{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T09:12:58Z","timestamp":1794042778357,"version":"4.8.0"},"reference-count":147,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"am","delay-in-days":336,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-17-1-0330"],"award-info":[{"award-number":["W81XWH-17-1-0330"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-18-1-0580"],"award-info":[{"award-number":["W81XWH-18-1-0580"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["P50 AG066509"],"award-info":[{"award-number":["P50 AG066509"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009157","name":"National Institute on Disability Independent Living and Rehabilitation Research","doi-asserted-by":"publisher","award":["90DPTB0009"],"award-info":[{"award-number":["90DPTB0009"]}],"id":[{"id":"10.13039\/100009157","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007512","name":"Nancy and Buster Alvord Endowment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["R01 AG061028"],"award-info":[{"award-number":["R01 AG061028"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["U54 NS115322"],"award-info":[{"award-number":["U54 NS115322"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["L30 NS113158"],"award-info":[{"award-number":["L30 NS113158"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["RF1NS115268"],"award-info":[{"award-number":["RF1NS115268"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["U54 NS115266"],"award-info":[{"award-number":["U54 NS115266"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.biopsych.2021.05.025","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T02:57:34Z","timestamp":1622602654000},"page":"498-507","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":431,"title":["Traumatic Brain Injury and Risk of Neurodegenerative Disorder"],"prefix":"10.1016","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2849-4658","authenticated-orcid":false,"given":"Benjamin L.","family":"Brett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel C.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Godbout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Dams-O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5291-1469","authenticated-orcid":false,"given":"C. Dirk","family":"Keene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2021.05.025_bib1","article-title":"Head injury as a risk factor for dementia and Alzheimer\u2019s disease: A systematic review and meta-analysis of 32 observational studies","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2021.05.025_bib2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s12883-018-1187-0","article-title":"Is traumatic brain injury a risk factor for neurodegeneration? A meta-analysis of population-based studies","volume":"18","author":"Huang","year":"2018","journal-title":"BMC Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib3","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3233\/JAD-200662","article-title":"Does mild traumatic brain injury increase the risk for dementia? A systematic review and meta-analysis","volume":"78","author":"Snowden","year":"2020","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.biopsych.2021.05.025_bib4","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S2215-0366(18)30065-8","article-title":"Long-term risk of dementia among people with traumatic brain injury in Denmark: A population-based observational cohort study","volume":"5","author":"Fann","year":"2018","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.biopsych.2021.05.025_bib5","first-page":"511","article-title":"Association of traumatic brain injury with subsequent neurological and psychiatric disease: A meta-analysis","volume":"124","author":"Perry","year":"2016","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.biopsych.2021.05.025_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002496","article-title":"Traumatic brain injury and the risk of dementia diagnosis: A nationwide cohort study","volume":"15","author":"Nordstr\u00f6m","year":"2018","journal-title":"PLoS Med"},{"key":"10.1016\/j.biopsych.2021.05.025_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002316","article-title":"Risk of hospitalization with neurodegenerative disease after moderate-to-severe traumatic brain injury in the working-age population: A retrospective cohort study using the Finnish national health registries","volume":"14","author":"Raj","year":"2017","journal-title":"PLoS Med"},{"key":"10.1016\/j.biopsych.2021.05.025_bib8","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1001\/jamaneurol.2014.2668","article-title":"Dementia risk after traumatic brain injury vs nonbrain trauma: The role of age and severity","volume":"71","author":"Gardner","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib9","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1136\/jnnp-2012-302633","article-title":"Population based study on patients with traumatic brain injury suggests increased risk of dementia","volume":"83","author":"Wang","year":"2012","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2021.05.025_bib10","doi-asserted-by":"crossref","first-page":"e1768","DOI":"10.1212\/WNL.0000000000010617","article-title":"Sex, race, and risk of dementia diagnosis after traumatic brain injury among older veterans","volume":"95","author":"Kornblith","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.05.025_bib11","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1001\/jamaneurol.2018.0815","article-title":"Association of mild traumatic brain injury with and without loss of consciousness with dementia in US military veterans","volume":"75","author":"Barnes","year":"2018","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1212\/WNL.0000000000000616","article-title":"Traumatic