{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:24:45Z","timestamp":1789507485506,"version":"build-2803163510"},"reference-count":150,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.biopsych.2017.10.007","type":"journal-article","created":{"date-parts":[[2017,10,14]],"date-time":"2017-10-14T17:00:38Z","timestamp":1508000438000},"page":"377-387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":122,"title":["Microglia-Mediated Neuroprotection, TREM2, and Alzheimer\u2019s Disease: Evidence From Optical\u00a0Imaging"],"prefix":"10.1016","volume":"83","author":[{"given":"Carlo","family":"Condello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4051-4447","authenticated-orcid":false,"given":"Peng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Grutzendler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2017.10.007_bib1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer\u2019s disease: An updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib3","doi-asserted-by":"crossref","first-page":"a006262","DOI":"10.1101\/cshperspect.a006262","article-title":"Biochemistry of amyloid \u03b2-protein and amyloid deposits in Alzheimer disease","volume":"2","author":"Masters","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib4","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nn.3028","article-title":"The toxic a\u03b2 oligomer and Alzheimer\u2019s disease: An emperor in need of clothes","volume":"15","author":"Benilova","year":"2012","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib5","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1111\/j.1582-4934.2008.00411.x","article-title":"Parenchymal and vascular\u00a0abeta-deposition and its effects on the degeneration of neurons and cognition in Alzheimer\u2019s disease","volume":"12","author":"Thal","year":"2008","journal-title":"J\u00a0Cell Mol Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib6","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1523\/JNEUROSCI.5147-10.2011","article-title":"Long-term in\u00a0vivo imaging of \u03b2-amyloid plaque appearance and growth in a mouse model of cerebral \u03b2-amyloidosis","volume":"31","author":"Hefendehl","year":"2011","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/srep00019","article-title":"Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition","volume":"1","author":"Condello","year":"2011","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopsych.2017.10.007_bib8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/2051-5960-2-30","article-title":"In\u00a0vivo imaging reveals sigmoidal growth kinetic of \u03b2-amyloid plaques","volume":"2","author":"Burgold","year":"2014","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.biopsych.2017.10.007_bib9","doi-asserted-by":"crossref","first-page":"10706","DOI":"10.1523\/JNEUROSCI.2637-09.2009","article-title":"Characterizing the appearance and growth of amyloid plaques in APP\/PS1 mice","volume":"29","author":"Yan","year":"2009","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid \u03b2 deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer\u2019s disease: A prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib11","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1212\/01.wnl.0000228230.26044.a4","article-title":"[11c]pib in a nondemented population: Potential antecedent marker of Alzheimer disease","volume":"67","author":"Mintun","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2017.10.007_bib12","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease neuropathologic changes with cognitive status: A review of the literature","volume":"71","author":"Nelson","year":"2012","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib13","first-page":"135","article-title":"Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer\u2019s disease","volume":"2","author":"Morris","year":"2014","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.biopsych.2017.10.007_bib14","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1194637","article-title":"Fate mapping analysis reveals that adult microglia derive from primitive macrophages","volume":"330","author":"Ginhoux","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2017.10.007_bib15","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A\u00a0unique microglia type associated with restricting development of Alzheimer\u2019s disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2017.10.007_bib16","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nn.4597","article-title":"Transcriptomic analysis of purified human cortical microglia reveals age-associated changes","volume":"20","author":"Galatro","year":"2017","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib17","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/nn.4610","article-title":"High-dimensional, single-cell characterization of the brain\u2019s immune compartment","volume":"20","author":"Korin","year":"2017","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib18","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nn1472","article-title":"Atp mediates rapid microglial response to local brain injury in\u00a0vivo","volume":"8","author":"Davalos","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib19","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.1110647","article-title":"Resting microglial cells are highly dynamic surveillants of brain parenchyma in\u00a0vivo","volume":"308","author":"Nimmerjahn","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2017.10.007_bib20","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/nn1997","article-title":"Microglia: Active sensor and versatile effector cells in the normal and pathologic brain","volume":"10","author":"Hanisch","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/acel.12149","article-title":"Homeostatic and injury-induced microglia behavior in the aging brain","volume":"13","author":"Hefendehl","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.biopsych.2017.10.007_bib22","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2017.10.007_bib23","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2017.10.007_bib24","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1523\/JNEUROSCI.4363-08.2009","article-title":"Resting