{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:31:11Z","timestamp":1793809871485,"version":"4.6.1"},"reference-count":150,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100002565","name":"Alzheimer&apos;s Drug Discovery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014605","name":"Sage Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017117","name":"Denali Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017117","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.biopsych.2021.11.021","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T01:53:49Z","timestamp":1639101229000},"page":"922-933","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Epigenetics of Autism Spectrum Disorder: Histone Deacetylases"],"prefix":"10.1016","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0592-335X","authenticated-orcid":false,"given":"Chieh-En Jane","family":"Tseng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"McDougle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob M.","family":"Hooker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0271-6304","authenticated-orcid":false,"given":"Nicole R.","family":"Z\u00fcrcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2021.11.021_bib1","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"10.1016\/j.biopsych.2021.11.021_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.tig.2016.01.001","article-title":"Autism and cancer share risk genes, pathways, and drug targets","volume":"32","author":"Crawley","year":"2016","journal-title":"Trends Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nature13772","article-title":"Synaptic, transcriptional and chromatin genes disrupted in autism","volume":"515","author":"De Rubeis","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2021.11.021_bib4","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.cell.2019.12.036","article-title":"Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism","volume":"180","author":"Satterstrom","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2021.11.021_bib5","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1001\/archgenpsychiatry.2011.76","article-title":"Genetic heritability and shared environmental factors among twin pairs with autism","volume":"68","author":"Hallmayer","year":"2011","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2021.11.021_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13229-017-0121-4","article-title":"Environmental risk factors for autism: An evidence-based review of systematic reviews and meta-analyses","volume":"8","author":"Modabbernia","year":"2017","journal-title":"Mol Autism"},{"key":"10.1016\/j.biopsych.2021.11.021_bib7","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3390\/ijerph13050504","article-title":"Epigenetic effect of environmental factors on autism spectrum disorders","volume":"13","author":"Kubota","year":"2016","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.biopsych.2021.11.021_bib8","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.cell.2016.10.031","article-title":"Histone acetylome-wide association study of autism spectrum disorder","volume":"167","author":"Sun","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2021.11.021_bib9","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/hmg\/ddz052","article-title":"Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue","volume":"28","author":"Wong","year":"2019","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib10","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1038\/s41467-020-18526-1","article-title":"Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism","volume":"11","author":"Ramaswami","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2021.11.021_bib11","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature10110","article-title":"Transcriptomic analysis of autistic brain reveals convergent molecular pathology","volume":"474","author":"Voineagu","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2021.11.021_bib12","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.1038\/ncomms6748","article-title":"Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism","volume":"5","author":"Gupta","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2021.11.021_bib13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev-med-120417-091431","article-title":"DNA methylation and susceptibility to autism spectrum disorder","volume":"70","author":"Tremblay","year":"2019","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.biopsych.2021.11.021_bib14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.nepig.2014.10.002","article-title":"Histone deacetylases (HDACs) and brain function","volume":"1","author":"Volmar","year":"2015","journal-title":"Neuroepigenetics"},{"key":"10.1016\/j.biopsych.2021.11.021_bib15","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1001\/jama.2013.2270","article-title":"Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism","volume":"309","author":"Christensen","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.biopsych.2021.11.021_bib16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbr.2013.09.049","article-title":"Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice","volume":"257","author":"Moldrich","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.biopsych.2021.11.021_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1017\/S1461145711001714","article-title":"Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid","volume":"16","author":"Kataoka","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib18","first-page":"1","article-title":"Prevalence of autism spectrum disorder among children aged 8 years \u2014 Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2014","author":"Baio","year":"2018","journal-title":"MMWR Surveill Summ 67(No. SS-6)"},{"key":"10.1016\/j.biopsych.2021.11.021_bib19","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/sj.npp.1300518","article-title":"Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism","volume":"30","author":"Schneider","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2021.11.021_bib20","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1007\/s11064-016-1969-y","article-title":"Prenatal exposure to histone deacetylase inhibitors affects gene expression of autism-related molecules and delays neuronal maturation","volume":"41","author":"Kawanai","year":"2016","journal-title":"Neurochem Res"},{"key":"10.1016\/j.biopsych.2021.11.021_bib21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41398-020-00911-5","article-title":"In\u00a0vivo human brain expression of histone deacetylases in bipolar disorder","volume":"10","author":"Tseng","year":"2020","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2021.11.021_bib22","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1172\/JCI123743","article-title":"PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia","volume":"129","author":"Gilbert","year":"2019","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.biopsych.2021.11.021_bib23","doi-asserted-by":"crossref","first-page":"106837","DOI":"10.1016\/j.ntt.2019.106837","article-title":"Paternal valproic acid exposure in mice triggers behavioral alterations in offspring","volume":"76","author":"Ibi","year":"2019","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.euroneuro.2017.11.014","article-title":"Impaired repair of DNA damage is associated with autistic-like traits in rats prenatally exposed to valproic acid","volume":"28","author":"Servadio","year":"2018","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fnbeh.2013.00088","article-title":"General developmental health in the VPA-rat model of autism","volume":"7","author":"Favre","year":"2013","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.toxlet.2010.12.018","article-title":"The critical period of valproate exposure to induce autistic symptoms in Sprague-Dawley rats","volume":"201","author":"Kim","year":"2011","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.biopsych.2021.11.021_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neulet.2009.12.054","article-title":"Behavior and serotonergic disorders in rats exposed prenatally to valproate: A model for autism","volume":"470","author":"Dufour-Rainfray","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.biopsych.2021.11.021_bib28","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.psym.2015.09.008","article-title":"Valproic acid for treatment of hyperactive or mixed delirium: Rationale and literature review","volume":"56","author":"Sher","year":"2015","journal-title":"Psychosomatics"},{"key":"10.1016\/j.biopsych.2021.11.021_bib29","first-page":"17","article-title":"Alteration of embryonic folate metabolism by valproic acid during organogenesis: Implications for mechanism of teratogenesis","volume":"42","author":"Wegner","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2021.11.021_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009226","article-title":"The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs","volume":"15","author":"Vaca","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.biopsych.2021.11.021_bib31","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/s41386-018-0073-1","article-title":"Histone deacetylase inhibitor MS-275 restores social and synaptic function in a Shank3-deficient mouse model of autism","volume":"43","author":"Ma","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2021.11.021_bib32","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41593-018-0110-8","article-title":"Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition [published correction appears in Nat Neurosci 2018; 21:1139]","volume":"21","author":"Qin","year":"2018","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib33","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuropharm.2015.11.003","article-title":"Sodium butyrate attenuates social behavior deficits and modifies the transcription of inhibitory\/excitatory genes in the frontal cortex of an autism model","volume":"102","author":"Kratsman","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopsych.2021.11.021_bib34","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1038\/nn.4347","article-title":"Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior","volume":"19","author":"Nott","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib35","doi-asserted-by":"crossref","first-page":"338","DOI":"10.9758\/cpn.2016.14.4.338","article-title":"Valproic acid exposure during early postnatal gliogenesis leads to autistic-like behaviors in rats","volume":"14","author":"Mony","year":"2016","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib36","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.neuropharm.2012.05.042","article-title":"Class I histone deacetylase inhibition ameliorates social cognition and cell adhesion molecule plasticity deficits in a rodent model of autism spectrum disorder","volume":"63","author":"Foley","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopsych.2021.11.021_bib37","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nn.3420","article-title":"Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles","volume":"16","author":"Wang","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib38","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.yhbeh.2016.04.001","article-title":"Trichostatin A (TSA) facilitates