{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:34:20Z","timestamp":1790174060225,"version":"4.1.0"},"reference-count":155,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005310","name":"Klarman Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH118278"],"award-info":[{"award-number":["R01MH118278"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH124839"],"award-info":[{"award-number":["R01MH124839"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES033630"],"award-info":[{"award-number":["R01ES033630"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","biologicalpsychiatryjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.biopsych.2023.08.023","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T08:01:16Z","timestamp":1694246476000},"page":"745-761","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Genetically Regulated Gene Expression in the Brain Associated With Chronic Pain: Relationships With Clinical Traits and Potential for Drug Repurposing"],"prefix":"10.1016","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1370-3149","authenticated-orcid":false,"given":"Keira J.A.","family":"Johnston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna C.","family":"Cote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Huckins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2023.08.023_bib1","doi-asserted-by":"crossref","first-page":"e273","DOI":"10.1016\/j.bja.2019.03.023","article-title":"Chronic pain: A review of its epidemiology and associated factors in population-based studies","volume":"123","author":"Mills","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.biopsych.2023.08.023_bib2","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.biopsych.2023.08.023_bib3","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1097\/j.pain.0000000000000676","article-title":"The epidemiology of chronic pain","volume":"157","author":"Macfarlane","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s40122-020-00170-8","article-title":"Lessons for better pain management in the future: Learning from the past","volume":"9","author":"Manchikanti","year":"2020","journal-title":"Pain Ther"},{"key":"10.1016\/j.biopsych.2023.08.023_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008164","article-title":"Genome-wide association study of multisite chronic pain in UK Biobank","volume":"15","author":"Johnston","year":"2019","journal-title":"PLoS Genet"},{"key":"10.1016\/j.biopsych.2023.08.023_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s42003-020-1051-9","article-title":"Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain conditions","volume":"3","author":"Tsepilov","year":"2020","journal-title":"Commun Biol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib7","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1136\/annrheumdis-2020-219624","article-title":"Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain","volume":"80","author":"Rahman","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.biopsych.2023.08.023_bib8","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1136\/annrheumdis-2020-219065","article-title":"Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 novel susceptibility loci","volume":"80","author":"Ha","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.biopsych.2023.08.023_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15539","article-title":"Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism","volume":"8","author":"Sapkota","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2023.08.023_bib10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41588-021-00990-0","article-title":"Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles","volume":"54","author":"Hautakangas","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2023.08.023_bib11","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1097\/j.pain.0000000000002726","article-title":"Omics approaches to discover pathophysiological pathways contributing to human pain","volume":"163","author":"Diatchenko","year":"2022","journal-title":"Pain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib12","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ng.3367","article-title":"A\u00a0gene-based association method for mapping traits using reference transcriptome data","volume":"47","author":"Gamazon","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2023.08.023_bib13","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1038\/s41467-018-03621-1","article-title":"Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics [no. 1]","volume":"9","author":"Barbeira","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2023.08.023_bib14","article-title":"From GWAS to gene: Transcriptome-wide association studies and other methods to functionally understand GWAS discoveries","volume":"12","author":"Li","year":"2021","journal-title":"Front Genet"},{"key":"10.1016\/j.biopsych.2023.08.023_bib15","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41588-019-0385-z","article-title":"Opportunities and challenges for transcriptome-wide association studies","volume":"51","author":"Wainberg","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2023.08.023_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106133","article-title":"Functional reorganization of the default mode network across chronic pain conditions","volume":"9","author":"Baliki","year":"2014","journal-title":"PLoS One"},{"issue":"suppl","key":"10.1016\/j.biopsych.2023.08.023_bib17","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/j.pain.2010.11.010","article-title":"Pain and the brain: Specificity and plasticity of the brain in clinical chronic