brain injury and risk of dementia in older veterans","volume":"83","author":"Barnes","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.05.025_bib13","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1212\/WNL.55.8.1158","article-title":"Documented head injury in early adulthood and risk of Alzheimer\u2019s disease and other dementias","volume":"55","author":"Plassman","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.05.025_bib14","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1212\/WNL.54.6.1316","article-title":"Head injury and the risk of AD in the MIRAGE study","volume":"54","author":"Guo","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.05.025_bib15","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/oxfordjournals.aje.a115523","article-title":"The association between head trauma and Alzheimer\u2019s disease","volume":"131","author":"Graves","year":"1990","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1136\/jnnp.62.2.119","article-title":"Alzheimer\u2019s disease after remote head injury: An incidence study","volume":"62","author":"Schofield","year":"1997","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2021.05.025_bib17","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1468-1331.2006.01391.x","article-title":"Risk factors for Alzheimer\u2019s disease in Russia: A case-control study","volume":"13","author":"Suhanov","year":"2006","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib18","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jalz.2018.12.015","article-title":"Failure to detect an association between self-reported traumatic brain injury and Alzheimer\u2019s disease neuropathology and dementia","volume":"15","author":"Sugarman","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.biopsych.2021.05.025_bib19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3233\/JAD-160585","article-title":"The effect of traumatic brain injury history with loss of consciousness on rate of cognitive decline among older adults with normal cognition and Alzheimer\u2019s disease dementia","volume":"59","author":"Tripodis","year":"2017","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.biopsych.2021.05.025_bib20","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1001\/jamaneurol.2016.1948","article-title":"Association of traumatic brain injury with late-life neurodegenerative conditions and neuropathologic findings","volume":"73","author":"Crane","year":"2016","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/jnnp-2012-303938","article-title":"Risk for late-life re-injury, dementia and death among individuals with traumatic brain injury: A population-based study","volume":"84","author":"Dams-O\u2019Connor","year":"2013","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2021.05.025_bib22","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3109\/02699052.2011.556104","article-title":"Incremental contribution of reported previous head injury to the prediction of diagnosis and cognitive functioning in older adults","volume":"25","author":"Helmes","year":"2011","journal-title":"Brain Inj"},{"key":"10.1016\/j.biopsych.2021.05.025_bib23","doi-asserted-by":"crossref","first-page":"e1771","DOI":"10.1212\/WNL.0000000000005522","article-title":"Mild TBI and risk of Parkinson disease: A Chronic Effects of Neurotrauma Consortium Study","volume":"90","author":"Gardner","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.05.025_bib24","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/mds.25458","article-title":"Head injury and risk of Parkinson disease: A systematic review and meta-analysis","volume":"28","author":"Jafari","year":"2013","journal-title":"Mov Disord"},{"key":"10.1016\/j.biopsych.2021.05.025_bib25","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s10654-017-0327-y","article-title":"Meta-analytic evaluation of the association between head injury and risk of amyotrophic lateral sclerosis","volume":"32","author":"Watanabe","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib26","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jalz.2011.03.011","article-title":"Medical and environmental risk factors associated with frontotemporal dementia: A case-control study in a veteran population","volume":"8","author":"Kalkonde","year":"2012","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.biopsych.2021.05.025_bib27","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1136\/jnnp.74.11.1574","article-title":"Medical and environmental risk factors for sporadic frontotemporal dementia: A retrospective case-control study","volume":"74","author":"Rosso","year":"2003","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2021.05.025_bib28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000369787","article-title":"Interactions between traumatic brain injury and frontotemporal degeneration","volume":"39","author":"Deutsch","year":"2015","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.biopsych.2021.05.025_bib29","article-title":"Increased risk of dementia in patients with mild traumatic brain injury: A nationwide cohort study","volume":"8","author":"Lee","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2021.05.025_bib30","article-title":"Associations between concussion and risk of diagnosis of psychological and neurological disorders: A retrospective population-based cohort study","volume":"8","author":"Morissette","year":"2020","journal-title":"Fam Med Community Health"},{"issue":"3 Suppl","key":"10.1016\/j.biopsych.2021.05.025_bib31","doi-asserted-by":"crossref","first-page":"S245","DOI":"10.1016\/j.apmr.2013.06.036","article-title":"Systematic review of the risk of dementia and chronic cognitive impairment after mild traumatic brain injury: Results of the International Collaboration on Mild