{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:25:08Z","timestamp":1792797908769,"version":"4.5.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01AG068093"],"award-info":[{"award-number":["R01AG068093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01AG053297"],"award-info":[{"award-number":["R01AG053297"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.biopsych.2021.08.021","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T05:16:06Z","timestamp":1630646166000},"page":"359-369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Personality Associations With Amyloid and Tau: Results From the Baltimore Longitudinal Study of Aging and Meta-analysis"],"prefix":"10.1016","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-8885","authenticated-orcid":false,"given":"Antonio","family":"Terracciano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5042-7422","authenticated-orcid":false,"given":"Murat","family":"Bilgel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0899-624X","authenticated-orcid":false,"given":"Damaris","family":"Aschwanden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Luchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Stephan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9464-1551","authenticated-orcid":false,"given":"Abhay R.","family":"Moghekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean F.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina R.","family":"Sutin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Resnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2021.08.021_bib1","first-page":"175","article-title":"An introduction to the Five-Factor Model and its applications","volume":"60","author":"McCrae","year":"1992","journal-title":"J\u00a0Pers"},{"key":"10.1016\/j.biopsych.2021.08.021_bib2","first-page":"759170","article-title":"Personality and longevity: Knowns, unknowns, and implications for public health and personalized medicine","volume":"2011","author":"Chapman","year":"2011","journal-title":"J\u00a0Aging Res"},{"key":"10.1016\/j.biopsych.2021.08.021_bib3","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1001\/archpsyc.63.10.1113","article-title":"Personality and major depression: A Swedish longitudinal, population-based twin study","volume":"63","author":"Kendler","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2021.08.021_bib4","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"10.1016\/j.biopsych.2021.08.021_bib5","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1001\/archpsyc.64.10.1204","article-title":"Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment","volume":"64","author":"Wilson","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2021.08.021_bib6","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1212\/WNL.0000000000000907","article-title":"Midlife personality and risk of Alzheimer disease and distress: A 38-year follow-up","volume":"83","author":"Johansson","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.08.021_bib7","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000492821","article-title":"Conscientiousness is associated with lower risk of dementia among black and white older adults","volume":"52","author":"Kaup","year":"2019","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.biopsych.2021.08.021_bib8","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1017\/S1355617719001358","article-title":"The relation between personality and biomarkers in sensitivity and conversion to Alzheimer-type dementia","volume":"26","author":"Duchek","year":"2020","journal-title":"J\u00a0Int Neuropsychol Soc"},{"key":"10.1016\/j.biopsych.2021.08.021_bib9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jalz.2013.03.002","article-title":"Personality and risk of Alzheimer\u2019s disease: New data and meta-analysis","volume":"10","author":"Terracciano","year":"2014","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.biopsych.2021.08.021_bib10","doi-asserted-by":"crossref","first-page":"101269","DOI":"10.1016\/j.arr.2021.101269","article-title":"Is personality associated with dementia risk? A meta-analytic investigation","volume":"67","author":"Aschwanden","year":"2021","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.biopsych.2021.08.021_bib11","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1017\/S1355617716000527","article-title":"Impact of personality on cognitive aging: A prospective cohort study","volume":"22","author":"Caselli","year":"2016","journal-title":"J\u00a0Int Neuropsychol Soc"},{"key":"10.1016\/j.biopsych.2021.08.021_bib12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3233\/JAD-190555","article-title":"Self-Reported Personality Traits And Informant-Rated Cognition: A 10-year prospective study","volume":"72","author":"Sutin","year":"2019","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.biopsych.2021.08.021_bib13","article-title":"Self-reported and mother-rated personality traits at age 16 are associated with cognitive function measured concurrently and 30 years later [published online ahead of print Mar 12]","author":"Sutin","year":"2021","journal-title":"Psychol Med"},{"key":"10.1016\/j.biopsych.2021.08.021_bib14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1001\/jamapsychiatry.2019.3120","article-title":"Association between high school personality phenotype and dementia 54 years later in results from a national US