{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:54:00Z","timestamp":1791971640735,"version":"4.3.4"},"reference-count":69,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.biopsych.2026.01.020","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T16:12:08Z","timestamp":1771431128000},"page":"1013-1021","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Link Between Weight Gain and Hippocampal Atrophy in Bipolar Disorder: A Longitudinal Investigation in 934 Participants"],"prefix":"10.1016","volume":"100","author":[{"given":"Julia","family":"Fraiha-Pegado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean R.","family":"McWhinney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Alda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Anmella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Ab\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Altegoer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco H.","family":"Benedetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erland","family":"B\u00f8en","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Bond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Boye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Bravi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dara M.","family":"Cannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily L.V.","family":"Corkum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Corley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorielle M.F.","family":"Dietze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Dannlowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbjorn","family":"Elvs\u00e5shagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Fuentes-Claramonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice M.","family":"Fullerton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin I.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janik","family":"Goltermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Grotegerd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Hidalgo-Mazzei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghee","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melody","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriana","family":"Karuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kody G.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilo","family":"Kircher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Luisa","family":"Klahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Land\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth J.","family":"Leehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Machado-Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"MacIntosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik F.","family":"Malt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colm","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Meinert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Melloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip B.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Nabulsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Nitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Opel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.G.","family":"Otaduy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brownyn J.","family":"Overs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Poletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Pomarol-Clotet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Radua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Salvador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Schofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Selitser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Straube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Teutenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia I.","family":"Thomopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Usemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars T.","family":"Westlye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzhi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi N.","family":"Yatham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole A.","family":"Andreassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.K.","family":"Ching","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0281-8458","authenticated-orcid":false,"given":"Tomas","family":"Hajek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2026.01.020_bib3","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s13679-023-00527-y","article-title":"Update on the obesity epidemic: After the sudden rise, is the upward trajectory beginning to flatten?","volume":"12","author":"Koliaki","year":"2023","journal-title":"Curr Obes Rep"},{"key":"10.1016\/j.biopsych.2026.01.020_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.769309","article-title":"Prevalence of overweight and obesity in people with severe mental illness: Systematic review and meta-analysis","volume":"12","author":"Afzal","year":"2021","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.biopsych.2026.01.020_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1176\/appi.ajp.20230012","article-title":"Recent secular trends of body mass index in individuals with bipolar disorders and in the general population","volume":"181","author":"Najar","year":"2024","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2026.01.020_bib6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.21037\/atm.2017.03.107","article-title":"Morbidity and mortality associated with obesity","volume":"5","author":"Abdelaal","year":"2017","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.biopsych.2026.01.020_bib7","series-title":"WHO European Regional Obesity Report 2022","article-title":"Word Health Organization","year":"2022"},{"key":"10.1016\/j.biopsych.2026.01.020_bib8","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1467-789X.2008.00473.x","article-title":"Obesity and central obesity as risk factors for incident dementia and its subtypes: A systematic review and meta-analysis","volume":"9","author":"Beydoun","year":"2008","journal-title":"Obes Rev"},{"key":"10.1016\/j.biopsych.2026.01.020_bib9","doi-asserted-by":"crossref","first-page":"e406","DOI":"10.1016\/S2666-7568(24)00061-8","article-title":"Population attributable fractions of modifiable risk factors for dementia: A systematic review and meta-analysis","volume":"5","author":"Stephan","year":"2024","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.biopsych.2026.01.020_bib10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neubiorev.2020.05.012","article-title":"Association