pain","volume":"152","author":"Apkarian","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib18","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1093\/brain\/awt211","article-title":"Shape shifting pain: Chronification of back pain shifts brain representation from nociceptive to emotional circuits","volume":"136","author":"Hashmi","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrn.2016.162","article-title":"Structural plasticity and reorganisation in chronic pain","volume":"18","author":"Kuner","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2023.08.023_bib20","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1093\/brain\/awab334","article-title":"Genetic basis to structural grey matter associations with chronic pain","volume":"144","author":"Farrell","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib21","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/brain\/awab359","article-title":"Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions","volume":"145","author":"Khoury","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib22","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41588-018-0092-1","article-title":"Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights","volume":"50","author":"Gusev","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2023.08.023_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddz253","article-title":"A\u00a0transcriptome-wide association study implicates specific pre- and post-synaptic abnormalities in schizophrenia","volume":"29","author":"Hall","year":"2020","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2023.08.023_bib24","doi-asserted-by":"crossref","DOI":"10.1172\/JCI141801","article-title":"Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis","volume":"131","author":"Doke","year":"2021","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.biopsych.2023.08.023_bib25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/ecco-jcc\/jjab131","article-title":"Transcriptome-wide association study for inflammatory bowel disease reveals novel candidate susceptibility genes in specific colon subsites and tissue categories","volume":"16","author":"D\u00edez-Obrero","year":"2022","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.biopsych.2023.08.023_bib26","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3389\/fgene.2019.00318","article-title":"A\u00a0convergent study of genetic variants associated with Crohn\u2019s disease: Evidence from GWAS, gene expression, methylation, eQTL and TWAS","volume":"10","author":"Dai","year":"2019","journal-title":"Front Genet"},{"key":"10.1016\/j.biopsych.2023.08.023_bib27","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1136\/annrheumdis-2022-222345","article-title":"Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study","volume":"81","author":"Yin","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.biopsych.2023.08.023_bib28","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1176\/appi.ajp.2019.18091085","article-title":"Penetrance and pleiotropy of polygenic risk scores for schizophrenia in 106,160 patients across four health care systems","volume":"176","author":"Zheutlin","year":"2019","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2023.08.023_bib29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000527022","article-title":"Thoughtful phenotype definitions empower participants and power studies","volume":"8","author":"Huckins","year":"2023","journal-title":"Complex Psychiatry"},{"key":"10.1016\/j.biopsych.2023.08.023_bib30","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1136\/jmedgenet-2021-107696","article-title":"Methodology in phenome-wide association studies: A systematic review","volume":"58","author":"Wang","year":"2021","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.biopsych.2023.08.023_bib31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/art.39851","article-title":"Phenome-wide association study of rheumatoid arthritis subgroups identifies association between seronegative disease and fibromyalgia","volume":"69","author":"Doss","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib32","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1038\/s41380-021-01335-3","article-title":"Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry","volume":"26","author":"Sanchez-Roige","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2023.08.023_bib33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/j.pain.0000000000001390","article-title":"The IASP classification of chronic pain for ICD-11: Chronic primary pain","volume":"160","author":"Nicholas","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/j.pain.0000000000001384","article-title":"Chronic pain as a symptom or a disease: The IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)","volume":"160","author":"Treede","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004219","article-title":"MAGMA: Generalized gene-set analysis of GWAS data","volume":"11","author":"de Leeuw","year":"2015","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib37","first-page":"1318","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","year":"2020"},{"key":"10.1016\/j.biopsych.2023.08.023_bib38","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng.3506","article-title":"Integrative approaches for large-scale transcriptome-wide association studies","volume":"48","author":"Gusev","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2023.08.023_bib39","article-title":"The genetic architecture of pain intensity in a sample of 598,339 U.S. veterans","author":"Toikumo","year":"2023","journal-title":"medRxiv"},{"key":"10.1016\/j.biopsych.2023.08.023_bib40","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","article-title":"Functional