{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:34:20Z","timestamp":1791480860380,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51521006"],"award-info":[{"award-number":["51521006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51578223"],"award-info":[{"award-number":["51578223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["2017SK2242"],"award-info":[{"award-number":["2017SK2242"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioresource Technology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.biortech.2019.02.120","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T17:23:57Z","timestamp":1551288237000},"page":"179-188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":146,"special_numbering":"C","title":["Metagenomic analysis reveals the effects of long-term antibiotic pressure on sludge anaerobic digestion and antimicrobial resistance risk"],"prefix":"10.1016","volume":"282","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3745-712X","authenticated-orcid":false,"given":"Rui","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ping","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Zheng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.biortech.2019.02.120_b0005","doi-asserted-by":"crossref","first-page":"8581","DOI":"10.1016\/j.biortech.2010.06.075","article-title":"The effect and fate of antibiotics during the anaerobic digestion of pig manure","volume":"101","author":"\u00c1lvarez","year":"2010","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2019.02.120_b0010","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/nar\/gkl951","article-title":"CDD: a conserved domain database for interactive domain family analysis","volume":"35","author":"Aron","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biortech.2019.02.120_b0015","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biortech.2018.12.066","article-title":"Sludge anaerobic digestion with high concentrations of tetracyclines and sulfonamides: dynamics of microbial communities and change of antibiotic resistance genes","volume":"276","author":"Bai","year":"2019","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2019.02.120_b0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biortech.2013.01.032","article-title":"The combined effect of cefazolin and oxytertracycline on biogas production from thermophilic anaerobic digestion of dairy manure","volume":"133","author":"Beneragama","year":"2013","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2019.02.120_b0025","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.envint.2015.11.011","article-title":"The urgent need for risk assessment on the antibiotic resistance spread via sewage sludge land application","volume":"87","author":"Bondarczuk","year":"2016","journal-title":"Environ. Int."},{"issue":"7586","key":"10.1016\/j.biortech.2019.02.120_b0030","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature17042","article-title":"Antibacterial drug discovery in the resistance era","volume":"529","author":"Brown","year":"2016","journal-title":"Nature"},{"issue":"5759","key":"10.1016\/j.biortech.2019.02.120_b0035","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1126\/science.1120800","article-title":"Sampling the antibiotic resistome","volume":"311","author":"Costa","year":"2006","journal-title":"Science"},{"issue":"23","key":"10.1016\/j.biortech.2019.02.120_b0040","doi-asserted-by":"crossref","first-page":"9128","DOI":"10.1021\/es102765a","article-title":"Effect of temperature on the fate of genes encoding tetracycline resistance and the integrase of Class 1 integrons within anaerobic and aerobic digesters treating municipal wastewater solids","volume":"44","author":"Diehl","year":"2010","journal-title":"Environ. Sci. Technol."},{"issue":"19","key":"10.1016\/j.biortech.2019.02.120_b0045","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"Edgar","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.biortech.2019.02.120_b0050","unstructured":"EU. 2017. A European one health action plan against antimicrobial resistance (AMR). (https:\/\/ec.europa.eu\/health\/amr\/sites\/amr\/files\/amr_action_plan_2017_en.pdf)."},{"key":"10.1016\/j.biortech.2019.02.120_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.watres.2015.11.071","article-title":"Antibiotic resistance genes and human bacterial pathogens: co-occurrence, removal, and enrichment in municipal sewage sludge digesters","volume":"91","author":"Feng","year":"2016","journal-title":"Water Res."},{"issue":"6098","key":"10.1016\/j.biortech.2019.02.120_b0060","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1126\/science.1220761","article-title":"The shared antibiotic resistome of soil bacteria and human pathogens","volume":"337","author":"Forsberg","year":"2012","journal-title":"Science"},{"issue":"7502","key":"10.1016\/j.biortech.2019.02.120_b0065","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nature13377","article-title":"Bacterial phylogeny structures soil resistomes across habitats","volume":"509","author":"Forsberg","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.biortech.2019.02.120_b0070","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.scitotenv.2012.01.061","article-title":"Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant","volume":"421\u2013422","author":"Gao","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biortech.2019.02.120_b0075","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.watres.2017.07.002","article-title":"Metagenomic analysis reveals wastewater treatment plants as hotspots of antibiotic resistance genes and mobile genetic