{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:02:33Z","timestamp":1793232153579,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32 DA007288"],"award-info":[{"award-number":["T32 DA007288"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA062041"],"award-info":[{"award-number":["DA062041"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01 DA032708"],"award-info":[{"award-number":["R01 DA032708"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["F32 DA047845"],"award-info":[{"award-number":["F32 DA047845"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["K01 DA046513"],"award-info":[{"award-number":["K01 DA046513"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["P50 DA046373"],"award-info":[{"award-number":["P50 DA046373"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["P20 GM148302"],"award-info":[{"award-number":["P20 GM148302"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12 HD055885"],"award-info":[{"award-number":["K12 HD055885"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.biopsych.2025.06.027","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T19:21:54Z","timestamp":1751916114000},"page":"479-491","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Histone Deacetylase 5 in Prelimbic Prefrontal Cortex Limits Context-Associated Cocaine Seeking"],"prefix":"10.1016","volume":"99","author":[{"given":"Sarah M.","family":"Barry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Huebschman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek M.","family":"Devries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"McCue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Tsvetkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose Marie","family":"Akiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Limbaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan M.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M.","family":"Siemsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Berto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Scofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel D.","family":"Penrod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2025.06.027_bib1","series-title":"Drug overdose deaths in the United States, 1999\u20132020. NCHS Data Brief No. 428","author":"Hedegaard","year":"2021"},{"key":"10.1016\/j.biopsych.2025.06.027_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax1532","article-title":"The treatment of cocaine use disorder","volume":"5","author":"Kampman","year":"2019","journal-title":"Sci Adv"},{"key":"10.1016\/j.biopsych.2025.06.027_bib3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.biopsych.2018.04.009","article-title":"Cocaine self-administration alters transcriptome-wide responses in the brain's reward circuitry","volume":"84","author":"Walker","year":"2018","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2025.06.027_bib4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.brainres.2014.09.069","article-title":"Cocaine triggers epigenetic alterations in the corticostriatal circuit","volume":"1628","author":"Sadri-Vakili","year":"2015","journal-title":"Brain Res"},{"key":"10.1016\/j.biopsych.2025.06.027_bib5","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/nn.2921","article-title":"Medial prefrontal cortex as an action-outcome predictor","volume":"14","author":"Alexander","year":"2011","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib6","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.neuron.2012.12.002","article-title":"The role of medial prefrontal cortex in memory and decision making","volume":"76","author":"Euston","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2025.06.027_bib7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.31887\/DCNS.2006.8.4\/smaier","article-title":"Behavioral control, the medial prefrontal cortex, and resilience","volume":"8","author":"Maier","year":"2006","journal-title":"Dialogues Clin Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tics.2010.11.004","article-title":"Emotional processing in anterior cingulate and medial prefrontal cortex","volume":"15","author":"Etkin","year":"2011","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.brainresrev.2010.09.001","article-title":"Prefrontal cortex and drug abuse vulnerability: Translation to prevention and treatment interventions","volume":"65","author":"Perry","year":"2011","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.biopsych.2025.06.027_bib10","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nrn3119","article-title":"Dysfunction of the prefrontal cortex in addiction: Neuroimaging findings and clinical implications","volume":"12","author":"Goldstein","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.neubiorev.2003.09.003","article-title":"The medial prefrontal cortex in the rat: Evidence for a dorso-ventral distinction based upon functional and anatomical characteristics","volume":"27","author":"Heidbreder","year":"2003","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.biopsych.2025.06.027_bib12","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.tins.2004.06.006","article-title":"Putting a spin on the dorsal\u2013ventral divide of the striatum","volume":"27","author":"Voorn","year":"2004","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib13","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1093\/cercor\/bhy299","article-title":"Cell-type specific D1 dopamine receptor modulation of projection neurons and interneurons in the prefrontal cortex","volume":"29","author":"Anastasiades","year":"2018","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2025.06.027_bib14","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.neuron.2011.01.017","article-title":"Drug-evoked synaptic plasticity in addiction: From molecular changes to circuit remodeling","volume":"69","author":"L\u00fcscher","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2025.06.027_bib15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1369-1600.2012.00479.x","article-title":"Optogenetic inhibition of cocaine seeking in rats","volume":"18","author":"Stefanik","year":"2012","journal-title":"Addict Biol"},{"key":"10.1016\/j.biopsych.2025.06.027_bib16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/bs.irn.2020.12.002","article-title":"Valence processing in the PFC: Reconciling circuit-level and systems-level views","volume":"158","author":"Coley","year":"2021","journal-title":"Int Rev Neurobiol"},{"key":"10.1016\/j.biopsych.2025.06.027_bib17","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.1523\/JNEUROSCI.1045-08.2008","article-title":"Infralimbic prefrontal cortex is responsible for inhibiting cocaine seeking in extinguished rats","volume":"28","author":"Peters","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib18","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1460-9568.2012.07991.x","article-title":"Neural circuit competition in cocaine-seeking: Roles of the infralimbic cortex and nucleus accumbens shell","volume":"35","author":"LaLumiere","year":"2012","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib19","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1111\/ejn.12578","article-title":"Prelimbic