sample","volume":"77","author":"Chapman","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.biopsych.2021.08.021_bib15","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.neurobiolaging.2012.08.008","article-title":"Personality and resilience to Alzheimer\u2019s disease neuropathology: A prospective autopsy study","volume":"34","author":"Terracciano","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.biopsych.2021.08.021_bib16","first-page":"6","article-title":"Associations between personality traits and cognitive resilience in older adults","volume":"76","author":"Graham","year":"2021","journal-title":"J\u00a0Gerontol B Psychol Sci Soc Sci"},{"key":"10.1016\/j.biopsych.2021.08.021_bib17","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1212\/WNL.0000000000005303","article-title":"Resistance vs resilience to Alzheimer disease: Clarifying terminology for preclinical studies","volume":"90","author":"Arenaza-Urquijo","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.08.021_bib18","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s00429-020-02071-0","article-title":"Personality factors and cerebral glucose metabolism in community-dwelling older adults","volume":"225","author":"Sohrabi","year":"2020","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.biopsych.2021.08.021_bib19","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.neurobiolaging.2009.12.009","article-title":"Exploring the relationship between personality and regional brain volume in healthy aging","volume":"32","author":"Jackson","year":"2011","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.biopsych.2021.08.021_bib20","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1037\/hea0000012","article-title":"Personality, health, and brain integrity: The Lothian birth cohort study 1936","volume":"33","author":"Booth","year":"2014","journal-title":"Health Psychol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib21","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.biopsych.2021.02.001","article-title":"Good news for dementia prevention: Multiple behavioral features are associated with markers of brain pathology in the preclinical phase of sporadic and autosomal dominant Alzheimer\u2019s disease","volume":"89","author":"Simon","year":"2021","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.08.021_bib22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer\u2019s disease: An updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib23","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.3233\/JAD-210185","article-title":"Neuroticism is associated with tau pathology in cognitively unimpaired individuals with autosomal dominant Alzheimer\u2019s disease","volume":"82","author":"Baena","year":"2021","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.biopsych.2021.08.021_bib24","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1007\/s11682-019-00163-y","article-title":"Association between personality and tau-PET binding in cognitively normal older adults","volume":"14","author":"Schultz","year":"2020","journal-title":"Brain Imaging Behav"},{"key":"10.1016\/j.biopsych.2021.08.021_bib25","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.biopsych.2020.01.023","article-title":"Amyloid and tau pathology associations with personality traits, neuropsychiatric symptoms, and cognitive lifestyle in the preclinical phases of sporadic and autosomal dominant Alzheimer\u2019s disease","volume":"89","author":"Pichet Binette","year":"2020","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.08.021_bib26","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1037\/pag0000582","article-title":"Conscientiousness is associated with less amyloid deposition in cognitively normal aging","volume":"35","author":"Yoon","year":"2020","journal-title":"Psychol Aging"},{"key":"10.1016\/j.biopsych.2021.08.021_bib27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/pcn.12983","article-title":"Neuroticism, conscientiousness, and in\u00a0vivo Alzheimer pathologies measured by amyloid PET and MRI","volume":"74","author":"Byun","year":"2020","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.biopsych.2021.08.021_bib28","series-title":"Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) Professional Manual","author":"Costa","year":"1992"},{"key":"10.1016\/j.biopsych.2021.08.021_bib29","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1177\/0146167206288599","article-title":"Personality plasticity after age 30","volume":"32","author":"Terracciano","year":"2006","journal-title":"Pers Soc Psychol Bull"},{"key":"10.1016\/j.biopsych.2021.08.021_bib30","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1037\/0022-3514.88.3.547","article-title":"Universal features of personality traits from the observer\u2019s perspective: Data from 50 cultures","volume":"88","author":"McCrae","year":"2005","journal-title":"J Per Soc Psychol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib31","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S0191-8869(99)00055-0","article-title":"Replicating the five factor model of personality in a psychiatric sample","volume":"27","author":"Bagby","year":"1999","journal-title":"Pers Indiv Differ"},{"key":"10.1016\/j.biopsych.2021.08.021_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jamda.2018.11.004","article-title":"Personality changes with dementia from the informant perspective: New data and meta-analysis","volume":"20","author":"Islam","year":"2019","journal-title":"J\u00a0Am Med Dir Assoc"},{"key":"10.1016\/j.biopsych.2021.08.021_bib33","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1177\/1073191117691844","article-title":"Cognitive