Traumatic Brain Injury Prognosis","volume":"95","author":"Godbolt","year":"2014","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.biopsych.2021.05.025_bib32","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1212\/WNL.53.9.1959","article-title":"Head trauma and risk of dementia and Alzheimer\u2019s disease: The Rotterdam Study","volume":"53","author":"Mehta","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.05.025_bib33","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/ana.24396","article-title":"Traumatic brain injury in later life increases risk for Parkinson disease","volume":"77","author":"Gardner","year":"2015","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/ana.20882","article-title":"Head injury and Parkinson\u2019s disease risk in twins","volume":"60","author":"Goldman","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib35","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1227\/01.NEU.0000175725.75780.DD","article-title":"Association between recurrent concussion and late-life cognitive impairment in retired professional football players","volume":"57","author":"Guskiewicz","year":"2005","journal-title":"Neurosurgery"},{"key":"10.1016\/j.biopsych.2021.05.025_bib36","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/brain\/awx350","article-title":"Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model","volume":"141","author":"Tagge","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.05.025_bib37","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.nec.2016.05.009","article-title":"Repetitive head impacts and chronic traumatic encephalopathy","volume":"27","author":"McKee","year":"2016","journal-title":"Neurosurg Clin N Am"},{"key":"10.1016\/j.biopsych.2021.05.025_bib38","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.dadm.2017.10.003","article-title":"White matter signal abnormalities in former National Football League players","volume":"10","author":"Alosco","year":"2018","journal-title":"Alzheimers Dement (Amst)"},{"key":"10.1016\/j.biopsych.2021.05.025_bib39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11916-015-0522-z","article-title":"Concussion in chronic traumatic encephalopathy","volume":"19","author":"Stein","year":"2015","journal-title":"Curr Pain Headache Rep"},{"key":"10.1016\/j.biopsych.2021.05.025_bib40","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1212\/WNL.0b013e31826daf50","article-title":"Neurodegenerative causes of death among retired National Football League players","volume":"79","author":"Lehman","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.05.025_bib41","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.4223","article-title":"Mortality among professional American-style football players and professional American baseball players","volume":"2","author":"Nguyen","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.biopsych.2021.05.025_bib42","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mayocp.2016.09.004","article-title":"High school football and late-life risk of neurodegenerative syndromes, 1956-1970","volume":"92","author":"Janssen","year":"2017","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.biopsych.2021.05.025_bib43","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1001\/jamaneurol.2017.1317","article-title":"Association of playing high school football with cognition and mental health later in life","volume":"74","author":"Deshpande","year":"2017","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib44","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1159\/000355478","article-title":"Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort","volume":"37","author":"Abner","year":"2014","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.biopsych.2021.05.025_bib45","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1750-3639.2011.00513.x","article-title":"Widespread tau and amyloid-beta pathology many years after a single traumatic brain injury in humans","volume":"22","author":"Johnson","year":"2012","journal-title":"Brain Pathol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib46","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.trci.2017.02.005","article-title":"Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer\u2019s disease in Vietnam Veterans using the Alzheimer\u2019s Disease Neuroimaging Initiative: Preliminary report","volume":"3","author":"Weiner","year":"2017","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.1016\/j.biopsych.2021.05.025_bib47","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1007\/s11682-020-00440-1","article-title":"Association of remote mild traumatic brain injury with cortical amyloid burden in clinically normal older adults","volume":"15","author":"Asken","year":"2021","journal-title":"Brain Imaging Behav"},{"key":"10.1016\/j.biopsych.2021.05.025_bib48","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s00259-018-4241-7","article-title":"Tauopathy in veterans with long-term posttraumatic stress disorder and traumatic brain injury","volume":"46","author":"Mohamed","year":"2019","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.biopsych.2021.05.025_bib49","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1056\/NEJMoa1900757","article-title":"Tau positron-emission tomography in former national football league players","volume":"380","author":"Stern","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.biopsych.2021.05.025_bib50","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1093\/brain\/awz238","article-title":"PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury","volume":"142","author":"Takahata","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.05.025_bib51","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1212\/WNL.0b013e318297eecf","article-title":"Traumatic