and infralimbic cortical regions differentially encode cocaine-associated stimuli and cocaine-seeking before and following abstinence","volume":"39","author":"West","year":"2014","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.brainres.2014.09.004","article-title":"Role of corticostriatal circuits in context-induced reinstatement of drug seeking","volume":"1628","author":"Marchant","year":"2015","journal-title":"Brain Res"},{"key":"10.1016\/j.biopsych.2025.06.027_bib21","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/npp.2015.253","article-title":"Corticostriatal afferents modulate responsiveness to psychostimulant drugs and drug-associated stimuli","volume":"41","author":"Kerstetter","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2025.06.027_bib22","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1038\/npp.2017.153","article-title":"Accumbens mechanisms for cued sucrose seeking","volume":"42","author":"Bobadilla","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2025.06.027_bib23","doi-asserted-by":"crossref","first-page":"11735","DOI":"10.1523\/JNEUROSCI.2328-10.2010","article-title":"Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine","volume":"30","author":"Sadri-Vakili","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib24","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012047","article-title":"Epigenetics and psychostimulant addiction","volume":"3","author":"Schmidt","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.biopsych.2025.06.027_bib25","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.neuron.2007.09.032","article-title":"Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli","volume":"56","author":"Renthal","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2025.06.027_bib26","doi-asserted-by":"crossref","first-page":"10187","DOI":"10.1523\/JNEUROSCI.2268-10.2010","article-title":"Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapse","volume":"30","author":"Wang","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib27","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neuron.2011.10.032","article-title":"Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import","volume":"73","author":"Taniguchi","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2025.06.027_bib28","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neuron.2017.09.015","article-title":"HDAC5 and its target gene, Npas4, function in the nucleus accumbens to regulate cocaine- conditioned behaviors","volume":"96","author":"Taniguchi","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2025.06.027_bib29","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2210953120","article-title":"Epigenetic function during heroin self-administration controls future relapse-associated behavior in a cell type-specific manner","volume":"120","author":"Anderson","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2025.06.027_bib30","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12929-016-0294-8","article-title":"Epigenetics of amphetamine-induced sensitization: HDAC5 expression and microRNA in neural remodeling","volume":"23","author":"Liu","year":"2016","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib31","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.bbrc.2017.05.157","article-title":"Ketamine induces brain-derived neurotrophic factor expression via phosphorylation of histone deacetylase 5 in rats","volume":"489","author":"Choi","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biopsych.2025.06.027_bib32","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/WNR.0000000000001587","article-title":"Comparison of the sensitizing effects of cocaine and ethanol on histone deacetylase isoforms in the rat brain","volume":"32","author":"Xu","year":"2021","journal-title":"NeuroReport"},{"key":"10.1016\/j.biopsych.2025.06.027_bib63","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.biopsych.2025.01.027","article-title":"Epigenetic control of an auxiliary subunit of voltage-gated sodium channels regulates the strength of drug-cue associations and relapse-like cocaine seeking","volume":"98","author":"Wood","year":"2025","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2025.06.027_bib33","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1126\/science.adp1562","article-title":"A long noncoding eRNA forms R-loops to shape emotional experience-induced behavioral adaptation","volume":"386","author":"Akiki","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2025.06.027_bib34","doi-asserted-by":"crossref","first-page":"8956","DOI":"10.1523\/JNEUROSCI.1332-18.2018","article-title":"Divergent prelimbic cortical pathways interact with BDNF to regulate cocaine-seeking","volume":"38","author":"Giannotti","year":"2018","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1101\/lm.1041309","article-title":"Extinction circuits for fear and addiction overlap in prefrontal cortex","volume":"16","author":"Peters","year":"2009","journal-title":"Learn Mem"},{"key":"10.1016\/j.biopsych.2025.06.027_bib36","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00213-022-06287-2","article-title":"Prelimbic and infralimbic medial prefrontal cortex neuron activity signals cocaine seeking variables across multiple timescales","volume":"240","author":"Moorman","year":"2023","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2025.06.027_bib37","doi-asserted-by":"crossref","first-page":"8655","DOI":"10.1523\/JNEUROSCI.21-21-08655.2001","article-title":"The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior","volume":"21","author":"McFarland","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib38","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1523\/JNEUROSCI.23-08-03531.2003","article-title":"Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior","volume":"23","author":"McFarland","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib39","doi-asserted-by":"crossref","first-page":"8700","DOI":"10.1523\/JNEUROSCI.1291-15.2016","article-title":"Prelimbic to accumbens core pathway is recruited in a dopamine-dependent manner to drive cued reinstatement of cocaine seeking","volume":"36","author":"McGlinchey","year":"2016","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib40","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/ijnp\/pyx107","article-title":"Cued reinstatement of cocaine but not sucrose seeking is dependent on dopamine signaling in prelimbic cortex and is associated with recruitment of prelimbic neurons that project to contralateral nucleus accumbens core","volume":"21","author":"James","year":"2018","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2025.06.027_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.844243","article-title":"A subset of nucleus accumbens neurons receiving dense and functional prelimbic cortical input are required for cocaine seeking","volume":"16","author":"Siemsen","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib42","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1523\/JNEUROSCI.20-02-00798.2000","article-title":"Fos