{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:30:36Z","timestamp":1791268236873,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioresource Technology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.biortech.2013.11.073","type":"journal-article","created":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T22:15:15Z","timestamp":1385936115000},"page":"95-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Hydroxylation and hydrolysis: Two main metabolic ways of spiramycin I in anaerobic digestion"],"prefix":"10.1016","volume":"153","author":[{"given":"Pei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daijie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-an","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.biortech.2013.11.073_b0005","doi-asserted-by":"crossref","first-page":"8581","DOI":"10.1016\/j.biortech.2010.06.075","article-title":"The effect and fate of antibiotics during the anaerobic digestion of pig manure","volume":"101","author":"Alvarez","year":"2010","journal-title":"Bioresour. Technol."},{"issue":"2\u20133","key":"10.1016\/j.biortech.2013.11.073_b0010","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jhazmat.2008.01.096","article-title":"Degradation and metabolization of chlortetracycline during the anaerobic digestion of manure from medicated calves","volume":"158","author":"Arikan","year":"2008","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.biortech.2013.11.073_b0015","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biortech.2013.01.032","article-title":"The combined effect of cefazolin and oxytertracycline on biogas production from thermophilic anaerobic digestion of dairy manure","volume":"133","author":"Beneragama","year":"2013","journal-title":"Bioresour. Technol."},{"issue":"4","key":"10.1016\/j.biortech.2013.11.073_b0020","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s00216-009-3318-3","article-title":"Fate of antibacterial spiramycin in river waters","volume":"396","author":"Calza","year":"2009","journal-title":"Anal. Bioanal. Chem."},{"issue":"1","key":"10.1016\/j.biortech.2013.11.073_b0025","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/es050991m","article-title":"Removal of pharmaceuticals in sewage treatment plants in Italy","volume":"40","author":"Castiglioni","year":"2006","journal-title":"Environ. Sci. Technol."},{"issue":"1\u20132","key":"10.1016\/j.biortech.2013.11.073_b0030","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF02491832","article-title":"Development and validation of an reversed-phase liquid chromatographic method for analysis of spiramycin and related substances","volume":"54","author":"Chepkwony","year":"2001","journal-title":"Chromatographia"},{"key":"10.1016\/j.biortech.2013.11.073_b0035","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.biortech.2012.08.077","article-title":"Effects of chlortetracycline amended feed on anaerobic sequencing batch reactor performance of swine manure digestion","volume":"125","author":"Dreher","year":"2012","journal-title":"Bioresour. Technol."},{"issue":"10","key":"10.1016\/j.biortech.2013.11.073_b0040","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.chemosphere.2006.08.040","article-title":"Anaerobic inhibition and biodegradation of antibiotics in ISO test schemes","volume":"66","author":"Gartiser","year":"2007","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.biortech.2013.11.073_b0045","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.chroma.2005.05.051","article-title":"Extraction and determination of sulfonamides, macrolides, and trimethoprim in sewage sludge","volume":"1085","author":"Gobel","year":"2005","journal-title":"J. Chromatogr. A"},{"issue":"11","key":"10.1016\/j.biortech.2013.11.073_b0050","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1021\/es048550a","article-title":"Occurrence and sorption behavior of sulfonamides, macrolides, and trimethoprim in activated sludge treatment","volume":"39","author":"Gobel","year":"2005","journal-title":"Environ. Sci. Technol."},{"issue":"12","key":"10.1016\/j.biortech.2013.11.073_b0055","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1002\/(SICI)1522-2683(19990801)20:12<2407::AID-ELPS2407>3.0.CO;2-O","article-title":"Analysis of spiramycin by capillary electrophoresis","volume":"20","author":"Gonz\u00e1lez","year":"1999","journal-title":"Electrophoresis"},{"issue":"7","key":"10.1016\/j.biortech.2013.11.073_b0060","doi-asserted-by":"crossref","first-page":"e1002158","DOI":"10.1371\/journal.ppat.1002158","article-title":"Selection of resistant bacteria at very low antibiotic concentrations","volume":"7","author":"Gullberg","year":"2011","journal-title":"PLoS Pathog."},{"issue":"1\u20132","key":"10.1016\/j.biortech.2013.11.073_b0065","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0048-9697(98)00337-4","article-title":"Occurrence of antibiotics in the aquatic environment","volume":"225","author":"Hirsch","year":"1999","journal-title":"Sci. Total Environ."},{"issue":"1\u20133","key":"10.1016\/j.biortech.2013.11.073_b0070","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.scitotenv.2005.06.030","article-title":"Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA","volume":"361","author":"Karthikeyan","year":"2006","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.biortech.2013.11.073_b0075","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.chemosphere.2006.03.014","article-title":"Degradation of macrolide antibiotics by ozone: a mechanistic case study with clarithromycin","volume":"65","author":"Lange","year":"2006","journal-title":"Chemosphere"},{"issue":"15","key":"10.1016\/j.biortech.2013.11.073_b0080","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1016\/j.watres.2010.06.020","article-title":"Fate of antibiotics during municipal water recycling treatment processes","volume":"44","author":"Le-Minh","year":"2010","journal-title":"Water Res."