microglia directly monitor the functional state of synapses in\u00a0vivo and determine the fate of ischemic terminals","volume":"29","author":"Wake","year":"2009","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib25","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.cell.2013.11.030","article-title":"Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor","volume":"155","author":"Parkhurst","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2017.10.007_bib26","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/BF00334499","article-title":"The complex of microglial cells and amyloid star in three-dimensional reconstruction","volume":"81","author":"Wegiel","year":"1990","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib27","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1038\/ncomms7176","article-title":"Microglia constitute a barrier that prevents neurotoxic protofibrillar a\u03b242 hotspots around plaques","volume":"6","author":"Condello","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2017.10.007_bib28","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-5728(89)90115-X","article-title":"Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease","volume":"24","author":"Itagaki","year":"1989","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib29","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00702-010-0433-4","article-title":"The role of microglia in amyloid clearance from the AD brain","volume":"117","author":"Lee","year":"2010","journal-title":"J\u00a0Neural Transm"},{"key":"10.1016\/j.biopsych.2017.10.007_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2174\/187152709787601821","article-title":"The role of microglia in antibody-mediated clearance of amyloid-beta from the brain","volume":"8","author":"Morgan","year":"2009","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.biopsych.2017.10.007_bib31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrn2038","article-title":"Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms","volume":"8","author":"Block","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib32","doi-asserted-by":"crossref","first-page":"eaaf6295","DOI":"10.1126\/scitranslmed.aaf6295","article-title":"Complement c3 deficiency protects against neurodegeneration in aged plaque-rich APP\/PS1 mice","volume":"9","author":"Shi","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib33","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2017.10.007_bib34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer\u2019s disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer\u2019s disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib36","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nri1106","article-title":"TREMs in the immune system and beyond","volume":"3","author":"Colonna","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib37","doi-asserted-by":"crossref","first-page":"222.e9","DOI":"10.1016\/j.neurobiolaging.2016.07.028","article-title":"TYROBP genetic variants in early onset Alzheimer\u2019s disease","volume":"48","author":"Pottier","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.biopsych.2017.10.007_bib38","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.neuron.2016.05.003","article-title":"Trem2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy","volume":"90","author":"Yuan","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2017.10.007_bib39","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jalz.2010.12.014","article-title":"Extended results of the Alzheimer\u2019s disease\u00a0anti-inflammatory prevention trial","volume":"7","author":"Breitner","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.biopsych.2017.10.007_bib40","doi-asserted-by":"crossref","first-page":"e1004606","DOI":"10.1371\/journal.pgen.1004606","article-title":"Genome-wide association meta-analysis of neuropathologic features of Alzheimer\u2019s disease and related dementias","volume":"10","author":"Beecham","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.biopsych.2017.10.007_bib41","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.4049\/jimmunol.177.6.3520","article-title":"Cutting edge: TREM-2 attenuates macrophage activation","volume":"177","author":"Turnbull","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib42","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/nn2014","article-title":"Local self-renewal can sustain CNS microglia maintenance and function throughout adult life","volume":"10","author":"Ajami","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib43","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1084\/jem.20151948","article-title":"Trem2-mediated early microglial response limits diffusion and toxicity of amyloid plaques","volume":"213","author":"Wang","year":"2016","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib44","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1084\/jem.20150478","article-title":"Replacement of brain-resident myeloid cells does not alter cerebral amyloid-\u03b2 deposition in mouse models of Alzheimer\u2019s disease","volume":"212","author":"Varvel","year":"2015","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib45","doi-asserted-by":"crossref","first-page":"11159","DOI":"10.1523\/JNEUROSCI.6209-10.2011","article-title":"Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer\u2019s disease","volume":"31","author":"Mildner","year":"2011","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib46","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.4049\/jimmunol.177.4.2051","article-title":"Cutting edge: Inhibition of TLR and FCR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12","volume":"177","author":"Hamerman","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib47","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1083\/jcb.200808080","article-title":"TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria","volume":"184","author":"N\u2019Diaye","year":"2009","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib48","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1084\/jem.20141732","article-title":"Trem-2 