","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.biopsych.2015.02.018_bib33","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0005-7967(76)90021-8","article-title":"Improvements in the community-reinforcement approach to alcoholism","volume":"14","author":"Azrin","year":"1976","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.biopsych.2015.02.018_bib34","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1037\/0022-006X.65.4.686","article-title":"Behavioral self-control program for windows: Results of a controlled clinical trial","volume":"65","author":"Hester","year":"1997","journal-title":"J Consult Clin Psychol"},{"issue":"suppl","key":"10.1016\/j.biopsych.2015.02.018_bib35","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1016\/j.ypmed.2012.03.013","article-title":"Maintenance of reinforcement to address the chronic nature of drug addiction","volume":"55","author":"Silverman","year":"2012","journal-title":"Prev Med"},{"key":"10.1016\/j.biopsych.2015.02.018_bib36","doi-asserted-by":"crossref","first-page":"e11592","DOI":"10.1371\/journal.pone.0011592","article-title":"Cocaine is low on the value ladder of rats: Possible evidence for resilience to addiction","volume":"5","author":"Cantin","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2015.02.018_bib37","doi-asserted-by":"crossref","first-page":"e698","DOI":"10.1371\/journal.pone.0000698","article-title":"Intense sweetness surpasses cocaine reward","volume":"2","author":"Lenoir","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2015.02.018_bib38","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.conb.2013.01.028","article-title":"Neurobiology of addiction versus drug use driven by lack of choice","volume":"23","author":"Ahmed","year":"2013","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.biopsych.2015.02.018_bib39","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12220","article-title":"Persistent palatable food preference in rats with a history of limited and extended access to methamphetamine self-administration [published online ahead of print January 12]","author":"Caprioli","year":"2015","journal-title":"Addict Biol."},{"key":"10.1016\/j.biopsych.2015.02.018_bib40","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.282.5387.298","article-title":"Transition from moderate to excessive drug intake: Change in hedonic set point","volume":"282","author":"Ahmed","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2015.02.018_bib41","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/978-1-60761-934-5_10","article-title":"Escalation of drug use","volume":"53","author":"Ahmed","year":"2011","journal-title":"Neuromethods"},{"key":"10.1016\/j.biopsych.2015.02.018_bib42","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1126\/science.1099020","article-title":"Evidence for addiction-like behavior in the rat","volume":"305","author":"Deroche-Gamonet","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2015.02.018_bib43","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00213-013-3224-4","article-title":"A multistep general theory of transition to addiction","volume":"229","author":"Piazza","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2015.02.018_bib44","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.tins.2011.06.001","article-title":"Neurobiology of the incubation of drug craving","volume":"34","author":"Pickens","year":"2011","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.biopsych.2015.02.018_bib45","unstructured":"Cross AJ (2013): AZD8529\u2013an mGluR2 positive allosteric modulator for the treatment of schizophrenia. Presented at the American College of Neuropsychopharmacology Annual Meeting, December 8-12, 2013, Hollywood, Florida."},{"key":"10.1016\/j.biopsych.2015.02.018_bib46","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.biopsych.2015.01.014","article-title":"The novel mGluR2 positive allosteric modulator, AZD8529, decreases nicotine self-administration and relapse in squirrel monkeys","volume":"78","author":"Justinova","year":"2015","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2015.02.018_bib47","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1124\/mol.64.4.798","article-title":"Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2","volume":"64","author":"Schaffhauser","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.biopsych.2015.02.018_bib48","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/jpet.106.102046","article-title":"Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice","volume":"318","author":"Galici","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.biopsych.2015.02.018_bib49","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0022-3565(24)29296-X","article-title":"Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system","volume":"299","author":"Schoepp","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.biopsych.2015.02.018_bib50","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.tips.2008.10.006","article-title":"Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia","volume":"30","author":"Conn","year":"2009","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.biopsych.2015.02.018_bib51","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.coph.2005.09.006","article-title":"Glutamate-based therapeutic approaches: Allosteric modulators of metabotropic glutamate receptors","volume":"6","author":"Marino","year":"2006","journal-title":"Curr Opin Pharmacol"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2015.02.018_bib52","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuropharm.2004.06.027","article-title":"Incubation of cocaine craving after withdrawal: A review of preclinical data","volume":"47","author":"Lu","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopsych.2015.02.018_bib53","doi-asserted-by":"crossref","DOI":"10.1038\/npp.2014.320","article-title":"The central amygdala nucleus is critical for incubation of methamphetamine craving [published online ahead of print December 5]","author":"Li","year":"2014","journal-title":"Neuropsychopharmacology."