formation of partner preference in male prairie voles (Microtus ochrogaster)","volume":"81","author":"Duclot","year":"2016","journal-title":"Horm Behav"},{"key":"10.1016\/j.biopsych.2021.11.021_bib39","doi-asserted-by":"crossref","first-page":"106444","DOI":"10.1016\/j.eplepsyres.2020.106444","article-title":"Ketogenic diet, neuroprotection, and antiepileptogenesis","volume":"167","author":"Murugan","year":"2020","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.biopsych.2021.11.021_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171643","article-title":"Ketogenic diet improves behaviors in a maternal immune activation model of autism spectrum disorder","volume":"12","author":"Ruskin","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2021.11.021_bib41","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/1028415X.2015.1133029","article-title":"The effect of ketogenic diet in an animal model of autism induced by prenatal exposure to valproic acid","volume":"20","author":"Castro","year":"2017","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065021","article-title":"Ketogenic diet improves core symptoms of autism in BTBR mice","volume":"8","author":"Ruskin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2021.11.021_bib43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.physbeh.2018.02.006","article-title":"A\u00a0modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder","volume":"188","author":"Lee","year":"2018","journal-title":"Physiol Behav"},{"key":"10.1016\/j.biopsych.2021.11.021_bib44","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1007\/s11011-017-0088-z","article-title":"Ketogenic diet versus gluten free casein free diet in autistic children: A case-control study","volume":"32","author":"El-Rashidy","year":"2017","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.biopsych.2021.11.021_bib45","doi-asserted-by":"crossref","first-page":"788","DOI":"10.7150\/ijms.8417","article-title":"Spatiotemporal expression of HDAC2 during the postnatal development of the rat hippocampus","volume":"11","author":"Hou","year":"2014","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib46","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1021\/acschemneuro.6b00372","article-title":"Expression of HDAC2 but not HDAC1 transcript is reduced in dorsolateral prefrontal cortex of patients with schizophrenia","volume":"8","author":"Schroeder","year":"2017","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib47","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41398-019-0608-1","article-title":"Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates","volume":"9","author":"Zhao","year":"2019","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2021.11.021_bib48","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1038\/nn.4395","article-title":"MeCP2 and histone deacetylases 1 and 2 in dorsal striatum collectively suppress repetitive behaviors","volume":"19","author":"Mahgoub","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib49","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1093\/emboj\/21.11.2672","article-title":"Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression","volume":"21","author":"Lagger","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.biopsych.2021.11.021_bib50","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature07925","article-title":"HDAC2 negatively regulates memory formation and synaptic plasticity","volume":"459","author":"Guan","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2021.11.021_bib51","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.biopsych.2013.03.020","article-title":"Prefrontal cortical dysfunction after overexpression of histone deacetylase 1","volume":"74","author":"Jakovcevski","year":"2013","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.11.021_bib52","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/sj.npp.1301453","article-title":"Abnormal fear conditioning and amygdala processing in an animal model of autism","volume":"33","author":"Markram","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2021.11.021_bib53","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.psyneuen.2008.02.011","article-title":"Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid","volume":"33","author":"Schneider","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.biopsych.2021.11.021_bib54","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1111\/bph.14435","article-title":"Sex-specific autistic endophenotypes induced by prenatal exposure to valproic acid involve anandamide signalling","volume":"175","author":"Melancia","year":"2018","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib55","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.fct.2018.02.061","article-title":"Behavioral alterations in autism model induced by valproic acid and translational analysis of circulating microRNA","volume":"115","author":"Hirsch","year":"2018","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib56","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1007\/s00213-021-05812-z","article-title":"Sodium phenylbutyrate reduces repetitive self-grooming behavior and rescues social and cognitive deficits in mouse models of autism","volume":"238","author":"Ryu","year":"2021","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2021.11.021_bib57","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1074\/jbc.M115.679332","article-title":"Transcriptional regulation of JARID1B\/KDM5B histone demethylase by Ikaros, histone deacetylase 1 (HDAC1), and casein kinase 2 (CK2) in B-cell acute lymphoblastic