elements","volume":"123","author":"Guo","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.biortech.2019.02.120_b0080","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.biortech.2016.09.036","article-title":"Removal of cephalosporin antibiotics 7-ACA from wastewater during the cultivation of lipid-accumulating microalgae","volume":"221","author":"Guo","year":"2016","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2019.02.120_b0085","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.scitotenv.2018.05.264","article-title":"Sulfamethazine (SMZ) affects fermentative short-chain fatty acids production from waste activated sludge","volume":"639","author":"Hu","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biortech.2019.02.120_b0090","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1038\/ncomms3151","article-title":"Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota","volume":"4","author":"Hu","year":"2013","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.biortech.2019.02.120_b0095","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40793-016-0138-x","article-title":"The standard operating procedure of the DOE-JGI Microbial Genome Annotation Pipeline (MGAP vol 4)","volume":"11","author":"Huntemann","year":"2016","journal-title":"Stand. Genomic Sci."},{"issue":"D1","key":"10.1016\/j.biortech.2019.02.120_b0100","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/nar\/gkw1004","article-title":"CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database","volume":"45","author":"Jia","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biortech.2019.02.120_b0105","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/ncomms2266","article-title":"Symptomatic atherosclerosis is associated with an altered gut metagenome","volume":"3","author":"Karlsson","year":"2012","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.biortech.2019.02.120_b0110","first-page":"649","article-title":"Metagenomic and network analysis reveal wide distribution and co-occurrence of environmental antibiotic resistance genes","volume":"47","author":"Li","year":"2015","journal-title":"ISME J."},{"key":"10.1016\/j.biortech.2019.02.120_b0115","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jprot.2017.09.011","article-title":"Quantitative proteomic analysis reveals that chemotaxis is involved in chlortetracycline resistance of Aeromonas hydrophila","volume":"172","author":"Li","year":"2018","journal-title":"J. Proteomics"},{"key":"10.1016\/j.biortech.2019.02.120_b0120","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.biortech.2018.01.146","article-title":"Influence of reflux ratio on two-stage anoxic\/oxic with MBR for leachate treatment: performance and microbial community structure","volume":"256","author":"Liu","year":"2018","journal-title":"Bioresour. Technol."},{"issue":"4","key":"10.1016\/j.biortech.2019.02.120_b0125","first-page":"322","article-title":"Rapid degradation of sulphamethoxazole and the further transformation of 3-amino-5-methylisoxazole in a microbial fuel cell","volume":"88","author":"Lu","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.biortech.2019.02.120_b0130","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.scitotenv.2018.06.187","article-title":"Evaluation of anaerobic digestion of food waste and waste activated sludge: soluble COD versus its chemical composition","volume":"643","author":"Ma","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biortech.2019.02.120_b0135","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.biortech.2017.05.154","article-title":"New insights into co-digestion of activated sludge and food waste: biogas versus biofertilizer","volume":"241","author":"Ma","year":"2017","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2019.02.120_b0140","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mib.2015.07.004","article-title":"Bioinformatics of antimicrobial resistance in the age of molecular epidemiology","volume":"27","author":"McArthur","year":"2015","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.biortech.2019.02.120_b0145","unstructured":"O\u2019Neill, J. 2014. Antimicrobial resistance: tackling a crisis for the health and wealth of nations. The Review on Antimicrobial Resistance, 20."},{"issue":"21","key":"10.1016\/j.biortech.2019.02.120_b0150","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1093\/bioinformatics\/btu494","article-title":"STAMP: statistical analysis of taxonomic and functional profiles","volume":"30","author":"Parks","year":"2014","journal-title":"Bioinformatics"},{"issue":"11","key":"10.1016\/j.biortech.2019.02.120_b0155","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1093\/bioinformatics\/bts174","article-title":"IDBA-UD: a de novo assembler for single-cell and metagenomic sequencing data with highly uneven depth","volume":"28","author":"Peng","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.biortech.2019.02.120_b0160","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.envint.2017.10.016","article-title":"Review of antibiotic resistance in China and its environment","volume":"110","author":"Qiao","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.biortech.2019.02.120_b0165","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ceb.2015.02.003","article-title":"Acetyl-CoA and the regulation of metabolism: mechanisms and consequences","volume":"33","author":"Shi","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"issue":"3","key":"10.1016\/j.biortech.2019.02.120_b0170","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/1574-6941.12148","article-title":"454 pyrosequencing analyses of bacterial and archaeal richness in 21 full-scale biogas digesters","volume":"85","author":"Sundberg","year":"2013","journal-title":"FEMS Microbiol. Ecol."