mapping and annotation of genetic associations with FUMA","volume":"8","author":"Watanabe","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2023.08.023_bib41","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2023.08.023_bib42","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A\u00a0next generation connectivity map: L1000 platform and the first 1,000,000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2023.08.023_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-biodatasci-122320-112352","article-title":"Using phecodes for research with the electronic health record: From PheWAS to PheRS","volume":"4","author":"Bastarache","year":"2021","journal-title":"Annu Rev Biomed Data Sci"},{"key":"10.1016\/j.biopsych.2023.08.023_bib44","doi-asserted-by":"crossref","DOI":"10.2196\/14325","article-title":"Mapping ICD-10 and ICD-10-CM codes to phecodes: Workflow development and initial evaluation","volume":"7","author":"Wu","year":"2019","journal-title":"JMIR Med Inform"},{"key":"10.1016\/j.biopsych.2023.08.023_bib45","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: Fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.biopsych.2023.08.023_bib46","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1017\/S0033291721004554","article-title":"Mapping anorexia nervosa genes to clinical phenotypes","volume":"53","author":"Johnson","year":"2022","journal-title":"Psychol Med"},{"key":"10.1016\/j.biopsych.2023.08.023_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e04115","article-title":"Molecular characterisation of ILRUN, a novel inhibitor of proinflammatory and antimicrobial cytokines","volume":"6","author":"Ambrose","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.biopsych.2023.08.023_bib48","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00327-21","article-title":"ILRUN downregulates ACE2 expression and blocks infection of human cells by SARS-CoV-2","volume":"95","author":"Tribolet","year":"2021","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib49","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1586\/14737175.2016.1150179","article-title":"The therapeutic potential of renin angiotensin aldosterone system (RAAS) in chronic pain: From preclinical studies to clinical trials","volume":"16","author":"Bessaguet","year":"2016","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.biopsych.2023.08.023_bib50","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/nyas.13061","article-title":"Assessment and treatment of pain in thalassemia","volume":"1368","author":"Lal","year":"2016","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.biopsych.2023.08.023_bib51","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/ajh.24820","article-title":"Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis, and management","volume":"92","author":"Cappellini","year":"2017","journal-title":"Am J Hematol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib52","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fmolb.2019.00116","article-title":"The role of iron regulation in immunometabolism and immune-related disease","volume":"6","author":"Cronin","year":"2019","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.biopsych.2023.08.023_bib53","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3390\/ph11040137","article-title":"Iron regulation: Macrophages in control","volume":"11","author":"Sukhbaatar","year":"2018","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.biopsych.2023.08.023_bib54","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nature08853","article-title":"Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells","volume":"464","author":"Kinchen","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2023.08.023_bib55","article-title":"Autoimmune regulation of chronic pain","volume":"6","author":"Lacagnina","year":"2021","journal-title":"PAIN Rep"},{"key":"10.1016\/j.biopsych.2023.08.023_bib56","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/cr.2016.34","article-title":"Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b","volume":"26","author":"Shao","year":"2016","journal-title":"Cell Res"},{"key":"10.1016\/j.biopsych.2023.08.023_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/srep35456","article-title":"Dynamics of the mouse brain cortical synaptic proteome during postnatal brain development","volume":"6","author":"Gonzalez-Lozano","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopsych.2023.08.023_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046199","article-title":"Evaluation of Parkinson disease risk variants as expression-QTLs","volume":"7","author":"Latourelle","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2023.08.023_bib59","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/s41467-020-15932-3","article-title":"Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants","volume":"11","author":"Persyn","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2023.08.023_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0223209","article-title":"Potential biomarker identification for Friedreich\u2019s ataxia using overlapping gene expression patterns in patient cells and mouse dorsal root ganglion","volume":"14","author":"McMackin","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2023.08.023_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4330\/wjc.v11.i1.1","article-title":"Heart disease in Friedreich\u2019s ataxia","volume":"11","author":"Hanson","year":"2019","journal-title":"World J Cardiol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib63","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S0954579401002012","article-title":"Vagal