{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:16:24Z","timestamp":1792523784149,"version":"4.5.0"},"reference-count":180,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.biopsych.2018.06.014","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T18:23:38Z","timestamp":1530123818000},"page":"150-163","source":"Crossref","is-referenced-by-count":183,"title":["Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease"],"prefix":"10.1016","volume":"85","author":[{"given":"Martin G.","family":"Codagnone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Spichak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhain M.","family":"O\u2019Mahony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia F.","family":"O\u2019Leary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Stanton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy G.","family":"Dinan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Cryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2018.06.014_bib1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1136\/bmj.301.6761.1111","article-title":"The fetal and infant origins of adult disease","volume":"301","author":"Barker","year":"1990","journal-title":"BMJ"},{"key":"10.1016\/j.biopsych.2018.06.014_bib2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0140-6736(89)90710-1","article-title":"Weight in infancy and death from ischaemic heart disease","volume":"2","author":"Barker","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.biopsych.2018.06.014_bib3","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/0140-6736(93)91224-A","article-title":"Fetal nutrition and cardiovascular disease in adult life","volume":"341","author":"Barker","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.biopsych.2018.06.014_bib4","doi-asserted-by":"crossref","first-page":"588S","DOI":"10.1080\/07315724.2004.10719428","article-title":"The developmental origins of adult disease","volume":"23","author":"Barker","year":"2004","journal-title":"J\u00a0Am Coll Nutr"},{"key":"10.1016\/j.biopsych.2018.06.014_bib5","first-page":"1874228","article-title":"\u2019Ome sweet \u2019omics\u2014A genealogical treasury of words","volume":"17","author":"Lederberg","year":"2001","journal-title":"The Scientist"},{"key":"10.1016\/j.biopsych.2018.06.014_bib6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.trsl.2012.05.003","article-title":"The human gut microbiome: Current knowledge, challenges, and future directions","volume":"160","author":"Dave","year":"2012","journal-title":"Transl Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib7","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1101\/gr.096651.109","article-title":"The NIH Human Microbiome Project","volume":"19","author":"Peterson","year":"2009","journal-title":"Genome Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib8","doi-asserted-by":"crossref","first-page":"e1001631","DOI":"10.1371\/journal.pbio.1001631","article-title":"Mom knows best: The universality of maternal microbial transmission","volume":"11","author":"Funkhouser","year":"2013","journal-title":"PLoS Biol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3920\/BM2012.0020","article-title":"Probiotics and nutrients for the first 1000 days of life in the developing world","volume":"4","author":"Enos","year":"2013","journal-title":"Benef Microbes"},{"key":"10.1016\/j.biopsych.2018.06.014_bib10","doi-asserted-by":"crossref","first-page":"e1002533","DOI":"10.1371\/journal.pbio.1002533","article-title":"Revised estimates for the number of human and bacteria cells in the body","volume":"14","author":"Sender","year":"2016","journal-title":"PLoS Biol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib11","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.neubiorev.2017.09.016","article-title":"Do bacteria shape our development? Crosstalk between intestinal microbiota and HPA axis","volume":"83","author":"de Weerth","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.biopsych.2018.06.014_bib12","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","article-title":"Host microbiota constantly control maturation and function of microglia in the CNS","volume":"18","author":"Erny","year":"2015","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2018.06.014_bib13","doi-asserted-by":"crossref","first-page":"16050","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve","volume":"108","author":"Bravo","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2018.06.014_bib14","doi-asserted-by":"crossref","first-page":"e196","DOI":"10.1038\/ctg.2016.54","article-title":"Human intestinal barrier function in health and disease","volume":"7","author":"K\u00f6nig","year":"2016","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib15","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.psyneuen.2012.03.007","article-title":"Regulation of the stress response by the gut microbiota: Implications for psychoneuroendocrinology","volume":"37","author":"Dinan","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.biopsych.2018.06.014_bib16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.trsl.2014.01.012","article-title":"Maternal short-chain fatty acids are associated with metabolic parameters in mothers and newborns","volume":"164","author":"Priyadarshini","year":"2014","journal-title":"Transl Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib17","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cell.2012.07.008","article-title":"Host remodeling of the gut microbiome and metabolic changes during pregnancy","volume":"150","author":"Koren","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2018.06.014_bib18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1017\/S0007114510000176","article-title":"Gut microbiota composition is associated with body weight, weight gain, and biochemical parameters in pregnant women","volume":"104","author":"Santacruz","year":"2010","journal-title":"Br J Nutr"},{"key":"10.1016\/j.biopsych.2018.06.014_bib19","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1093\/ajcn\/88.4.894","article-title":"Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women","volume":"88","author":"Collado","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.biopsych.2018.06.014_bib20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/gutjnl-2012-303249","article-title":"Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by caesarean section","volume":"63","author":"Jakobsson","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.biopsych.2018.06.014_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/dnares\/dsm018","article-title":"Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes","volume":"14","author":"Kurokawa","year":"2007","journal-title":"DNA Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2049-2618-2-4","article-title":"The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women","volume":"2","author":"Romero","year":"2014","journal-title":"Microbiome"},{"issue":"Suppl 