leukemia","volume":"291","author":"Wang","year":"2016","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.biopsych.2021.11.021_bib58","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1128\/MCB.00882-06","article-title":"Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2","volume":"27","author":"Gr\u00e9goire","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib59","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s11689-011-9078-3","article-title":"Role of MeCP2, DNA methylation, and HDACs in regulating synapse function","volume":"3","author":"Kavalali","year":"2011","journal-title":"J\u00a0Neurodev Disord"},{"key":"10.1016\/j.biopsych.2021.11.021_bib60","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41580-018-0076-0","article-title":"Integrative regulation of physiology by histone deacetylase 3","volume":"20","author":"Emmett","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib61","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.cell.2012.03.028","article-title":"Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries","volume":"149","author":"Talkowski","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2021.11.021_bib62","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1093\/hmg\/ddq189","article-title":"CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome","volume":"19","author":"Batsukh","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib63","doi-asserted-by":"crossref","first-page":"5775","DOI":"10.1038\/s41467-020-19502-5","article-title":"CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks","volume":"11","author":"Rother","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2021.11.021_bib64","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ajhg.2010.07.011","article-title":"Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems","volume":"87","author":"Williams","year":"2010","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib65","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nm.4071","article-title":"Advancing the understanding of autism disease mechanisms through genetics","volume":"22","author":"de la Torre-Ubieta","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.biopsych.2021.11.021_bib66","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1038\/s41598-019-41744-7","article-title":"Histone deacetylase inhibitors restore normal hippocampal synaptic plasticity and seizure threshold in a mouse model of tuberous sclerosis complex","volume":"9","author":"Basu","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopsych.2021.11.021_bib67","doi-asserted-by":"crossref","first-page":"103661","DOI":"10.1016\/j.ejmg.2019.04.018","article-title":"Chemical screens in a zebrafish model of CHARGE syndrome identifies small molecules that ameliorate disease-like phenotypes in embryo","volume":"63","author":"Asad","year":"2020","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib68","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.pcl.2015.03.004","article-title":"Prader-Willi, Angelman, and 15q11-q13 duplication syndromes","volume":"62","author":"Kalsner","year":"2015","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.biopsych.2021.11.021_bib69","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/hmg\/10.6.645","article-title":"Association of acetylated histones with paternally expressed genes in the Prader\u2013Willi deletion region","volume":"10","author":"Fulmer-Smentek","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib70","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1086\/302917","article-title":"Parent-of-origin specific histone acetylation and reactivation of a key imprinted gene locus in Prader-Willi syndrome","volume":"66","author":"Saitoh","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib71","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/hmg\/ddi097","article-title":"MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS\/AS imprinting center that affects UBE3A expression","volume":"14","author":"Makedonski","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib72","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/npp.2012.73","article-title":"Epigenetics of the depressed brain: Role of histone acetylation and methylation","volume":"38","author":"Sun","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2021.11.021_bib73","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/syn.20995","article-title":"Increased expression of histone deacetylases 2 in temporal lobe epilepsy: A study of epileptic patients and rat models","volume":"66","author":"Huang","year":"2012","journal-title":"Synapse"},{"key":"10.1016\/j.biopsych.2021.11.021_bib74","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.expneurol.2015.07.026","article-title":"Rapid changes in expression of class I and IV histone deacetylases during epileptogenesis in mouse models of temporal lobe epilepsy [published correction appears in Exp Neurol 2016; 278:144]","volume":"273","author":"Jagirdar","year":"2015","journal-title":"Exp Neurol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib75","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0197-0186(00)00013-9","article-title":"Mechanisms of action of valproate: A commentary","volume":"37","author":"Johannessen","year":"2000","journal-title":"Neurochem Int"},{"key":"10.1016\/j.biopsych.2021.11.021_bib76","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.eplepsyres.2008.04.019","article-title":"Increase in antiepileptic efficacy during prolonged treatment with valproic acid: Role of inhibition of histone deacetylases?","volume":"81","author":"Hoffmann","year":"2008","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.biopsych.2021.11.021_bib77","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41398-018-0206-7","article-title":"Effect