{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:54:08Z","timestamp":1792889648474,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002946","name":"Deutsches Zentrum f\u00fcr Luft und Raumfahrt","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002946","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH106435"],"award-info":[{"award-number":["MH106435"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011110","name":"UCB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1451"],"award-info":[{"award-number":["SFB 1451"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["424778381"],"award-info":[{"award-number":["424778381"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["410169619"],"award-info":[{"award-number":["410169619"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["424778381 \\u2013 TRR 295"],"award-info":[{"award-number":["424778381 \\u2013 TRR 295"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["431549029 \\u2013SFB 1451"],"award-info":[{"award-number":["431549029 \\u2013SFB 1451"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013278","name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.biopsych.2021.07.010","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T17:23:21Z","timestamp":1626715401000},"page":"678-688","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":116,"title":["Connectomic Deep Brain Stimulation for Obsessive-Compulsive Disorder"],"prefix":"10.1016","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5851-9268","authenticated-orcid":false,"given":"Juan Carlos","family":"Baldermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Sch\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2316-7706","authenticated-orcid":false,"given":"Sina","family":"Kohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Voon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3315-3591","authenticated-orcid":false,"given":"Ningfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0104-6927","authenticated-orcid":false,"given":"Barbara","family":"Hollunder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"Figee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-1941","authenticated-orcid":false,"given":"Suzanne N.","family":"Haber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-8965","authenticated-orcid":false,"given":"Sameer A.","family":"Sheth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-3419","authenticated-orcid":false,"given":"Philip E.","family":"Mosley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9124-4128","authenticated-orcid":false,"given":"Daniel","family":"Huys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6556-8957","authenticated-orcid":false,"given":"Kara A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Butson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Ackermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Bouwens van der Vlis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert F.G.","family":"Leentjens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Barbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerle","family":"Visser-Vandewalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4719-5293","authenticated-orcid":false,"given":"Jens","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2021.07.010_bib1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41398-021-01307-9","article-title":"A\u00a0randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder","volume":"11","author":"Mosley","year":"2021","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib2","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archgenpsychiatry.2010.122","article-title":"Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder","volume":"67","author":"Denys","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib3","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa0708514","article-title":"Subthalamic nucleus stimulation in severe obsessive-compulsive disorder","volume":"359","author":"Mallet","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.biopsych.2021.07.010_bib4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41380-020-00933-x","article-title":"Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): Emerging or established therapy?","volume":"26","author":"Wu","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133591","article-title":"Deep brain stimulation for obsessive-compulsive disorder: A meta-analysis of treatment outcome and predictors of response","volume":"10","author":"Alonso","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2021.07.010_bib6","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s12888-014-0214-y","article-title":"Deep brain stimulation for treatment-refractory obsessive compulsive disorder: A systematic review","volume":"14","author":"Kohl","year":"2014","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib7","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nn.3344","article-title":"Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder","volume":"16","author":"Figee","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2021.07.010_bib8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.brs.2019.09.008","article-title":"Prefrontal delta oscillations during deep brain stimulation predict treatment success in patients with obsessive-compulsive