{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:14:28Z","timestamp":1785158068680,"version":"3.55.0"},"reference-count":126,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K23MH101498"],"award-info":[{"award-number":["K23MH101498"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006373","name":"Ohio Department of Mental Health and Addiction Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.biopsych.2020.12.006","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T15:10:58Z","timestamp":1608131458000},"page":"85-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Neurobiology of the Rapid-Acting Antidepressant Effects of Ketamine: Impact and Opportunities"],"prefix":"10.1016","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5279-2642","authenticated-orcid":false,"given":"Ryota","family":"Shinohara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George K.","family":"Aghajanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5783-6181","authenticated-orcid":false,"given":"Chadi G.","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2020.12.006_bib1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1001\/archpsyc.1994.03950030035004","article-title":"Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses","volume":"51","author":"Krystal","year":"1994","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0006-3223(99)00230-9","article-title":"Antidepressant effects of ketamine in depressed patients","volume":"47","author":"Berman","year":"2000","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(90)90204-J","article-title":"Functional antagonists at the NMDA receptor complex exhibit antidepressant actions","volume":"185","author":"Trullas","year":"1990","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib4","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","article-title":"A\u00a0randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression","volume":"63","author":"Zarate","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib5","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2020.12.006_bib6","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.biopsych.2010.12.015","article-title":"Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure","volume":"69","author":"Li","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib7","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuron.2019.02.005","article-title":"Ketamine: A paradigm shift for depression research and treatment","volume":"101","author":"Krystal","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2020.12.006_bib8","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.neuron.2018.05.018","article-title":"Glutamatergic signaling in the central nervous system: Ionotropic and metabotropic receptors in concert","volume":"98","author":"Reiner","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2020.12.006_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/sj.npp.1301559","article-title":"Synaptic plasticity: Multiple forms, functions, and mechanisms","volume":"33","author":"Citri","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib10","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1085\/jgp.201812032","article-title":"Structure, function, and allosteric modulation of NMDA receptors","volume":"150","author":"Hansen","year":"2018","journal-title":"J\u00a0Gen Physiol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn3504","article-title":"NMDA receptor subunit diversity: Impact on receptor properties, synaptic plasticity and disease","volume":"14","author":"Paoletti","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib12","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1523\/JNEUROSCI.17-08-02921.1997","article-title":"Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex","volume":"17","author":"Moghaddam","year":"1997","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib13","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/mp.2016.34","article-title":"Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects","volume":"22","author":"Chowdhury","year":"2017","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib14","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nm.4050","article-title":"Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants","volume":"22","author":"Duman","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2020.12.006_bib15","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/nm.2886","article-title":"Decreased expression of synapse-related genes and loss of synapses in major depressive disorder","volume":"18","author":"Kang","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2020.12.006_bib16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuron.2013.06.028","article-title":"The brain on stress: Vulnerability and plasticity of the prefrontal cortex over the life course","volume":"79","author":"McEwen","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2020.12.006_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/npp.2015.171","article-title":"Stress effects on neuronal structure: Hippocampus, amygdala, and prefrontal cortex","volume":"41","author":"McEwen","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.biopsych.2007.05.028","article-title":"Cellular mechanisms underlying the antidepressant effects of ketamine: Role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors","volume":"63","author":"Maeng","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature10130","article-title":"NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses","volume":"475","author":"Autry","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2020.12.006_bib20","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0166-2236(03)00162-0","article-title":"Structure-stability-function relationships of dendritic spines","volume":"26","author":"Kasai","year":"2003","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tins.2009.11.003","article-title":"mTOR signaling: At the crossroads of plasticity, memory and disease","volume":"33","author":"Hoeffer","year":"2010","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib22","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.neuron.2019.02.041","article-title":"A\u00a0synaptic