of valproate and pregabalin on human anxiety-like behaviour in a randomised controlled trial","volume":"8","author":"Bach","year":"2018","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2021.11.021_bib78","first-page":"169","article-title":"Valproic acid for the treatment of social anxiety disorder","volume":"18","author":"Kinrys","year":"2003","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib79","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.eurpsy.2007.08.001","article-title":"Valproate (depakine-chrono) in the acute treatment of outpatients with generalized anxiety disorder without psychiatric comorbidity: Randomized, double-blind placebo-controlled study","volume":"23","author":"Aliyev","year":"2008","journal-title":"Eur Psychiatry"},{"key":"10.1016\/j.biopsych.2021.11.021_bib80","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1080\/24750573.2017.1317382","article-title":"Treatment response to valproate in case with generalized anxiety disorder resistant to antidepressants","volume":"27","author":"Vay\u0131so\u011flu","year":"2017","journal-title":"Psychiatry Clin Psychopharmacol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib81","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.neuropharm.2012.07.045","article-title":"Valproic acid but not D-cycloserine facilitates sleep-dependent offline learning of extinction and habituation of conditioned fear in humans","volume":"64","author":"Kuriyama","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopsych.2021.11.021_bib82","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00213-011-2353-x","article-title":"Effect of D-cycloserine and valproic acid on the extinction of reinstated fear-conditioned responses and habituation of fear conditioning in healthy humans: A randomized controlled trial","volume":"218","author":"Kuriyama","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2021.11.021_bib83","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1101\/lm.036012.114","article-title":"A\u00a0role for histone deacetylases in the cellular and behavioral mechanisms underlying learning and memory","volume":"21","author":"Mahgoub","year":"2014","journal-title":"Learn Mem"},{"key":"10.1016\/j.biopsych.2021.11.021_bib84","doi-asserted-by":"crossref","first-page":"34341","DOI":"10.1074\/jbc.M114.606392","article-title":"Class IIa histone deacetylases are conserved regulators of circadian function","volume":"289","author":"Fogg","year":"2014","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.biopsych.2021.11.021_bib85","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cell.2008.07.002","article-title":"The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control","volume":"134","author":"Nakahata","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2021.11.021_bib86","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2008.06.050","article-title":"SIRT1 regulates circadian clock gene expression through PER2 deacetylation","volume":"134","author":"Asher","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2021.11.021_bib87","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1523\/JNEUROSCI.5166-10.2011","article-title":"SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons","volume":"31","author":"Panossian","year":"2011","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib88","doi-asserted-by":"crossref","first-page":"13156","DOI":"10.1038\/s41598-018-31584-2","article-title":"Class II histone deacetylases require P\/Q-type Ca2+ channels and CaMKII to maintain gamma oscillations in the pedunculopontine nucleus","volume":"8","author":"Urbano","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopsych.2021.11.021_bib89","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1111\/nmo.12675","article-title":"Early-life stress-induced visceral hypersensitivity and anxiety behavior is reversed by histone deacetylase inhibition","volume":"27","author":"Moloney","year":"2015","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.biopsych.2021.11.021_bib90","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/mp.2014.122","article-title":"Epigenetic modulation of chronic anxiety and pain by histone deacetylation","volume":"20","author":"Tran","year":"2015","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.11.021_bib91","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.psyneuen.2012.09.016","article-title":"Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress","volume":"38","author":"Tran","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.biopsych.2021.11.021_bib92","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature12687","article-title":"Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis","volume":"504","author":"Alenghat","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2021.11.021_bib93","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1210\/en.2011-0193","article-title":"Histone deacetylation during brain development is essential for permanent masculinization of sexual behavior","volume":"152","author":"Matsuda","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopsych.2021.11.021_bib94","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.nbd.2017.05.010","article-title":"Rescue of altered HDAC activity recovers behavioural abnormalities in a mouse model of Angelman syndrome","volume":"105","author":"Jamal","year":"2017","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.biopsych.2021.11.021_bib95","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3389\/fnmol.2019.00289","article-title":"Simvastatin restores HDAC1\/2 activity and improves behavioral deficits in Angelman syndrome model