promotes macrophage survival and lung disease after respiratory viral infection","volume":"212","author":"Wu","year":"2015","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib49","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1523\/JNEUROSCI.2620-14.2015","article-title":"Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke","volume":"35","author":"Kawabori","year":"2015","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib50","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00401-015-1388-1","article-title":"Trem2 regulates microglial cell activation in response to demyelination in\u00a0vivo","volume":"129","author":"Cantoni","year":"2015","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib51","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1172\/JCI77983","article-title":"TREM2 sustains microglial expansion during aging and response to demyelination","volume":"125","author":"Poliani","year":"2015","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.biopsych.2017.10.007_bib52","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1084\/jem.20041611","article-title":"Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2","volume":"201","author":"Takahashi","year":"2005","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib53","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1086\/342259","article-title":"Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype","volume":"71","author":"Paloneva","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2017.10.007_bib54","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1084\/jem.20022220","article-title":"Impaired differentiation of osteoclasts in TREM-2-deficient individuals","volume":"198","author":"Cella","year":"2003","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib55","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1084\/jem.20030027","article-title":"DAP12\/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features","volume":"198","author":"Paloneva","year":"2003","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib56","doi-asserted-by":"crossref","first-page":"243ra86","DOI":"10.1126\/scitranslmed.3009093","article-title":"Trem2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis","volume":"6","author":"Kleinberger","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib57","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40478-016-0367-7","article-title":"Rare TREM2 variants associated with Alzheimer\u2019s disease display reduced cell surface expression","volume":"4","author":"Sirkis","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.biopsych.2017.10.007_bib58","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1523\/JNEUROSCI.2110-16.2016","article-title":"Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer\u2019s disease","volume":"37","author":"Jay","year":"2017","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib59","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.20142322","article-title":"TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer\u2019s disease mouse models","volume":"212","author":"Jay","year":"2015","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib60","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"Trem2 lipid sensing sustains the microglial response in an Alzheimer\u2019s disease model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2017.10.007_bib61","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neuron.2016.06.015","article-title":"TREM2 binds to apolipoproteins, including APOE and CLU\/APOJ, and thereby facilitates uptake of amyloid-beta by microglia","volume":"91","author":"Yeh","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2017.10.007_bib62","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1750-1326-9-20","article-title":"Altered microglial response to a\u03b2 plaques in APPPS1-21 mice heterozygous for TREM2","volume":"9","author":"Ulrich","year":"2014","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.biopsych.2017.10.007_bib63","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1084\/jem.20160844","article-title":"Soluble TREM2 induces inflammatory responses and enhances microglial survival","volume":"214","author":"Zhong","year":"2017","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib64","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1523\/JNEUROSCI.2459-16.2017","article-title":"TREM2 promotes microglial survival by activating WNT\/\u03b2-catenin pathway","volume":"37","author":"Zheng","year":"2017","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib65","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cell.2017.07.023","article-title":"TREM2 maintains microglial metabolic fitness in Alzheimer\u2019s disease","volume":"170","author":"Ulland","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2017.10.007_bib66","doi-asserted-by":"crossref","first-page":"444.e1","DOI":"10.1016\/j.neurobiolaging.2013.08.011","article-title":"Assessing the role of the TREM2 P.R47H variant as a risk factor for Alzheimer\u2019s disease and frontotemporal dementia","volume":"35","author":"Ruiz","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.biopsych.2017.10.007_bib67","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.jalz.2014.12.009","article-title":"The role of TREM2 R47H as a risk factor for Alzheimer\u2019s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease","volume":"11","author":"Lill","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.biopsych.2017.10.007_bib68","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1001\/jamaneurol.2013.579","article-title":"Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement","volume":"70","author":"Guerreiro","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib69","doi-asserted-by":"crossref","first-page":"726.e11","DOI":"10.1016\/j.neurobiolaging.2013.09.009","article-title":"Investigating the role of rare heterozygous TREM2 variants in Alzheimer\u2019s disease and frontotemporal