disorder","volume":"13","author":"Smith","year":"2020","journal-title":"Brain Stimul"},{"key":"10.1016\/j.biopsych.2021.07.010_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-020-01007-8","article-title":"Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder [published online ahead of print Jan 7]","author":"Shephard","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib10","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/brain\/awaa100","article-title":"Deep brain stimulation modulates directional limbic connectivity in obsessive-compulsive disorder","volume":"143","author":"Fridgeirsson","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.07.010_bib11","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.brs.2018.12.226","article-title":"Personalized striatal targets for deep brain stimulation in obsessive-compulsive disorder","volume":"12","author":"Barcia","year":"2019","journal-title":"Brain Stimul"},{"key":"10.1016\/j.biopsych.2021.07.010_bib12","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.biopsych.2021.04.006","article-title":"A\u00a0unified functional network target for deep brain stimulation in obsessive-compulsive disorder","volume":"90","author":"Li","year":"2021","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib13","series-title":"Deep Brain Stimul","first-page":"93","article-title":"Deep brain stimulation for obsessive compulsive disorder","author":"Banks","year":"2019"},{"key":"10.1016\/j.biopsych.2021.07.010_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01402207","article-title":"Treatment of chronic obsessive compulsive states with stereotactic anterior capsulotomy or cingulotomy","volume":"62","author":"Fodstad","year":"1982","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.biopsych.2021.07.010_bib15","first-page":"77","article-title":"Dorsal anterior cingulotomy and anterior capsulotomy for severe, refractory obsessive-compulsive disorder: A systematic review of observational studies","volume":"124","author":"Brown","year":"2016","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.biopsych.2021.07.010_bib16","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/S0140-6736(99)02376-4","article-title":"Electrical stimulation in anterior limbs of internal capsules in patients with obsessive-compulsive disorder","volume":"354","author":"Nuttin","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.biopsych.2021.07.010_bib17","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1038\/sj.npp.1301165","article-title":"Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder","volume":"31","author":"Greenberg","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2021.07.010_bib18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jchemneu.2003.09.003","article-title":"The nucleus accumbens: A target for deep brain stimulation in obsessive-compulsive- and anxiety-disorders","volume":"26","author":"Sturm","year":"2003","journal-title":"J\u00a0Chem Neuroanat"},{"key":"10.1016\/j.biopsych.2021.07.010_bib19","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.wneu.2014.12.024","article-title":"Deep brain stimulation of the nucleus accumbens and bed nucleus of stria terminalis for obsessive-compulsive disorder: A case series","volume":"83","author":"Islam","year":"2015","journal-title":"World Neurosurg"},{"key":"10.1016\/j.biopsych.2021.07.010_bib20","doi-asserted-by":"crossref","first-page":"102165","DOI":"10.1016\/j.nicl.2020.102165","article-title":"Tractographic description of major subcortical projection pathways passing the anterior limb of the internal capsule. Corticopetal organization of networks relevant for psychiatric disorders","volume":"25","author":"Coenen","year":"2020","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.biopsych.2021.07.010_bib21","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.biopsych.2020.06.031","article-title":"Four deep brain stimulation targets for obsessive-compulsive disorder: Are they different?","volume":"90","author":"Haber","year":"2021","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib22","doi-asserted-by":"crossref","first-page":"S30.e17","DOI":"10.1016\/j.wneu.2012.07.010","article-title":"Electrical stimulation of the inferior thalamic peduncle in the treatment of major depression and obsessive compulsive disorders","volume":"80","author":"Jim\u00e9nez","year":"2013","journal-title":"World Neurosurg"},{"key":"10.1016\/j.biopsych.2021.07.010_bib23","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1017\/S1092852916000286","article-title":"The medial forebrain bundle as a target for deep brain stimulation for obsessive-compulsive disorder","volume":"22","author":"Coenen","year":"2017","journal-title":"CNS Spectr"},{"key":"10.1016\/j.biopsych.2021.07.010_bib24","doi-asserted-by":"crossref","first-page":"117180","DOI":"10.1016\/j.neuroimage.2020.117180","article-title":"Opportunities of connectomic neuromodulation","volume":"221","author":"Horn","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2021.07.010_bib25","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3389\/fnins.2015.00519","article-title":"Tractography activation patterns in dorsolateral prefrontal cortex suggest better clinical responses in OCD DBS","volume":"9","author":"Hartmann","year":"2016","journal-title":"Front