brain injury may be an independent risk factor for stroke","volume":"81","author":"Burke","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.05.025_bib52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/brain\/aws307","article-title":"The spectrum of disease in chronic traumatic encephalopathy","volume":"136","author":"McKee","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.05.025_bib53","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/jama.2017.8334","article-title":"Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football","volume":"318","author":"Mez","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.biopsych.2021.05.025_bib54","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00401-017-1680-3","article-title":"Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) players","volume":"133","author":"Ling","year":"2017","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib55","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-019-02030-y","article-title":"Chronic traumatic encephalopathy is a common co-morbidity, but less frequent primary dementia in former soccer and rugby players","volume":"138","author":"Lee","year":"2019","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib56","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/jnen\/nly092","article-title":"Chronic traumatic encephalopathy within an amyotrophic lateral sclerosis brain bank cohort","volume":"77","author":"Walt","year":"2018","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib57","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/jnen\/nlx101","article-title":"Dementia after moderate-severe traumatic brain injury: Coexistence of multiple proteinopathies","volume":"77","author":"Kenney","year":"2018","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib58","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00401-011-0909-9","article-title":"Acute and chronically increased immunoreactivity to phosphorylation-independent but not pathological TDP-43 after a single traumatic brain injury in humans","volume":"122","author":"Johnson","year":"2011","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib59","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/jnen\/nlz122","article-title":"Early-onset dementia in war veterans: Brain polypathology and clinicopathologic complexity","volume":"79","author":"Iacono","year":"2020","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib60","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00401-015-1502-4","article-title":"Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank","volume":"130","author":"Bieniek","year":"2015","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib61","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1093\/brain\/awy146","article-title":"Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated","volume":"141","author":"Robinson","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.05.025_bib62","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/jnnp.57.4.419","article-title":"Beta amyloid protein deposition in the brain after severe head injury: Implications for the pathogenesis of Alzheimer\u2019s disease","volume":"57","author":"Roberts","year":"1994","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2021.05.025_bib63","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12974-020-01800-w","article-title":"Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice","volume":"17","author":"Early","year":"2020","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.biopsych.2021.05.025_bib64","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.expneurol.2007.06.018","article-title":"Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans","volume":"208","author":"Uryu","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib65","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.expneurol.2004.06.011","article-title":"Alzheimer\u2019s pathology in human temporal cortex surgically excised after severe brain injury","volume":"190","author":"Ikonomovic","year":"2004","journal-title":"Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib66","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1089\/neu.2000.17.123","article-title":"Altered expression of amyloid precursors proteins after traumatic brain injury in rats: In situ hybridization and immunohistochemical study","volume":"17","author":"Masumura","year":"2000","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.biopsych.2021.05.025_bib67","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1093\/jnen\/61.12.1056","article-title":"Long-term accumulation of amyloid-beta in axons following brain trauma without persistent upregulation of amyloid precursor protein genes","volume":"61","author":"Iwata","year":"2002","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib68","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1089\/089771502753754073","article-title":"Caspase-3-mediated cleavage of amyloid precursor protein and formation of amyloid beta peptide in traumatic axonal injury","volume":"19","author":"Stone","year":"2002","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.biopsych.2021.05.025_bib69","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/0140-6736(91)92724-G","article-title":"Beta A4 amyloid protein deposition in brain after head trauma","volume":"338","author":"Roberts","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.biopsych.2021.05.025_bib70","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1089\/neu.2017.5491","article-title":"Transactive response DNA-binding Protein 43 abnormalities after traumatic brain injury","volume":"36","author":"Tan","year":"2018","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.biopsych.2021.05.025_bib71","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.expneurol.2012.01.013","article-title":"Axonal