dementia","volume":"35","author":"Cuyvers","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.biopsych.2017.10.007_bib70","doi-asserted-by":"crossref","first-page":"2077.e11","DOI":"10.1016\/j.neurobiolaging.2013.02.016","article-title":"Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer\u2019s disease","volume":"34","author":"Giraldo","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.biopsych.2017.10.007_bib71","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1212\/01.WNL.0000160304.00003.CA","article-title":"The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2","volume":"64","author":"Kl\u00fcnemann","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2017.10.007_bib72","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1471-4159.2009.06042.x","article-title":"A\u00a0role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia","volume":"109","author":"Hsieh","year":"2009","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.biopsych.2017.10.007_bib73","doi-asserted-by":"crossref","first-page":"17091","DOI":"10.1523\/JNEUROSCI.4403-10.2010","article-title":"Cx3cr1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-\u03b2 phagocytosis","volume":"30","author":"Liu","year":"2010","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib74","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1523\/JNEUROSCI.5572-08.2009","article-title":"Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis","volume":"29","author":"Mandrekar","year":"2009","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib75","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF00227813","article-title":"Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils","volume":"84","author":"Frackowiak","year":"1992","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib76","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nm1555","article-title":"CCR2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease","volume":"13","author":"El Khoury","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib77","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1523\/JNEUROSCI.3268-10.2011","article-title":"Cd45 deficiency drives amyloid-\u03b2 peptide oligomers and neuronal loss in Alzheimer\u2019s disease mice","volume":"31","author":"Zhu","year":"2011","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib78","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1742-2094-8-92","article-title":"TLR4 mutation reduces microglial activation, increases A\u03b2 deposits and exacerbates cognitive deficits in a mouse model of Alzheimer\u2019s disease","volume":"8","author":"Song","year":"2011","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.biopsych.2017.10.007_bib79","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.2353\/ajpath.2010.100265","article-title":"Cx3cr1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer\u2019s disease mouse models","volume":"177","author":"Lee","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib80","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2017.10.007_bib81","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1172\/JCI25410","article-title":"Anti-abeta42- and anti-abeta40-specific MABS attenuate amyloid deposition in an Alzheimer disease mouse model","volume":"116","author":"Levites","year":"2006","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.biopsych.2017.10.007_bib82","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1523\/JNEUROSCI.5077-10.2011","article-title":"Robust amyloid clearance in a mouse model of Alzheimer\u2019s disease provides novel insights into the mechanism of amyloid-beta immunotherapy","volume":"31","author":"Wang","year":"2011","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib83","doi-asserted-by":"crossref","first-page":"6144","DOI":"10.1523\/JNEUROSCI.1090-04.2004","article-title":"Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition","volume":"24","author":"Wilcock","year":"2004","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib84","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature19323","article-title":"The antibody aducanumab reduces a\u03b2 plaques in Alzheimer\u2019s disease","volume":"537","author":"Sevigny","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2017.10.007_bib85","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1474-4422(10)70043-0","article-title":"11c-pib pet assessment of change in fibrillar amyloid-beta load in patients with Alzheimer\u2019s disease treated with bapineuzumab: A phase 2, double-blind, placebo-controlled, ascending-dose study","volume":"9","author":"Rinne","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib86","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1097\/01.jnen.0000240466.10758.ce","article-title":"Abeta species removal after abeta42 immunization","volume":"65","author":"Nicoll","year":"2006","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib87","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1365-2990.2010.01156.x","article-title":"Microglial alterations in human Alzheimer\u2019s disease following a\u03b242 immunization","volume":"37","author":"Zotova","year":"2011","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib88","doi-asserted-by":"crossref","first-page":"9677","DOI":"10.1523\/JNEUROSCI.4742-11.2012","article-title":"An effector-reduced anti-\u03b2-amyloid (a\u03b2) antibody with unique a\u03b2 binding properties promotes neuroprotection and glial engulfment of a\u03b2","volume":"32","author":"Adolfsson","year":"2012","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib89","doi-asserted-by":"crossref","first-page":"11621","DOI":"10.1523\/JNEUROSCI.1405-14.2014","article-title":"Combined treatment with a bace inhibitor and anti-a\u03b2 antibody gantenerumab enhances amyloid reduction in applondon mice","volume":"34","author":"Jacobsen","year":"2014","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib90","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/nen.0b013e31815f38d2","article-title":"Limited clearance of pre-existing amyloid plaques after intracerebral injection of abeta antibodies in