tone, development, and gray\u2019s motivational theory: Toward an integrated model of autonomic nervous system functioning in psychopathology","volume":"13","author":"Beauchaine","year":"2001","journal-title":"Dev Psychopathol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib64","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/AJP.0000000000000242","article-title":"Chronic pain and heart rate variability in a cross-sectional occupational sample: Evidence for impaired vagal control","volume":"32","author":"Koenig","year":"2016","journal-title":"Clin J Pain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib65","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/pm\/pnaa445","article-title":"An alternative role for the pain physician: Utilization of stellate block for treatment resistant cardiac arrhythmias","volume":"22","author":"Deshpande","year":"2021","journal-title":"Pain Med"},{"key":"10.1016\/j.biopsych.2023.08.023_bib66","doi-asserted-by":"crossref","first-page":"8621","DOI":"10.1073\/pnas.1801196115","article-title":"Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production","volume":"115","author":"He","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biopsych.2023.08.023_bib67","series-title":"Textbook of Aging Skin","first-page":"91","article-title":"The extracellular matrix Protein 1 (ECM1) in molecular-based skin biology","author":"Oyama","year":"2017"},{"key":"10.1016\/j.biopsych.2023.08.023_bib68","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/2047487319886404","article-title":"The metabolic syndrome \u2013 What is it and how should it be managed?","volume":"26","author":"Nilsson","year":"2019","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib69","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1210\/er.2008-0024","article-title":"The metabolic syndrome","volume":"29","author":"Cornier","year":"2008","journal-title":"Endocr Rev"},{"key":"10.1016\/j.biopsych.2023.08.023_bib70","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5223\/pghn.2020.23.3.189","article-title":"Novel insights into the pathogenesis and management of the metabolic syndrome","volume":"23","author":"Wang","year":"2020","journal-title":"Pediatr Gastroenterol Hepatol Nutr"},{"key":"10.1016\/j.biopsych.2023.08.023_bib71","doi-asserted-by":"crossref","first-page":"eaai7616","DOI":"10.1126\/sciimmunol.aai7616","article-title":"Type I interferon responses drive intrahepatic T cells to promote metabolic syndrome","volume":"2","author":"Ghazarian","year":"2017","journal-title":"Sci Immunol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib72","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.coi.2010.05.002","article-title":"Metabolic syndrome, hormones, and maintenance of T cells during aging","volume":"22","author":"Hsu","year":"2010","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib73","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/xJAHA.111.000125","article-title":"Effector Memory T cells Are Associated with Atherosclerosis in Humans and Animal Models","volume":"1","author":"Ammirati","year":"2012","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.biopsych.2023.08.023_bib74","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3389\/fnmol.2019.00216","article-title":"T\u00a0cells as an emerging target for chronic pain therapy","volume":"12","author":"Laumet","year":"2019","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.biopsych.2023.08.023_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.641588","article-title":"Role of peripheral immune cells for development and recovery of chronic pain","volume":"12","author":"Bethea","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib76","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12974-019-1684-0","article-title":"MHCII-restricted T helper cells: An emerging trigger for chronic tactile allodynia after nerve injuries","volume":"17","author":"Ding","year":"2020","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.biopsych.2023.08.023_bib77","article-title":"The role of T-lymphocytes in neuropathic pain initiation, development of chronicity and treatment","volume":"18","author":"Galvin","year":"2021","journal-title":"Brain Behav Immun Health"},{"key":"10.1016\/j.biopsych.2023.08.023_bib78","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/jnr.23841","article-title":"Sex differences in pain","volume":"95","author":"Sorge","year":"2017","journal-title":"J\u00a0Neurosci Res"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2023.08.023_bib79","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1097\/j.pain.0000000000000389","article-title":"Sex differences in pain: A tale of two immune cells","volume":"157","author":"Mapplebeck","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib80","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13783","article-title":"PACSIN proteins in\u00a0vivo: Roles in development and physiology","volume":"234","author":"Dumont","year":"2022","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.biopsych.2023.08.023_bib81","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejpn.2021.03.011","article-title":"Natural history of TRPV4-Related disorders: From skeletal dysplasia to neuromuscular phenotype","volume":"32","author":"\u00dcrel-Demir","year":"2021","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib82","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.3390\/ijms22063065","article-title":"The role of TRPA1 in skin physiology and pathology","volume":"22","author":"Maglie","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.biopsych.2023.08.023_bib83","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.3390\/ijms22147591","article-title":"Emerging