protein expression and cocaine-seeking behavior in rats after exposure to a cocaine self-administration environment","volume":"20","author":"Neisewander","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.brainres.2014.11.005","article-title":"Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction","volume":"1628","author":"Cruz","year":"2015","journal-title":"Brain Res"},{"key":"10.1016\/j.biopsych.2025.06.027_bib44","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nn.3280","article-title":"Epigenetic inheritance of a cocaine-resistance phenotype","volume":"16","author":"Vassoler","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib45","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1046\/j.1471-4159.2002.01083.x","article-title":"Repeated cocaine administration alters the expression of genes in corticolimbic circuitry after a 3-week withdrawal: A DNA macroarray study","volume":"82","author":"Toda","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopsych.2025.06.027_bib46","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1038\/s41598-017-05720-3","article-title":"Gene network dysregulation in dorsolateral prefrontal cortex neurons of humans with cocaine use disorder","volume":"7","author":"Ribeiro","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopsych.2025.06.027_bib47","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12640-017-9728-7","article-title":"Cocaine administration and its withdrawal enhance the expression of genes encoding histone-modifying enzymes and histone acetylation in the rat prefrontal cortex","volume":"32","author":"Sadakierska-Chudy","year":"2017","journal-title":"Neurotox Res"},{"key":"10.1016\/j.biopsych.2025.06.027_bib48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/sj.tpj.6500146","article-title":"Transcriptional profiling in the human prefrontal cortex: Evidence for two activational states associated with cocaine abuse","volume":"3","author":"Lehrmann","year":"2003","journal-title":"Pharmacogenom J"},{"key":"10.1016\/j.biopsych.2025.06.027_bib49","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0169-328X(02)00197-3","article-title":"Changes in rat frontal cortex gene expression following chronic cocaine","volume":"104","author":"Freeman","year":"2002","journal-title":"Mol Brain Res"},{"key":"10.1016\/j.biopsych.2025.06.027_bib50","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0006-291X(02)02632-3","article-title":"Altered cocaine effects in mice lacking Cav2.3(alpha1E) calcium channel","volume":"299","author":"Wenhua","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biopsych.2025.06.027_bib51","doi-asserted-by":"crossref","first-page":"22","DOI":"10.21767\/2471-853X.100022","article-title":"Cocaine self-administration elevates GluN2B within dmPFC mediating heightened cue-elicited operant responding","volume":"2","author":"Szumlinski","year":"2016","journal-title":"J Drug Abuse"},{"key":"10.1016\/j.biopsych.2025.06.027_bib52","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00213-013-3120-y","article-title":"The reinstatement model of drug relapse: Recent neurobiological findings, emerging research topics, and translational research","volume":"229","author":"Bossert","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2025.06.027_bib53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.pnpbp.2018.01.002","article-title":"Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms","volume":"87","author":"Farrell","year":"2018","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2025.06.027_bib54","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1523\/JNEUROSCI.5146-05.2006","article-title":"Different neural substrates mediate cocaine seeking after abstinence versus extinction training: A critical role for the dorsolateral caudate-putamen","volume":"26","author":"Fuchs","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib55","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.neuron.2013.01.005","article-title":"Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation","volume":"77","author":"Gipson","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2025.06.027_bib56","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/sj.npp.1300579","article-title":"The role of the dorsomedial prefrontal cortex, basolateral amygdala and dorsal hippocampus in contextual reinstatement of cocaine seeking in rats","volume":"30","author":"Fuchs","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2025.06.027_bib57","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1523\/JNEUROSCI.0697-23.2023","article-title":"Brain-wide projections and differential encoding of prefrontal neuronal classes underlying learned and innate threat avoidance","volume":"43","author":"Gongwer","year":"2023","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib58","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41593-022-01041-5","article-title":"Single-neuron projectome of mouse prefrontal cortex","volume":"25","author":"Gao","year":"2022","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib59","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrn3492","article-title":"The contextual brain: Implications for fear conditioning, extinction and psychopathology","volume":"14","author":"Maren","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2025.06.027_bib60","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/s41467-020-15121-2","article-title":"Encoding of contextual fear memory in hippocampal-amygdala circuit","volume":"11","author":"Kim","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2025.06.027_bib61","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.biopsych.2020.04.014","article-title":"Molecularly defined hippocampal inputs regulate population dynamics in the prelimbic cortex to suppress context fear memory retrieval","volume":"88","author":"Hallock","year":"2020","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2025.06.027_bib62","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1523\/JNEUROSCI.1453-19.2020","article-title":"Ventral hippocampal input to the prelimbic cortex dissociates the context from the cue association in trace fear memory","volume":"40","author":"Twining","year":"2020","journal-title":"J Neurosci"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322325013010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322325013010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:15:03Z","timestamp":1777943703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322325013010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0006322325013010"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2025.06.027","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.09.21.614125","asserted-by":"object"}]},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histone Deacetylase 5 in Prelimbic Prefrontal Cortex Limits Context-Associated Cocaine Seeking","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2025.06.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc on behalf of Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}