},{"issue":"2","key":"10.1016\/j.biortech.2019.02.120_b0175","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1128\/MMBR.68.2.301-319.2004","article-title":"Diversity in chemotaxis mechanisms among the bacteria and archaea","volume":"68","author":"Szurmant","year":"2004","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.biortech.2019.02.120_b0180","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.watres.2016.12.010","article-title":"Correlating methane production to microbiota in anaerobic digesters fed synthetic wastewater","volume":"110","author":"Venkiteshwaran","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.biortech.2019.02.120_b0185","series-title":"Global Priority List of Antibiotic-resistant Bacteria to Guide Research, Discovery, and Development of New Antibiotics","year":"2017"},{"key":"10.1016\/j.biortech.2019.02.120_b0190","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.mib.2018.01.010","article-title":"Exploring the function of bacterial chemotaxis","volume":"45","author":"Wong-Ng","year":"2018","journal-title":"Curr. Opin. Microbiol."},{"issue":"112","key":"10.1016\/j.biortech.2019.02.120_b0195","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.scitotenv.2017.08.295","article-title":"Rapid startup of thermophilic anaerobic digester to remove tetracycline and sulfonamides resistance genes from sewage sludge","volume":"612","author":"Xu","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biortech.2019.02.120_b0200","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.biortech.2018.04.083","article-title":"Organic loading rate and hydraulic retention time shape distinct ecological networks of anaerobic digestion related microbiome","volume":"262","author":"Xu","year":"2018","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2019.02.120_b0205","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.biortech.2017.07.056","article-title":"Depth-resolved microbial community analyses in the anaerobic co-digester of dewatered sewage sludge with food waste","volume":"244","author":"Xu","year":"2017","journal-title":"Bioresour. Technol."},{"issue":"18","key":"10.1016\/j.biortech.2019.02.120_b0210","doi-asserted-by":"crossref","first-page":"10197","DOI":"10.1021\/es4017365","article-title":"Exploring variation of antibiotic resistance genes in activated sludge over a four-year period through a metagenomic approach","volume":"47","author":"Yang","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"27","key":"10.1016\/j.biortech.2019.02.120_b0215","first-page":"97","article-title":"Fate of antibiotic resistance genes in sewage treatment plant revealed by metagenomic approach","volume":"62","author":"Yang","year":"2014","journal-title":"Water Res."},{"key":"10.1016\/j.biortech.2019.02.120_b0220","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.watres.2018.01.062","article-title":"Enhancing sludge methanogenesis with improved redox activity of extracellular polymeric substances by hematite in red mud","volume":"134","author":"Ye","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.biortech.2019.02.120_b0225","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.biortech.2017.08.063","article-title":"Red mud enhances methanogenesis with the simultaneous improvement of hydrolysis-acidification and electrical conductivity","volume":"247","author":"Ye","year":"2017","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2019.02.120_b0230","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.watres.2016.12.020","article-title":"Anaerobic treatment of antibiotic production wastewater pretreated with enhanced hydrolysis: simultaneous reduction of COD and ARGs","volume":"110","author":"Yi","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.biortech.2019.02.120_b0235","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.biortech.2018.01.100","article-title":"Variation of antibiotics in sludge pretreatment and anaerobic digestion processes: degradation and solid-liquid distribution","volume":"255","author":"Zhang","year":"2018","journal-title":"Bioresour. Technol."},{"issue":"1","key":"10.1016\/j.biortech.2019.02.120_b0240","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02288-14","article-title":"High-throughput metagenomic technologies for complex microbial community analysis: open and closed formats","volume":"6","author":"Zhou","year":"2015","journal-title":"Mbio"},{"issue":"10","key":"10.1016\/j.biortech.2019.02.120_b0245","doi-asserted-by":"crossref","first-page":"16270","DOI":"10.1038\/nmicrobiol.2016.270","article-title":"Continental-scale pollution of estuaries with antibiotic resistance genes","volume":"2","author":"Zhu","year":"2017","journal-title":"Nat. Microbiol."}],"container-title":["Bioresource Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960852419303281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960852419303281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T03:11:45Z","timestamp":1722913905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960852419303281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":49,"alternative-id":["S0960852419303281"],"URL":"https:\/\/doi.org\/10.1016\/j.biortech.2019.02.120","relation":{},"ISSN":["0960-8524"],"issn-type":[{"value":"0960-8524","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metagenomic analysis reveals the effects of long-term antibiotic pressure on sludge anaerobic digestion and antimicrobial resistance risk","name":"articletitle","label":"Article Title"},{"value":"Bioresource Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biortech.2019.02.120","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}