two mouse models of Alzheimer disease","volume":"67","author":"Tucker","year":"2008","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib91","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nn.2432","article-title":"Formation and maintenance of Alzheimer\u2019s disease beta-amyloid plaques in the absence of microglia","volume":"12","author":"Grathwohl","year":"2009","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib92","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/brain\/aww016","article-title":"Eliminating microglia in Alzheimer\u2019s mice prevents neuronal loss without modulating amyloid-\u03b2 pathology","volume":"139","author":"Spangenberg","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2017.10.007_bib93","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12974-015-0366-9","article-title":"Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice","volume":"12","author":"Dagher","year":"2015","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.biopsych.2017.10.007_bib94","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1093\/brain\/awv379","article-title":"Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer\u2019s-like pathology","volume":"139","author":"Olmos-Alonso","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2017.10.007_bib95","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13024-017-0188-6","article-title":"Microglia limit the expansion of \u03b2-amyloid plaques in a mouse model of Alzheimer\u2019s disease","volume":"12","author":"Zhao","year":"2017","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.biopsych.2017.10.007_bib96","doi-asserted-by":"crossref","first-page":"e0119768","DOI":"10.1371\/journal.pone.0119768","article-title":"Fibrillar amyloid plaque formation precedes microglial activation","volume":"10","author":"Jung","year":"2015","journal-title":"PLoS One"},{"issue":"suppl 2","key":"10.1016\/j.biopsych.2017.10.007_bib97","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3233\/JAD-2011-102100","article-title":"Curcuminoid binds to amyloid-\u03b21-42 oligomer and fibril","volume":"24","author":"Yanagisawa","year":"2011","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.biopsych.2017.10.007_bib98","doi-asserted-by":"crossref","first-page":"14411","DOI":"10.1523\/JNEUROSCI.3537-10.2010","article-title":"Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils","volume":"30","author":"O\u2019Nuallain","year":"2010","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib99","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s004010050920","article-title":"Plaque biogenesis in brain aging and Alzheimer\u2019s disease. II. Progressive transformation and developmental sequence of dystrophic neurites","volume":"96","author":"Su","year":"1998","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib100","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/exnr.1998.7010","article-title":"Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer\u2019s disease","volume":"156","author":"Dickson","year":"1999","journal-title":"Exp Neurol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib101","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00401-017-1737-3","article-title":"Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer\u2019s pathology","volume":"134","author":"Haure-Mirande","year":"2017","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib102","doi-asserted-by":"crossref","first-page":"e20391","DOI":"10.7554\/eLife.20391","article-title":"Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms","volume":"5","author":"Kober","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.biopsych.2017.10.007_bib103","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/bip.20820","article-title":"Dense-core and diffuse abeta plaques in TgCRND8 mice studied with synchrotron FTIR microspectroscopy","volume":"87","author":"Rak","year":"2007","journal-title":"Biopolymers"},{"key":"10.1016\/j.biopsych.2017.10.007_bib104","doi-asserted-by":"crossref","first-page":"13489","DOI":"10.1038\/srep13489","article-title":"Plaque-associated lipids in Alzheimer\u2019s diseased brain tissue visualized by nonlinear microscopy","volume":"5","author":"Kiskis","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopsych.2017.10.007_bib105","doi-asserted-by":"crossref","first-page":"30148","DOI":"10.1074\/jbc.M109.002832","article-title":"Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding","volume":"284","author":"Zhou","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.biopsych.2017.10.007_bib106","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nn.4222","article-title":"Microglial brain region-dependent diversity and selective regional sensitivities to aging","volume":"19","author":"Grabert","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib107","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.tins.2006.07.001","article-title":"Microglial senescence: Does the brain\u2019s immune system have an expiration date?","volume":"29","author":"Streit","year":"2006","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib108","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1523\/JNEUROSCI.0616-08.2008","article-title":"Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer\u2019s disease mice","volume":"28","author":"Hickman","year":"2008","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib109","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nn.3599","article-title":"Identification of a unique TGF-\u03b2-dependent molecular and functional signature in microglia","volume":"17","author":"Butovsky","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib110","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1474-4422(10)70325-2","article-title":"Apolipoprotein E in Alzheimer\u2019s disease and other neurological disorders","volume":"10","author":"Verghese","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib111","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.biopsych.2017.10.007_bib112","doi-asserted-by":"crossref","first-page":"26043","DOI":"10.1074\/jbc.M115.679043","article-title":"Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)","volume":"290","author":"Atagi","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.biopsych.2017.10.007_bib113","doi-asserted-by":"crossref","first-page":"26033","DOI":"10.1074\/jbc.M115.677286","article-title":"The