mouse","volume":"12","author":"Kumar","year":"2019","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib96","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1021\/acschemneuro.8b00600","article-title":"Brain penetrable histone deacetylase 6 inhibitor SW-100 ameliorates memory and learning impairments in a mouse model of fragile X syndrome","volume":"10","author":"Kozikowski","year":"2019","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib97","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.91782","article-title":"Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in fragile X syndrome mice","volume":"2","author":"Pardo","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.biopsych.2021.11.021_bib98","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.ajhg.2014.05.004","article-title":"Transcriptional consequences of 16p11.2 deletion and duplication in mouse cortex and multiplex autism families","volume":"94","author":"Blumenthal","year":"2014","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib99","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41398-021-01233-w","article-title":"Synergistic inhibition of histone modifiers produces therapeutic effects in adult Shank3-deficient mice","volume":"11","author":"Zhang","year":"2021","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2021.11.021_bib100","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/open.201600125","article-title":"A\u00a0multi-target small molecule for targeted transcriptional activation of therapeutically significant nervous system genes","volume":"5","author":"Wei","year":"2016","journal-title":"ChemistryOpen"},{"key":"10.1016\/j.biopsych.2021.11.021_bib101","doi-asserted-by":"crossref","first-page":"103ra97","DOI":"10.1126\/scitranslmed.3002627","article-title":"Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice","volume":"3","author":"Smith","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.biopsych.2021.11.021_bib102","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature11316","article-title":"HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle","volume":"489","author":"Deardorff","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2021.11.021_bib103","first-page":"46","article-title":"Cornelia de Lange syndrome type 5: Report of two new cases","volume":"7","author":"Le Taillandier de Gabory","year":"2018","journal-title":"Middle East J Med Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib104","doi-asserted-by":"crossref","first-page":"6501","DOI":"10.1021\/acs.biochem.5b00881","article-title":"Biochemical and structural characterization of HDAC8 mutants associated with Cornelia de Lange syndrome spectrum disorders","volume":"54","author":"Decroos","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.biopsych.2021.11.021_bib105","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1093\/hmg\/ddu002","article-title":"Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance","volume":"23","author":"Kaiser","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib106","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/jhg.2014.60","article-title":"Exome sequencing identifies a de novo mutation in HDAC8 associated with Cornelia de Lange syndrome [published correction appears in J Hum Genet 2015; 60:165]","volume":"59","author":"Feng","year":"2014","journal-title":"J\u00a0Hum Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib107","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/ajmg.a.61101","article-title":"A\u00a0de novo HDAC2 variant in a patient with features consistent with Cornelia de Lange syndrome phenotype","volume":"179","author":"Wagner","year":"2019","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.biopsych.2021.11.021_bib108","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1038\/s41467-018-04869-3","article-title":"Reducing histone acetylation rescues cognitive deficits in a mouse model of fragile X syndrome","volume":"9","author":"Li","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2021.11.021_bib109","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/ajmg.a.33484","article-title":"Treatment with valproic acid ameliorates ADHD symptoms in fragile X syndrome boys","volume":"152A","author":"Torrioli","year":"2010","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.biopsych.2021.11.021_bib110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000017","article-title":"SIRT1 inhibition alleviates gene silencing in fragile X mental retardation syndrome","volume":"4","author":"Biacsi","year":"2008","journal-title":"PLoS Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib111","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/8807","article-title":"Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells [published correction appears in Nat Genet 1999; 22:209]","volume":"22","author":"Coffee","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib112","doi-asserted-by":"crossref","first-page":"3582601","DOI":"10.1155\/2017\/3582601","article-title":"Inhibitors of histone deacetylases are weak activators of the FMR1 gene in fragile X syndrome cell lines","volume":"2017","author":"Dolskiy","year":"2017","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.biopsych.2021.11.021_bib113","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1016\/j.celrep.2019.02.026","article-title":"FMR1 reactivating treatments in fragile X iPSC-derived neural progenitors in\u00a0vitro and in\u00a0vivo","volume":"26","author":"Vershkov","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.biopsych.2021.11.021_bib114","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1093\/hmg\/8.12.2317","article-title":"Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene","volume":"8","author":"Chiurazzi","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib115","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/FPC.0b013e32830500a1","article-title":"Modest