{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:13:01Z","timestamp":1790273581187,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"NRF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MSIT","award":["2018R1A2B3005232"],"award-info":[{"award-number":["2018R1A2B3005232"]}]},{"name":"Human Resources Program in Energy Technology"},{"DOI":"10.13039\/501100003052","name":"MOTIE","doi-asserted-by":"publisher","award":["20144030200460"],"award-info":[{"award-number":["20144030200460"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioresource Technology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.biortech.2019.02.106","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T08:09:59Z","timestamp":1551082199000},"page":"401-411","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Single and combined inhibition of Methanosaeta concilii by ammonia, sodium ion and hydrogen sulfide"],"prefix":"10.1016","volume":"281","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2179-0035","authenticated-orcid":false,"given":"Joonyeob","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokhwan","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biortech.2019.02.106_b0005","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fnmol.2016.00057","article-title":"Ammonia as a potential neurotoxic factor in alzheimer's disease","volume":"9","author":"Adlimoghaddam","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.biortech.2019.02.106_b0010","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.watres.2017.05.067","article-title":"Generalized parameter estimation and calibration for biokinetic models using correlation and single variable optimisations: application to sulfate reduction modelling in anaerobic digestion","volume":"122","author":"Ahmed","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.biortech.2019.02.106_b0015","unstructured":"Anderson, G., Donnelly, T., McKeown, K., 1982. Identification and control of inhibition in the anaerobic treatment of industrial wastewaters."},{"issue":"4","key":"10.1016\/j.biortech.2019.02.106_b0020","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/BF00242955","article-title":"Thermophilic anaerobic digestion of livestock waste: the effect of ammonia","volume":"38","author":"Angelidaki","year":"1993","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"5","key":"10.1016\/j.biortech.2019.02.106_b0025","doi-asserted-by":"crossref","first-page":"927","DOI":"10.2166\/wst.2009.040","article-title":"Defining the biomethane potential (BMP) of solid organic wastes and energy crops: a proposed protocol for batch assays","volume":"59","author":"Angelidaki","year":"2009","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.biortech.2019.02.106_b0030","series-title":"Anaerobic Biodegradation, Activity and Inhibition (ABAI) Task Group Meeting 9th to 10th October 2006, in Prague","first-page":"8791855446","author":"Angelidaki","year":"2007"},{"key":"10.1016\/j.biortech.2019.02.106_b0035","series-title":"Standard Methods for the examination of water and wastewater","author":"APHA-AWWA-WEF","year":"2005"},{"issue":"6","key":"10.1016\/j.biortech.2019.02.106_b0040","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.pecs.2008.06.002","article-title":"Principles and potential of the anaerobic digestion of waste-activated sludge","volume":"34","author":"Appels","year":"2008","journal-title":"Prog. Energy Combust. Sci."},{"key":"10.1016\/j.biortech.2019.02.106_b0045","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.watres.2015.05.063","article-title":"Development and validation of a rapid test for anaerobic inhibition and toxicity","volume":"81","author":"Astals","year":"2015","journal-title":"Water Res."},{"key":"10.1016\/j.biortech.2019.02.106_b0050","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.watres.2018.06.021","article-title":"Characterising and modelling free ammonia and ammonium inhibition in anaerobic systems","volume":"143","author":"Astals","year":"2018","journal-title":"Water Res."},{"issue":"14","key":"10.1016\/j.biortech.2019.02.106_b0055","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1128\/JB.05031-11","article-title":"Complete genome sequence of Methanosaeta concilii, a specialist in aceticlastic methanogenesis","volume":"193","author":"Barber","year":"2011","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.biortech.2019.02.106_b0060","series-title":"Statistics for Experimenters: Design, Innovation, and Discovery","author":"Box","year":"2005"},{"issue":"3\u20134","key":"10.1016\/j.biortech.2019.02.106_b0065","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.procbio.2004.05.008","article-title":"Effects of high free ammonia concentrations on the performances of anaerobic bioreactors","volume":"40","author":"Calli","year":"2005","journal-title":"Process Biochem."},{"issue":"Web Server issue","key":"10.1016\/j.biortech.2019.02.106_b0070","doi-asserted-by":"crossref","first-page":"W441","DOI":"10.1093\/nar\/gkp253","article-title":"IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding","volume":"37","author":"Cer","year":"2009","journal-title":"Nucl. Acids Res."},{"issue":"8","key":"10.1016\/j.biortech.2019.02.106_b0075","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.biotechadv.2014.10.005","article-title":"Toxicants inhibiting anaerobic digestion: a review","volume":"32","author":"Chen","year":"2014","journal-title":"Biotechnol. Adv."},{"issue":"10","key":"10.1016\/j.biortech.2019.02.106_b0080","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1016\/j.biortech.2007.01.057","article-title":"Inhibition of anaerobic digestion process: a review","volume":"99","author":"Chen","year":"2008","journal-title":"Bioresour. Technol."