impairment, dementia, and personality stability among older adults","volume":"25","author":"Terracciano","year":"2018","journal-title":"Assessment"},{"key":"10.1016\/j.biopsych.2021.08.021_bib34","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.dadm.2019.07.007","article-title":"Tau pathology in cognitively normal older adults","volume":"11","author":"Ziontz","year":"2019","journal-title":"Alzheimer Dement (Amst)"},{"issue":"Suppl 1","key":"10.1016\/j.biopsych.2021.08.021_bib35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1017\/S1041610297004870","article-title":"Clinical dementia rating: A reliable and valid diagnostic and staging measure for dementia of the Alzheimer type","volume":"9","author":"Morris","year":"1997","journal-title":"Int Psychogeriatr"},{"key":"10.1016\/j.biopsych.2021.08.021_bib36","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1192\/bjp.114.512.797","article-title":"The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects","volume":"114","author":"Blessed","year":"1968","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.biopsych.2021.08.021_bib37","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: Clinical characterization and outcome","volume":"56","author":"Petersen","year":"1999","journal-title":"Arch Neurol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib38","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1987"},{"key":"10.1016\/j.biopsych.2021.08.021_bib39","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.08.021_bib40","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1037\/0882-7974.12.2.277","article-title":"Center for Epidemiologic Studies Depression Scale (CES-D) as a screening instrument for depression among community-residing older adults","volume":"12","author":"Lewinsohn","year":"1997","journal-title":"Psychol Aging"},{"key":"10.1016\/j.biopsych.2021.08.021_bib41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neurobiolaging.2020.02.004","article-title":"Less agreeable, better preserved? A PET amyloid and MRI study in a community-based cohort","volume":"89","author":"Giannakopoulos","year":"2020","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.biopsych.2021.08.021_bib42","doi-asserted-by":"crossref","first-page":"e388","DOI":"10.1212\/WNL.0000000000004887","article-title":"Comparing 18F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease","volume":"90","author":"Mattsson","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.08.021_bib43","article-title":"Relationships between big-five personality factors and Alzheimer\u2019s disease pathology in autosomal dominant Alzheimer\u2019s disease","volume":"12","author":"Aschenbrenner","year":"2020","journal-title":"Alzheimers Dement (Amst)"},{"key":"10.1016\/j.biopsych.2021.08.021_bib44","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jagp.2015.01.008","article-title":"Subjective cognitive complaints, personality and brain amyloid-beta in cognitively normal older adults","volume":"23","author":"Snitz","year":"2015","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.biopsych.2021.08.021_bib45","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jpsychires.2016.12.024","article-title":"Relations between personality changes and cerebrospinal fluid biomarkers of Alzheimer\u2019s disease pathology","volume":"90","author":"Tautvydaite","year":"2017","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.biopsych.2021.08.021_bib46","doi-asserted-by":"crossref","first-page":"d4002","DOI":"10.1136\/bmj.d4002","article-title":"Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials","volume":"343","author":"Sterne","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.biopsych.2021.08.021_bib47","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev-psych-010418-103244","article-title":"Personality across the life span","volume":"70","author":"Costa","year":"2019","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib48","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1001\/jamaneurol.2020.1941","article-title":"Association of early-life cognitive enrichment with Alzheimer disease pathological changes and cognitive decline","volume":"77","author":"Oveisgharan","year":"2020","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib49","doi-asserted-by":"crossref","first-page":"e2144","DOI":"10.1212\/WNL.0000000000008534","article-title":"Cognition at age 70: Life course predictors and associations with brain pathologies","volume":"93","author":"Lu","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.08.021_bib50","doi-asserted-by":"crossref","first-page":"362","DOI":"10.2174\/1567205016666190315095151","article-title":"Physical activity as a moderator of Alzheimer pathology: A systematic review of observational studies","volume":"16","author":"Frederiksen","year":"2019","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.biopsych.2021.08.021_bib51","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1001\/jamaneurol.2020.0387","article-title":"Association of factors with elevated amyloid burden in clinically normal older individuals","volume":"77","author":"Sperling","year":"2020","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib52","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1001\/jamaneurol.2017.0244","article-title":"Evaluation of amyloid protective factors and Alzheimer disease neurodegeneration protective factors in elderly