role of transient receptor potential vanilloid 4 (TRPV4) ion channel in acute and chronic itch","volume":"22","author":"Zhang","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.biopsych.2023.08.023_bib84","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.it.2018.10.001","article-title":"The itch\u2013scratch cycle: A neuroimmune perspective","volume":"39","author":"Mack","year":"2018","journal-title":"Trends Immunol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib85","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00424-020-02460-8","article-title":"TRPV4 and TRPM8 as putative targets for chronic low back pain alleviation","volume":"473","author":"Fozzato","year":"2021","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.biopsych.2023.08.023_bib86","article-title":"Analgesic effect of electroacupuncture in a mouse fibromyalgia model: Roles of TRPV1, TRPV4, and pERK","volume":"10","author":"Lin","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biopsych.2023.08.023_bib87","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00210-014-1078-x","article-title":"TRPV4 as a therapeutic target for joint diseases","volume":"388","author":"McNulty","year":"2015","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib88","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jaci.2020.02.013","article-title":"Autoimmune bullous skin diseases, pemphigus and pemphigoid","volume":"145","author":"Egami","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib89","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1749-6632.2009.04737.x","article-title":"Autoimmune bullous dermatoses: A review","volume":"1173","author":"Patr\u00edcio","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.biopsych.2023.08.023_bib90","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.3389\/fimmu.2019.01477","article-title":"Complement activation in autoimmune bullous dermatoses: A comprehensive review","volume":"10","author":"Edwards","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib91","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.3389\/fimmu.2019.01974","article-title":"Serological diagnosis of autoimmune bullous skin diseases","volume":"10","author":"Saschenbrecker","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib92","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/ijd.14678","article-title":"Pain and pruritus: A study of their similarities and differences","volume":"59","author":"Anzelc","year":"2020","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib93","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.3390\/cancers13122930","article-title":"Regulation of RAD51 at the transcriptional and functional levels: What prospects for cancer therapy?","volume":"13","author":"Orhan","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.biopsych.2023.08.023_bib94","doi-asserted-by":"crossref","first-page":"E6045","DOI":"10.1073\/pnas.1604807113","article-title":"Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics","volume":"113","author":"Subramanyam","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biopsych.2023.08.023_bib95","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ajhg.2011.12.002","article-title":"RAD51 haploinsufficiency causes congenital mirror movements in humans","volume":"90","author":"Depienne","year":"2012","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2023.08.023_bib96","doi-asserted-by":"crossref","first-page":"zcaa024","DOI":"10.1093\/narcan\/zcaa024","article-title":"Regulation and pharmacological targeting of RAD51 in cancer","volume":"2","author":"Grundy","year":"2020","journal-title":"NAR Cancer"},{"key":"10.1016\/j.biopsych.2023.08.023_bib97","series-title":"Medical Genetics Summaries","article-title":"Methylenetetrahydrofolate reductase deficiency","author":"Dean","year":"2012"},{"key":"10.1016\/j.biopsych.2023.08.023_bib98","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.leukres.2006.01.016","article-title":"Influence of genetic polymorphisms on the risk of developing leukemia and on disease progression","volume":"30","author":"Bolufer","year":"2006","journal-title":"Leuk Res"},{"key":"10.1016\/j.biopsych.2023.08.023_bib99","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3988\/jcn.2014.10.4.281","article-title":"Hyperhomocysteinemia and neurologic disorders: A review","volume":"10","author":"Ansari","year":"2014","journal-title":"J\u00a0Clin Neurol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib100","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1083\/jcb.201406099","article-title":"Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells","volume":"208","author":"Zellweger","year":"2015","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib101","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.15252\/emmm.201404824","article-title":"Folate levels modulate oncogene-induced replication stress and tumorigenicity","volume":"7","author":"Lamm","year":"2015","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.biopsych.2023.08.023_bib102","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1097\/j.pain.0000000000001669","article-title":"A\u00a0potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy","volume":"160","author":"Gaifullina","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib103","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/ncb1862","article-title":"SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of \u03b21-integrin","volume":"11","author":"Brandt","year":"2009","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib104","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbrc.2014.04.098","article-title":"Downregulation