pathology in traumatic brain injury","volume":"246","author":"Johnson","year":"2013","journal-title":"Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib72","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/00001199-200501000-00008","article-title":"Update of neuropathology and neurological recovery after traumatic brain injury","volume":"20","author":"Povlishock","year":"2005","journal-title":"J\u00a0Head Trauma Rehabil"},{"key":"10.1016\/j.biopsych.2021.05.025_bib73","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/brain\/awaa372","article-title":"Detecting axonal injury in individual patients after traumatic brain injury","volume":"144","author":"Jolly","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.05.025_bib74","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-2559.1989.tb03040.x","article-title":"Diffuse axonal injury in head injury: Definition, diagnosis and grading","volume":"15","author":"Adams","year":"1989","journal-title":"Histopathology"},{"key":"10.1016\/j.biopsych.2021.05.025_bib75","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.expneurol.2011.10.030","article-title":"Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury","volume":"233","author":"Tang-Schomer","year":"2012","journal-title":"Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib76","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1089\/neu.2000.17.927","article-title":"Apoptosis after traumatic brain injury","volume":"17","author":"Raghupathi","year":"2000","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.biopsych.2021.05.025_bib77","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1096\/fj.09-142844","article-title":"Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration","volume":"24","author":"Tang-Schomer","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.biopsych.2021.05.025_bib78","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1093\/brain\/awaa316","article-title":"Diffuse axonal injury predicts neurodegeneration after moderate-severe traumatic brain injury","volume":"143","author":"Graham","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.05.025_bib79","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz6892","article-title":"The evolution of white matter microstructural changes after mild traumatic brain injury: A longitudinal DTI and NODDI study","volume":"6","author":"Palacios","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.biopsych.2021.05.025_bib80","doi-asserted-by":"crossref","first-page":"e781","DOI":"10.1212\/WNL.0000000000009930","article-title":"Longitudinal white-matter abnormalities in sports-related concussion: A diffusion MRI study","volume":"95","author":"Wu","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.05.025_bib81","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1002\/hbm.24500","article-title":"White matter during concussion recovery: Comparing diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI)","volume":"40","author":"Churchill","year":"2019","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.biopsych.2021.05.025_bib82","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1093\/brain\/awu236","article-title":"Diffuse white matter tract abnormalities in clinically normal ageing retired athletes with a history of sports-related concussions","volume":"137","author":"Tremblay","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.05.025_bib83","doi-asserted-by":"crossref","first-page":"fcz031","DOI":"10.1093\/braincomms\/fcz031","article-title":"Longitudinal neuroimaging following combat concussion: Sub-acute, 1 year and 5 years post-injury","volume":"1","author":"Mac Donald","year":"2019","journal-title":"Brain Commun"},{"key":"10.1016\/j.biopsych.2021.05.025_bib84","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10571-016-0400-1","article-title":"Pathophysiology associated with traumatic brain injury: Current treatments and potential novel therapeutics","volume":"37","author":"Pearn","year":"2017","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib85","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2979\/VIC.2008.51.1.7","article-title":"Gerard Manley Hopkins and the kinesthetics of conviction","volume":"51","author":"Chambers","year":"2008","journal-title":"Vic Stud"},{"key":"10.1016\/j.biopsych.2021.05.025_bib86","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0002-9440(10)63303-2","article-title":"Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma","volume":"165","author":"Chen","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib87","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1126\/science.1105681","article-title":"Axonopathy and transport deficits early in the pathogenesis of Alzheimer\u2019s disease","volume":"307","author":"Stokin","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2021.05.025_bib88","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/414643a","article-title":"Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP","volume":"414","author":"Kamal","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2021.05.025_bib89","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1385\/NMM:2:2:151","article-title":"Axonal transport, tau protein, and neurodegeneration in Alzheimer\u2019s disease","volume":"2","author":"Terwel","year":"2002","journal-title":"Neuromolecular Med"},{"key":"10.1016\/j.biopsych.2021.05.025_bib90","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1046\/j.1365-2990.2003.00488.x","article-title":"Tau immunohistochemistry in acute brain