},{"key":"10.1016\/j.biopsych.2015.02.018_bib54","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.neuropharm.2013.07.014","article-title":"Psychobiology of cocaine addiction: Contribution of a multi-symptomatic animal model of loss of control","volume":"76","author":"Deroche-Gamonet","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopsych.2015.02.018_bib55","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.biopsych.2012.12.019","article-title":"Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving","volume":"73","author":"Theberge","year":"2013","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2015.02.018_bib56","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/npp.2010.239","article-title":"Loss of alternative non-drug reinforcement induces relapse of cocaine-seeking in rats: Role of dopamine D(1) receptors","volume":"36","author":"Quick","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2015.02.018_bib57","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/01.fbp.0000224385.09486.ba","article-title":"Resurgence of alcohol seeking produced by discontinuing non-drug reinforcement as an animal model of drug relapse","volume":"17","author":"Podlesnik","year":"2006","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.biopsych.2015.02.018_bib58","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ypmed.2014.06.010","article-title":"Why behavior change is difficult to sustain","volume":"68C","author":"Bouton","year":"2014","journal-title":"Prev Med"},{"key":"10.1016\/j.biopsych.2015.02.018_bib59","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.169.3942.301","article-title":"Reinforcement of competing behavior during extinction","volume":"169","author":"Leitenberg","year":"1970","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2015.02.018_bib60","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.lmot.2011.01.002","article-title":"Mechanisms of resurgence II: Response-contingent reinforcers can reinstate a second extinguished behavior","volume":"42","author":"Winterbauer","year":"2011","journal-title":"Learn Motiv"},{"key":"10.1016\/j.biopsych.2015.02.018_bib61","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev.clinpsy.2.022305.095219","article-title":"Contingency management for treatment of substance abuse","volume":"2","author":"Stitzer","year":"2006","journal-title":"Annu Rev Clin Psychol"},{"key":"10.1016\/j.biopsych.2015.02.018_bib62","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1176\/appi.ajp.159.10.1642","article-title":"Drug addiction and its underlying neurobiological basis: Neuroimaging evidence for the involvement of the frontal cortex","volume":"159","author":"Goldstein","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2015.02.018_bib63","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.neuron.2005.02.005","article-title":"Unmanageable motivation in addiction: A pathology in prefrontal-accumbens glutamate transmission","volume":"45","author":"Kalivas","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2015.02.018_bib64","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.neuroscience.2011.08.014","article-title":"The science of making drug-addicted animals","volume":"211","author":"Ahmed","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2015.02.018_bib65","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1038\/npp.2010.82","article-title":"The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats","volume":"35","author":"Jin","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2015.02.018_bib66","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.tips.2004.03.009","article-title":"The ups and downs of addiction: Role of metabotropic glutamate receptors","volume":"25","author":"Kenny","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.biopsych.2015.02.018_bib67","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2165\/00023210-200822090-00001","article-title":"Role of the glutamatergic system in nicotine dependence: Implications for the discovery and development of new pharmacological smoking cessation therapies","volume":"22","author":"Liechti","year":"2008","journal-title":"CNS Drugs"},{"key":"10.1016\/j.biopsych.2015.02.018_bib68","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1124\/jpet.102.039735","article-title":"Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine","volume":"303","author":"Xi","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.biopsych.2015.02.018_bib69","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0306-4522(01)00305-0","article-title":"Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic sites","volume":"106","author":"Tamaru","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2015.02.018_bib70","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1021\/jm980616n","volume":"42","author":"Monn","year":"1999","journal-title":"J Med Chem"},{"key":"10.1016\/j.biopsych.2015.02.018_bib71","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bbr.2006.03.032","article-title":"The metabotropic glutamate 2\/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats","volume":"171","author":"Rodd","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.biopsych.2015.02.018_bib72","doi-asserted-by":"crossref","first-page":"10726","DOI":"10.1523\/JNEUROSCI.3207-04.2004","article-title":"A role of ventral