{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:47:58Z","timestamp":1791229678477,"version":"4.1.0"},"reference-count":107,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.biopsych.2017.09.010","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T06:16:34Z","timestamp":1506060994000},"page":"731-738","source":"Crossref","is-referenced-by-count":52,"title":["What Can Mitochondrial DNA Analysis Tell Us About Mood Disorders?"],"prefix":"10.1016","volume":"83","author":[{"given":"Takaoki","family":"Kasahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7856-3952","authenticated-orcid":false,"given":"Tadafumi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2017.09.010_bib1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1146\/annurev.biochem.76.060305.152028","article-title":"DNA replication and transcription in mammalian mitochondria","volume":"76","author":"Larsson","year":"2007","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.biopsych.2017.09.010_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mito.2014.10.005","article-title":"Tissue-specific mtDNA abundance from exome data and its correlation with mitochondrial transcription, mass and respiratory activity","volume":"20","author":"D\u2019Erchia","year":"2015","journal-title":"Mitochondrion"},{"key":"10.1016\/j.biopsych.2017.09.010_bib3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/290457a0","article-title":"Sequence and organization of the human mitochondrial genome","volume":"290","author":"Anderson","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2017.09.010_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13323-015-0022-2","article-title":"Maternal ancestry and population history from whole mitochondrial genomes","volume":"6","author":"Kivisild","year":"2015","journal-title":"Investig Genet"},{"key":"10.1016\/j.biopsych.2017.09.010_bib5","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1086\/502682","article-title":"The power to detect disease associations with mitochondrial DNA haplogroups","volume":"78","author":"Samuels","year":"2006","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2017.09.010_bib6","doi-asserted-by":"crossref","first-page":"e1004369","DOI":"10.1371\/journal.pgen.1004369","article-title":"Recent mitochondrial DNA mutations increase the risk of developing common late-onset human diseases","volume":"10","author":"Hudson","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.biopsych.2017.09.010_bib7","doi-asserted-by":"crossref","first-page":"e128","DOI":"10.1371\/journal.pgen.0020128","article-title":"Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix pH and intracellular calcium dynamics","volume":"2","author":"Kazuno","year":"2006","journal-title":"PLoS Genet"},{"key":"10.1016\/j.biopsych.2017.09.010_bib8","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrg3966","article-title":"The dynamics of mitochondrial DNA heteroplasmy: Implications for human health and disease","volume":"16","author":"Stewart","year":"2015","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.biopsych.2017.09.010_bib9","series-title":"MELAS, GeneReviews at Gene Tests: Medical Genetics Information Resource","author":"DiMauro","year":"2013"},{"key":"10.1016\/j.biopsych.2017.09.010_bib10","doi-asserted-by":"crossref","first-page":"E3622","DOI":"10.1073\/pnas.1311660110","article-title":"Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model","volume":"110","author":"H\u00e4m\u00e4l\u00e4inen","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2017.09.010_bib11","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1007\/s13238-015-0175-z","article-title":"A\u00a0peep into mitochondrial disorder: Multifaceted from mitochondrial DNA mutations to nuclear gene modulation","volume":"6","author":"Chen","year":"2015","journal-title":"Protein Cell"},{"key":"10.1016\/j.biopsych.2017.09.010_bib12","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1093\/genetics\/152.3.1079","article-title":"Estimation of past demographic parameters from the distribution of pairwise differences when the mutation rates vary among sites: Application to human mitochondrial DNA","volume":"152","author":"Schneider","year":"1999","journal-title":"Genetics"},{"key":"10.1016\/j.biopsych.2017.09.010_bib13","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1474-9726.2009.00505.x","article-title":"Quantification of mitochondrial DNA mutation load","volume":"8","author":"Greaves","year":"2009","journal-title":"Aging Cell"},{"key":"10.1016\/j.biopsych.2017.09.010_bib14","doi-asserted-by":"crossref","first-page":"e02935","DOI":"10.7554\/eLife.02935","article-title":"Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer","volume":"3","author":"Ju","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.biopsych.2017.09.010_bib15","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1034\/j.1399-5618.2000.020305.x","article-title":"Mitochondrial dysfunction in bipolar disorder","volume":"2","author":"Kato","year":"2000","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.biopsych.2017.09.010_bib16","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrn3229","article-title":"Impaired mitochondrial function in