injury","volume":"29","author":"Smith","year":"2003","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib91","doi-asserted-by":"crossref","first-page":"9513","DOI":"10.1523\/JNEUROSCI.0858-11.2011","article-title":"Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-beta accumulation and independently accelerates the development of tau abnormalities","volume":"31","author":"Tran","year":"2011","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2021.05.025_bib92","first-page":"2685","article-title":"Induction of a transmissible tau pathology by traumatic brain injury","volume":"141","author":"Zanier","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.05.025_bib93","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/s41467-017-01068-4","article-title":"Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae","volume":"8","author":"Albayram","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2021.05.025_bib94","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13024-020-00391-7","article-title":"Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer\u2019s disease","volume":"15","author":"Guo","year":"2020","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.biopsych.2021.05.025_bib95","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/NEN.0b013e3182456aed","article-title":"Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic mice","volume":"71","author":"Tran","year":"2012","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib96","doi-asserted-by":"crossref","first-page":"101730","DOI":"10.1016\/j.pneurobio.2019.101730","article-title":"Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer\u2019s disease pathology","volume":"185","author":"Wu","year":"2020","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib97","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-016-0143-y","article-title":"The release and trans-synaptic transmission of Tau via exosomes","volume":"12","author":"Wang","year":"2017","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.biopsych.2021.05.025_bib98","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/embor.2013.15","article-title":"Physiological release of endogenous tau is stimulated by neuronal activity","volume":"14","author":"Pooler","year":"2013","journal-title":"EMBO Rep"},{"key":"10.1016\/j.biopsych.2021.05.025_bib99","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/nn.4328","article-title":"Neuronal activity enhances tau propagation and tau pathology in\u00a0vivo","volume":"19","author":"Wu","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2021.05.025_bib100","doi-asserted-by":"crossref","first-page":"16180","DOI":"10.1523\/JNEUROSCI.3020-14.2014","article-title":"Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury","volume":"34","author":"Iliff","year":"2014","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2021.05.025_bib101","doi-asserted-by":"crossref","first-page":"13110","DOI":"10.1523\/JNEUROSCI.2569-11.2011","article-title":"In\u00a0vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice","volume":"31","author":"Yamada","year":"2011","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2021.05.025_bib102","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1001\/jamaneurol.2014.3558","article-title":"Inflammation and neuroprotection in traumatic brain injury","volume":"72","author":"Corps","year":"2015","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib103","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/NEN.0000000000000021","article-title":"Progressive neurodegeneration after experimental brain trauma: Association with chronic microglial activation","volume":"73","author":"Loane","year":"2014","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib104","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1089\/neu.2007.0377","article-title":"Prolonged microgliosis in the rhesus monkey central nervous system after traumatic brain injury","volume":"24","author":"Nagamoto-Combs","year":"2007","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.biopsych.2021.05.025_bib105","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12974-015-0445-y","article-title":"Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage","volume":"12","author":"Scott","year":"2015","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.biopsych.2021.05.025_bib106","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ana.22455","article-title":"Inflammation after trauma: Microglial activation and traumatic brain injury","volume":"70","author":"Ramlackhansingh","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib107","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1523\/JNEUROSCI.2469-20.2020","article-title":"Traumatic brain injury causes chronic cortical inflammation and neuronal dysfunction mediated by microglia","volume":"41","author":"Witcher","year":"2021","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2021.05.025_bib108","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1523\/JNEUROSCI.2516-19.2020","article-title":"Interferon-beta plays a detrimental role in experimental traumatic brain injury by enhancing neuroinflammation that drives chronic neurodegeneration","volume":"40","author":"Barrett","year":"2020","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2021.05.025_bib109","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2021.05.025_bib110","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1001\/jamaneurol.2016.3764","article-title":"Imaging of glial cell activation and white matter integrity in brains of active and recently retired national football league players","volume":"74","author":"Coughlin","year":"2017","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib111","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.expneurol.2015.08.018","article-title":"Microglia in the TBI brain: The good, the bad, and the