reactivation of the mutant FMR1 gene by valproic acid is accompanied by histone modifications but not DNA demethylation","volume":"18","author":"Tabolacci","year":"2008","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.biopsych.2021.11.021_bib116","first-page":"180","article-title":"Molecular analysis of FMR1 reactivation in fragile-X induced pluripotent stem cells and their neuronal derivatives","volume":"4","author":"Bar-Nur","year":"2012","journal-title":"J\u00a0Mol Cell Biol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib117","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s11689-019-9267-z","article-title":"In the line-up: Deleted genes associated with DiGeorge\/22q11.2 deletion syndrome: are they all suspects?","volume":"11","author":"Motahari","year":"2019","journal-title":"J\u00a0Neurodev Disord"},{"key":"10.1016\/j.biopsych.2021.11.021_bib118","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2021.11.021_bib119","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1523\/JNEUROSCI.4225-08.2009","article-title":"MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome","volume":"29","author":"Adachi","year":"2009","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib120","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4161\/epi.1.1.2339","article-title":"Dynamic changes in histone H3 lysine 9 acetylation localization patterns during neuronal maturation require MeCP2","volume":"1","author":"Thatcher","year":"2006","journal-title":"Epigenetics"},{"key":"10.1016\/j.biopsych.2021.11.021_bib121","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00109-014-1202-x","article-title":"MeCP2 deficiency is associated with reduced levels of tubulin acetylation and can be restored using HDAC6 inhibitors","volume":"93","author":"Gold","year":"2015","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.biopsych.2021.11.021_bib122","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/hmg\/10.10.1085","article-title":"MECP2 truncating mutations cause histone H4 hyperacetylation in Rett syndrome","volume":"10","author":"Wan","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2021.11.021_bib123","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/ajmg.a.30764","article-title":"Mutation analysis of the HDAC 1, 2, 8 and CDKL5 genes in Rett syndrome patients without mutations in MECP2","volume":"137","author":"Huppke","year":"2005","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.biopsych.2021.11.021_bib124","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4161\/epi.5.1.10630","article-title":"MeCP2 deficiency downregulates specific nuclear proteins that could be partially recovered by valproic acid in vitro","volume":"5","author":"Vecsler","year":"2010","journal-title":"Epigenetics"},{"key":"10.1016\/j.biopsych.2021.11.021_bib125","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fncel.2014.00068","article-title":"A\u00a0selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: Implications for Rett syndrome","volume":"8","author":"Xu","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib126","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.yexcr.2018.05.001","article-title":"iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated \u03b1-tubulin defect which improves after iHDAC6 treatment in Rett syndrome","volume":"368","author":"Landucci","year":"2018","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.biopsych.2021.11.021_bib127","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/brain\/awx364","article-title":"A\u00a0novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target","volume":"141","author":"Ibhazehiebo","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2021.11.021_bib128","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1124\/jpet.117.244939","article-title":"Epigenetic histone deacetylation inhibition prevents the development and persistence of temporal lobe epilepsy","volume":"364","author":"Reddy","year":"2018","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.biopsych.2021.11.021_bib129","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s12035-019-01712-8","article-title":"Effects of histone deacetylase inhibitors on the development of epilepsy and psychiatric comorbidity in WAG\/Rij rats","volume":"57","author":"Citraro","year":"2020","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib130","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12868-016-0264-9","article-title":"Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4\/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation","volume":"17","author":"Hu","year":"2016","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib131","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1523\/JNEUROSCI.1001-12.2013","article-title":"Loss of histone deacetylase 2 improves working memory and accelerates extinction learning","volume":"33","author":"Morris","year":"2013","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib132","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jpsychires.2012.01.026","article-title":"Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene","volume":"46","author":"Fujita","year":"2012","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.biopsych.2021.11.021_bib133","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.biopsych.2011.12.012","article-title":"Increasing histone acetylation in the hippocampus-infralimbic network enhances fear