of SCAI enhances glioma cell invasion and stem cell like phenotype by activating Wnt\/\u03b2-catenin signaling","volume":"448","author":"Chen","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biopsych.2023.08.023_bib105","first-page":"6376","article-title":"Expression profiling of spinal genes in peripheral neuropathy model rats with type 2 diabetes mellitus","volume":"9","author":"Hong","year":"2016","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.biopsych.2023.08.023_bib106","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1080\/19336950.2016.1207024","article-title":"Regulation and function of the SLC38A3\/SNAT3 glutamine transporter","volume":"10","author":"Rubio-Aliaga","year":"2016","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.biopsych.2023.08.023_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.03.003","article-title":"Exchange-mode glutamine transport across CNS cell membranes","volume":"161","author":"Albrecht","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopsych.2023.08.023_bib108","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.3390\/nu10111564","article-title":"Glutamine: Metabolism and immune function, supplementation and clinical translation","volume":"10","author":"Cruzat","year":"2018","journal-title":"Nutrients"},{"issue":"suppl","key":"10.1016\/j.biopsych.2023.08.023_bib109","first-page":"40S","article-title":"Glutamine metabolism and its physiologic importance","volume":"14","author":"Smith","year":"1990","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1016\/j.biopsych.2023.08.023_bib110","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/s12276-020-00504-8","article-title":"Glutamine reliance in cell metabolism","volume":"52","author":"Yoo","year":"2020","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.biopsych.2023.08.023_bib111","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41422-020-0379-5","article-title":"Metabolic signaling in T cells","volume":"30","author":"Shyer","year":"2020","journal-title":"Cell Res"},{"key":"10.1016\/j.biopsych.2023.08.023_bib112","series-title":"The Glutamate\/GABA-Glutamine Cycle: Amino Acid Neurotransmitter Homeostasis","first-page":"327","article-title":"Glutamine synthetase: Role in neurological disorders","author":"Jayakumar","year":"2016"},{"key":"10.1016\/j.biopsych.2023.08.023_bib113","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.665334","article-title":"Astroglial glutamine synthetase and the pathogenesis of mesial temporal lobe epilepsy","volume":"12","author":"Sandhu","year":"2021","journal-title":"Front Neurol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib114","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12199-018-0757-5","article-title":"Glutamine protects against oxidative stress injury through inhibiting the activation of PI3K\/Akt signaling pathway in parkinsonian cell model","volume":"24","author":"Zhao","year":"2019","journal-title":"Environ Health Prev Med"},{"key":"10.1016\/j.biopsych.2023.08.023_bib115","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13041-020-00658-6","article-title":"Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia","volume":"13","author":"Aldana","year":"2020","journal-title":"Mol Brain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib116","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.745159","article-title":"GABAergic gene regulatory elements used in adeno-associated viral vectors","volume":"12","author":"Duba-Kiss","year":"2021","journal-title":"Front Neurol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib117","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1001\/archneur.58.3.365","article-title":"Glutamate transporters in neurologic disease","volume":"58","author":"Maragakis","year":"2001","journal-title":"Arch Neurol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib118","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.schres.2020.02.001","article-title":"The role of glutamate and GABA in cognitive dysfunction in schizophrenia and mood disorders \u2013 A systematic review of magnetic resonance spectroscopy studies","volume":"249","author":"Reddy-Thootkur","year":"2022","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2023.08.023_bib119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-018-0261-0","article-title":"Electrophysiological evidence for abnormal glutamate-GABA association following psychosis onset","volume":"8","author":"Koshiyama","year":"2018","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2023.08.023_bib120","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1212\/WNL.0000000000005807","article-title":"Glutamatergic synaptic plasticity and dysfunction in Alzheimer disease: Emerging mechanisms","volume":"91","author":"Benarroch","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2023.08.023_bib121","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00424-010-0809-1","article-title":"Glutamate receptors, neurotoxicity and neurodegeneration","volume":"460","author":"Lau","year":"2010","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.biopsych.2023.08.023_bib122","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.4155\/fmc.12.122","article-title":"Glutamate transporter EAAT2: A new target for the treatment of neurodegenerative diseases","volume":"4","author":"Lin","year":"2012","journal-title":"Future Med Chem"},{"key":"10.1016\/j.biopsych.2023.08.023_bib123","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1523\/JNEUROSCI.1655-19.2020","article-title":"The relationship between glutamate dynamics and activity-dependent synaptic