psychiatric disorders","volume":"13","author":"Manji","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2017.09.010_bib17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.schres.2016.10.037","article-title":"Neurobiological basis of bipolar disorder: Mitochondrial dysfunction hypothesis and beyond","volume":"187","author":"Kato","year":"2017","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2017.09.010_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/srep00013","article-title":"Phylogenomic evidence for a common ancestor of mitochondria and the SAR11 clade","volume":"1","author":"Thrash","year":"2011","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopsych.2017.09.010_bib19","doi-asserted-by":"crossref","first-page":"e30520","DOI":"10.1371\/journal.pone.0030520","article-title":"The SAR11 group of alpha-proteobacteria is not related to the origin of mitochondria","volume":"7","author":"Rodr\u00edguez-Ezpeleta","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2017.09.010_bib20","doi-asserted-by":"crossref","first-page":"D1251","DOI":"10.1093\/nar\/gkv1003","article-title":"MitoCarta2.0: An updated inventory of mammalian mitochondrial proteins","volume":"44","author":"Calvo","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biopsych.2017.09.010_bib21","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1073\/pnas.76.4.1967","article-title":"Rapid evolution of animal mitochondrial DNA","volume":"76","author":"Brown","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2017.09.010_bib22","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature14963","article-title":"Endosymbiotic origin and differential loss of eukaryotic genes","volume":"524","author":"Ku","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2017.09.010_bib23","doi-asserted-by":"crossref","first-page":"a012641","DOI":"10.1101\/cshperspect.a012641","article-title":"The maintenance of mitochondrial DNA integrity\u2014critical analysis and update","volume":"5","author":"Alexeyev","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.biopsych.2017.09.010_bib24","doi-asserted-by":"crossref","first-page":"25409","DOI":"10.1074\/jbc.272.41.25409","article-title":"Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells","volume":"272","author":"Croteau","year":"1997","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.biopsych.2017.09.010_bib25","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.bbabio.2006.03.003","article-title":"Mitochondrial DNA and ageing","volume":"1757","author":"Trifunovic","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.biopsych.2017.09.010_bib26","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/nrg3275","article-title":"Human mitochondrial DNA:\u00a0Roles of inherited and somatic mutations","volume":"13","author":"Schon","year":"2012","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.biopsych.2017.09.010_bib27","doi-asserted-by":"crossref","first-page":"5521","DOI":"10.1073\/pnas.072670199","article-title":"Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues","volume":"99","author":"Nekhaeva","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2017.09.010_bib28","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/acn3.133","article-title":"Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions","volume":"1","author":"Fuke","year":"2014","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.biopsych.2017.09.010_bib29","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1091\/mbc.e15-05-0260","article-title":"Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions","volume":"27","author":"Tadi","year":"2016","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.biopsych.2017.09.010_bib30","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.molcel.2016.12.014","article-title":"Single-molecule analysis of mtDNA replication uncovers the basis of the common deletion","volume":"65","author":"Phillips","year":"2017","journal-title":"Mol Cell"},{"key":"10.1016\/j.biopsych.2017.09.010_bib31","doi-asserted-by":"crossref","first-page":"e1000834","DOI":"10.1371\/journal.pgen.1000834","article-title":"Molecular poltergeists: Mitochondrial DNA copies (numts) in sequenced nuclear genomes","volume":"6","author":"Hazkani-Covo","year":"2010","journal-title":"PLoS Genet"},{"key":"10.1016\/j.biopsych.2017.09.010_bib32","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1093\/bioinformatics\/btu483","article-title":"MToolBox: A highly automated pipeline for heteroplasmy annotation and prioritization analysis of human mitochondrial variants in high-throughput sequencing","volume":"30","author":"Calabrese","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.biopsych.2017.09.010_bib33","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s13311-013-0177-6","article-title":"Mitochondrial DNA depletion syndromes: Review and updates of genetic basis, manifestations, and therapeutic options","volume":"10","author":"El-Hattab","year":"2013","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.biopsych.2017.09.010_bib34","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2017.09.010_bib35","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: In sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2017.09.010_bib36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nrendo.2016.151","article-title":"Mitochondrial disease and endocrine dysfunction","volume":"13","author":"Chow","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.biopsych.2017.09.010_bib37","doi-asserted-by":"crossref","first-page":"a009332","DOI":"10.1101\/cshperspect.a009332","article-title":"Mitochondrial biology and Parkinson\u2019s disease","volume":"2","author":"Perier","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.biopsych.2017.09.010_bib38","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40035-016-0060-6","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease","volume":"5","author":"Hu","year":"2016","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.biopsych.2017.09.010_bib39","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/jnc.13731","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease","volume":"139","author":"Bose","year":"2016","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.biopsych.2017.09.010_bib40","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/humu.21277","article-title":"Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: A mutation update","volume":"31","author":"Nuytemans","year":"2010","journal-title":"Hum Mutat"},{"key":"10.1016\/j.biopsych.2017.09.010_bib41","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/gm566","article-title":"Genetics and genomics of Parkinson\u2019s disease","volume":"6","author":"Lin","year":"2014","journal-title":"Genome Med"},{"key":"10.1016\/j.biopsych.2017.09.010_bib42","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2174\/138920209789503879","article-title":"Do mtDNA mutations participate in the pathogenesis of sporadic Parkinson\u2019s disease?","volume":"10","author":"Kirches","year":"2009","journal-title":"Curr Genomics"},{"key":"10.1016\/j.biopsych.2017.09.010_bib43","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0140-6736(04)16983-3","article-title":"Parkinsonism, premature menopause, and mitochondrial DNA polymerase \u03b3 mutations: Clinical and molecular genetic study","volume":"364","author":"Luoma","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.biopsych.2017.09.010_bib44","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/ana.20831","article-title":"Early-onset familial parkinsonism due to POLG mutations","volume":"59","author":"Davidzon","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopsych.2017.09.010_bib45","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ng1769","article-title":"High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease","volume":"38","author":"Bender","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2017.09.010_bib46","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0006-3223(94)91135-5","article-title":"Novel strategies in molecular genetics of mental illness","volume":"35","author":"Baron","year":"1994","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2017.09.010_bib47","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/sj.mp.4000926","article-title":"The other, forgotten genome: Mitochondrial DNA and mental disorders","volume":"6","author":"Kato","year":"2001","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2017.09.010_bib48","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.biopsych.2004.11.041","article-title":"Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia","volume":"57","author":"Munakata","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2017.09.010_bib49","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0006-3223(93)90317-7","article-title":"The possible association between affective disorder and partially deleted mitochondrial DNA","volume":"33","author":"Stine","year":"1993","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2017.09.010_bib50","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0006-3223(97)00012-7","article-title":"Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder","volume":"42","author":"Kato","year":"1997","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2017.09.010_bib51","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/07853890801923753","article-title":"Mitochondrial involvement in psychiatric disorders","volume":"40","author":"Shao","year":"2008","journal-title":"Ann Med"},{"key":"10.1016\/j.biopsych.2017.09.010_bib52","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fgene.2012.00103","article-title":"Mitochondrial mutations and polymorphisms in psychiatric disorders","volume":"3","author":"Sequeira","year":"2012","journal-title":"Front Genet"},{"key":"10.1016\/j.biopsych.2017.09.010_bib53","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.schres.2014.08.026","article-title":"The somatic common deletion in mitochondrial DNA is decreased in schizophrenia","volume":"159","author":"Mamdani","year":"2014","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2017.09.010_bib54","doi-asserted-by":"crossref","first-page":"e4913","DOI":"10.1371\/journal.pone.0004913","article-title":"Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder","volume":"4","author":"Rollins","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2017.09.010_bib55","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1086\/302507","article-title":"Mitochondrial