Neurosci"},{"key":"10.1016\/j.biopsych.2021.07.010_bib26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.brs.2018.11.014","article-title":"Individual white matter bundle trajectories are associated with deep brain stimulation response in obsessive-compulsive disorder","volume":"12","author":"Liebrand","year":"2019","journal-title":"Brain Stimul"},{"key":"10.1016\/j.biopsych.2021.07.010_bib27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1176\/appi.neuropsych.11080180","article-title":"Human medial forebrain bundle (MFB) and anterior thalamic radiation (ATR): Imaging of two major subcortical pathways and the dynamic balance of opposite affects in understanding depression","volume":"24","author":"Coenen","year":"2012","journal-title":"J\u00a0Neuropsychiatry Clin Neurosci"},{"key":"10.1016\/j.biopsych.2021.07.010_bib28","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.biopsych.2018.12.019","article-title":"Connectivity profile predictive of effective deep brain stimulation in obsessive-compulsive disorder","volume":"85","author":"Baldermann","year":"2019","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib29","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1038\/s41467-020-16734-3","article-title":"A\u00a0unified connectomic target for deep brain stimulation in obsessive-compulsive disorder","volume":"11","author":"Li","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2021.07.010_bib30","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.biopsych.2019.01.017","article-title":"A\u00a0randomized trial directly comparing ventral capsule and anteromedial subthalamic nucleus stimulation in obsessive-compulsive disorder: Clinical and imaging evidence for dissociable effects","volume":"85","author":"Tyagi","year":"2019","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib31","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.neuron.2019.09.030","article-title":"Holographic reconstruction of axonal pathways in the human brain","volume":"104","author":"Petersen","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2021.07.010_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brs.2020.10.016","article-title":"Replicable effects of deep brain stimulation for obsessive-compulsive disorder","volume":"14","author":"Smith","year":"2021","journal-title":"Brain Stimul"},{"key":"10.1016\/j.biopsych.2021.07.010_bib33","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/ner.13339","article-title":"Ventral capsule\/ventral striatum stimulation in obsessive-compulsive disorder: Toward a unified connectomic target for deep brain stimulation?","volume":"24","author":"van der Vlis","year":"2021","journal-title":"Neuromodulation"},{"key":"10.1016\/j.biopsych.2021.07.010_bib34","first-page":"961","article-title":"Basal ganglia pathways associated with therapeutic pallidal deep brain stimulation for Tourette syndrome","volume":"6","author":"Johnson","year":"2021","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"10.1016\/j.biopsych.2021.07.010_bib35","first-page":"1087","article-title":"Acute deep brain stimulation changes in regional cerebral blood flow in obsessive-compulsive disorder","volume":"125","author":"Dougherty","year":"2016","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.biopsych.2021.07.010_bib36","doi-asserted-by":"crossref","first-page":"951","DOI":"10.2967\/jnumed.113.126409","article-title":"Differences in metabolic network modulation between capsulotomy and deep-brain stimulation for refractory obsessive-compulsive disorder","volume":"55","author":"Suetens","year":"2014","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.biopsych.2021.07.010_bib37","doi-asserted-by":"crossref","first-page":"117138","DOI":"10.1016\/j.neuroimage.2020.117138","article-title":"A\u00a0brief demonstration of frontostriatal connectivity in OCD patients with intracranial electrodes","volume":"220","author":"Smith","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2021.07.010_bib38","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/s41467-019-09557-4","article-title":"Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function","volume":"10","author":"Widge","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2021.07.010_bib39","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature11239","article-title":"Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation","volume":"488","author":"Sheth","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2021.07.010_bib40","first-page":"132","article-title":"Role of the dorsal anterior cingulate cortex in obsessive-compulsive disorder: Converging evidence from cognitive neuroscience and psychiatric neurosurgery","volume":"126","author":"McGovern","year":"2017","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.biopsych.2021.07.010_bib41","first-page":"491","article-title":"Limbic system surgery for treatment-refractory obsessive-compulsive disorder: A prospective long-term follow-up of 64 patients","volume":"118","author":"Sheth","year":"2013","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.biopsych.2021.07.010_bib42","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/ana.25906","article-title":"Subthalamic nucleus deep brain stimulation modulates 2 distinct neurocircuits","volume":"88","author":"Shen","year":"2020","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopsych.2021.07.010_bib43","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1227\/01.NEU.0000345631.54446.06","article-title":"Medial