},{"issue":"1","key":"10.1016\/j.biortech.2019.02.106_b0085","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF00872194","article-title":"Anaerobic treatment of sulphate-containing waste streams","volume":"67","author":"Colleran","year":"1995","journal-title":"Antonie Van Leeuwenhoek"},{"issue":"5","key":"10.1016\/j.biortech.2019.02.106_b0090","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2175\/106143006X95393","article-title":"Growth kinetics and competition between methanosarcina and methanosaeta in mesophilic anaerobic digestion","volume":"78","author":"Conklin","year":"2006","journal-title":"Water Environ. Res."},{"issue":"5","key":"10.1016\/j.biortech.2019.02.106_b0095","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0043-1354(84)90201-X","article-title":"Influence of high NaCl and NH4Cl salt levels on methanogenic associations","volume":"18","author":"de Baere","year":"1984","journal-title":"Water Res."},{"issue":"2","key":"10.1016\/j.biortech.2019.02.106_b0100","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0141-0229(94)00011-F","article-title":"Sodium inhibition in the anaerobic digestion process: antagonism and adaptation phenomena","volume":"17","author":"Feijoo","year":"1995","journal-title":"Enzyme Microb. Technol."},{"issue":"17","key":"10.1016\/j.biortech.2019.02.106_b0105","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1016\/j.watres.2009.05.044","article-title":"Modeling of ammonia speciation in anaerobic digesters","volume":"43","author":"Hafner","year":"2009","journal-title":"Water Res."},{"issue":"2","key":"10.1016\/j.biortech.2019.02.106_b0110","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s11356-017-1103-y","article-title":"Temporal variation in bacterial and methanogenic communities of three full-scale anaerobic digesters treating swine wastewater","volume":"26","author":"Han","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"18","key":"10.1016\/j.biortech.2019.02.106_b0115","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1016\/j.scitotenv.2009.10.067","article-title":"Interactions between effects of environmental chemicals and natural stressors: a review","volume":"408","author":"Holmstrup","year":"2010","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.biortech.2019.02.106_b0120","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1128\/AEM.51.3.572-579.1986","article-title":"Sulfate reduction relative to methane production in high-rate anaerobic digestion: technical aspects","volume":"51","author":"Isa","year":"1986","journal-title":"Appl. Environ. Microbiol."},{"issue":"6","key":"10.1016\/j.biortech.2019.02.106_b0125","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1128\/AEM.35.6.1027-1034.1978","article-title":"Effect of sulfur-containing compounds on anaerobic degradation of cellulose to methane by mixed cultures obtained from sewage sludge","volume":"35","author":"Khan","year":"1978","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.biortech.2019.02.106_b0130","series-title":"Anaerobic Biotechnology for Bioenergy Production: Principles and Applications","author":"Khanal","year":"2011"},{"key":"10.1016\/j.biortech.2019.02.106_b0135","first-page":"97","article-title":"Cation toxicity and stimulation in anaerobic waste treatment","author":"Kugelman","year":"1965","journal-title":"J. Water Pollut. Control Feder."},{"key":"10.1016\/j.biortech.2019.02.106_b0140","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.biortech.2014.02.012","article-title":"Improvement of anaerobic digestion performance by continuous nitrogen removal with a membrane contactor treating a substrate rich in ammonia and sulfide","volume":"158","author":"Lauterbock","year":"2014","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2019.02.106_b0145","series-title":"The Effect of Simultaneous Inhibition of Ammonia and Sodium Ion on Methanogenesis of Acetate: Lab- and Full-scale Processes","author":"Lee","year":"2018"},{"key":"10.1016\/j.biortech.2019.02.106_b0150","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cej.2016.04.097","article-title":"Seasonal monitoring of bacteria and archaea in a full-scale thermophilic anaerobic digester treating food waste-recycling wastewater: correlations between microbial community characteristics and process variables","volume":"300","author":"Lee","year":"2016","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.biortech.2019.02.106_b0155","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.biortech.2018.03.052","article-title":"Microbial communities underpinning mesophilic anaerobic digesters treating food wastewater or sewage sludge: a full-scale study","volume":"259","author":"Lee","year":"2018","journal-title":"Bioresour. Technol."},{"issue":"1","key":"10.1016\/j.biortech.2019.02.106_b0160","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00253-006-0799-2","article-title":"Impact of increasing NaCl concentrations on the performance and community composition of two anaerobic reactors","volume":"75","author":"Lefebvre","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biortech.2019.02.106_b0165","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.cej.2017.02.098","article-title":"Methanogenic population dynamics regulated by bacterial community responses to protein-rich organic wastes in a high solid anaerobic digester","volume":"317","author":"Li","year":"2017","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.biortech.2019.02.106_b0170","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.nbt.2018.02.013","article-title":"Relationship between microbial community, operational factors and ammonia inhibition resilience in anaerobic digesters at low and moderate ammonia background concentrations","volume":"44","author":"Lu","year":"2018","journal-title":"Nano Biotechnol."