of body mass index with risk of cognitive impairment and dementia: A systematic review and meta-analysis of prospective studies","volume":"115","author":"Qu","year":"2020","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.biopsych.2026.01.020_bib11","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/sj.ijo.802225","article-title":"Lower cognitive function in the presence of obesity and hypertension: The Framingham Heart Study","volume":"27","author":"Elias","year":"2003","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.biopsych.2026.01.020_bib12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.neubiorev.2017.11.020","article-title":"Executive function performance in obesity and overweight individuals: A meta-analysis and review","volume":"84","author":"Yang","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.biopsych.2026.01.020_bib13","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1017\/S0033291724000345","article-title":"Neurocognitive correlates of metabolic dysregulation in individuals with mood disorders: A systematic review and meta-analysis","volume":"54","author":"Maksyutynska","year":"2024","journal-title":"Psychol Med"},{"key":"10.1016\/j.biopsych.2026.01.020_bib14","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1148\/radiol.2019181012","article-title":"Obesity, brain volume, and white matter microstructure at MRI: A cross-sectional UK Biobank study","volume":"291","author":"Dekkers","year":"2019","journal-title":"Radiology"},{"key":"10.1016\/j.biopsych.2026.01.020_bib15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuroimage.2015.07.086","article-title":"Association between waist circumference and gray matter volume in 2344 individuals from two adult community-based samples","volume":"122","author":"Janowitz","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2026.01.020_bib16","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.1038\/s41380-020-0774-9","article-title":"Brain structural abnormalities in obesity: Relation to age, genetic risk, and common psychiatric disorders: Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group","volume":"26","author":"Opel","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2026.01.020_bib17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/hbm.20870","article-title":"Brain structure and obesity","volume":"31","author":"Raji","year":"2010","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.biopsych.2026.01.020_bib18","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/ijo.2015.106","article-title":"Being overweight is associated with hippocampal atrophy: The PATH through Life Study","volume":"39","author":"Cherbuin","year":"2015","journal-title":"Int J Obes"},{"key":"10.1016\/j.biopsych.2026.01.020_bib19","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.17257","article-title":"Associations of regional brain structural differences with aging, modifiable risk factors for dementia, and cognitive performance","volume":"2","author":"Suzuki","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.biopsych.2026.01.020_bib20","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/oby.22819","article-title":"Longitudinal changes in fat mass and the hippocampus","volume":"28","author":"Ambikairajah","year":"2020","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.biopsych.2026.01.020_bib21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/hbm.25249","article-title":"In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from the Enhancing Neuro Imaging Genetics Through Meta-Analysis Bipolar Disorder Working Group","volume":"43","author":"Haukvik","year":"2022","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.biopsych.2026.01.020_bib22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1503\/jpn.110143","article-title":"Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: A meta-analysis","volume":"37","author":"Hajek","year":"2012","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.biopsych.2026.01.020_bib23","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.1017\/S0033291723000223","article-title":"Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants","volume":"53","author":"McWhinney","year":"2023","journal-title":"Psychol Med"},{"key":"10.1016\/j.biopsych.2026.01.020_bib24","doi-asserted-by":"crossref","first-page":"6806","DOI":"10.1038\/s41380-021-01098-x","article-title":"Association between body mass index and subcortical brain volumes in bipolar disorders\u2013ENIGMA study in 2735 individuals","volume":"26","author":"McWhinney","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2026.01.020_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.eatbeh.2020.101435","article-title":"Impulsivity as a risk factor for weight gain and body roundness change among college freshmen","volume":"39","author":"Bjorlie","year":"2020","journal-title":"Eat Behav"},{"key":"10.1016\/j.biopsych.2026.01.020_bib26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3390\/nu9030217","article-title":"Association between impulsivity and weight status in a general population","volume":"9","author":"B\u00e9nard","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.biopsych.2026.01.020_bib27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.psyneuen.2015.08.014","article-title":"Hypothalamic-pituitary-adrenal axis dysregulation and cortisol activity in obesity: A systematic review","volume":"62","author":"Incollingo Rodriguez","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.biopsych.2026.01.020_bib28","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.neuron.2011.02.016","article-title":"Reward mechanisms in obesity: New insights and future directions","volume":"69","author":"Kenny","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2026.01.020_bib29","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/hbm.23407","article-title":"Brain reward system\u2019s alterations in response to food and monetary stimuli in overweight and obese individuals","volume":"38","author":"Verdejo-Rom\u00e1n","year":"2017","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.biopsych.2026.01.020_bib30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in obesity, diabetes, and related disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.biopsych.2026.01.020_bib31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.7555\/JBR.36.20200020","article-title":"The contribution of astrocytes to obesity-associated metabolic disturbances","volume":"36","author":"Obara-Michlewska","year":"2022","journal-title":"J Biomed