},{"issue":"1","key":"10.1016\/j.biortech.2013.11.073_b0085","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0021-9673(96)00876-X","article-title":"Liquid chromatography of spiramycin on poly (styrene\u2013divinylbenzene)","volume":"764","author":"Liu","year":"1997","journal-title":"J. Chromatogr. A"},{"issue":"1\u20132","key":"10.1016\/j.biortech.2013.11.073_b0090","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0731-7085(99)00024-2","article-title":"Interlaboratory study comparing the microbiological potency of spiramycins I, II and III","volume":"20","author":"Liu","year":"1999","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.biortech.2013.11.073_b0095","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ecoenv.2012.09.004","article-title":"Antioxidant responses and degradation of two antibiotic contaminants in Microcystis aeruginosa","volume":"86","author":"Liu","year":"2012","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"7","key":"10.1016\/j.biortech.2013.11.073_b0100","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1021\/es802042d","article-title":"Degradation and elimination of various sulfonamides during anaerobic fermentation: a promising step on the way to sustainable pharmacy?","volume":"43","author":"Mohring","year":"2009","journal-title":"Environ. Sci. Technol."},{"issue":"4","key":"10.1016\/j.biortech.2013.11.073_b0105","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.chemosphere.2011.03.048","article-title":"Residues of pharmaceutical products in recycled organic manure produced from sewage sludge and solid waste from livestock and relationship to their fermentation level","volume":"84","author":"Motoyama","year":"2011","journal-title":"Chemosphere"},{"issue":"1\u20132","key":"10.1016\/j.biortech.2013.11.073_b0110","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0378-4347(97)00477-5","article-title":"Study of the metabolism of spiramycin in pig liver","volume":"704","author":"Mourier","year":"1997","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"issue":"7","key":"10.1016\/j.biortech.2013.11.073_b0115","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1128\/jb.172.7.3790-3798.1990","article-title":"Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis","volume":"172","author":"Richardson","year":"1990","journal-title":"J. Bacteriol."},{"issue":"5","key":"10.1016\/j.biortech.2013.11.073_b0120","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/jac\/42.5.572","article-title":"Spiramycin renaissance","volume":"42","author":"Rubinstein","year":"1998","journal-title":"J. Antimicrob. Chemother."},{"issue":"5","key":"10.1016\/j.biortech.2013.11.073_b0125","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.chemosphere.2006.03.026","article-title":"A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment","volume":"65","author":"Sarmah","year":"2006","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.biortech.2013.11.073_b0130","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0013-9351(02)00086-5","article-title":"Aerobic degradation of tylosin in cattle, chicken, and swine excreta","volume":"93","author":"Scott Teeter","year":"2003","journal-title":"Environ. Res."},{"issue":"3","key":"10.1016\/j.biortech.2013.11.073_b0135","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jpba.2004.07.037","article-title":"Acid catalysed degradation of some spiramycin derivatives found in the antibiotic bitespiramycin","volume":"36","author":"Shi","year":"2004","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.biortech.2013.11.073_b0140","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/bit.21864","article-title":"Inhibitory effects of the macrolide antimicrobial tylosin on anaerobic treatment","volume":"101","author":"Shimada","year":"2008","journal-title":"Biotechnol. Bioeng."},{"issue":"1\u20133","key":"10.1016\/j.biortech.2013.11.073_b0145","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jhazmat.2009.10.127","article-title":"Relationships between chemical oxygen demand (COD) components and toxicity in a sequential anaerobic baffled reactor\/aerobic completely stirred reactor system treating Kemicetine","volume":"176","author":"Sponza","year":"2010","journal-title":"J. Hazard. Mater."},{"issue":"3","key":"10.1016\/j.biortech.2013.11.073_b0150","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1128\/MMBR.68.3.474-500.2004","article-title":"Bacterial transcriptional regulators for degradation pathways of aromatic compounds","volume":"68","author":"Tropel","year":"2004","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"7","key":"10.1016\/j.biortech.2013.11.073_b0155","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/j.watres.2009.01.027","article-title":"Phototransformation of selected human-used macrolides in surface water: kinetics, model predictions and degradation pathways","volume":"43","author":"Vione","year":"2009","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.biortech.2013.11.073_b0160","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.envpol.2006.05.038","article-title":"Determination of selected antibiotics in the Victoria Harbour and the Pearl River, South China using high-performance liquid chromatography\u2013electrospray ionization tandem mass spectrometry","volume":"145","author":"Xu","year":"2007","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.biortech.2013.11.073_b0165","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.marenvres.2012.03.007","article-title":"Occurrence and distribution of antibiotics in the Beibu Gulf, China: impacts of river discharge and aquaculture activities","volume":"78","author":"Zheng","year":"2012","journal-title":"Mar. Environ. Res."},{"issue":"10","key":"10.1016\/j.biortech.2013.11.073_b0170","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1016\/j.envpol.2011.04.037","article-title":"Occurrence and distribution of antibiotics in coastal water of the Bohai Bay, China: impacts of river discharge and aquaculture activities","volume":"159","author":"Zou","year":"2011","journal-title":"Environ. Pollut."}],"container-title":["Bioresource Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960852413017999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960852413017999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,4]],"date-time":"2019-08-04T09:03:27Z","timestamp":1564909407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960852413017999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":34,"alternative-id":["S0960852413017999"],"URL":"https:\/\/doi.org\/10.1016\/j.biortech.2013.11.073","relation":{},"ISSN":["0960-8524"],"issn-type":[{"value":"0960-8524","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydroxylation and hydrolysis: Two main metabolic ways of spiramycin I in anaerobic digestion","name":"articletitle","label":"Article Title"},{"value":"Bioresource Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biortech.2013.11.073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}