plasticity","volume":"40","author":"Barnes","year":"2020","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.biopsych.2023.08.023_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116532","article-title":"Brain GABA and glutamate levels across pain conditions: A systematic literature review and meta-analysis of 1H-MRS studies using the MRS-Q quality assessment tool","volume":"210","author":"Peek","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2023.08.023_bib125","doi-asserted-by":"crossref","first-page":"e952","DOI":"10.1097\/PR9.0000000000000952","article-title":"Brain gamma-aminobutyric acid, but not glutamine and glutamate levels are lower in older adults with chronic musculoskeletal pain: Considerations by sex and brain location","volume":"6","author":"Cruz-Almeida","year":"2021","journal-title":"PAIN Rep"},{"key":"10.1016\/j.biopsych.2023.08.023_bib126","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/phar.2329","article-title":"Systematic Review of l-glutamine for Prevention of vaso-occlusive Pain Crisis in Patients with sickle cell disease","volume":"39","author":"Cieri-Hutcherson","year":"2019","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.biopsych.2023.08.023_bib127","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1097\/j.pain.0000000000000634","article-title":"Combined glutamate and glutamine levels in pain-processing brain regions are associated with individual pain sensitivity","volume":"157","author":"Zunhammer","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib128","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s10194-018-0885-8","article-title":"Increased thalamic glutamate\/glutamine levels in migraineurs","volume":"19","author":"Bathel","year":"2018","journal-title":"J\u00a0Headache Pain"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2023.08.023_bib129","article-title":"L-glutamine decreases opioid use in individuals with sickle cell disease and chronic pain: A case series","volume":"134","author":"Wilson","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.biopsych.2023.08.023_bib130","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s41687-018-0053-6","article-title":"Response scale selection in adult pain measures: Results from a literature review","volume":"2","author":"Safikhani","year":"2017","journal-title":"J\u00a0Patient Rep Outcomes"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2023.08.023_bib131","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1007\/s00586-005-1044-x","article-title":"Pain assessment","volume":"15","author":"Haefeli","year":"2006","journal-title":"Eur Spine J"},{"key":"10.1016\/j.biopsych.2023.08.023_bib132","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1093\/pm\/pnab110","article-title":"Associations of pain numeric rating scale scores collected during usual care with research administered patient reported pain outcomes","volume":"22","author":"Nugent","year":"2021","journal-title":"Pain Med"},{"key":"10.1016\/j.biopsych.2023.08.023_bib133","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/ner.13212","article-title":"Composite score is a better reflection of patient response to chronic pain therapy compared with pain intensity alone","volume":"24","author":"Pilitsis JG Fahey","year":"2021","journal-title":"Neuromodulation"},{"key":"10.1016\/j.biopsych.2023.08.023_bib134","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s11606-007-0321-2","article-title":"Accuracy of the pain numeric rating scale as a screening test in primary care","volume":"22","author":"Krebs","year":"2007","journal-title":"J\u00a0Gen Intern Med"},{"key":"10.1016\/j.biopsych.2023.08.023_bib135","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12916-016-0775-3","article-title":"Pain relief that matters to patients: Systematic review of empirical studies assessing the minimum clinically important difference in acute pain","volume":"15","author":"Olsen","year":"2017","journal-title":"BMC Med"},{"key":"10.1016\/j.biopsych.2023.08.023_bib136","doi-asserted-by":"crossref","first-page":"e1184","DOI":"10.1097\/j.pain.0000000000002692","article-title":"Reliability and responsivity of pain intensity scales in individuals with chronic pain","volume":"163","author":"Euasobhon","year":"2022","journal-title":"Pain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib137","doi-asserted-by":"crossref","DOI":"10.5812\/aapm.103532","article-title":"The Influence of Chronic Pain on Number Sense and Numeric Rating Scale: A prospective Cohort Study","volume":"10","author":"Majedi","year":"2020","journal-title":"Anesth Pain Med"},{"key":"10.1016\/j.biopsych.2023.08.023_bib138","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.3155","article-title":"Comparison of a pain tolerability question with the numeric rating scale for assessment of self-reported chronic pain","volume":"3","author":"Markman","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.biopsych.2023.08.023_bib139","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.12659\/MSM.911260","article-title":"Prevalence of chronic pain, particularly with neuropathic component, and its effect on overall functioning of elderly patients","volume":"25","author":"Stomp\u00f3r","year":"2019","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.biopsych.2023.08.023_bib140","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s40359-019-0366-0","article-title":"Patients with chronic pain: Evaluating depression and their quality of life in a single center study in Greece","volume":"7","author":"Rapti","year":"2019","journal-title":"BMC Psychol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib141","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fpsyt.2019.00048","article-title":"Initial