{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:17:44Z","timestamp":1792664264685,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"am","delay-in-days":333,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100017970","name":"Alzheimer's Disease Research Center, University of Pittsburgh","doi-asserted-by":"publisher","award":["P30AG066507"],"award-info":[{"award-number":["P30AG066507"]}],"id":[{"id":"10.13039\/100017970","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG065169"],"award-info":[{"award-number":["AG065169"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH053608"],"award-info":[{"award-number":["MH053608"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS097966"],"award-info":[{"award-number":["NS097966"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["27824"],"award-info":[{"award-number":["27824"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.biopsych.2023.02.008","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T15:23:07Z","timestamp":1676388187000},"page":"706-720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["NMDA Receptor\u2013Arc Signaling Is Required for Memory Updating and Is Disrupted in Alzheimer\u2019s Disease"],"prefix":"10.1016","volume":"94","author":[{"given":"Liuqing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-An","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Redding-Ochoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Kirkwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena V.","family":"Savonenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Worley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2023.02.008_bib1","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/hipo.23213","article-title":"The history of long-term potentiation as a memory mechanism: Controversies, confirmation, and some lessons to remember","volume":"30","author":"Dringenberg","year":"2020","journal-title":"Hippocampus"},{"key":"10.1016\/j.biopsych.2023.02.008_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw4325","article-title":"Memory engrams: Recalling the past and imagining the future","volume":"367","author":"Josselyn","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2023.02.008_bib3","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2016.0260","article-title":"Glutamatergic synapses are structurally and biochemically complex because of multiple plasticity processes: Long-term potentiation, long-term depression, short-term potentiation and scaling","volume":"372","author":"Lisman","year":"2017","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"10.1016\/j.biopsych.2023.02.008_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/nrn2356","article-title":"Metaplasticity: Tuning synapses and networks for plasticity","volume":"9","author":"Abraham","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2023.02.008_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fnmol.2014.00012","article-title":"Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders","volume":"7","author":"Gross","year":"2014","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.biopsych.2023.02.008_bib6","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1128\/MCB.15.8.4453","article-title":"The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase","volume":"15","author":"Pons","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.biopsych.2023.02.008_bib7","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1037\/a0015568","article-title":"Delaying interference enhances memory consolidation in amnesic patients","volume":"23","author":"Dewar","year":"2009","journal-title":"Neuropsychology"},{"key":"10.1016\/j.biopsych.2023.02.008_bib8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bandc.2011.12.005","article-title":"Insights into spared memory capacity in amnestic MCI and Alzheimer\u2019s disease via minimal interference","volume":"78","author":"Dewar","year":"2012","journal-title":"Brain Cogn"},{"key":"10.1016\/j.biopsych.2023.02.008_bib9","doi-asserted-by":"crossref","first-page":"48108","DOI":"10.1074\/jbc.M106388200","article-title":"Characterization of the mechanism underlying the reversal of long term potentiation by low frequency stimulation at hippocampal CA1 synapses","volume":"276","author":"Huang","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.biopsych.2023.02.008_bib10","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1523\/JNEUROSCI.0878-15.2016","article-title":"Metabotropic glutamate receptors induce a form of LTP controlled by translation and Arc signaling in the hippocampus","volume":"36","author":"Wang","year":"2016","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2023.02.008_bib11","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.neuron.2015.03.030","article-title":"Structural basis of Arc binding to synaptic proteins: Implications for cognitive disease","volume":"86","author":"Zhang","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2023.02.008_bib12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.neuron.2006.08.033","article-title":"Arc\/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking","volume":"52","author":"Chowdhury","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2023.02.008_bib13","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1126\/science.1150799","article-title":"The structure of a human p110\u03b1\/p85\u03b1 complex elucidates the effects of oncogenic PI3K\u03b1 mutations","volume":"318","author":"Huang","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2023.02.008_bib14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1126\/science.1135394","article-title":"Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit","volume":"317","author":"Miled","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2023.02.008_bib15","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cell.2017.07.029","article-title":"The PI3K pathway in human disease","volume":"170","author":"Fruman","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2023.02.008_bib16","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.cub.2006.08.001","article-title":"mSin1 is necessary for Akt\/PKB phosphorylation, and its isoforms define three distinct mTORC2s","volume":"16","author":"Frias","year":"2006","journal-title":"Curr Biol"},{"key":"10.1016\/j.biopsych.2023.02.008_bib17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cell.2006.08.033","article-title":"SIN1\/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity","volume":"127","author":"Jacinto","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2023.02.008_bib18","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1158\/2159-8290.CD-15-0460","article-title":"PtdIns(3,4,5)P3-dependent activation of the mTORC2 kinase complex","volume":"5","author":"Liu","year":"2015","journal-title":"Cancer Discov"},{"key":"10.1016\/j.biopsych.2023.02.008_bib19","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1046\/j.1471-4159.2002.01031.x","article-title":"Activity-dependent NMDA receptor-mediated activation of protein kinase B\/Akt in cortical neuronal cultures","volume":"82","author":"Sutton","year":"2002","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.biopsych.2023.02.008_bib20","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1523\/JNEUROSCI.3607-06.2007","article-title":"Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis","volume":"27","author":"Chen","year":"2007","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2023.02.008_bib21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molcel.2019.05.004","article-title":"Arc