genetic analyses suggest selection against maternal lineages in bipolar affective disorder","volume":"65","author":"Kirk","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2017.09.010_bib56","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.ygeno.2004.08.015","article-title":"Mitochondrial DNA 3644T>C mutation associated with bipolar disorder","volume":"84","author":"Munakata","year":"2004","journal-title":"Genomics"},{"key":"10.1016\/j.biopsych.2017.09.010_bib57","doi-asserted-by":"crossref","first-page":"e0127280","DOI":"10.1371\/journal.pone.0127280","article-title":"Mitochondrial mutations in subjects with psychiatric disorders","volume":"10","author":"Sequeira","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2017.09.010_bib58","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/sj.mp.4001830","article-title":"Mitochondrial-related gene expression changes are sensitive to agonal-pH state: Implications for brain disorders","volume":"11","author":"Vawter","year":"2006","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2017.09.010_bib59","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1017\/S1461145705005213","article-title":"Quantitative analysis of mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia","volume":"8","author":"Kakiuchi","year":"2005","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2017.09.010_bib60","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/j.cub.2015.10.065","article-title":"Genetic control over mtDNA and its relationship to major depressive disorder","volume":"25","author":"Cai","year":"2015","journal-title":"Curr Biol"},{"key":"10.1016\/j.biopsych.2017.09.010_bib61","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.biopsych.2014.12.025","article-title":"Alterations of mitochondrial DNA copy number and telomere length with early adversity and psychopathology","volume":"79","author":"Tyrka","year":"2016","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2017.09.010_bib62","article-title":"The relationship between circulating mitochondrial DNA and inflammatory cytokines in patients with major depression","author":"Kageyama","year":"2017","journal-title":"J\u00a0Affect Disord"},{"key":"10.1016\/j.biopsych.2017.09.010_bib63","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1673-8527(08)60099-5","article-title":"Number matters: Control of mammalian mitochondrial DNA copy number","volume":"36","author":"Clay Montier","year":"2009","journal-title":"J\u00a0Genet Genomics"},{"key":"10.1016\/j.biopsych.2017.09.010_bib64","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2004.11.003","article-title":"The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses","volume":"119","author":"Li","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2017.09.010_bib65","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41467-017-00043-3","article-title":"Dendritic mitoflash as a putative signal for stabilizing long-term synaptic plasticity","volume":"8","author":"Fu","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2017.09.010_bib66","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41537-017-0013-9","article-title":"Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder\u2014A systematic review of the magnetic resonance neuroimaging literature","volume":"3","author":"Birur","year":"2017","journal-title":"NPJ Schizophr"},{"key":"10.1016\/j.biopsych.2017.09.010_bib67","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neulet.2008.05.009","article-title":"Quantitative analysis of the 4977-bp common deletion of mitochondrial DNA in postmortem frontal cortex from patients with bipolar disorder and schizophrenia","volume":"439","author":"Fuke","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.biopsych.2017.09.010_bib68","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0006-2952(93)90404-K","article-title":"Valproate and mitochondria","volume":"46","author":"Ponchaut","year":"1993","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.biopsych.2017.09.010_bib69","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/BF02980205","article-title":"Differential effects of typical and atypical neuroleptics on mitochondrial function in\u00a0vitro","volume":"26","author":"Modica-Napolitano","year":"2003","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.biopsych.2017.09.010_bib70","doi-asserted-by":"crossref","first-page":"648","DOI":"10.2174\/1389200217666160322143631","article-title":"The role of therapeutic drugs on acquired mitochondrial toxicity","volume":"17","author":"Moren","year":"2016","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.biopsych.2017.09.010_bib71","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.tins.2008.07.007","article-title":"Molecular neurobiology of bipolar disorder: A disease of \u2018mood-stabilizing neurons\u2019?","volume":"31","author":"Kato","year":"2008","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.biopsych.2017.09.010_bib72","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1017\/S1092852900015303","article-title":"Psychiatric comorbidity