{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T04:03:59Z","timestamp":1793678639733,"version":"4.5.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004963","name":"European Union Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP2007-2013"],"award-info":[{"award-number":["FP2007-2013"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.biopsych.2015.08.028","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T21:48:49Z","timestamp":1441316929000},"page":"302-311","source":"Crossref","is-referenced-by-count":129,"title":["Dendritic Spine Instability in a Mouse Model of CDKL5 Disorder Is Rescued by Insulin-like Growth Factor 1"],"prefix":"10.1016","volume":"80","author":[{"given":"Grazia","family":"Della Sala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Putignano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Chelini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-8193","authenticated-orcid":false,"given":"Riccardo","family":"Melani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Calcagno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian","family":"Michele Ratto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Amendola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius T.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Giustetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5614-0668","authenticated-orcid":false,"given":"Tommaso","family":"Pizzorusso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2015.08.028_bib1","first-page":"32048","article-title":"Functional consequences of mutations in CDKL5, an X-linked gene involved in infantile spasms and mental retardation","volume":"281","author":"Bertani","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2015.08.028_bib2","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1093\/hmg\/ddi198","article-title":"CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome","volume":"14","author":"Mari","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2015.08.028_bib3","doi-asserted-by":"crossref","first-page":"21516","DOI":"10.1073\/pnas.1216988110","article-title":"Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice","volume":"109","author":"Wang","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2015.08.028_bib4","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1093\/brain\/awn197","article-title":"Key clinical features to identify girls with CDKL5 mutations","volume":"131","author":"Bahi-Buisson","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2015.08.028_bib5","doi-asserted-by":"crossref","first-page":"30101","DOI":"10.1074\/jbc.M804613200","article-title":"CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail","volume":"283","author":"Rusconi","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2015.08.028_bib6","doi-asserted-by":"crossref","first-page":"12777","DOI":"10.1523\/JNEUROSCI.1102-10.2010","article-title":"CDKL5, a protein associated with Rett syndrome, regulates neuronal morphogenesis via Rac1 signaling","volume":"30","author":"Chen","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2015.08.028_bib7","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1093\/hmg\/ddp426","article-title":"CDKL5 influences RNA splicing activity by its association to the nuclear speckle molecular machinery","volume":"18","author":"Ricciardi","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2015.08.028_bib8","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/ncb2566","article-title":"CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons","volume":"14","author":"Ricciardi","year":"2012","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.biopsych.2015.08.028_bib9","first-page":"1341","article-title":"Capping of the N-terminus of PSD-95 by calmodulin triggers its postsynaptic release","volume":"33","author":"Zhang","year":"2014","journal-title":"EMBO J"},{"key":"10.1016\/j.biopsych.2015.08.028_bib10","doi-asserted-by":"crossref","first-page":"9118","DOI":"10.1073\/pnas.1300003110","article-title":"Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2015.08.028_bib11","doi-asserted-by":"crossref","first-page":"e91613","DOI":"10.1371\/journal.pone.0091613","article-title":"Mapping pathological phenotypes in a mouse model of CDKL5 disorder","volume":"9","author":"Amendola","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2015.08.028_bib12","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neuron.2005.01.003","article-title":"Transient and persistent dendritic spines in the neocortex in vivo","volume":"45","author":"Holtmaat","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2015.08.028_bib13","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bbr.2008.04.005","article-title":"Imaging of experience-dependent structural plasticity in the mouse neocortex in vivo","volume":"192","author":"Holtmaat","year":"2008","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.biopsych.2015.08.028_bib14","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1101\/pdb.prot069617","article-title":"Imaging neocortical neurons through a chronic cranial window","volume":"2012","author":"Holtmaat","year":"2012","journal-title":"Cold Spring Harb Protoc"},{"key":"10.1016\/j.biopsych.2015.08.028_bib15","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2174\/138161207780249146","article-title":"The IGF-I signaling pathway","volume":"13","author":"Laviola","year":"2007","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.biopsych.2015.08.028_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijdevneu.2014.03.006","article-title":"Dysregulation of the IGF-I\/PI3K\/AKT\/mTOR signaling pathway in autism spectrum