1","key":"10.1016\/j.biopsych.2018.06.014_bib23","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1073\/pnas.1002611107","article-title":"Vaginal microbiome of reproductive-age women","volume":"108","author":"Ravel","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2018.06.014_bib24","doi-asserted-by":"crossref","first-page":"11060","DOI":"10.1073\/pnas.1502875112","article-title":"Temporal and spatial variation of the human microbiota during pregnancy","volume":"112","author":"DiGiulio","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2018.06.014_bib25","doi-asserted-by":"crossref","first-page":"8988","DOI":"10.1038\/srep08988","article-title":"The vaginal microbiome during pregnancy and the postpartum period in a European population","volume":"5","author":"MacIntyre","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopsych.2018.06.014_bib26","doi-asserted-by":"crossref","first-page":"e36466","DOI":"10.1371\/journal.pone.0036466","article-title":"A\u00a0metagenomic approach to characterization of the vaginal microbiome signature in pregnancy","volume":"7","author":"Aagaard","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2018.06.014_bib27","doi-asserted-by":"crossref","first-page":"11971","DOI":"10.1073\/pnas.1002601107","article-title":"Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns","volume":"107","author":"Dominguez-Bello","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2018.06.014_bib28","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.cell.2006.02.017","article-title":"Ecological and evolutionary forces shaping microbial diversity in the human intestine","volume":"124","author":"Ley","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2018.06.014_bib29","doi-asserted-by":"crossref","first-page":"E840","DOI":"10.1152\/ajpendo.00171.2015","article-title":"The short-chain fatty acid receptor, FFA2, contributes to gestational glucose homeostasis","volume":"309","author":"Fuller","year":"2015","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.biopsych.2018.06.014_bib30","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1080\/19490976.2015.1086056","article-title":"Pregnancy-related changes in the maternal gut microbiota are dependent upon the mother\u2019s periconceptional diet","volume":"6","author":"Gohir","year":"2015","journal-title":"Gut Microbes"},{"key":"10.1016\/j.biopsych.2018.06.014_bib31","doi-asserted-by":"crossref","first-page":"44182","DOI":"10.1038\/srep44182","article-title":"Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner","volume":"7","author":"Ja\u0161arevi\u0107","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopsych.2018.06.014_bib32","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-genet-110711-155532","article-title":"The relationship between the human genome and microbiome comes into view","volume":"51","author":"Goodrich","year":"2017","journal-title":"Annu Rev Genet"},{"key":"10.1016\/j.biopsych.2018.06.014_bib33","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nature25973","article-title":"Environment dominates over host genetics in shaping human gut microbiota","volume":"555","author":"Rothschild","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2018.06.014_bib34","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.cell.2012.04.037","article-title":"Gut immune maturation depends on colonization with a host-specific microbiota","volume":"149","author":"Chung","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2018.06.014_bib35","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/d41586-018-00664-8","article-title":"Could baby\u2019s first bacteria take root before birth?","volume":"553","author":"Willyard","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2018.06.014_bib36","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40168-017-0268-4","article-title":"A\u00a0critical assessment of the \u201csterile womb\u201d and \u201cin utero colonization\u201d hypotheses: Implications for research on the pioneer infant microbiome","volume":"5","author":"Perez-Mu\u00f1oz","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.biopsych.2018.06.014_bib37","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.resmic.2007.12.007","article-title":"Is meconium from healthy newborns actually sterile?","volume":"159","author":"Jim\u00e9nez","year":"2008","journal-title":"Res Microbiol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib38","doi-asserted-by":"crossref","first-page":"e90784","DOI":"10.1371\/journal.pone.0090784","article-title":"Meconium microbiome analysis identifies bacteria correlated with premature birth","volume":"9","author":"Ardissone","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2018.06.014_bib39","doi-asserted-by":"crossref","first-page":"226.e1","DOI":"10.1016\/j.ajog.2013.01.018","article-title":"Identification of intracellular bacteria in the basal plate of the human placenta in term and preterm gestations","volume":"208","author":"Stout","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib40","first-page":"237ra265","article-title":"The placenta harbors a unique microbiome","volume":"6","author":"Aagaard","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.biopsych.2018.06.014_bib41","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s00284-005-0020-3","article-title":"Isolation of commensal bacteria from umbilical cord blood of healthy neonates born by cesarean section","volume":"51","author":"Jim\u00e9nez","year":"2005","journal-title":"Curr Microbiol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib42","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/apt.14451","article-title":"Systematic review: Human gut dysbiosis induced by non-antibiotic prescription medications","volume":"47","author":"Le Bastard","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.biopsych.2018.06.014_bib43","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.pnpbp.2016.06.010","article-title":"Maternal gut and fetal brain connection: Increased anxiety and reduced social interactions in Wistar rat offspring following peri-conceptional antibiotic exposure","volume":"71","author":"Degroote","year":"2016","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib44","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbi.2013.12.005","article-title":"Altered gut microbiota and activity in a murine model of autism spectrum disorders","volume":"37","author":"de Theije","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2018.06.014_bib45","doi-asserted-by":"crossref","first-page":"e309","DOI":"10.1038\/tp.2013.83","article-title":"Antipsychotics and the gut microbiome: Olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat","volume":"3","author":"Davey","year":"2013","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib46","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nature25979","article-title":"Extensive impact of non-antibiotic drugs on human gut bacteria","volume":"555","author":"Maier","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2018.06.014_bib47","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12916-016-0636-0","article-title":"Antibiotic use during pregnancy: How bad is it?","volume":"14","author":"Kuperman","year":"2016","journal-title":"BMC Med"},{"key":"10.1016\/j.biopsych.2018.06.014_bib48","doi-asserted-by":"crossref","first-page":"e0138293","DOI":"10.1371\/journal.pone.0138293","article-title":"Administration of non-absorbable antibiotics to pregnant mice to perturb the maternal gut microbiota is associated with alterations in offspring behavior","volume":"11","author":"Tochitani","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2018.06.014_bib49","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/mp.2013.65","article-title":"Microbiota is essential for social development in the mouse","volume":"19","author":"Desbonnet","year":"2014","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib50","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.cell.2017.11.042","article-title":"Microbiome influences prenatal and adult microglia in a sex-specific manner","volume":"172","author":"Thion","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2018.06.014_bib51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.brainres.2014.11.032","article-title":"Microglia function during brain development: New insights from animal models","volume":"1617","author":"Bilimoria","year":"2015","journal-title":"Brain Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib52","first-page":"2267","article-title":"Mechanism of action of tricyclic drugs on Escherichia coli and Yersinia enterocolitica plasmid maintenance and replication","volume":"12","author":"Csiszar","year":"1992","journal-title":"Anticancer Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib53","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0924-8579(99)00154-5","article-title":"Antimicrobial activity of psychotropic drugs: Selective serotonin reuptake inhibitors","volume":"14","author":"Munoz-Bellido","year":"2000","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.biopsych.2018.06.014_bib54","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/s41398-017-0031-4","article-title":"Possible role of the gut microbiota-brain axis in the antidepressant effects of (R)-ketamine in a social defeat stress model","volume":"7","author":"Yang","year":"2017","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib55","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tips.2009.11.003","article-title":"New perspectives on the neurodevelopmental effects of SSRIs","volume":"31","author":"Homberg","year":"2010","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.biopsych.2018.06.014_bib56","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00213-013-3115-8","article-title":"Central nervous system effects of prenatal selective serotonin reuptake inhibitors: Sensing the signal through the noise","volume":"227","author":"Gur","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2018.06.014_bib57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.reprotox.2018.02.004","article-title":"Perinatal selective serotonin reuptake inhibitor (SSRI) effects on body weight at birth and beyond: A review of animal and human studies","volume":"77","author":"Hutchison","year":"2018","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib58","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ajog.2012.02.009","article-title":"Antidepressant use during pregnancy: The benefit\u2013risk ratio","volume":"207","author":"Koren","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib59","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/hep.24018","article-title":"Enteric dysbiosis associated with a mouse model of alcoholic liver disease","volume":"53","author":"Yan","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.biopsych.2018.06.014_bib60","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1111\/j.1530-0277.2009.01022.x","article-title":"Intestinal dysbiosis: A possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats","volume":"33","author":"Mutlu","year":"2009","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib61","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bbr.2017.01.049","article-title":"Drunk bugs: Chronic vapour alcohol exposure induces marked changes in the gut microbiome in mice","volume":"323","author":"Peterson","year":"2017","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib62","doi-asserted-by":"crossref","first-page":"35455","DOI":"10.1038\/srep35455","article-title":"Alterations of the host microbiome affect behavioral responses to cocaine","volume":"6","author":"Kiraly","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopsych.2018.06.014_bib63","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1001\/jama.290.22.2996","article-title":"Fetal alcohol spectrum disorder","volume":"290","author":"Sokol","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.biopsych.2018.06.014_bib64","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1001\/jama.2013.2270","article-title":"Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism","volume":"309","author":"Christensen","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.biopsych.2018.06.014_bib65","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/sj.npp.1300518","article-title":"Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism","volume":"30","author":"Schneider","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2018.06.014_bib66","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000375489","article-title":"Differential local connectivity and neuroinflammation profiles in the medial prefrontal cortex and hippocampus in the valproic acid rat model of autism","volume":"37","author":"Codagnone","year":"2015","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.biopsych.2018.06.014_bib67","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.biopsych.2018.06.014_bib68","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0301-0082(98)00075-6","article-title":"Valproate: A reappraisal of its pharmacodynamic properties and mechanisms of action","volume":"58","author":"L\u00f6scher","year":"1999","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib69","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/jcpp.12000","article-title":"Research review: Maternal prenatal distress and poor nutrition\u2014Mutually influencing risk factors affecting infant neurocognitive