in 36 adults with mitochondrial cytopathies","volume":"12","author":"Fattal","year":"2007","journal-title":"CNS Spectr"},{"key":"10.1016\/j.biopsych.2017.09.010_bib73","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jad.2008.06.023","article-title":"Major depression in adolescent children consecutively diagnosed with mitochondrial disorder","volume":"114","author":"Koene","year":"2009","journal-title":"J\u00a0Affect Disord"},{"key":"10.1016\/j.biopsych.2017.09.010_bib74","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.nmd.2010.12.008","article-title":"Disease impact in chronic progressive external ophthalmoplegia: More than meets the eye","volume":"21","author":"Smits","year":"2011","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.biopsych.2017.09.010_bib75","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1038\/tp.2012.107","article-title":"Psychiatric symptoms correlate with metabolic indices in the hippocampus and cingulate in patients with mitochondrial disorders","volume":"2","author":"Anglin","year":"2012","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2017.09.010_bib76","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10072-011-0901-0","article-title":"Psychiatric involvement in adult patients with mitochondrial disease","volume":"34","author":"Mancuso","year":"2013","journal-title":"Neurol Sci"},{"key":"10.1016\/j.biopsych.2017.09.010_bib77","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1744-9081-8-9","article-title":"Psychiatric symptoms of patients with primary mitochondrial DNA disorders","volume":"8","author":"Inczedy-Farkas","year":"2012","journal-title":"Behav Brain Funct"},{"key":"10.1016\/j.biopsych.2017.09.010_bib78","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/sj.mp.4001824","article-title":"Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes","volume":"11","author":"Kasahara","year":"2006","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2017.09.010_bib79","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev.med.59.053006.104646","article-title":"Inherited mitochondrial diseases of DNA replication","volume":"59","author":"Copeland","year":"2008","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.biopsych.2017.09.010_bib80","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1172\/JCI115856","article-title":"Multiple deletions of mitochondrial DNA in several tissues of a patient with severe retarded depression and familial progressive external ophthalmoplegia","volume":"90","author":"Suomalainen","year":"1992","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.biopsych.2017.09.010_bib81","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0960-8966(02)00221-3","article-title":"Autosomal dominant external ophthalmoplegia and bipolar affective disorder associated with a mutation in the ANT1 gene","volume":"13","author":"Siciliano","year":"2003","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.biopsych.2017.09.010_bib82","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jad.2007.05.016","article-title":"Autosomal dominant psychiatric disorders and mitochondrial DNA multiple deletions: Report of a family","volume":"106","author":"Mancuso","year":"2008","journal-title":"J\u00a0Affect Disord"},{"key":"10.1016\/j.biopsych.2017.09.010_bib83","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/82826","article-title":"Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes","volume":"26","author":"Inoue","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2017.09.010_bib84","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.1073\/pnas.0408666102","article-title":"Rare creation of recombinant mtDNA haplotypes in mammalian tissues","volume":"102","author":"Sato","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2017.09.010_bib85","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature02517","article-title":"Premature ageing in mice expressing defective mitochondrial DNA polymerase","volume":"429","author":"Trifunovic","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2017.09.010_bib86","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1112125","article-title":"Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging","volume":"309","author":"Kujoth","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2017.09.010_bib87","series-title":"Diagnostic and Statistical Manual of Mental Disorders, 5th ed","year":"2013"},{"key":"10.1016\/j.biopsych.2017.09.010_bib88","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/mp.2015.156","article-title":"Depression-like episodes in mice harboring mtDNA deletions in paraventricular thalamus","volume":"21","author":"Kasahara","year":"2016","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2017.09.010_bib89","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1016\/j.febslet.2007.03.004","article-title":"A\u00a0dynamic machinery for import of mitochondrial precursor proteins","volume":"581","author":"Bohnert","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1016\/j.biopsych.2017.09.010_bib90","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1042\/CS20120130","article-title":"Toll-like receptor 9 activation: A novel mechanism linking