extinction","volume":"72","author":"Stafford","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2021.11.021_bib134","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1037\/0735-7044.121.5.1125","article-title":"Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction","volume":"121","author":"Lattal","year":"2007","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.biopsych.2021.11.021_bib135","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1101\/lm.801108","article-title":"The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear","volume":"15","author":"Bredy","year":"2008","journal-title":"Learn Mem"},{"key":"10.1016\/j.biopsych.2021.11.021_bib136","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.neuropharm.2012.06.001","article-title":"Deep brain stimulation, histone deacetylase inhibitors and glutamatergic drugs rescue resistance to fear extinction in a genetic mouse model","volume":"64","author":"Whittle","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopsych.2021.11.021_bib137","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1101\/lm.500907","article-title":"Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear","volume":"14","author":"Bredy","year":"2007","journal-title":"Learn Mem"},{"key":"10.1016\/j.biopsych.2021.11.021_bib138","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.physbeh.2016.02.032","article-title":"Social isolation mediated anxiety like behavior is associated with enhanced expression and regulation of BDNF in the female mouse brain","volume":"158","author":"Kumari","year":"2016","journal-title":"Physiol Behav"},{"key":"10.1016\/j.biopsych.2021.11.021_bib139","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/ijnp\/pyz004","article-title":"Epigenetic mechanisms within the cingulate cortex regulate innate anxiety-like behavior","volume":"22","author":"Sah","year":"2019","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib140","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1016\/j.celrep.2016.08.004","article-title":"Tcf4 regulates synaptic plasticity, DNA methylation, and memory function","volume":"16","author":"Kennedy","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.biopsych.2021.11.021_bib141","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/s41467-019-13918-4","article-title":"Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome","volume":"11","author":"Cooper","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2021.11.021_bib142","doi-asserted-by":"crossref","first-page":"256ra135","DOI":"10.1126\/scitranslmed.3009278","article-title":"Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome","volume":"6","author":"Bjornsson","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.biopsych.2021.11.021_bib143","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/ajmg.a.36759","article-title":"A\u00a0new syndrome of intellectual disability with dysmorphism due to TBL1XR1 deletion","volume":"167A","author":"Pons","year":"2015","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.biopsych.2021.11.021_bib144","doi-asserted-by":"crossref","first-page":"pyv004","DOI":"10.1093\/ijnp\/pyv004","article-title":"Aberrant monoaminergic system in thyroid hormone receptor-\u03b2 deficient mice as a model of attention-deficit\/hyperactivity disorder","volume":"18","author":"Ookubo","year":"2015","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib145","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jpsychires.2015.03.006","article-title":"Multiple epigenetic factors predict the attention deficit\/hyperactivity disorder among the Chinese Han children","volume":"64","author":"Xu","year":"2015","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.biopsych.2021.11.021_bib146","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001839","article-title":"A\u00a0novel protein, CHRONO, functions as a core component of the mammalian circadian clock","volume":"12","author":"Goriki","year":"2014","journal-title":"PLoS Biol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib147","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1126\/science.1196766","article-title":"A\u00a0molecular mechanism for circadian clock negative feedback","volume":"332","author":"Duong","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2021.11.021_bib148","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nsmb.2746","article-title":"Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes","volume":"21","author":"Duong","year":"2014","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib149","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.1128\/MCB.24.14.6278-6287.2004","article-title":"Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation","volume":"24","author":"Naruse","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.biopsych.2021.11.021_bib150","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature01314","article-title":"Rhythmic histone acetylation underlies transcription in the mammalian circadian clock","volume":"421","author":"Etchegaray","year":"2003","journal-title":"Nature"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322321018321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322321018321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:07:21Z","timestamp":1762099641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322321018321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":150,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0006322321018321"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2021.11.021","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetics of Autism Spectrum Disorder: Histone Deacetylases","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2021.11.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}