oligomerization is regulated by CaMKII phosphorylation of the GAG domain: An essential mechanism for plasticity and memory formation","volume":"75","author":"Zhang","year":"2019","journal-title":"Mol Cell"},{"key":"10.1016\/j.biopsych.2023.02.008_bib22","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1002\/cpim.58","article-title":"Proximity ligation assay (PLA)","volume":"123","author":"Alam","year":"2018","journal-title":"Curr Protoc Immunol"},{"key":"10.1016\/j.biopsych.2023.02.008_bib23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41592-020-0760-9","article-title":"Rapid mesoscale volumetric imaging of neural activity with synaptic resolution","volume":"17","author":"Lu","year":"2020","journal-title":"Nat Methods"},{"key":"10.1016\/j.biopsych.2023.02.008_bib24","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/16046","article-title":"Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles","volume":"2","author":"Guzowski","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2023.02.008_bib25","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.neuron.2020.04.023","article-title":"Cortical observation by synchronous multifocal optical sampling reveals widespread population encoding of actions","volume":"107","author":"Kauvar","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2023.02.008_bib26","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuron.2007.01.029","article-title":"LTP inhibits LTD in the hippocampus via regulation of GSK3beta","volume":"53","author":"Peineau","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2023.02.008_bib27","doi-asserted-by":"crossref","DOI":"10.1177\/2398212820948686","article-title":"Na\u00efve to expert: Considering the role of previous knowledge in memory","volume":"4","author":"Alonso","year":"2020","journal-title":"Brain Neurosci Adv"},{"key":"10.1016\/j.biopsych.2023.02.008_bib28","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.tins.2018.08.006","article-title":"Memory, novelty and prior knowledge","volume":"41","author":"Fern\u00e1ndez","year":"2018","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.biopsych.2023.02.008_bib29","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jalz.2007.08.005","article-title":"Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD): The first twenty years","volume":"4","author":"Fillenbaum","year":"2008","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.biopsych.2023.02.008_bib30","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.biopsych.2023.02.008_bib31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nrn2963","article-title":"Making memories last: The synaptic tagging and capture hypothesis","volume":"12","author":"Redondo","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2023.02.008_bib32","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.cell.2012.02.062","article-title":"Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc\/Arg3.1 with CaMKII\u03b2","volume":"149","author":"Okuno","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2023.02.008_bib33","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0896-6273(00)80591-7","article-title":"Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites","volume":"21","author":"Steward","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2023.02.008_bib34","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.neuron.2016.06.017","article-title":"Real-time imaging reveals properties of glutamate-induced Arc\/Arg 3.1 translation in neuronal dendrites","volume":"91","author":"Na","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2023.02.008_bib35","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.cell.2013.07.001","article-title":"A\u00a0prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization","volume":"154","author":"Park","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2023.02.008_bib36","doi-asserted-by":"crossref","first-page":"10067","DOI":"10.1523\/JNEUROSCI.22-23-10067.2002","article-title":"Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks","volume":"22","author":"Vazdarjanova","year":"2002","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2023.02.008_bib37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.brainres.2015.06.037","article-title":"Homer 1a and mGluR5 phosphorylation in reward-sensitive metaplasticity: A hypothesis of neuronal selection and bidirectional synaptic plasticity","volume":"1628","author":"Marton","year":"2015","journal-title":"Brain Res"},{"key":"10.1016\/j.biopsych.2023.02.008_bib38","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tics.2013.01.001","article-title":"Decay happens: The role of active forgetting in memory","volume":"17","author":"Hardt","year":"2013","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.biopsych.2023.02.008_bib39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature08637","article-title":"Preventing the return of fear in humans using reconsolidation update mechanisms","volume":"463","author":"Schiller","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2023.02.008_bib40","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev.psych.093008.100523","article-title":"Hippocampal-neocortical interactions in memory formation, consolidation, and reconsolidation","volume":"61","author":"Wang","year":"2010","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.biopsych.2023.02.008_bib41","doi-asserted-by":"crossref","first-page":"E10313","DOI":"10.1073\/pnas.1800755115","article-title":"Comparing continual task learning in minds and machines","volume":"115","author":"Flesch","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biopsych.2023.02.008_bib42","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neunet.2020.05.011","article-title":"Progressive learning: A deep learning framework for continual learning","volume":"128","author":"Fayek","year":"2020","journal-title":"Neural Netw"},{"key":"10.1016\/j.biopsych.2023.02.008_bib43","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/s41593-020-0652-4","article-title":"Memory trace interference impairs recall in a mouse model of Alzheimer\u2019s disease","volume":"23","author":"Poll","year":"2020","journal-title":"Nat Neurosci"}],"updated-by":[{"DOI":"10.1016\/j.biopsych.2023.08.012","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000}}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322323000823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322323000823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:19:50Z","timestamp":1757776790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322323000823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S0006322323000823"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2023.02.008","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.biopsych.2023.08.012","asserted-by":"object"}]},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NMDA Receptor\u2013Arc Signaling Is Required for Memory Updating and Is Disrupted in Alzheimer\u2019s Disease","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2023.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}