perspective of fragile X syndrome and autism spectrum disorders","volume":"101","author":"Bagni","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2020.12.006_bib23","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1172\/JCI126859","article-title":"Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation","volume":"129","author":"Kato","year":"2019","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.biopsych.2020.12.006_bib24","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/s41386-020-0644-9","article-title":"Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin","volume":"45","author":"Abdallah","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib25","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.biopsych.2011.09.030","article-title":"Brain-derived neurotrophic factor Val66Met\u00a0allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex","volume":"71","author":"Liu","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib26","doi-asserted-by":"crossref","first-page":"pyu033","DOI":"10.1093\/ijnp\/pyu033","article-title":"BDNF release is required for the behavioral actions of ketamine","volume":"18","author":"Lepack","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.biopsych.2018.12.014","article-title":"Neurotrophic and antidepressant actions of brain-derived neurotrophic factor require vascular endothelial growth factor","volume":"86","author":"Deyama","year":"2019","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib28","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1038\/mp.2017.220","article-title":"BDNF release and signaling are required for the antidepressant actions of GLYX-13","volume":"23","author":"Kato","year":"2018","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat8078","article-title":"Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation","volume":"364","author":"Moda-Sava","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2020.12.006_bib30","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1038\/s41386-019-0501-x","article-title":"N-methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects","volume":"44","author":"Fogaca","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib31","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nrn1519","article-title":"Interneurons of the neocortical inhibitory system","volume":"5","author":"Markram","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib32","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1038\/s41386-018-0136-3","article-title":"The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects","volume":"43","author":"Abdallah","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib33","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/npp.2009.168","article-title":"Gamma and delta neural oscillations and association with clinical symptoms under subanesthetic ketamine","volume":"35","author":"Hong","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib34","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/mp.2013.130","article-title":"Lanicemine: A low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects","volume":"19","author":"Sanacora","year":"2014","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib35","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1038\/s41380-019-0400-x","article-title":"Neurobiology of rapid-acting antidepressants: Convergent effects on GluA1-synaptic function","volume":"24","author":"Duman","year":"2019","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuropharm.2015.07.028","article-title":"Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition","volume":"100","author":"Miller","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib37","doi-asserted-by":"crossref","first-page":"11496","DOI":"10.1523\/JNEUROSCI.2213-07.2007","article-title":"NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons","volume":"27","author":"Homayoun","year":"2007","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib38","doi-asserted-by":"crossref","first-page":"E3007","DOI":"10.1073\/pnas.1718883115","article-title":"Disinhibition of CA1 pyramidal cells by low-dose ketamine and other antagonists with rapid antidepressant efficacy","volume":"115","author":"Widman","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2020.12.006_bib39","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nn.3051","article-title":"Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex","volume":"15","author":"Gentet","year":"2012","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib40","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41467-019-13809-8","article-title":"Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines","volume":"11","author":"Ali","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2020.12.006_bib41","article-title":"Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses [published online ahead of print Oct 17]","author":"Foga\u00e7a","year":"2020","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib42","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1172\/JCI130808","article-title":"GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions","volume":"130","author":"Gerhard","year":"2020","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.biopsych.2020.12.006_bib43","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1172\/JCI85033","article-title":"GABA interneurons mediate the rapid antidepressant-like effects of scopolamine","volume":"126","author":"Wohleb","year":"2016","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.biopsych.2020.12.006_bib44","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/JCP.0b013e31818a6cea","article-title":"An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder","volume":"28","author":"Preskorn","year":"2008","journal-title":"J\u00a0Clin Psychopharmacol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib45","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.biopsych.2009.11.021","article-title":"Replication of scopolamine's antidepressant efficacy in major depressive disorder: A