forebrain bundle stimulation as a pathophysiological mechanism for hypomania in subthalamic nucleus deep brain stimulation for Parkinson\u2019s disease","volume":"64","author":"Coenen","year":"2009","journal-title":"Neurosurgery"},{"key":"10.1016\/j.biopsych.2021.07.010_bib44","series-title":"The Human Central Nervous System: A Synopsis and Atlas","author":"Nieuwenhuys","year":"2008"},{"key":"10.1016\/j.biopsych.2021.07.010_bib45","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1002\/cne.24080","article-title":"Comprehensive cellular-resolution atlas of the adult human brain","volume":"524","author":"Ding","year":"2016","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.biopsych.2021.07.010_bib46","series-title":"The Human Nervous System","author":"Mai","year":"2012"},{"key":"10.1016\/j.biopsych.2021.07.010_bib47","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.brs.2019.07.014","article-title":"Surgical decision making for deep brain stimulation should not be based on aggregated normative data mining","volume":"12","author":"Coenen","year":"2019","journal-title":"Brain Stimul"},{"key":"10.1016\/j.biopsych.2021.07.010_bib48","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1523\/JNEUROSCI.2335-17.2017","article-title":"Functional segmentation of the anterior limb of the internal capsule: Linking white matter abnormalities to specific connections","volume":"38","author":"Safadi","year":"2018","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2021.07.010_bib49","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1176\/appi.ajp.159.2.269","article-title":"Prospective long-term follow-up of 44 patients who received cingulotomy for treatment-refractory obsessive-compulsive disorder","volume":"159","author":"Dougherty","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib50","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1176\/appi.ajp.2019.18101180","article-title":"Efficacy and safety of deep transcranial magnetic stimulation for obsessive-compulsive disorder: A prospective multicenter randomized double-blind placebo-controlled trial","volume":"176","author":"Carmi","year":"2019","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuron.2019.01.046","article-title":"Obsessive-compulsive disorder: Puzzles and prospects","volume":"102","author":"Robbins","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2021.07.010_bib52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tics.2011.11.003","article-title":"Obsessive-compulsive disorder: Beyond segregated cortico-striatal pathways","volume":"16","author":"Milad","year":"2012","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.biopsych.2021.07.010_bib53","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1176\/appi.ajp.2014.14020138","article-title":"The NIMH Research Domain Criteria (RDoC) project: Precision medicine for psychiatry","volume":"171","author":"Insel","year":"2014","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib54","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1126\/science.1234733","article-title":"Repeated cortico-striatal stimulation generates persistent OCD-like behavior","volume":"340","author":"Ahmari","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2021.07.010_bib55","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1126\/science.1232380","article-title":"Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors","volume":"340","author":"Burgui\u00e8re","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2021.07.010_bib56","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1038\/npp.2015.20","article-title":"Enhancement of fear extinction with deep brain stimulation: Evidence for medial orbitofrontal involvement","volume":"40","author":"Rodriguez-Romaguera","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2021.07.010_bib57","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.euroneuro.2015.12.005","article-title":"Brain circuitry of compulsivity","volume":"26","author":"van den Heuvel","year":"2016","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2021.07.010_bib58","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41591-020-01173-w","article-title":"High-frequency neuromodulation improves obsessive-compulsive behavior","volume":"27","author":"Grover","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2021.07.010_bib59","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.biopsych.2018.05.011","article-title":"Differential effects of deep brain stimulation of the internal capsule and the striatum on excessive grooming in Sapap3 mutant mice","volume":"84","author":"Pinhal","year":"2018","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib60","doi-asserted-by":"crossref","first-page":"102640","DOI":"10.1016\/j.nicl.2021.102640","article-title":"Deep brain stimulation response in obsessive\u2013compulsive disorder is associated with preoperative nucleus accumbens volume","volume":"30","author":"Liebrand","year":"2021","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.biopsych.2021.07.010_bib61","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1136\/jnnp-2018-318996","article-title":"Open-label trial of anterior limb of internal capsule-nucleus accumbens deep brain