development","volume":"54","author":"Monk","year":"2013","journal-title":"J\u00a0Child Psychol Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib70","article-title":"Control diet in a high-fat diet study in mice: Regular chow and purified low-fat diet have similar effects on phenotypic, metabolic, and behavioral outcomes","author":"Almeida-Suhett","year":"2017","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.biopsych.2018.06.014_bib71","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12986-018-0243-5","article-title":"The common use of improper control diets in diet-induced metabolic disease research confounds data interpretation: The fiber factor","volume":"15","author":"Pellizzon","year":"2018","journal-title":"Nutr Metab (Lond)"},{"key":"10.1016\/j.biopsych.2018.06.014_bib72","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1021\/acs.jproteome.6b00973","article-title":"Metabolic in\u00a0vivo labeling highlights differences of metabolically active microbes from the mucosal gastrointestinal microbiome between high-fat and normal chow diet","volume":"16","author":"Oberbach","year":"2017","journal-title":"J\u00a0Proteome Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib73","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.cell.2016.06.001","article-title":"Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring","volume":"165","author":"Buffington","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2018.06.014_bib74","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1038\/ncomms4889","article-title":"High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model","volume":"5","author":"Ma","year":"2014","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.biopsych.2018.06.014_bib75","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201600141","article-title":"Maternal exposure to a Western-style diet causes differences in intestinal microbiota composition and gene expression of suckling mouse pups","volume":"Jan;61","author":"Steegenga","year":"2017","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib76","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jnutbio.2010.12.003","article-title":"Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4\/NF\u03baBp65 signaling in adult offspring","volume":"23","author":"Pimentel","year":"2012","journal-title":"J\u00a0Nutr Biochem"},{"key":"10.1016\/j.biopsych.2018.06.014_bib77","doi-asserted-by":"crossref","first-page":"623.e1","DOI":"10.1016\/j.ajog.2016.02.054","article-title":"Males are from Mars, and females are from Venus: Sex-specific fetal brain gene expression signatures in a mouse model of maternal diet-induced obesity","volume":"214","author":"Edlow","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib78","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.bbi.2016.08.005","article-title":"Maternal high fat diet exposure is associated with increased hepcidin levels, decreased myelination, and neurobehavioral changes in male offspring","volume":"58","author":"Graf","year":"2016","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2018.06.014_bib79","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.neuroscience.2015.07.022","article-title":"The hypothalamic transcriptional response to stress is severely impaired in offspring exposed to adverse nutrition during gestation","volume":"342","author":"Grissom","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2018.06.014_bib80","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1101\/gad.191031.112","article-title":"Maternal Western diet causes inflammatory milk and TLR2\/4-dependent neonatal toxicity","volume":"26","author":"Du","year":"2012","journal-title":"Genes Dev"},{"key":"10.1016\/j.biopsych.2018.06.014_bib81","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1017\/S0007114514000117","article-title":"Impact of dietary fatty acids on metabolic activity and host intestinal microbiota composition in C57BL\/6J mice","volume":"111","author":"Patterson","year":"2014","journal-title":"Br J Nutr"},{"key":"10.1016\/j.biopsych.2018.06.014_bib82","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbi.2016.07.145","article-title":"Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood","volume":"59","author":"Robertson","year":"2017","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2018.06.014_bib83","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1194\/jlr.M055558","article-title":"Dietary DHA during development affects depression-like behaviors and biomarkers that emerge after puberty in adolescent rats","volume":"56","author":"Weiser","year":"2015","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib84","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1017\/S0007114517002999","article-title":"Deficiency of essential dietary n-3 PUFA disrupts the caecal microbiome and metabolome in mice","volume":"118","author":"Robertson","year":"2017","journal-title":"Br J Nutr"},{"key":"10.1016\/j.biopsych.2018.06.014_bib85","doi-asserted-by":"crossref","first-page":"e0139721","DOI":"10.1371\/journal.pone.0139721","article-title":"N-3 polyunsaturated fatty acids (PUFAs) reverse the impact of early-life stress on the gut microbiota","volume":"10","author":"Pusceddu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2018.06.014_bib86","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics","volume":"14","author":"Gibson","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib87","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/all.12777","article-title":"Maternal exposure to GOS\/inulin mixture prevents food allergies and promotes tolerance in offspring in mice","volume":"71","author":"Bouchaud","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.biopsych.2018.06.014_bib88","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1002\/mnfr.201600118","article-title":"Prenatal caprine milk oligosaccharide consumption affects the development of mice offspring","volume":"60","author":"Thum","year":"2016","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib89","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.chom.2017.11.003","article-title":"Fiber-mediated nourishment of gut microbiota protects against diet-induced obesity by restoring IL-22-mediated colonic health","volume":"23","author":"Zou","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.biopsych.2018.06.014_bib90","doi-asserted-by":"crossref","first-page":"e666","DOI":"10.1542\/peds.2013-0246","article-title":"Probiotic administration in early life, atopy, and asthma: A meta-analysis of clinical trials","volume":"132","author":"Elazab","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.biopsych.2018.06.014_bib91","doi-asserted-by":"crossref","first-page":"f6471","DOI":"10.1136\/bmj.f6471","article-title":"Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: Systematic review and