randomized, placebo-controlled clinical trial","volume":"67","author":"Drevets","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib46","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/archpsyc.63.10.1121","article-title":"Antidepressant efficacy of the antimuscarinic drug scopolamine: A randomized, placebo-controlled clinical trial","volume":"63","author":"Furey","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib47","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/ijnp\/pyy051","article-title":"Neurophysiological changes associated with antidepressant response to ketamine not observed in a negative trial of scopolamine in major depressive disorder","volume":"22","author":"Park","year":"2019","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib48","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1124\/jpet.114.216804","article-title":"M1 and m2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine","volume":"351","author":"Witkin","year":"2014","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.biopsych.2020.12.006_bib49","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.nbd.2015.06.012","article-title":"Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors","volume":"82","author":"Navarria","year":"2015","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.biopsych.2020.12.006_bib50","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.biopsych.2013.04.025","article-title":"Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses","volume":"74","author":"Voleti","year":"2013","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib51","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.biopsych.2017.06.017","article-title":"Activity-dependent brain-derived neurotrophic factor release is required for the rapid antidepressant actions of scopolamine","volume":"83","author":"Ghosal","year":"2018","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib52","doi-asserted-by":"crossref","first-page":"6441","DOI":"10.1073\/pnas.1819540116","article-title":"(2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions","volume":"116","author":"Zanos","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2020.12.006_bib53","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature17998","article-title":"NMDAR inhibition-independent antidepressant actions of ketamine metabolites","volume":"533","author":"Zanos","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2020.12.006_bib54","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1073\/pnas.1814709116","article-title":"Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2 R,6 R)-hydroxynorketamine","volume":"116","author":"Fukumoto","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2020.12.006_bib55","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.136","article-title":"R-ketamine: A rapid-onset and sustained antidepressant without psychotomimetic side effects","volume":"5","author":"Yang","year":"2015","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib56","doi-asserted-by":"crossref","first-page":"107947","DOI":"10.1016\/j.neuropharm.2020.107947","article-title":"Ketamine increases vmPFC activity: Effects of (R)- and (S)-stereoisomers and (2R,6R)-hydroxynorketamine metabolite","volume":"166","author":"Hare","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib57","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/ijnp\/pyz041","article-title":"(R)-ketamine induces a greater increase in prefrontal 5-HT release than (S)-ketamine and ketamine metabolites via an AMPA receptor-independent mechanism","volume":"22","author":"Ago","year":"2019","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib58","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.biopsych.2012.09.006","article-title":"The role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine","volume":"73","author":"Monteggia","year":"2013","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib59","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03581","article-title":"GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine","volume":"3","author":"Miller","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.biopsych.2020.12.006_bib60","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neuron.2011.09.023","article-title":"A\u00a0critical role for GluN2B-containing NMDA receptors in cortical development and function","volume":"72","author":"Wang","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2020.12.006_bib61","article-title":"Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression","volume":"1","author":"Banasr","year":"2017","journal-title":"Chronic Stress (Thousand Oaks)"},{"key":"10.1016\/j.biopsych.2020.12.006_bib62","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.biopsych.2017.05.024","article-title":"Somatostatin-positive gamma-aminobutyric acid interneuron deficits in depression: Cortical microcircuit and therapeutic perspectives","volume":"82","author":"Fee","year":"2017","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib63","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuron.2019.03.013","article-title":"Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments","volume":"102","author":"Duman","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2020.12.006_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.181","article-title":"Impaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stress","volume":"6","author":"Ma","year":"2016","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib65","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/bs.apha.2014.11.003","article-title":"GABAergic control of depression-related brain states","volume":"73","author":"Luscher","year":"2015","journal-title":"Adv Pharmacol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib66","doi-asserted-by":"crossref","first-page":"104669","DOI":"10.1016\/j.nbd.2019.104669","article-title":"Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodents","volume":"134","author":"Ghosal","year":"2020","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.biopsych.2020.12.006_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cobeha.2016.09.012","article-title":"Prefrontal