disorders","volume":"35","author":"Chen","year":"2014","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.biopsych.2015.08.028_bib17","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1073\/pnas.0812394106","article-title":"Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice","volume":"106","author":"Tropea","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2015.08.028_bib18","doi-asserted-by":"crossref","first-page":"9941","DOI":"10.1073\/pnas.1311685111","article-title":"Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome","volume":"111","author":"Castro","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2015.08.028_bib19","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1073\/pnas.1311141111","article-title":"Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome","volume":"111","author":"Khwaja","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2015.08.028_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0896-6273(00)00084-2","article-title":"Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP","volume":"28","author":"Feng","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2015.08.028_bib21","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nprot.2009.89","article-title":"Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window","volume":"4","author":"Holtmaat","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1016\/j.biopsych.2015.08.028_bib22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/srep00045","article-title":"The short-time structural plasticity of dendritic spines is altered in a model of Rett syndrome","volume":"1","author":"Landi","year":"2011","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopsych.2015.08.028_bib23","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nature04783","article-title":"Experience-dependent and cell-type-specific spine growth in the neocortex","volume":"441","author":"Holtmaat","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2015.08.028_bib24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nprot.2009.222","article-title":"Thinned-skull cranial window technique for long-term imaging of the cortex in live mice","volume":"5","author":"Yang","year":"2010","journal-title":"Nat Protoc"},{"key":"10.1016\/j.biopsych.2015.08.028_bib25","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.tibs.2006.04.003","article-title":"Ribosomal protein S6 phosphorylation: From protein synthesis to cell size","volume":"31","author":"Ruvinsky","year":"2006","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.biopsych.2015.08.028_bib26","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1523\/JNEUROSCI.3353-13.2014","article-title":"The relationship between PSD-95 clustering and spine stability in vivo","volume":"34","author":"Cane","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2015.08.028_bib27","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1126\/science.1206593","article-title":"Adult neural function requires MeCP2","volume":"333","author":"McGraw","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2015.08.028_bib28","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.1138389","article-title":"Reversal of neurological defects in a mouse model of Rett syndrome","volume":"315","author":"Guy","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2015.08.028_bib29","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0092-8674(02)00683-9","article-title":"Synaptic strength regulated by palmitate cycling on PSD-95","volume":"108","author":"El-Husseini","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2015.08.028_bib30","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/dneu.22114","article-title":"Synaptic plasticity and signaling in Rett syndrome","volume":"74","author":"Della Sala","year":"2014","journal-title":"Dev Neurobiol"},{"key":"10.1016\/j.biopsych.2015.08.028_bib31","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/hmg\/ddq563","article-title":"Reduced AKT\/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model","volume":"20","author":"Ricciardi","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2015.08.028_bib32","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.neuron.2010.08.007","article-title":"Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS","volume":"67","author":"Nishijima","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2015.08.028_bib33","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1089\/scd.2013.0400","article-title":"Insulin-like growth factor 1 receptor and p38 mitogen-activated protein kinase signals inversely regulate signal transducer and activator of transcription 3 activity to control human dental pulp stem cell quiescence, propagation, and differentiation","volume":"23","author":"Vandomme","year":"2014","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.biopsych.2015.08.028_bib34","doi-asserted-by":"crossref","first-page":"9947","DOI":"10.1073\/pnas.1309426111","article-title":"beta2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome","volume":"111","author":"Mellios","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2015.08.028_bib35","first-page":"267","article-title":"SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients","volume":"503","author":"Shcheglovitov","year":"2013"},{"key":"10.1016\/j.biopsych.2015.08.028_bib36","doi-asserted-by":"crossref","first-page":"19518","DOI":"10.1523\/JNEUROSCI.1745-13.2013","article-title":"Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome","volume":"33","author":"Jiang","year":"2013","journal-title":"J Neurosci"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322315007271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322315007271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T07:24:44Z","timestamp":1655450684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322315007271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0006322315007271"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2015.08.028","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]}}}