evaluation of pain intensity among depressed patients as a possible mediator between depression and pain complaints","volume":"10","author":"Nitzan","year":"2019","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.biopsych.2023.08.023_bib142","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s42466-020-00057-1","volume":"2","author":"Diener","year":"2020","journal-title":"Neurol Res Pract"},{"key":"10.1016\/j.biopsych.2023.08.023_bib143","series-title":"CADTH Issues in Emerging Health Technologies","article-title":"Monoclonal antibodies to prevent migraine headaches","author":"Ibekwe","year":"2016"},{"key":"10.1016\/j.biopsych.2023.08.023_bib144","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s10194-021-01335-2","article-title":"CGRP monoclonal antibodies in migraine: An efficacy and tolerability comparison with standard prophylactic drugs","volume":"22","author":"Vandervorst","year":"2021","journal-title":"J\u00a0Headache Pain"},{"key":"10.1016\/j.biopsych.2023.08.023_bib145","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.tips.2014.05.006","article-title":"Glycine transport inhibitors for the treatment of pain","volume":"35","author":"Vandenberg","year":"2014","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.biopsych.2023.08.023_bib146","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.phrs.2016.12.019","article-title":"New approaches to target glycinergic neurotransmission for the treatment of chronic pain","volume":"116","author":"Imlach","year":"2017","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.biopsych.2023.08.023_bib147","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/1440-1681.12536","article-title":"Hypoxia inducible factor-1\u03b1 inhibition produced anti-allodynia effect and suppressed inflammatory cytokine production in early stage of mouse complex regional pain syndrome model","volume":"43","author":"Hsiao","year":"2016","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib148","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bja.2020.10.039","article-title":"Perioperative use of physostigmine to reduce opioid consumption and peri-incisional hyperalgesia: A randomised controlled trial","volume":"126","author":"Klivinyi","year":"2021","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.biopsych.2023.08.023_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113446","article-title":"TREK-1 potassium channels participate in acute and long-lasting nociceptive hypersensitivity induced by formalin in rats","volume":"413","author":"Garc\u00eda","year":"2021","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.biopsych.2023.08.023_bib150","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12958-017-0272-3","article-title":"Arcyriaflavin a, a cyclin D1\u2013cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: A potential therapeutic agent in endometriosis","volume":"15","author":"Hirakawa","year":"2017","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib151","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1573406414666180524082445","article-title":"Sorbinil, an aldose reductase inhibitor, in Fighting Against Diabetic Complications","volume":"15","author":"Huang","year":"2019","journal-title":"Med Chem"},{"key":"10.1016\/j.biopsych.2023.08.023_bib152","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113846","article-title":"Drug repurposing \u2013 A search for novel therapy for the treatment of diabetic neuropathy","volume":"156","author":"Paul","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.biopsych.2023.08.023_bib153","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/fcp.12223","article-title":"Effect of ursolic acid in attenuating chronic constriction injury-induced neuropathic pain in rats","volume":"30","author":"Bhat","year":"2016","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib154","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/bcp.13020","article-title":"Palmitoylethanolamide for the treatment of pain: Pharmacokinetics, safety and efficacy","volume":"82","author":"Gabrielsson","year":"2016","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib155","article-title":"Luteolin: A promising natural agent in management of pain in chronic conditions","volume":"4","author":"Ntalouka","year":"2023","journal-title":"Front Pain Res (Lausanne)"},{"key":"10.1016\/j.biopsych.2023.08.023_bib156","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.642820","article-title":"Modulation of pathological pain by epidermal growth factor receptor","volume":"12","author":"Borges","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.biopsych.2023.08.023_bib157","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/bioinformatics\/btw726","article-title":"cerebroViz: An R package for anatomical visualization of spatiotemporal brain data","volume":"33","author":"Bahl","year":"2017","journal-title":"Bioinformatics"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322323015548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322323015548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:42:00Z","timestamp":1715820120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322323015548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":155,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S0006322323015548"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2023.08.023","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetically Regulated Gene Expression in the Brain Associated With Chronic Pain: Relationships With Clinical Traits and Potential for Drug Repurposing","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2023.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}