cortex GABAergic deficits and circuit dysfunction in the pathophysiology and treatment of chronic stress and depression","volume":"14","author":"Ghosal","year":"2017","journal-title":"Curr Opin Behav Sci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib68","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.biopsych.2016.02.009","article-title":"Bidirectional homeostatic regulation of a depression-related brain state by gamma-aminobutyric acidergic deficits and ketamine treatment","volume":"80","author":"Ren","year":"2016","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib69","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1038\/s41386-018-0043-7","article-title":"Prophylactic ketamine alters nucleotide and neurotransmitter metabolism in brain and plasma following stress","volume":"43","author":"McGowan","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib70","doi-asserted-by":"crossref","first-page":"e469","DOI":"10.1038\/tp.2014.105","article-title":"Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression","volume":"4","author":"Lally","year":"2014","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib71","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1177\/0269881114568041","article-title":"Neural correlates of change in major depressive disorder anhedonia following open-label ketamine","volume":"29","author":"Lally","year":"2015","journal-title":"J\u00a0Psychopharmacol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib72","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1038\/npp.2017.49","article-title":"The nucleus accumbens and ketamine treatment in major depressive disorder","volume":"42","author":"Abdallah","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib73","article-title":"Ketamine modulates fronto-striatal circuitry in depressed and healthy individuals [published online ahead of print Sep 14]","author":"Mkrtchian","year":"2020","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib74","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1124\/jpet.116.233627","article-title":"The rapidly acting antidepressant ketamine and the mGlu2\/3 receptor antagonist LY341495 rapidly engage dopaminergic mood circuits","volume":"358","author":"Witkin","year":"2016","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.biopsych.2020.12.006_bib75","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1111\/j.1471-4159.2008.05597.x","article-title":"Dopamine receptors regulate NMDA receptor surface expression in prefrontal cortex neurons","volume":"106","author":"Gao","year":"2008","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.biopsych.2020.12.006_bib76","doi-asserted-by":"crossref","first-page":"7342","DOI":"10.1523\/JNEUROSCI.4603-04.2005","article-title":"Dopamine receptor stimulation modulates AMPA receptor synaptic insertion in prefrontal cortex neurons","volume":"25","author":"Sun","year":"2005","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib77","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0306-4522(01)00096-3","article-title":"Stimulation of D1-type dopamine receptors enhances excitability in prefrontal cortical pyramidal neurons in a state-dependent manner","volume":"104","author":"Lavin","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2020.12.006_bib78","doi-asserted-by":"crossref","first-page":"RC106","DOI":"10.1523\/JNEUROSCI.20-22-j0003.2000","article-title":"Essential role of D1 but not D2 receptors in the NMDA receptor-dependent long-term potentiation at hippocampal-prefrontal cortex synapses in\u00a0vivo","volume":"20","author":"Gurden","year":"2000","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib79","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.euroneuro.2017.01.014","article-title":"The novel antipsychotic drug brexpiprazole, alone and in combination with escitalopram, facilitates prefrontal glutamatergic transmission via a dopamine D1 receptor-dependent mechanism","volume":"27","author":"Bjorkholm","year":"2017","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib80","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1523\/JNEUROSCI.23-03-00867.2003","article-title":"Dopamine enhances EPSCs in layer II-III pyramidal neurons in rat prefrontal cortex","volume":"23","author":"Gonzalez-Islas","year":"2003","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib81","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1038\/mp.2017.177","article-title":"Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice","volume":"23","author":"Shinohara","year":"2018","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib82","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41467-018-08168-9","article-title":"Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects","volume":"10","author":"Hare","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2020.12.006_bib83","article-title":"Cell-type specific modulation of NMDA receptors triggers antidepressant actions [published online ahead of print Jun 2]","author":"Pothula","year":"2020","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib84","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1523\/JNEUROSCI.5952-11.2012","article-title":"Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice","volume":"32","author":"Tanaka","year":"2012","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib85","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrn3138","article-title":"The stressed synapse: The impact of stress and glucocorticoids on glutamate transmission","volume":"13","author":"Popoli","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib86","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/pcn.12901","article-title":"Neural mechanisms underlying adaptive and maladaptive consequences of stress: Roles of dopaminergic and inflammatory responses","volume":"73","author":"Furuyashiki","year":"2019","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib87","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1017\/S1461145714000649","article-title":"Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex","volume":"17","author":"Nishitani","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib88","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1016\/j.biopsych.2017.10.020","article-title":"Common