{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T21:24:52Z","timestamp":1794259492344,"version":"4.9.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.biopsych.2026.09.016","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:14:32Z","timestamp":1790608472000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ketamine Alters Tuning of Neural and Behavioral Spatial Working Memory Precision"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6978-1376","authenticated-orcid":false,"given":"Masih","family":"Rahmati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Moujaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3930-6571","authenticated-orcid":false,"given":"Nina Purg","family":"Sulji\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie Lisa","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5098-7921","authenticated-orcid":false,"given":"Lucie","family":"Berkovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7760-8079","authenticated-orcid":false,"given":"Kangjoo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Fonteneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8411-0968","authenticated-orcid":false,"given":"Charles H.","family":"Schleifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan D.","family":"Adkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Savi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Santamauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zailyn","family":"Tamayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7792-7400","authenticated-orcid":false,"given":"Caroline","family":"Diehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonija","family":"Kolobaric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Camarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton E.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grega","family":"Repov\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Fineberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4015-1957","authenticated-orcid":false,"given":"Peter T.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-7672","authenticated-orcid":false,"given":"Katrin H.","family":"Preller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Krystal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngsun T.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Anticevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2026.09.016_bib1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00213-003-1582-z","article-title":"NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: Toward a paradigm shift in medication development","volume":"169","author":"Krystal","year":"2003","journal-title":"Psychopharmacol (Berl)"},{"key":"10.1016\/j.biopsych.2026.09.016_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nature10360","article-title":"Neocortical excitation\/inhibition balance in information processing and social dysfunction","volume":"477","author":"Yizhar","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2026.09.016_bib3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00213-004-1982-8","article-title":"Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects","volume":"179","author":"Krystal","year":"2005","journal-title":"Psychopharmacol (Berl)"},{"key":"10.1016\/j.biopsych.2026.09.016_bib4","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.tics.2012.10.008","article-title":"The role of default network deactivation in cognition and disease","volume":"16","author":"Anticevic","year":"2012","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.biopsych.2026.09.016_bib5","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.neuron.2012.12.032","article-title":"NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex","volume":"77","author":"Wang","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2026.09.016_bib6","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1523\/JNEUROSCI.2121-19.2020","article-title":"The contribution of AMPA and NMDA receptors to persistent firing in the dorsolateral prefrontal cortex in working memory","volume":"40","author":"van Vugt","year":"2020","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2026.09.016_bib7","doi-asserted-by":"crossref","first-page":"6688","DOI":"10.1038\/s41380-021-01082-5","article-title":"Ketamine disrupts naturalistic coding of working memory in primate lateral prefrontal cortex networks","volume":"26","author":"Roussy","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2026.09.016_bib8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1152\/jn.1989.61.2.331","article-title":"Mnemonic coding of visual space in the monkey\u2019s dorsolateral prefrontal cortex","volume":"61","author":"Funahashi","year":"1989","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.biopsych.2026.09.016_bib9","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0896-6273(95)90304-6","article-title":"Cellular basis of working memory","volume":"14","author":"Goldman-Rakic","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2026.09.016_bib10","doi-asserted-by":"crossref","first-page":"9587","DOI":"10.1523\/JNEUROSCI.19-21-09587.1999","article-title":"Synaptic basis of cortical persistent activity: The importance of NMDA receptors to working memory","volume":"19","author":"Wang","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2026.09.016_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/archpsyc.57.1.65","article-title":"Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia","volume":"57","author":"Glantz","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2026.09.016_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nrn3155","article-title":"Interneuron dysfunction in psychiatric disorders","volume":"13","author":"Mar\u00edn","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2026.09.016_bib13","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1093\/cercor\/10.9.910","article-title":"Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model","volume":"10","author":"Compte","year":"2000","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2026.09.016_bib14","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/cercor\/bhs370","article-title":"Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model","volume":"24","author":"Murray","year":"2014","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.biopsych.2026.09.016_bib15","doi-asserted-by":"crossref","first-page":"16720","DOI":"10.1073\/pnas.1208494109","article-title":"NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia","volume":"109","author":"Anticevic","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2026.09.016_bib16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuroimage.2012.09.037","article-title":"Test\u2013retest reliability of the BOLD pharmacological MRI response to ketamine in healthy volunteers","volume":"64","author":"De Simoni","year":"2013","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2026.09.016_bib17","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.euroneuro.2016.03.006","article-title":"Comparing the actions of lanicemine and ketamine in depression: Key role of the anterior cingulate","volume":"26","author":"Downey","year":"2016","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2026.09.016_bib18","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/mp.2012.194","article-title":"Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans","volume":"18","author":"Driesen","year":"2013","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2026.09.016_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.84173","article-title":"Ketamine induces multiple individually distinct whole-brain functional connectivity signatures","volume":"13","author":"Moujaes","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.biopsych.2026.09.016_bib20","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.neuron.2008.02.005","article-title":"Inhibition, spike