dysregulated","volume":"275","author":"Loane","year":"2016","journal-title":"Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib112","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1093\/brain\/awl165","article-title":"Essential protective roles of reactive astrocytes in traumatic brain injury","volume":"129","author":"Myer","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.05.025_bib113","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.expneurol.2015.03.020","article-title":"Astrocyte roles in traumatic brain injury","volume":"275","author":"Burda","year":"2016","journal-title":"Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib114","doi-asserted-by":"crossref","first-page":"7153","DOI":"10.1523\/JNEUROSCI.21-18-07153.2001","article-title":"Astrocytes give rise to new neurons in the adult mammalian hippocampus","volume":"21","author":"Seri","year":"2001","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2021.05.025_bib115","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/s41593-018-0242-x","article-title":"Microglia in neurodegeneration","volume":"21","author":"Hickman","year":"2018","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2021.05.025_bib116","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1523\/JNEUROSCI.0820-04.2004","article-title":"Absence of glial fibrillary acidic protein and vimentin prevents hypertrophy of astrocytic processes and improves post-traumatic regeneration","volume":"24","author":"Wilhelmsson","year":"2004","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2021.05.025_bib117","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.expneurol.2012.06.009","article-title":"Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways","volume":"237","author":"Wang","year":"2012","journal-title":"Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib118","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1089\/neu.2016.4870","article-title":"Repetitive closed-head impact model of engineered rotational acceleration induces long-term cognitive impairments with persistent astrogliosis and microgliosis in mice","volume":"34","author":"Chen","year":"2017","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.biopsych.2021.05.025_bib119","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/brain\/aws322","article-title":"Inflammation and white matter degeneration persist for years after a single traumatic brain injury","volume":"136","author":"Johnson","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.05.025_bib120","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1002\/glia.23523","article-title":"Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation","volume":"66","author":"Witcher","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.biopsych.2021.05.025_bib121","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.biopsych.2013.10.014","article-title":"Immune activation promotes depression 1 month after diffuse brain injury: A role for primed microglia","volume":"76","author":"Fenn","year":"2014","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.05.025_bib122","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1089\/neu.1997.14.715","article-title":"Progressive atrophy and neuron death for one year following brain trauma in the rat","volume":"14","author":"Smith","year":"1997","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.biopsych.2021.05.025_bib123","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/1742-2094-9-247","article-title":"Rod microglia: Elongation, alignment, and coupling to form trains across the somatosensory cortex after experimental diffuse brain injury","volume":"9","author":"Ziebell","year":"2012","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.biopsych.2021.05.025_bib124","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1523\/JNEUROSCI.2402-19.2020","article-title":"Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits","volume":"40","author":"Henry","year":"2020","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2021.05.025_bib125","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.nbd.2007.11.012","article-title":"Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration","volume":"30","author":"Palin","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.biopsych.2021.05.025_bib126","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tins.2015.08.002","article-title":"Priming the inflammatory pump of the CNS after traumatic brain injury","volume":"38","author":"Witcher","year":"2015","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.biopsych.2021.05.025_bib127","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.bbi.2008.09.002","article-title":"Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines","volume":"23","author":"Henry","year":"2009","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.biopsych.2021.05.025_bib128","doi-asserted-by":"crossref","first-page":"664","DOI":"10.14336\/AD.2018.0720","article-title":"Reactive astrocytes in neurodegenerative diseases","volume":"10","author":"Li","year":"2019","journal-title":"Aging Dis"},{"key":"10.1016\/j.biopsych.2021.05.025_bib129","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.neuroscience.2008.06.025","article-title":"Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia","volume":"158","author":"Candelario-Jalil","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2021.05.025_bib130","first-page":"92","article-title":"The role of hypoxia-inducible factor-1alpha, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury","volume":"114","author":"Higashida","year":"2011","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.biopsych.2021.05.025_bib131","doi-asserted-by":"crossref","first-page":"113257","DOI":"10.1016\/j.expneurol.2020.113257","article-title":"Brain injury-induced dysfunction