neurotransmission recruited in (R,S)-ketamine and (2R,6R)-hydroxynorketamine-induced sustained antidepressant-like effects","volume":"84","author":"Pham","year":"2018","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib89","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/npp.2015.233","article-title":"The antidepressant effects of an mGlu2\/3 receptor antagonist and ketamine require AMPA receptor stimulation in the mPFC and subsequent activation of the 5-HT neurons in the DRN","volume":"41","author":"Fukumoto","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib90","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/ijnp\/pyx116","article-title":"Role of 5-HT1A receptor stimulation in the medial prefrontal cortex in the sustained antidepressant effects of ketamine","volume":"21","author":"Fukumoto","year":"2018","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib91","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00213-013-3024-x","article-title":"Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism","volume":"228","author":"Gigliucci","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2020.12.006_bib92","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1038\/s41386-020-0705-0","article-title":"Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT1A receptor stimulation","volume":"45","author":"Fukumoto","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib93","doi-asserted-by":"crossref","first-page":"8106","DOI":"10.1073\/pnas.1414728112","article-title":"Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions","volume":"112","author":"Fuchikami","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2020.12.006_bib94","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fncir.2014.00054","article-title":"Subcircuit-specific neuromodulation in the prefrontal cortex","volume":"8","author":"Dembrow","year":"2014","journal-title":"Front Neural Circuits"},{"key":"10.1016\/j.biopsych.2020.12.006_bib95","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/mp.2015.176","article-title":"Activation of a ventral hippocampus-medial prefrontal cortex pathway is both necessary and sufficient for an antidepressant response to ketamine","volume":"21","author":"Carreno","year":"2016","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib96","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuron.2019.09.044","article-title":"mGlu2 and mGlu3 negative allosteric modulators divergently enhance thalamocortical transmission and exert rapid antidepressant-like effects","volume":"105","author":"Joffe","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2020.12.006_bib97","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/nn.3779","article-title":"Reward processing by the lateral habenula in normal and depressive behaviors","volume":"17","author":"Proulx","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2020.12.006_bib98","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.conb.2017.10.024","article-title":"Lateral habenula in the pathophysiology of depression","volume":"48","author":"Yang","year":"2018","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib99","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature25509","article-title":"Ketamine blocks bursting in the lateral habenula to rapidly relieve depression","volume":"554","author":"Yang","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2020.12.006_bib100","doi-asserted-by":"crossref","first-page":"112628","DOI":"10.1016\/j.bbr.2020.112628","article-title":"Ketamine and rapid acting antidepressants: Are we ready to cure, rather than treat depression?","volume":"390","author":"Abdallah","year":"2020","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.biopsych.2020.12.006_bib101","doi-asserted-by":"crossref","first-page":"e573","DOI":"10.1038\/tp.2015.66","article-title":"The positive effect on ketamine as a priming adjuvant in antidepressant treatment","volume":"5","author":"Melo","year":"2015","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib102","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev-pharmtox-010818-021701","article-title":"The neurobiology and pharmacotherapy of posttraumatic stress disorder","volume":"59","author":"Abdallah","year":"2019","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib103","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pharmthera.2018.05.010","article-title":"The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?","volume":"190","author":"Abdallah","year":"2018","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.biopsych.2020.12.006_bib104","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1126\/science.1222939","article-title":"Synaptic dysfunction in depression: Potential therapeutic targets","volume":"338","author":"Duman","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2020.12.006_bib105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2470547017692328","article-title":"Neurobiological and systemic effects of chronic stress","volume":"1","author":"McEwen","year":"2017","journal-title":"Chronic Stress"},{"key":"10.1016\/j.biopsych.2020.12.006_bib106","article-title":"The role of stress in the pathogenesis and maintenance of obsessive-compulsive disorder","volume":"2","author":"Adams","year":"2018","journal-title":"Chronic Stress (Thousand Oaks)"},{"key":"10.1016\/j.biopsych.2020.12.006_bib107","article-title":"Neurophysiological correlates and differential drug response in subjects with a family history of an alcohol use disorder","volume":"3","author":"Comstock","year":"2019","journal-title":"Chronic Stress (Thousand Oaks)"},{"key":"10.1016\/j.biopsych.2020.12.006_bib108","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00429-008-0189-x","article-title":"Brain structural and functional abnormalities in mood disorders: Implications for neurocircuitry models of depression","volume":"213","author":"Drevets","year":"2008","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.biopsych.2020.12.006_bib109","article-title":"Frontal