meta-analysis","volume":"347","author":"Azad","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.biopsych.2018.06.014_bib92","first-page":"1477","article-title":"Taking probiotics during pregnancy. Are they useful therapy for mothers and newborns?","volume":"51","author":"Reid","year":"2005","journal-title":"Can Fam Physician"},{"key":"10.1016\/j.biopsych.2018.06.014_bib93","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.physbeh.2016.07.014","article-title":"Cognitive and affective alterations by prenatal and postnatal stress interaction","volume":"165","author":"Lee","year":"2016","journal-title":"Physiol Behav"},{"key":"10.1016\/j.biopsych.2018.06.014_bib94","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neulet.2014.10.011","article-title":"Inborn stress reactivity shapes adult behavioral consequences of early-life maternal separation stress","volume":"584","author":"Rana","year":"2015","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.biopsych.2018.06.014_bib95","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nrn3818","article-title":"Epigenetic and transgenerational reprogramming of brain development","volume":"16","author":"Bale","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2018.06.014_bib96","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuroscience.2016.01.055","article-title":"Sex-dependent programming effects of prenatal glucocorticoid treatment on the developing serotonin system and stress-related behaviors in adulthood","volume":"320","author":"Hiroi","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2018.06.014_bib97","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.psyneuen.2015.06.002","article-title":"Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood","volume":"60","author":"Golubeva","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.biopsych.2018.06.014_bib98","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1210\/en.2015-1177","article-title":"Alterations in the vaginal microbiome by maternal stress are associated with metabolic reprogramming of the offspring gut and brain","volume":"156","author":"Ja\u0161arevi\u0107","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopsych.2018.06.014_bib99","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbi.2016.12.021","article-title":"Prenatal stress affects placental cytokines and neurotrophins, commensal microbes, and anxiety-like behavior in adult female offspring","volume":"64","author":"Gur","year":"2017","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2018.06.014_bib100","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/da.22272","article-title":"The relationship between maternal depressive, anxious, and stress symptoms during pregnancy and adult offspring behavioral and emotional problems","volume":"32","author":"Betts","year":"2015","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.biopsych.2018.06.014_bib101","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.psyneuen.2015.01.006","article-title":"Maternal prenatal stress is associated with the infant intestinal microbiota","volume":"53","author":"Zijlmans","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.biopsych.2018.06.014_bib102","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbi.2017.10.007","article-title":"Maternal depressive symptoms linked to reduced fecal immunoglobulin A concentrations in infants","volume":"68","author":"Kang","year":"2018","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2018.06.014_bib103","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1126\/science.aag3194","article-title":"Maternal immune activation: Implications for neuropsychiatric disorders","volume":"353","author":"Estes","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2018.06.014_bib104","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.cell.2013.11.024","article-title":"Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders","volume":"155","author":"Hsiao","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2018.06.014_bib105","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.schres.2011.06.018","article-title":"Microglial activation in a neuroinflammational animal model of schizophrenia\u2014A pilot study","volume":"131","author":"Juckel","year":"2011","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib106","doi-asserted-by":"crossref","first-page":"e6354","DOI":"10.1371\/journal.pone.0006354","article-title":"Prenatal immune challenge is an environmental risk factor for brain and behavior change relevant to schizophrenia: Evidence from MRI in a mouse model","volume":"4","author":"Li","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2018.06.014_bib107","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.bbi.2012.01.011","article-title":"Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism","volume":"26","author":"Malkova","year":"2012","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2018.06.014_bib108","doi-asserted-by":"crossref","first-page":"688","DOI":"10.2174\/1570159X14666151215095359","article-title":"Animal models of maternal immune activation in depression research","volume":"14","author":"Ronovsky","year":"2016","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib109","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neuroscience.2015.04.065","article-title":"Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood","volume":"299","author":"Depino","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2018.06.014_bib110","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.bbi.2012.01.015","article-title":"Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response","volume":"26","author":"Oskvig","year":"2012","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2018.06.014_bib111","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.biopsych.2011.01.009","article-title":"Early, time-dependent disturbances of hippocampal synaptic transmission and plasticity after in utero immune challenge","volume":"70","author":"Escobar","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib112","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1038\/sj.npp.1301292","article-title":"Neurobehavioral and immunological consequences of prenatal immune activation in rats: Influence of antipsychotics","volume":"32","author":"Romero","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2018.06.014_bib113","doi-asserted-by":"crossref","first-page":"e12816","DOI":"10.1111\/aji.12816","article-title":"Lipopolysaccharide-induced maternal inflammation induces direct placental injury without alteration in placental blood flow and induces a secondary fetal intestinal injury that persists into adulthood","volume":"79","author":"Fricke","year":"2018","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib114","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.molmed.2014.12.002","article-title":"The