Res"},{"key":"10.1016\/j.biopsych.2026.01.020_bib32","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3389\/fnins.2019.00508","article-title":"Obesity as a risk factor for Alzheimer\u2019s disease: Implication of leptin and glutamate","volume":"13","author":"Lloret","year":"2019","journal-title":"Front Neurosci"},{"key":"10.1016\/j.biopsych.2026.01.020_bib33","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2337\/dc12-0922","article-title":"Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults","volume":"36","author":"Willette","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopsych.2026.01.020_bib34","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1038\/npp.2014.148","article-title":"Insulin resistance, diabetes mellitus, and brain structure in bipolar disorders","volume":"39","author":"Hajek","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2026.01.020_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/YCO.0000000000000215","article-title":"Bipolar disorders, type 2 diabetes mellitus, and the brain","volume":"29","author":"Hajek","year":"2016","journal-title":"Curr Opin Psychiatry"},{"key":"10.1016\/j.biopsych.2026.01.020_bib36","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/j.1471-4159.2010.06865.x","article-title":"High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: Implications for decreased Nrf2 signaling","volume":"114","author":"Morrison","year":"2010","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopsych.2026.01.020_bib37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4093\/dmj.2018.0221","article-title":"Mitochondrial dysfunction in adipocytes as a primary cause of adipose tissue inflammation","volume":"43","author":"Woo","year":"2019","journal-title":"Diabetes Metab J"},{"key":"10.1016\/j.biopsych.2026.01.020_bib38","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1001\/archpsyc.57.10.925","article-title":"Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders","volume":"57","author":"Sapolsky","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2026.01.020_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.785640","article-title":"Prevalence and predictors of cerebral microangiopathy determined by pulsatility index in an asymptomatic population from the ILERVAS project","volume":"12","author":"Purroy","year":"2021","journal-title":"Front Neurol"},{"key":"10.1016\/j.biopsych.2026.01.020_bib40","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.biopsych.2021.09.008","article-title":"Longitudinal structural brain changes in bipolar disorder: A multicenter neuroimaging study of 1232 individuals by the ENIGMA Bipolar Disorder Working Group","volume":"91","author":"Ab\u00e9","year":"2022","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2026.01.020_bib41","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/bdi.12722","article-title":"Weight gain as a predictor of frontal and temporal lobe volume loss in bipolar disorder: A prospective MRI study","volume":"21","author":"Bond","year":"2019","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.biopsych.2026.01.020_bib42","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1017\/S0033291721000544","article-title":"Weight gain as a risk factor for progressive neurochemical abnormalities in first episode mania patients: A longitudinal magnetic resonance spectroscopy study","volume":"52","author":"Bond","year":"2022","journal-title":"Psychol Med"},{"key":"10.1016\/j.biopsych.2026.01.020_bib43","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1749-6632.2001.tb05830.x","article-title":"Plasticity of the hippocampus: Adaptation to chronic stress and allostatic load","volume":"933","author":"McEwen","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.biopsych.2026.01.020_bib44","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.neubiorev.2013.03.010","article-title":"Effects of diabetes on hippocampal neurogenesis: Links to cognition and depression","volume":"37","author":"Ho","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.biopsych.2026.01.020_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-73401-9","article-title":"Deficits in hippocampal neurogenesis in obesity-dependent and -independent type-2 diabetes mellitus mouse models","volume":"10","author":"Bonds","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopsych.2026.01.020_bib46","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1093\/schbul\/sbab064","article-title":"Obesity as a risk factor for accelerated brain ageing in first-episode psychosis-A longitudinal study","volume":"47","author":"McWhinney","year":"2021","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.biopsych.2026.01.020_bib47","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1038\/s41380-022-01616-5","article-title":"Obesity and brain structure in schizophrenia\u2014ENIGMA study in 3021 individuals","volume":"27","author":"McWhinney","year":"2022","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2026.01.020_bib48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis. I. Segmentation and surface reconstruction","volume":"9","author":"Dale","year":"1999","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2026.01.020_bib49","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/cercor\/bhg087","article-title":"Automatically parcellating the human cerebral cortex","volume":"14","author":"Fischl","year":"2004","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2026.01.020_bib50","doi-asserted-by":"crossref","first-page":"11050","DOI":"10.1073\/pnas.200033797","article-title":"Measuring the thickness of the human cerebral cortex from magnetic resonance images","volume":"97","author":"Fischl","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2026.01.020_bib51","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/j.neuroimage.2004.07.016","article-title":"Sequence-independent segmentation of magnetic resonance images","volume":"23","author":"Fischl","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2026.01.020_bib52","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.neuroimage.2012.02.084","article-title":"Within-subject template estimation for unbiased longitudinal image analysis","volume":"61","author":"Reuter","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2026.01.020_bib54","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1017\/S0033291713001165","article-title":"Neuroprotective effect of lithium on hippocampal volumes in bipolar disorder independent of long-term treatment response","volume":"44","author":"Hajek","year":"2014","journal-title":"Psychol