tegmental area glutamate in contextual cue-induced relapse to heroin seeking","volume":"24","author":"Bossert","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2015.02.018_bib73","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bbr.2006.06.008","article-title":"The mGluR2\/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats","volume":"173","author":"Bossert","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.biopsych.2015.02.018_bib74","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1523\/JNEUROSCI.0176-04.2004","article-title":"Preferential effects of the metabotropic glutamate 2\/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: Comparison between cocaine and a potent conventional reinforcer","volume":"24","author":"Baptista","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2015.02.018_bib75","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00213-006-0372-9","article-title":"The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats","volume":"186","author":"Peters","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2015.02.018_bib76","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.neuropharm.2012.05.037","article-title":"Attenuation of methamphetamine seeking by the mGluR2\/3 agonist LY379268 in rats with histories of restricted and escalated self-administration","volume":"66","author":"Kufahl","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopsych.2015.02.018_bib77","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1124\/jpet.106.105387","article-title":"Pharmacological stimulation of group II metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeys","volume":"318","author":"Adewale","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.biopsych.2015.02.018_bib78","doi-asserted-by":"crossref","first-page":"9077","DOI":"10.1523\/JNEUROSCI.1766-07.2007","article-title":"Metabotropic glutamate 2\/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence","volume":"27","author":"Liechti","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2015.02.018_bib79","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.drugalcdep.2013.07.024","article-title":"The group II metabotropic glutamate receptor agonist, LY379268, decreases methamphetamine self-administration in rats","volume":"132","author":"Crawford","year":"2013","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.biopsych.2015.02.018_bib80","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.biopsych.2006.04.011","article-title":"Systemic and central amygdala injections of the mGluR(2\/3) agonist LY379268 attenuate the expression of incubation of cocaine craving","volume":"61","author":"Lu","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2015.02.018_bib81","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nn.3590","article-title":"Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving","volume":"17","author":"Loweth","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2015.02.018_bib82","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.neuron.2014.08.023","article-title":"Bidirectional modulation of incubation of cocaine craving by silent synapse-based remodeling of prefrontal cortex to accumbens projections","volume":"83","author":"Ma","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2015.02.018_bib83","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/nn.3533","article-title":"Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving","volume":"16","author":"Lee","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2015.02.018_bib84","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1021\/jm1012165","article-title":"Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats","volume":"54","author":"Dhanya","year":"2011","journal-title":"J Med Chem"},{"key":"10.1016\/j.biopsych.2015.02.018_bib85","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.neubiorev.2003.11.009","article-title":"Opponent process properties of self-administered cocaine","volume":"27","author":"Ettenberg","year":"2004","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.biopsych.2015.02.018_bib86","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.pbb.2008.11.003","article-title":"The runway model of drug self-administration","volume":"91","author":"Ettenberg","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.biopsych.2015.02.018_bib87","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.conb.2013.03.010","article-title":"Substance-specific environmental influences on drug use and drug preference in animals and humans","volume":"23","author":"Badiani","year":"2013","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.biopsych.2015.02.018_bib88","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrn3104","article-title":"Opiate versus psychostimulant addiction: The differences do matter","volume":"12","author":"Badiani","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2015.02.018_bib89","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.tips.2013.10.004","article-title":"Targeting cocaine versus heroin memories: Divergent roles within ventromedial prefrontal cortex","volume":"34","author":"Peters","year":"2013","journal-title":"Trends Pharmacol Sci"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322315001298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322315001298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T22:50:09Z","timestamp":1747695009000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322315001298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":89,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0006322315001298"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2015.02.018","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}