of the blood brain barrier as a risk for dementia","volume":"328","author":"Abrahamson","year":"2020","journal-title":"Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib132","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1038\/s41467-020-18113-4","article-title":"Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis","volume":"11","author":"Bolte","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2021.05.025_bib133","doi-asserted-by":"crossref","first-page":"100857","DOI":"10.1016\/j.yfrne.2020.100857","article-title":"Blood-brain barrier integrity in the pathogenesis of Alzheimer\u2019s disease","volume":"59","author":"Huang","year":"2020","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib134","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainresbull.2011.10.004","article-title":"Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases","volume":"87","author":"Smith","year":"2012","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.biopsych.2021.05.025_bib135","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1089\/neu.2008.0683","article-title":"Cerebral atrophy after traumatic white matter injury: Correlation with acute neuroimaging and outcome","volume":"25","author":"Ding","year":"2008","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.biopsych.2021.05.025_bib136","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1089\/neu.2009.1215","article-title":"Resting cerebral blood flow alterations in chronic traumatic brain injury: An arterial spin labeling perfusion FMRI study","volume":"27","author":"Kim","year":"2010","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.biopsych.2021.05.025_bib137","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1089\/neu.2013.3318","article-title":"Chronology and chronicity of altered resting-state functional connectivity after traumatic brain injury","volume":"32","author":"Venkatesan","year":"2015","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.biopsych.2021.05.025_bib138","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1093\/brain\/awab057","article-title":"Neuroinflammation is highest in areas of disease progression in semantic dementia","volume":"144","author":"Pascual","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.05.025_bib139","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1093\/brain\/awx228","article-title":"Neuroinflammation and its relationship to changes in brain volume and white matter lesions in multiple sclerosis","volume":"140","author":"Datta","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.05.025_bib140","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/brain\/awaa399","article-title":"Time course of phosphorylated-tau181 in\u00a0blood across the Alzheimer\u2019s disease spectrum","volume":"144","author":"Moscoso","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.05.025_bib141","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nature25456","article-title":"High performance plasma amyloid-beta biomarkers for Alzheimer\u2019s disease","volume":"554","author":"Nakamura","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2021.05.025_bib142","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1001\/jamaneurol.2020.4986","article-title":"Longitudinal associations of\u00a0blood phosphorylated Tau181 and neurofilament light chain with\u00a0neurodegeneration in Alzheimer disease","volume":"78","author":"Moscoso","year":"2021","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.biopsych.2021.05.025_bib143","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1212\/01.WNL.0000158281.08946.68","article-title":"Serum inflammatory proteins and cognitive decline in older persons","volume":"64","author":"Dik","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.05.025_bib144","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1134\/S0006297918090079","article-title":"Anti-amyloid therapy of Alzheimer\u2019s disease: Current state and prospects","volume":"83","author":"Kozin","year":"2018","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.biopsych.2021.05.025_bib145","doi-asserted-by":"crossref","first-page":"157","DOI":"10.14283\/jpad.2019.14","article-title":"Anti-tau trials for Alzheimer\u2019s disease: A report from the EU\/US\/CTAD task force","volume":"6","author":"Cummings","year":"2019","journal-title":"J\u00a0Prev Alzheimers Dis"},{"key":"10.1016\/j.biopsych.2021.05.025_bib146","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3233\/JAD-180766","article-title":"Treatment combinations for Alzheimer\u2019s disease: Current and future pharmacotherapy options","volume":"67","author":"Cummings","year":"2019","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.biopsych.2021.05.025_bib147","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1089\/neu.2017.5457","article-title":"Multimodal characterization of the late effects of\u00a0traumatic brain injury: A methodological overview of the late\u00a0effects of traumatic brain injury project","volume":"35","author":"Edlow","year":"2018","journal-title":"J\u00a0Neurotrauma"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322321013597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322321013597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:39:24Z","timestamp":1790278764000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322321013597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":147,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0006322321013597"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2021.05.025","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Traumatic Brain Injury and Risk of Neurodegenerative Disorder","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2021.05.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}