Med"},{"key":"10.1016\/j.biopsych.2026.01.020_bib55","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1176\/appi.ajp.2013.12050674","article-title":"Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: A prospective longitudinal MRI study","volume":"170","author":"Andreasen","year":"2013","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2026.01.020_bib56","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.neubiorev.2013.06.001","article-title":"Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies","volume":"37","author":"Fusar-Poli","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.biopsych.2026.01.020_bib57","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1001\/archgenpsychiatry.2011.72","article-title":"Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease","volume":"68","author":"Tariot","year":"2011","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2026.01.020_bib58","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neurobiolaging.2021.02.010","article-title":"Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: A Mendelian randomization study","volume":"102","author":"Mulugeta","year":"2021","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.biopsych.2026.01.020_bib59","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3390\/brainsci13060892","article-title":"Genetic insights into obesity and brain: Combine Mendelian randomization study and gene expression analysis","volume":"13","author":"Chen","year":"2023","journal-title":"Brain Sci"},{"key":"10.1016\/j.biopsych.2026.01.020_bib60","doi-asserted-by":"crossref","first-page":"9409","DOI":"10.1093\/cercor\/bhad214","article-title":"Obesity causally influencing brain cortical structure: A Mendelian randomization study","volume":"33","author":"Chen","year":"2023","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2026.01.020_bib61","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1002\/hbm.23272","article-title":"Bariatric surgery induces white and grey matter density recovery in the morbidly obese: A voxel-based morphometric study","volume":"37","author":"Tuulari","year":"2016","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.biopsych.2026.01.020_bib62","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/ijo.2016.98","article-title":"Recovery of brain structural abnormalities in morbidly obese patients after bariatric surgery","volume":"40","author":"Zhang","year":"2016","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.biopsych.2026.01.020_bib63","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/ijo.2015.106","article-title":"Being overweight is associated with hippocampal atrophy: The PATH through Life Study","volume":"39","author":"Cherbuin","year":"2015","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.biopsych.2026.01.020_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.42","article-title":"Diagnosis and body mass index effects on hippocampal volumes and neurochemistry in bipolar disorder","volume":"7","author":"Bond","year":"2017","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.biopsych.2026.01.020_bib65","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/acps.12677","article-title":"Brain volume change in first-episode psychosis: An effect of antipsychotic medication independent of BMI change","volume":"135","author":"J\u00f8rgensen","year":"2017","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.biopsych.2026.01.020_bib66","first-page":"S36","article-title":"From neuroprogression to neuroprotection: Implications for clinical care","volume":"193","author":"Berk","year":"2010","journal-title":"Med J Aust"},{"key":"10.1016\/j.biopsych.2026.01.020_bib67","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/acps.13594","article-title":"Weight and metabolic changes in early psychosis-Association with daily quantification of medication exposure during the first hospitalization","volume":"148","author":"Vochoskova","year":"2023","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.biopsych.2026.01.020_bib68","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1192\/j.eurpsy.2024.1761","article-title":"Trajectories of daily antipsychotic use and weight gain in people hospitalized for the first episode of psychosis","volume":"67","author":"Vochoskova","year":"2024","journal-title":"Eur Psychiatry"},{"key":"10.1016\/j.biopsych.2026.01.020_bib69","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/JCP.0000000000001318","article-title":"Comparison of the metabolic characteristics of newer second generation antipsychotics: Brexpiprazole, lurasidone, asenapine, cariprazine, and iloperidone with olanzapine as a comparator","volume":"41","author":"Greger","year":"2021","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.biopsych.2026.01.020_bib70","doi-asserted-by":"crossref","first-page":"862","DOI":"10.2174\/1567205013666160219112712","article-title":"Neuroprotective effects of lithium in human brain? Food for thought","volume":"13","author":"Hajek","year":"2016","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.biopsych.2026.01.020_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2021.07.011","article-title":"Lithium therapy and weight change in people with bipolar disorder: A systematic review and meta-analysis","volume":"134","author":"Gomes-da-Costa","year":"2022","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.biopsych.2026.01.020_bib72","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/bdi.13435","article-title":"Early intervention, relapse prevention, and neuroprogression in bipolar disorder: The evidence matters","volume":"26","author":"Yatham","year":"2024","journal-title":"Bipolar Disord"}],"updated-by":[{"DOI":"10.1016\/j.biopsych.2026.04.011","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000}},{"DOI":"10.1016\/j.biopsych.2026.04.011","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000}}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322326000624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322326000624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:31:29Z","timestamp":1791970289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322326000624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":69,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0006322326000624"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2026.01.020","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Link Between Weight Gain and Hippocampal Atrophy in Bipolar Disorder: A Longitudinal Investigation in 934 Participants","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2026.01.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}