triggering receptor expressed on myeloid cells 2 binds apolipoprotein E","volume":"290","author":"Bailey","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.biopsych.2017.10.007_bib114","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0006-8993(91)91092-F","article-title":"Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer\u2019s disease and kuru plaque amyloid in Creutzfeldt-Jakob disease","volume":"541","author":"Namba","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.biopsych.2017.10.007_bib115","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1096\/fj.14-262683","article-title":"Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin e2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia","volume":"29","author":"Li","year":"2015","journal-title":"FASEB J"},{"key":"10.1016\/j.biopsych.2017.10.007_bib116","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1742-2094-11-111","article-title":"Human apoe4 increases microglia reactivity at a\u03b2 plaques in a mouse model of a\u03b2 deposition","volume":"11","author":"Rodriguez","year":"2014","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.biopsych.2017.10.007_bib117","doi-asserted-by":"crossref","first-page":"41774","DOI":"10.1074\/jbc.M112.407957","article-title":"APOE4-specific changes in a\u03b2 accumulation in a new transgenic mouse model of Alzheimer disease","volume":"287","author":"Youmans","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.biopsych.2017.10.007_bib118","doi-asserted-by":"crossref","first-page":"89ra57","DOI":"10.1126\/scitranslmed.3002156","article-title":"Human apoe isoforms differentially regulate brain amyloid-\u03b2 peptide clearance","volume":"3","author":"Castellano","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib119","doi-asserted-by":"crossref","first-page":"15181","DOI":"10.1523\/JNEUROSCI.1542-12.2012","article-title":"Apolipoprotein E, especially apolipoprotein e4, increases the oligomerization of amyloid \u03b2 peptide","volume":"32","author":"Hashimoto","year":"2012","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib120","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cell.2016.12.044","article-title":"Apoe2, apoe3, and apoe4 differentially stimulate APP transcription and a\u03b2 secretion","volume":"168","author":"Huang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2017.10.007_bib121","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2017.08.008","article-title":"The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases","volume":"47","author":"Krasemann","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.biopsych.2017.10.007_bib122","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature24016","article-title":"ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy","volume":"549","author":"Shi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2017.10.007_bib123","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1523\/JNEUROSCI.4315-03.2004","article-title":"Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice","volume":"24","author":"Brecht","year":"2004","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib124","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nrn2194","article-title":"Tau-mediated neurodegeneration in Alzheimer\u2019s disease and related disorders","volume":"8","author":"Ballatore","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/glia.22359","article-title":"Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx","volume":"61","author":"Linnartz","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.biopsych.2017.10.007_bib126","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0065-2776(07)96005-8","article-title":"Fc-receptors as regulators of immunity","volume":"96","author":"Nimmerjahn","year":"2007","journal-title":"Adv Immunol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib127","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1084\/jem.20121274","article-title":"Anti-apoe immunotherapy inhibits amyloid accumulation in a transgenic mouse model of a\u03b2 amyloidosis","volume":"209","author":"Kim","year":"2012","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib128","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1042\/BJ20150520","article-title":"AZD8797 is an allosteric non-competitive modulator of the human CX3CR1 receptor","volume":"473","author":"Cederblad","year":"2016","journal-title":"Biochem J"},{"key":"10.1016\/j.biopsych.2017.10.007_bib129","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1126\/science.1102901","article-title":"CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance","volume":"307","author":"Niess","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2017.10.007_bib130","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuron.2010.08.023","article-title":"Regulation of tau pathology by the microglial fractalkine receptor","volume":"68","author":"Bhaskar","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2017.10.007_bib131","article-title":"Association of the CX3CR1-V249I variant with neurofibrillary pathology progression in late-onset Alzheimer\u2019s disease","author":"L\u00f3pez-L\u00f3pez","year":"2017","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.biopsych.2017.10.007_bib132","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3233\/JAD-161074","article-title":"Amyloid-\u03b2 deposition and long-term progression in mild cognitive impairment due to Alzheimer\u2019s disease defined with amyloid PET imaging","volume":"57","author":"Hatashita","year":"2017","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.biopsych.2017.10.007_bib133","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1093\/brain\/awv050","article-title":"Clinicopathologic and 11C-Pittsburgh compound B implications of thal amyloid phase across the Alzheimer\u2019s disease