},{"issue":"4","key":"10.1016\/j.biortech.2019.02.106_b0175","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1128\/MMBR.63.4.923-967.1999","article-title":"Stress genes and proteins in the archaea","volume":"63","author":"Macario","year":"1999","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"1","key":"10.1016\/j.biortech.2019.02.106_b0180","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF00353945","article-title":"Ammonium ion transport\u2014a cause of cell death","volume":"22","author":"Martinelle","year":"1996","journal-title":"Cytotechnology"},{"issue":"6","key":"10.1016\/j.biortech.2019.02.106_b0185","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.mib.2005.10.011","article-title":"Stress response by solute accumulation in archaea","volume":"8","author":"M\u00fcller","year":"2005","journal-title":"Curr. Opin. Microbiol."},{"issue":"5","key":"10.1016\/j.biortech.2019.02.106_b0190","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0032-9592(98)00018-1","article-title":"Effect of pH on growth kinetics and sulphide toxicity thresholds of a range of methanogenic, syntrophic and sulphate-reducing bacteria","volume":"33","author":"O'Flaherty","year":"1998","journal-title":"Process Biochem."},{"issue":"9","key":"10.1016\/j.biortech.2019.02.106_b0195","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1002\/jctb.1923","article-title":"Osmoprotectants enhance methane production from the anaerobic digestion of food wastes containing a high content of salt","volume":"83","author":"Oh","year":"2008","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"10.1016\/j.biortech.2019.02.106_b0200","series-title":"Life at high salt concentrations","first-page":"263","author":"Oren","year":"2006"},{"issue":"1","key":"10.1016\/j.biortech.2019.02.106_b0205","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0141-0229(88)90094-4","article-title":"Sodium inhibition of acetoclastic methanogens in granular sludge from a UASB reactor","volume":"10","author":"Rinzema","year":"1988","journal-title":"Enzyme Microb. Technol."},{"issue":"6","key":"10.1016\/j.biortech.2019.02.106_b0210","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.watres.2006.01.024","article-title":"Inhibition of biohydrogen production by ammonia","volume":"40","author":"Salerno","year":"2006","journal-title":"Water Res."},{"issue":"2","key":"10.1016\/j.biortech.2019.02.106_b0215","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.biosystemseng.2013.08.005","article-title":"Effect of ammonia and nitrate on biogas production from food waste via anaerobic digestion","volume":"116","author":"Sheng","year":"2013","journal-title":"Biosyst. Eng."},{"key":"10.1016\/j.biortech.2019.02.106_b0220","series-title":"Anaerobic Biotechnology for Industrial Wastewaters","author":"Speece","year":"1996"},{"issue":"2\u20133","key":"10.1016\/j.biortech.2019.02.106_b0225","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0723-2020(86)80034-0","article-title":"Ammonia toxicity in pure cultures of methanogenic bacteria","volume":"7","author":"Sprott","year":"1986","journal-title":"Syst. Appl. Microbiol."},{"issue":"1","key":"10.1016\/j.biortech.2019.02.106_b0230","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0045-6535(03)00434-X","article-title":"Ammonia inhibition on thermophilic anaerobic digestion","volume":"53","author":"Sung","year":"2003","journal-title":"Chemosphere"},{"key":"10.1016\/j.biortech.2019.02.106_b0235","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.biortech.2012.08.091","article-title":"Overcoming sodium toxicity by utilizing grass leaves as co-substrate during the start-up of batch thermophilic anaerobic digestion","volume":"125","author":"Suwannoppadol","year":"2012","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2019.02.106_b0240","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1749-6632.1983.tb47929.x","article-title":"Continuous anaerobic digestion with methanosarcina barkeri","volume":"413","author":"Wandrey","year":"1983","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biortech.2019.02.106_b0245","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.biombioe.2011.12.022","article-title":"Oleaginous yeast Cryptococcus curvatus for biofuel production: ammonia\u2019s effect","volume":"37","author":"Zheng","year":"2012","journal-title":"Biomass Bioenergy"},{"issue":"6","key":"10.1016\/j.biortech.2019.02.106_b0250","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1128\/AEM.56.6.1875-1881.1990","article-title":"Modeling of the bacterial growth curve","volume":"56","author":"Zwietering","year":"1990","journal-title":"Appl. Environ. Microbiol."}],"container-title":["Bioresource Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960852419303141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960852419303141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T13:33:06Z","timestamp":1606570386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960852419303141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":50,"alternative-id":["S0960852419303141"],"URL":"https:\/\/doi.org\/10.1016\/j.biortech.2019.02.106","relation":{},"ISSN":["0960-8524"],"issn-type":[{"value":"0960-8524","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single and combined inhibition of Methanosaeta concilii by ammonia, sodium ion and hydrogen sulfide","name":"articletitle","label":"Article Title"},{"value":"Bioresource Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biortech.2019.02.106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}