stimulation for obsessive-compulsive disorder: Insights gained","volume":"90","author":"Huys","year":"2019","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s40473-015-0036-3","article-title":"Clinical outcome and mechanisms of deep brain stimulation for obsessive-compulsive disorder","volume":"2","author":"van Westen","year":"2015","journal-title":"Curr Behav Neurosci Rep"},{"key":"10.1016\/j.biopsych.2021.07.010_bib63","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1136\/jnnp-2020-323421","article-title":"Deep brain stimulation of the subthalamic nucleus in obsessive-compulsives disorders: Long-term follow-up of an open, prospective, observational cohort","volume":"91","author":"Chabardes","year":"2020","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib64","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/mp.2015.124","article-title":"Electrical stimulation in the bed nucleus of the stria terminalis alleviates severe obsessive-compulsive disorder","volume":"21","author":"Luyten","year":"2016","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib65","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/j.brs.2020.09.001","article-title":"Deep brain stimulation of terminating axons","volume":"13","author":"Bower","year":"2020","journal-title":"Brain Stimul"},{"key":"10.1016\/j.biopsych.2021.07.010_bib66","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/ner.13350","article-title":"StimVision v2: Examples and applications in subthalamic deep brain stimulation for Parkinson\u2019s disease","volume":"24","author":"Noecker","year":"2021","journal-title":"Neuromodulation"},{"key":"10.1016\/j.biopsych.2021.07.010_bib67","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.brs.2021.03.009","article-title":"Image-based biophysical modeling predicts cortical potentials evoked with subthalamic deep brain stimulation","volume":"14","author":"Howell","year":"2021","journal-title":"Brain Stimul"},{"key":"10.1016\/j.biopsych.2021.07.010_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176132","article-title":"Creating and parameterizing patient-specific deep brain stimulation pathway-activation models using the hyperdirect pathway as an example","volume":"12","author":"Gunalan","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2021.07.010_bib69","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S2215-0366(19)30415-8","article-title":"Long versus short pulse width subcallosal cingulate stimulation for treatment-resistant depression: A randomised, double-blind, crossover trial","volume":"7","author":"Ramasubbu","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib70","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/mp.2017.59","article-title":"A\u00a0connectomic approach for subcallosal cingulate deep brain stimulation surgery: Prospective targeting in treatment-resistant depression","volume":"23","author":"Riva-Posse","year":"2018","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib71","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1176\/appi.ajp.2019.18121427","article-title":"Long-term outcomes of subcallosal cingulate deep brain stimulation for treatment-resistant depression","volume":"176","author":"Crowell","year":"2019","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib72","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.biopsych.2017.11.034","article-title":"Gamma ventral capsulotomy in intractable obsessive-compulsive disorder","volume":"84","author":"Rasmussen","year":"2018","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib73","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3340\/jkns.2017.0505.004","article-title":"The potential usefulness of magnetic resonance guided focused ultrasound for obsessive compulsive disorders","volume":"61","author":"Jung","year":"2018","journal-title":"J\u00a0Korean Neurosurg Soc"},{"key":"10.1016\/j.biopsych.2021.07.010_bib74","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1136\/jnnp-2012-303826","article-title":"Bilateral stereotactic anterior capsulotomy for obsessive-compulsive disorder: Long-term follow-up","volume":"84","author":"D\u2019Astous","year":"2013","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2021.07.010_bib75","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/j.1532-2149.2013.00320.x","article-title":"H-coil repetitive transcranial magnetic stimulation for pain relief in patients with diabetic neuropathy","volume":"17","author":"Onesti","year":"2013","journal-title":"Eur J Pain"},{"key":"10.1016\/j.biopsych.2021.07.010_bib76","series-title":"Atlas of the Human Brain","author":"Mai","year":"2007"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000632232101461X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000632232101461X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:02:35Z","timestamp":1777402955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000632232101461X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":76,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S000632232101461X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2021.07.010","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Connectomic Deep Brain Stimulation for Obsessive-Compulsive Disorder","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2021.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}