infant microbiome development: Mom matters","volume":"21","author":"Mueller","year":"2015","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.biopsych.2018.06.014_bib115","first-page":"1796S","article-title":"Cesarean delivery may affect the early biodiversity of intestinal bacteria","volume":"138","author":"Biasucci","year":"2008","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.biopsych.2018.06.014_bib116","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.chom.2015.04.004","article-title":"Dynamics and stabilization of the human gut microbiome during the first year of life","volume":"17","author":"B\u00e4ckhed","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.biopsych.2018.06.014_bib117","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1001\/jamapediatrics.2015.3732","article-title":"Association of cesarean delivery and formula supplementation with the intestinal microbiome of 6-week-old infants","volume":"170","author":"Madan","year":"2016","journal-title":"JAMA Pediatr"},{"issue":"Suppl 1","key":"10.1016\/j.biopsych.2018.06.014_bib118","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.earlhumdev.2010.01.004","article-title":"Mode of delivery affects the bacterial community in the newborn gut","volume":"86","author":"Biasucci","year":"2010","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.biopsych.2018.06.014_bib119","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1503\/cmaj.121189","article-title":"Gut microbiota of healthy Canadian infants: Profiles by mode of delivery and infant diet at 4 months","volume":"185","author":"Azad","year":"2013","journal-title":"CMAJ"},{"key":"10.1016\/j.biopsych.2018.06.014_bib120","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1136\/gut.2004.041640","article-title":"Influence of mode of delivery on gut microbiota composition in seven year old children","volume":"53","author":"Salminen","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.biopsych.2018.06.014_bib121","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/MPG.0000000000001124","article-title":"Mode of delivery determines neonatal pharyngeal bacterial composition and early intestinal colonization","volume":"63","author":"Brumbaugh","year":"2016","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.biopsych.2018.06.014_bib122","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02419-14","article-title":"Dynamics of infant gut microbiota are influenced by delivery mode and gestational duration and are associated with subsequent adiposity","volume":"6","author":"Dogra","year":"2015","journal-title":"MBio"},{"key":"10.1016\/j.biopsych.2018.06.014_bib123","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.anaerobe.2015.07.004","article-title":"Gut Bifidobacterium microbiota in one-month-old Brazilian newborns","volume":"35","author":"Grze\u015bkowiak","year":"2015","journal-title":"Anaerobe"},{"key":"10.1016\/j.biopsych.2018.06.014_bib124","doi-asserted-by":"crossref","first-page":"e0158498","DOI":"10.1371\/journal.pone.0158498","article-title":"Early-life events, including mode of delivery and type of feeding, siblings and gender, shape the developing gut microbiota","volume":"11","author":"Martin","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2018.06.014_bib125","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40168-016-0213-y","article-title":"Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET cohort","volume":"5","author":"Hill","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.biopsych.2018.06.014_bib126","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1001\/jamapediatrics.2017.5535","article-title":"Roles of birth mode and infant gut microbiota in intergenerational transmission of overweight and obesity from mother to offspring","volume":"172","author":"Tun","year":"2018","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.biopsych.2018.06.014_bib127","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nm.4272","article-title":"Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery","volume":"23","author":"Chu","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2018.06.014_bib128","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.4049\/jimmunol.1400085","article-title":"Mode of delivery shapes gut colonization pattern and modulates regulatory immunity in mice","volume":"193","author":"Hansen","year":"2014","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib129","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/nm.4039","article-title":"Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer","volume":"22","author":"Dominguez-Bello","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2018.06.014_bib130","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1365-2222.2008.02939.x","article-title":"Caesarean delivery and risk of atopy and allergic disease: Meta-analyses","volume":"38","author":"Bager","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.biopsych.2018.06.014_bib131","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1007\/s00125-008-0941-z","article-title":"Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: A meta-analysis of observational studies","volume":"51","author":"Cardwell","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.biopsych.2018.06.014_bib132","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/schbul\/sbv152","article-title":"Birth by caesarean section and the risk of adult psychosis: A population-based cohort study","volume":"42","author":"O\u2019Neill","year":"2016","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.biopsych.2018.06.014_bib133","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00406-016-0708-3","article-title":"Birth by cesarean section and schizophrenia: Results from the multicenter FACE-SZ data-set","volume":"267","author":"Fond","year":"2017","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.biopsych.2018.06.014_bib134","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/nutrit\/nuw069","article-title":"Intervention strategies for cesarean section-induced alterations in the microbiota-gut-brain axis","volume":"75","author":"Moya-P\u00e9rez","year":"2017","journal-title":"Nutr Rev"},{"key":"10.1016\/j.biopsych.2018.06.014_bib135","doi-asserted-by":"crossref","first-page":"eaao1874","DOI":"10.1126\/sciadv.aao1874","article-title":"Increased weight gain by C-section: Functional significance of the primordial microbiome","volume":"3","author":"Martinez","year":"2017","journal-title":"Sci Adv"},{"key":"10.1016\/j.biopsych.2018.06.014_bib136","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12884-017-1304-x","article-title":"Birth by caesarean section and school performance in Swedish adolescents\u2014A population-based