placenta-derived mitochondrial DNA and vascular dysfunction in pre-eclampsia","volume":"123","author":"Goulopoulou","year":"2012","journal-title":"Clin Sci"},{"key":"10.1016\/j.biopsych.2017.09.010_bib91","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/eurheartj\/ehu047","article-title":"Mitochondrial damage-associated molecular patterns and vascular function","volume":"35","author":"Wenceslau","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.biopsych.2017.09.010_bib92","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/mp.2016.3","article-title":"A\u00a0meta-analysis of blood cytokine network alterations in psychiatric patients: Comparisons between schizophrenia, bipolar disorder and depression","volume":"21","author":"Goldsmith","year":"2016","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2017.09.010_bib93","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/acps.12698","article-title":"Peripheral cytokine and chemokine alterations in depression: A meta-analysis of 82 studies","volume":"135","author":"K\u00f6hler","year":"2017","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.biopsych.2017.09.010_bib94","first-page":"e3266","article-title":"Visualization of mitochondrial respiratory function using cytochrome c oxidase\/succinate dehydrogenase (COX\/SDH) double-labeling histochemistry","volume":"57","author":"Ross","year":"2011","journal-title":"J\u00a0Vis Exp"},{"key":"10.1016\/j.biopsych.2017.09.010_bib95","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nprot.2012.058","article-title":"Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells","volume":"7","author":"Spinazzi","year":"2012","journal-title":"Nat Protoc"},{"key":"10.1016\/j.biopsych.2017.09.010_bib96","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/pcn.12496","article-title":"Enrichment of deleterious variants of mitochondrial DNA polymerase gene (POLG1) in bipolar disorder","volume":"71","author":"Kasahara","year":"2017","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.biopsych.2017.09.010_bib97","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/nn.2647","article-title":"Animal models of neuropsychiatric disorders","volume":"13","author":"Nestler","year":"2010","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2017.09.010_bib98","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1038\/ncomms4339","article-title":"Genome-wide association study reveals two new risk loci for bipolar disorder","volume":"5","author":"M\u00fchleisen","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2017.09.010_bib99","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/mp.2016.259","article-title":"A\u00a0genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder","volume":"23","author":"Ikeda","year":"2018","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2017.09.010_bib100","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/mp.2016.69","article-title":"Exome sequencing for bipolar disorder points to roles of de novo loss-of-function and protein-altering mutations","volume":"21","author":"Kataoka","year":"2016","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2017.09.010_bib101","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.neuron.2014.11.022","article-title":"Mitochondrial DNA: Impacting central and peripheral nervous systems","volume":"84","author":"Carelli","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2017.09.010_bib102","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/nan.12333","article-title":"Review: Central nervous system involvement in mitochondrial disease","volume":"43","author":"Lax","year":"2017","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.biopsych.2017.09.010_bib103","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/13779","article-title":"Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA","volume":"23","author":"Andrews","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2017.09.010_bib104","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2017.09.010_bib105","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1038\/sj.onc.1205478","article-title":"Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain","volume":"21","author":"Pandey","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.biopsych.2017.09.010_bib106","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1086\/427564","article-title":"Impaired mitochondrial glutamate transport in autosomal recessive neonatal myoclonic epilepsy","volume":"76","author":"Molinari","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2017.09.010_bib107","first-page":"801","volume":"135","author":"Caccamo","year":"1989","journal-title":"Am J Pathol"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322317319947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322317319947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T05:35:08Z","timestamp":1659504908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322317319947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":107,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0006322317319947"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2017.09.010","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}