lobe circuitry in posttraumatic stress disorder","volume":"3","author":"Selemon","year":"2019","journal-title":"Chronic Stress (Thousand Oaks)"},{"key":"10.1016\/j.biopsych.2020.12.006_bib110","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.euroneuro.2012.05.009","article-title":"A\u00a0pilot study of hippocampal volume and N-acetylaspartate (NAA) as response biomarkers in riluzole-treated patients with GAD","volume":"23","author":"Abdallah","year":"2013","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib111","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.euroneuro.2015.04.025","article-title":"Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder","volume":"25","author":"Abdallah","year":"2015","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib112","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.euroneuro.2017.02.010","article-title":"Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD","volume":"27","author":"Wrocklage","year":"2017","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2020.12.006_bib113","doi-asserted-by":"crossref","DOI":"10.1177\/2470547017724714","article-title":"Combat exposure severity is associated with reduced cortical thickness in combat veterans: A preliminary report","volume":"1","author":"Averill","year":"2017","journal-title":"Chronic Stress"},{"key":"10.1016\/j.biopsych.2020.12.006_bib114","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A\u00a0neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib115","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41398-020-00945-9","article-title":"Volumetric changes in subcortical structures following repeated ketamine treatment in patients with major depressive disorder: a longitudinal analysis","volume":"10","author":"Zhou","year":"2020","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib116","first-page":"566","article-title":"Prefrontal connectivity and glutamate transmission: Relevance to depression pathophysiology and ketamine treatment","volume":"2","author":"Abdallah","year":"2017","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"10.1016\/j.biopsych.2020.12.006_bib117","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.biopsych.2014.06.024","article-title":"In\u00a0vivo ketamine-induced changes in [(11)C]ABP688 binding to metabotropic glutamate receptor subtype 5","volume":"77","author":"DeLorenzo","year":"2015","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib118","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/mp.2017.58","article-title":"Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [(11)C]ABP688 and PET imaging study in depression","volume":"23","author":"Esterlis","year":"2018","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2020.12.006_bib119","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/npp.2016.186","article-title":"Ketamine treatment and global brain connectivity in major depression","volume":"42","author":"Abdallah","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib120","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/s41386-020-0624-0","article-title":"Evaluating global brain connectivity as an imaging marker for depression: Influence of preprocessing strategies and placebo-controlled ketamine treatment","volume":"45","author":"Kraus","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib121","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1002\/hbm.23235","article-title":"Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder","volume":"37","author":"Murrough","year":"2016","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.biopsych.2020.12.006_bib122","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/npp.2017.229","article-title":"Multimodal investigation of network level effects using intrinsic functional connectivity, anatomical covariance, and structure-to-function correlations in unmedicated major depressive disorder","volume":"43","author":"Scheinost","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib123","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/hbm.22241","article-title":"Overlapping and segregated resting-state functional connectivity in patients with major depressive disorder with and without childhood neglect","volume":"35","author":"Wang","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.biopsych.2020.12.006_bib124","doi-asserted-by":"crossref","DOI":"10.1177\/2470547018796102","article-title":"Ketamine, but not the NMDAR antagonist lanicemine, increases prefrontal global connectivity in depressed patients","volume":"2","author":"Abdallah","year":"2018","journal-title":"Chronic Stress"},{"key":"10.1016\/j.biopsych.2020.12.006_bib125","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/s41386-020-00864-9","article-title":"A\u00a0robust and reproducible connectome fingerprint of ketamine is highly associated with the connectomic signature of antidepressants","volume":"46","author":"Abdallah","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2020.12.006_bib126","doi-asserted-by":"crossref","first-page":"100800","DOI":"10.1016\/j.isci.2019.100800","article-title":"A\u00a0unique brain connectome fingerprint predates and predicts response to antidepressants","volume":"23","author":"Nemati","year":"2020","journal-title":"iScience"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322320321144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322320321144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:04:30Z","timestamp":1762099470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322320321144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":126,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0006322320321144"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2020.12.006","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurobiology of the Rapid-Acting Antidepressant Effects of Ketamine: Impact and Opportunities","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2020.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc on behalf of Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}