study","volume":"17","author":"Curran","year":"2017","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.biopsych.2018.06.014_bib137","doi-asserted-by":"crossref","first-page":"343ra381","DOI":"10.1126\/scitranslmed.aad0917","article-title":"Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability","volume":"8","author":"Yassour","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.biopsych.2018.06.014_bib138","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/ijo.2014.119","article-title":"Infant antibiotic exposure and the development of childhood overweight and central adiposity","volume":"38","author":"Azad","year":"2014","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.biopsych.2018.06.014_bib139","doi-asserted-by":"crossref","first-page":"15062","DOI":"10.1038\/ncomms15062","article-title":"Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior","volume":"8","author":"Leclercq","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2018.06.014_bib140","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature11400","article-title":"Antibiotics in early life alter the murine colonic microbiome and adiposity","volume":"488","author":"Cho","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2018.06.014_bib141","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.neuroscience.2014.07.054","article-title":"Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats","volume":"277","author":"O\u2019Mahony","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2018.06.014_bib142","doi-asserted-by":"crossref","first-page":"e796","DOI":"10.1542\/peds.2013-1985","article-title":"The transfer of drugs and therapeutics into human breast milk: An update on selected topics","volume":"132","author":"Sachs","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.biopsych.2018.06.014_bib143","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijdevneu.2016.04.008","article-title":"Of rodents and humans: A comparative review of the neurobehavioral effects of early life SSRI exposure in preclinical and clinical research","volume":"51","author":"Glover","year":"2016","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.biopsych.2018.06.014_bib144","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1126\/science.1101678","article-title":"Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice","volume":"306","author":"Ansorge","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2018.06.014_bib145","doi-asserted-by":"crossref","first-page":"12379","DOI":"10.1523\/JNEUROSCI.1020-13.2014","article-title":"Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC function","volume":"34","author":"Rebello","year":"2014","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2018.06.014_bib146","doi-asserted-by":"crossref","first-page":"e115225","DOI":"10.1371\/journal.pone.0115225","article-title":"The antipsychotic olanzapine interacts with the gut microbiome to cause weight gain in mouse","volume":"9","author":"Morgan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2018.06.014_bib147","doi-asserted-by":"crossref","first-page":"e652","DOI":"10.1038\/tp.2015.135","article-title":"Use of the second-generation antipsychotic, risperidone, and secondary weight gain are associated with an altered gut microbiota in children","volume":"5","author":"Bahr","year":"2015","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib148","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1542\/peds.2005-2824","article-title":"Factors influencing the composition of the intestinal microbiota in early infancy","volume":"118","author":"Penders","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.biopsych.2018.06.014_bib149","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","article-title":"Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome","volume":"3","author":"Turnbaugh","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.biopsych.2018.06.014_bib150","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neuroscience.2008.02.023","article-title":"Post weaning high fat feeding affects rats\u2019 behavior and hypothalamic pituitary adrenal axis at the onset of puberty in a sexually dimorphic manner","volume":"153","author":"Boukouvalas","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2018.06.014_bib151","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbi.2014.03.005","article-title":"Impairment of hippocampal-dependent memory induced by juvenile high-fat diet intake is associated with enhanced hippocampal inflammation in rats","volume":"40","author":"Boitard","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2018.06.014_bib152","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuropharm.2016.09.020","article-title":"Effects of bingeing on fat during adolescence on the reinforcing effects of cocaine in adult male mice","volume":"113","author":"Blanco-Gand\u00eda","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopsych.2018.06.014_bib153","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.jaci.2010.07.022","article-title":"Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants","volume":"126","author":"Gr\u00fcber","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib154","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuroscience.2017.06.064","article-title":"Anxiogenic effects of a Lactobacillus, inulin and the synbiotic on healthy juvenile rats","volume":"359","author":"Barrera-Bugue\u00f1o","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2018.06.014_bib155","doi-asserted-by":"crossref","first-page":"e483","DOI":"10.3390\/nu8080483","article-title":"Effect of probiotics on depression: A systematic review and meta-analysis of randomized controlled trials","volume":"8","author":"Huang","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.biopsych.2018.06.014_bib156","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/pr.2015.51","article-title":"A\u00a0possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: A randomized trial","volume":"77","author":"P\u00e4rtty","year":"2015","journal-title":"Pediatr Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib157","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.cell.2013.11.035","article-title":"Toward effective probiotics for autism and other neurodevelopmental disorders","volume":"155","author":"Gilbert","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2018.06.014_bib158","doi-asserted-by":"crossref","first-page":"e823","DOI":"10.1038\/tp.2016.94","article-title":"The effects of a probiotic formulation (Lactobacillus rhamnosus and L.