threshold, and stimulus selectivity in primary visual cortex","volume":"57","author":"Priebe","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2026.09.016_bib21","doi-asserted-by":"crossref","first-page":"13992","DOI":"10.1523\/JNEUROSCI.3577-09.2009","article-title":"Decoding and reconstructing color from responses in human visual cortex","volume":"29","author":"Brouwer","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2026.09.016_bib22","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0098-18.2018","article-title":"Inverted encoding models assay population-level stimulus representations, not single-unit neural tuning","volume":"5","author":"Sprague","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.biopsych.2026.09.016_bib23","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1523\/JNEUROSCI.16-13-04207.1996","article-title":"Linear systems analysis of functional magnetic resonance imaging in human V1","volume":"16","author":"Boynton","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2026.09.016_bib24","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/cne.902010405","article-title":"Visual topography of V2 in the macaque","volume":"201","author":"Gattass","year":"1981","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.biopsych.2026.09.016_bib25","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1073\/pnas.93.6.2382","article-title":"Mapping striate and extrastriate visual areas in human cerebral cortex","volume":"93","author":"DeYoe","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2026.09.016_bib26","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.22974","article-title":"Visual field map clusters in human frontoparietal cortex","volume":"6","author":"Mackey","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.biopsych.2026.09.016_bib27","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.neuroimage.2007.09.034","article-title":"Population receptive field estimates in human visual cortex","volume":"39","author":"Dumoulin","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2026.09.016_bib28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuroimage.2018.10.006","article-title":"Mapping the human brain\u2019s cortical-subcortical functional network organization","volume":"185","author":"Ji","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2026.09.016_bib29","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1523\/JNEUROSCI.17-08-02921.1997","article-title":"Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex","volume":"17","author":"Moghaddam","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2026.09.016_bib30","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.35082","article-title":"Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor","volume":"7","author":"Preller","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.biopsych.2026.09.016_bib31","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1038\/nn.3574","article-title":"Attention modulates spatial priority maps in the human occipital, parietal and frontal cortices","volume":"16","author":"Sprague","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2026.09.016_bib32","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1162\/jocn_a_01196","article-title":"Population dynamics of early visual cortex during working memory","volume":"30","author":"Rahmati","year":"2018","journal-title":"J Cogn Neurosci"},{"key":"10.1016\/j.biopsych.2026.09.016_bib33","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1001\/archgenpsychiatry.2007.37","article-title":"Glutamate and the neural basis of the subjective effects of ketamine: A pharmaco-magnetic resonance imaging study","volume":"65","author":"William Deakin","year":"2008","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2026.09.016_bib34","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/FBP.0000000000000354","article-title":"Ketamine and pharmacological imaging: Use of functional magnetic resonance imaging to evaluate mechanisms of action","volume":"28","author":"Maltbie","year":"2017","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.biopsych.2026.09.016_bib35","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/sj.npp.1300438","article-title":"Acute ketamine administration alters the brain responses to executive demands in a verbal working memory task: An FMRI study","volume":"29","author":"Honey","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopsych.2026.09.016_bib36","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.neuroscience.2008.10.031","article-title":"N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia","volume":"158","author":"Ehrlichman","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2026.09.016_bib37","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jad.2024.10.118","article-title":"Effect of ketamine on task-based functional magnetic resonance imaging findings in major depressive disorder: A mini-review","volume":"370","author":"Ramezani","year":"2025","journal-title":"J Affect Disord"},{"key":"10.1016\/j.biopsych.2026.09.016_bib38","first-page":"253","article-title":"Effects of acute ketamine infusion on visual working memory: Event-related potentials","volume":"2","author":"Koychev","year":"2017","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"10.1016\/j.biopsych.2026.09.016_bib39","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1038\/s41467-021-24973-1","article-title":"Working memory representations in visual cortex mediate distraction effects","volume":"12","author":"Hallenbeck","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.biopsych.2026.09.016_bib40","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1523\/JNEUROSCI.3061-17.2018","article-title":"Flexible coding of visual working memory representations during distraction","volume":"38","author":"Lorenc","year":"2018","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2026.09.016_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2023.1094226","article-title":"Mnemonic representations in human lateral geniculate nucleus","volume":"17","author":"Rahmati","year":"2023","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.biopsych.2026.09.016_bib42","doi-asserted-by":"crossref","first-page":"E11047","DOI":"10.1073\/pnas.1704877114","article-title":"Encoding model of temporal processing in human visual cortex","volume":"114","author":"Stigliani","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2026.09.016_bib43","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1001\/archneur.63.10.1372","article-title":"Cognitive dysfunction in schizophrenia: Convergence of gamma-aminobutyric acid and glutamate alterations","volume":"63","author":"Lewis","year":"2006","journal-title":"Arch Neurol"},{"key":"10.1016\/j.biopsych.2026.09.016_bib44","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/syn.20754","article-title":"Expression of the NR2B-NMDA receptor subunit and its Tbr-1\/CINAP regulatory proteins in postmortem brain suggest altered receptor processing in schizophrenia","volume":"64","author":"Kristiansen","year":"2010","journal-title":"Synapse"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322326015751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322326015751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T20:30:49Z","timestamp":1794256249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322326015751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":44,"alternative-id":["S0006322326015751"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2026.09.016","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ketamine Alters Tuning of Neural and Behavioral Spatial Working Memory Precision","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2026.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}