individuals","volume":"74","author":"Vemuri","year":"2017","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib53","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1001\/jamaneurol.2019.3774","article-title":"Associations between vascular risk across adulthood and brain pathology in late life: Evidence from a British birth cohort","volume":"77","author":"Lane","year":"2020","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib54","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.20780","article-title":"Association of vascular risk factors with \u03b2-amyloid peptide and tau burdens in cognitively unimpaired individuals and its interaction with vascular medication use","volume":"3","author":"K\u00f6be","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.biopsych.2021.08.021_bib55","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/gps.4782","article-title":"Self-reported personality traits are prospectively associated with proxy-reported behavioral and psychological symptoms of dementia at the end of life","volume":"33","author":"Sutin","year":"2018","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.biopsych.2021.08.021_bib56","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev-clinpsy-032210-104540","article-title":"Personality and depression: Explanatory models and review of the evidence","volume":"7","author":"Klein","year":"2011","journal-title":"Annu Rev Clin Psychol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib57","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1017\/S1041610217002368","article-title":"Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: The Mayo Clinic Study of Aging","volume":"30","author":"Krell-Roesch","year":"2018","journal-title":"Int Psychogeriatr"},{"key":"10.1016\/j.biopsych.2021.08.021_bib58","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.jagp.2016.08.007","article-title":"\u03b2-Amyloid, APOE and BDNF genotype, and depressive and anxiety symptoms in cognitively normal older women and men","volume":"24","author":"Holmes","year":"2016","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.biopsych.2021.08.021_bib59","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/0004867414557161","article-title":"Amyloid-beta and depression in healthy older adults: A systematic review","volume":"49","author":"Harrington","year":"2015","journal-title":"Aust N Z J Psychiatry"},{"key":"10.1016\/j.biopsych.2021.08.021_bib60","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3233\/JAD-191078","article-title":"Depression is associated with tau and not amyloid positron emission tomography in cognitively normal adults","volume":"74","author":"Babulal","year":"2020","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.biopsych.2021.08.021_bib61","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3233\/JAD-210232","article-title":"Association of midlife depressive symptoms with regional amyloid-\u03b2 and tau in the Framingham Heart Study","volume":"82","author":"Gonzales","year":"2021","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.biopsych.2021.08.021_bib62","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1176\/appi.ajp.2017.17040442","article-title":"Longitudinal association of amyloid beta and anxious-depressive symptoms in cognitively normal older adults","volume":"175","author":"Donovan","year":"2018","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2021.08.021_bib63","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1001\/jamapsychiatry.2017.2816","article-title":"Personality change in the preclinical phase of Alzheimer disease","volume":"74","author":"Terracciano","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.biopsych.2021.08.021_bib64","first-page":"251","article-title":"Increases in neuroticism may be an early indicator of dementia: A coordinated analysis","volume":"75","author":"Yoneda","year":"2020","journal-title":"J\u00a0Gerontol B Psychol Sci Soc Sci"},{"key":"10.1016\/j.biopsych.2021.08.021_bib65","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1017\/S0033291709992029","article-title":"High neuroticism and low conscientiousness are associated with interleukin-6","volume":"40","author":"Sutin","year":"2010","journal-title":"Psychol Med"},{"key":"10.1016\/j.biopsych.2021.08.021_bib66","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00401-013-1177-7","article-title":"The amyloid cascade-inflammatory hypothesis of Alzheimer disease: Implications for therapy","volume":"126","author":"McGeer","year":"2013","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib67","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/brain\/awaa405","article-title":"Depression, dementia and immune dysregulation","volume":"144","author":"Hayley","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.08.021_bib68","doi-asserted-by":"crossref","first-page":"15066","DOI":"10.1038\/s41598-019-51469-2","article-title":"Time-resolved connectome of the five-factor model of personality","volume":"9","author":"Passamonti","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopsych.2021.08.021_bib69","doi-asserted-by":"crossref","first-page":"eabd1327","DOI":"10.1126\/sciadv.abd1327","article-title":"Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer\u2019s disease","volume":"6","author":"Franzmeier","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.biopsych.2021.08.021_bib70","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/alz.12209","article-title":"Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia","volume":"17","author":"Tsvetanov","year":"2021","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.biopsych.2021.08.021_bib71","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41398-021-01253-6","article-title":"Neuroticism