\u00a0helveticus) on developmental trajectories of emotional learning in stressed infant rats","volume":"6","author":"Cowan","year":"2016","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib159","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1111\/nmo.12427","article-title":"Bifidobacteria exert strain-specific effects on stress-related behavior and physiology in BALB\/c mice","volume":"26","author":"Savignac","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.biopsych.2018.06.014_bib160","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1111\/dom.13240","article-title":"Specific synbiotics in early life protect against diet-induced obesity in adult mice","volume":"20","author":"Mischke","year":"2018","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.biopsych.2018.06.014_bib161","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0006-3223(01)01157-X","article-title":"The role of childhood trauma in the neurobiology of mood and anxiety disorders: Preclinical and clinical studies","volume":"49","author":"Heim","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib162","doi-asserted-by":"crossref","first-page":"21958","DOI":"10.1038\/srep21958","article-title":"Maternal weaning modulates emotional behavior and regulates the gut-brain axis","volume":"6","author":"Farshim","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopsych.2018.06.014_bib163","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bbi.2017.10.024","article-title":"Post-weaning social isolation of rats leads to long-term disruption of the gut microbiota-immune-brain axis","volume":"68","author":"Doherty","year":"2018","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2018.06.014_bib164","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.biopsych.2008.06.026","article-title":"Early life stress alters behavior, immunity, and microbiota in rats: Implications for irritable bowel syndrome and psychiatric illnesses","volume":"65","author":"O\u2019Mahony","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib165","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2004.063388","article-title":"Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice","volume":"558","author":"Sudo","year":"2004","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib166","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/mp.2012.77","article-title":"The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner","volume":"18","author":"Clarke","year":"2013","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib167","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/jama.289.1.49","article-title":"Prevalence of autism in a US metropolitan area","volume":"289","author":"Yeargin-Allsopp","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.biopsych.2018.06.014_bib168","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.jaac.2010.05.017","article-title":"Lifetime prevalence of mental disorders in U.S. adolescents: Results from the National Comorbidity Survey Replication\u2013Adolescent Supplement (NCS-A)","volume":"49","author":"Merikangas","year":"2010","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib169","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/archpsyc.60.6.565","article-title":"Sex differences in the risk of schizophrenia: Evidence from meta-analysis","volume":"60","author":"Aleman","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib170","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2014.06.008","article-title":"Sublime microglia: Expanding roles for the guardians of the CNS","volume":"158","author":"Salter","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2018.06.014_bib171","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.it.2014.07.010","article-title":"Modulation of immune development and function by intestinal microbiota","volume":"35","author":"Kabat","year":"2014","journal-title":"Trends Immunol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib172","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature11551","article-title":"Reciprocal interactions of the intestinal microbiota and immune system","volume":"489","author":"Maynard","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2018.06.014_bib173","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.pharmthera.2011.01.014","article-title":"Immune system to brain signaling: Neuropsychopharmacological implications","volume":"130","author":"Capuron","year":"2011","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.biopsych.2018.06.014_bib174","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: When the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2018.06.014_bib175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2011.12.049","article-title":"Can bipolar disorder be viewed as a multi-system inflammatory disease?","volume":"141","author":"Leboyer","year":"2012","journal-title":"J\u00a0Affect Disord"},{"key":"10.1016\/j.biopsych.2018.06.014_bib176","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.psychres.2006.04.023","article-title":"Autoantibody reactivity in serum of patients with major depression, schizophrenia and healthy controls","volume":"158","author":"Laske","year":"2008","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.biopsych.2018.06.014_bib177","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.biopsych.2013.06.010","article-title":"Immune system disturbances in schizophrenia","volume":"75","author":"Horv\u00e1th","year":"2014","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib178","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jneuroim.2008.12.002","article-title":"Elevated immune response in the brain of autistic patients","volume":"207","author":"Li","year":"2009","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.biopsych.2018.06.014_bib179","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/mp.2011.165","article-title":"A\u00a0review of research trends in physiological abnormalities in autism spectrum disorders: Immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures","volume":"17","author":"Rossignol","year":"2012","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2018.06.014_bib180","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ebiom.2017.09.013","article-title":"Effect of Lactobacillus rhamnosus HN001 in pregnancy on postpartum symptoms of depression and anxiety: A randomised double-blind placebo-controlled trial","volume":"24","author":"Slykerman","year":"2017","journal-title":"EBioMedicine"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322318316056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322318316056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T22:25:38Z","timestamp":1571523938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322318316056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":180,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0006322318316056"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2018.06.014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733717754.793569644","asserted-by":"object"}]},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}