spectrum","volume":"138","author":"Murray","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2017.10.007_bib134","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/jnc.12815","article-title":"A\u00a0distinct subfraction of a\u03b2 is responsible for the high-affinity Pittsburgh compound B-binding site in Alzheimer\u2019s disease brain","volume":"131","author":"Matveev","year":"2014","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.biopsych.2017.10.007_bib135","doi-asserted-by":"crossref","first-page":"11550","DOI":"10.1039\/C4CC03731F","article-title":"A\u00a0bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer\u2019s disease","volume":"50","author":"Zhang","year":"2014","journal-title":"Chem Commun (Camb)"},{"key":"10.1016\/j.biopsych.2017.10.007_bib136","doi-asserted-by":"crossref","first-page":"15257","DOI":"10.1021\/ja9047043","article-title":"Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in\u00a0vivo detection of amyloid-beta deposits","volume":"131","author":"Ran","year":"2009","journal-title":"J\u00a0Am Chem Soc"},{"key":"10.1016\/j.biopsych.2017.10.007_bib137","doi-asserted-by":"crossref","first-page":"15716","DOI":"10.1523\/JNEUROSCI.0996-15.2015","article-title":"In\u00a0vivo detection of age- and disease-related increases in neuroinflammation by 18F-GE180 TSPO microPET imaging in wild-type and Alzheimer\u2019s transgenic mice","volume":"35","author":"Liu","year":"2015","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib138","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2967\/jnumed.114.141648","article-title":"PET imaging of translocator protein (18 kDa) in a mouse\u00a0model of Alzheimer\u2019s disease using n-(2,5-dimethoxybenzyl)-2-18F-fluoro-n-(2-phenoxyphenyl)acetamide","volume":"56","author":"James","year":"2015","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.biopsych.2017.10.007_bib139","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/glia.22978","article-title":"In\u00a0vivo imaging of microglial activation by positron emission tomography with [(11)C]PBR28 in the 5XFAD model of Alzheimer\u2019s disease","volume":"64","author":"Mirzaei","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.biopsych.2017.10.007_bib140","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1093\/brain\/awt145","article-title":"In\u00a0vivo radioligand binding to translocator protein correlates with severity of Alzheimer\u2019s disease","volume":"136","author":"Kreisl","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2017.10.007_bib141","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neurobiolaging.2016.04.011","article-title":"(11)C-PBR28 binding to translocator protein increases with progression of Alzheimer\u2019s disease","volume":"44","author":"Kreisl","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.biopsych.2017.10.007_bib142","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2017.10.007_bib143","doi-asserted-by":"crossref","first-page":"2889.e11","DOI":"10.1016\/j.neurobiolaging.2013.06.004","article-title":"Assessment of TREM2 rs75932628 association with Alzheimer\u2019s disease in a population-based sample: The cache county study","volume":"34","author":"Gonzalez Murcia","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.biopsych.2017.10.007_bib144","doi-asserted-by":"crossref","first-page":"2443.e21","DOI":"10.1016\/j.neurobiolaging.2015.04.012","article-title":"More evidence for association of a rare TREM2 mutation\u00a0(R47H) with Alzheimer\u2019s disease risk","volume":"36","author":"Rosenthal","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.biopsych.2017.10.007_bib145","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13024-015-0016-9","article-title":"TREM2 is associated with increased risk for Alzheimer\u2019s disease in African Americans","volume":"10","author":"Jin","year":"2015","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.biopsych.2017.10.007_bib146","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.1093\/hmg\/ddu277","article-title":"Coding variants in TREM2 increase risk for Alzheimer\u2019s disease","volume":"23","author":"Jin","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2017.10.007_bib147","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.3233\/JAD-140225","article-title":"Lack of genetic association between TREM2 and late-onset Alzheimer\u2019s disease in a Japanese population","volume":"41","author":"Miyashita","year":"2014","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.biopsych.2017.10.007_bib148","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jalz.2014.05.1751","article-title":"R47H TREM2 variant increases risk of typical early onset Alzheimer\u2019s disease but not of prion or frontotemporal dementia","volume":"10","author":"Slattery","year":"2014","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.biopsych.2017.10.007_bib149","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1212\/WNL.0000000000000855","article-title":"The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk","volume":"83","author":"Hooli","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2017.10.007_bib150","doi-asserted-by":"crossref","first-page":"546.e9","DOI":"10.1016\/j.neurobiolaging.2014.08.001","article-title":"TREM2 analysis and increased risk of Alzheimer\u2019s disease","volume":"36","author":"Finelli","year":"2015","journal-title":"Neurobiol Aging"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322317320632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322317320632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T14:59:24Z","timestamp":1757775564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322317320632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":150,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S0006322317320632"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2017.10.007","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microglia-Mediated Neuroprotection, TREM2, and Alzheimer\u2019s Disease: Evidence From Optical\u00a0Imaging","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2017.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}