alters the transcriptome of the frontal cortex to contribute to the cognitive decline and onset of Alzheimer\u2019s disease","volume":"11","author":"De Jager","year":"2021","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2021.08.021_bib72","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jpsychires.2018.10.015","article-title":"Polygenic score for Alzheimer disease and cognition: The mediating role of personality","volume":"107","author":"Stephan","year":"2018","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.biopsych.2021.08.021_bib73","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/s41588-018-0151-7","article-title":"Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways","volume":"50","author":"Nagel","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2021.08.021_bib74","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/j.neurobiolaging.2013.12.023","article-title":"Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia","volume":"35","author":"Cook","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.biopsych.2021.08.021_bib75","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1037\/0278-6133.25.1.57","article-title":"Forty years on: Teachers\u2019 assessments of children\u2019s personality traits predict self-reported health behaviors and outcomes at midlife","volume":"25","author":"Hampson","year":"2006","journal-title":"Health Psychol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib76","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s11556-020-00251-9","article-title":"Personality traits and physical functioning: A cross-sectional multimethod facet-level analysis","volume":"17","author":"Kek\u00e4l\u00e4inen","year":"2020","journal-title":"Eur Rev Aging Phys Act"},{"key":"10.1016\/j.biopsych.2021.08.021_bib77","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s12529-019-09828-w","article-title":"Personality traits and the subjective and objective experience of sleep","volume":"27","author":"Sutin","year":"2020","journal-title":"Int J Behav Med"},{"key":"10.1016\/j.biopsych.2021.08.021_bib78","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1097\/PSY.0000000000000734","article-title":"Personality and hearing acuity: Evidence from the Health and Retirement Study and the English Longitudinal Study of Ageing","volume":"81","author":"Stephan","year":"2019","journal-title":"Psychosom Med"},{"key":"10.1016\/j.biopsych.2021.08.021_bib79","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1037\/hea0000003","article-title":"Personality and risk of diabetes in adults: Pooled analysis of 5 cohort studies","volume":"33","author":"Jokela","year":"2014","journal-title":"Health Psychol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1525\/collabra.112","article-title":"Only so many hours: Correlations between personality and daily time use in a representative German panel","volume":"4","author":"Rohrer","year":"2018","journal-title":"Collabra Psychol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib81","article-title":"The association between facets of conscientiousness and performance-based and informant-rated cognition, affect, and activities in older adults [published online ahead of print Jun 25]","author":"Sutin","year":"2021","journal-title":"J\u00a0Pers"},{"key":"10.1016\/j.biopsych.2021.08.021_bib82","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neurobiolaging.2019.03.022","article-title":"Brain reserve, cognitive reserve, compensation, and maintenance: Operationalization, validity, and mechanisms of cognitive resilience","volume":"83","author":"Stern","year":"2019","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.biopsych.2021.08.021_bib83","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1037\/0022-3514.93.1.116","article-title":"Personality predictors of academic outcomes: Big five correlates of GPA and SAT scores","volume":"93","author":"Noftle","year":"2007","journal-title":"J\u00a0Pers Soc Psychol"},{"key":"10.1016\/j.biopsych.2021.08.021_bib84","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jalz.2012.11.007","article-title":"The global prevalence of dementia: A systematic review and metaanalysis","volume":"9","author":"Prince","year":"2013","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.biopsych.2021.08.021_bib85","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/gps.5491","article-title":"Neuroticism, negative life events, and dementia in older White and Black Brazilians","volume":"36","author":"Capuano","year":"2021","journal-title":"Int J Geriatr Psychiatry"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322321015663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322321015663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:31:40Z","timestamp":1788982300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322321015663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":85,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S0006322321015663"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2021.08.021","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Personality Associations With Amyloid and Tau: Results From the Baltimore Longitudinal Study of Aging and Meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2021.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}