{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:37:20Z","timestamp":1793723840976,"version":"4.6.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre Poland","doi-asserted-by":"publisher","award":["2017\/25\/N\/ST8\/01795"],"award-info":[{"award-number":["2017\/25\/N\/ST8\/01795"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"National Science Centre Poland","doi-asserted-by":"publisher","award":["2017\/26\/E\/ST8\/00007"],"award-info":[{"award-number":["2017\/26\/E\/ST8\/00007"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004442","name":"Narodowym Centrum Nauki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004442","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioresource Technology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.biortech.2023.130123","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T20:21:35Z","timestamp":1701375695000},"page":"130123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Simultaneous medium chain carboxylic acids and 1,3-propanediol production in a bioaugmented lactate-based chain elongation induced with glycerol"],"prefix":"10.1016","volume":"393","author":[{"given":"Anna","family":"Duber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Zagrodnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Juzwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Gutowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Oleskowicz-Popiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biortech.2023.130123_b0005","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1128\/aem.35.5.872-877.1978","article-title":"Production of branched-chain volatile fatty acids by certain anaerobic bacteria","volume":"35","author":"Allison","year":"1978","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.biortech.2023.130123_b0010","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1021\/acs.est.5b04847","article-title":"Chain elongation with reactor microbiomes: open-culture biotechnology to produce biochemicals","volume":"50","author":"Angenent","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.biortech.2023.130123_b0015","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.3390\/microorganisms8071092","article-title":"Skin bacteria mediate glycerol fermentation to produce electricity and resist UV-B","volume":"8","author":"Balasubramaniam","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.biortech.2023.130123_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2020.123895","article-title":"Co-production of hydrogen and caproate for an effective bioprocessing of waste","volume":"318","author":"Brodowski","year":"2020","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2023.130123_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149885","article-title":"Effect of external acetate on lactate-based carboxylate platform: Shifted lactate overloading limit and hydrogen co-production","volume":"802","author":"Brodowski","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biortech.2023.130123_b0030","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s11157-015-9380-8","article-title":"How to use molecular biology tools for the study of the anaerobic digestion process?","volume":"14","author":"Cabezas","year":"2015","journal-title":"Rev. Environ. Sci. Biotechnol."},{"key":"10.1016\/j.biortech.2023.130123_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.116396","article-title":"Mildly acidic pH selects for chain elongation to caproic acid over alternative pathways during lactic acid fermentation","volume":"186","author":"Candry","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.biortech.2023.130123_b0040","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/jctb.5132","article-title":"Isobutyrate biosynthesis via methanol chain elongation: converting organic wastes to platform chemicals","volume":"92","author":"Chen","year":"2017","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"10.1016\/j.biortech.2023.130123_b0045","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s12155-021-10353-6","article-title":"Bioconversion of glycerol into biofuels\u2014Opportunities and challenges","volume":"15","author":"Chilakamarry","year":"2022","journal-title":"Bioenerg. Res."},{"key":"10.1016\/j.biortech.2023.130123_b0050","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1007\/s12010-013-0310-3","article-title":"In situ biphasic extractive fermentation for hexanoic acid production from sucrose by Megasphaera elsdenii NCIMB 702410","volume":"171","author":"Choi","year":"2013","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.biortech.2023.130123_b0055","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1039\/C7FD00070G","article-title":"Organic waste as a sustainable feedstock for platform chemicals","volume":"202","author":"Coma","year":"2017","journal-title":"Faraday Discuss."},{"key":"10.1016\/j.biortech.2023.130123_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2019.115215","article-title":"Consecutive lactate formation and chain elongation to reduce exogenous chemicals input in repeated-batch food waste fermentation","volume":"169","author":"Contreras-D\u00e1vila","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.biortech.2023.130123_b0065","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/fermentation7010041","article-title":"Lactate metabolism and microbiome composition are affected by nitrogen gas supply in continuous lactate-based chain elongation","volume":"7","author":"Contreras-D\u00e1vila","year":"2021","journal-title":"Fermentation"},{"key":"10.1016\/j.biortech.2023.130123_b0070","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1021\/acsestengg.1c00214","article-title":"Designing a selective n-caproate adsorption-recovery process with granular activated carbon and screening of conductive materials in chain elongation","volume":"2","author":"Contreras-D\u00e1vila","year":"2022","journal-title":"ACS EST Eng."},{"key":"10.1016\/j.biortech.2023.130123_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biombioe.2018.07.023","article-title":"Production of medium-chain carboxylic acids by anaerobic fermentation of glycerol using a bioaugmented open culture","volume":"118","author":"Dams","year":"2018","journal-title":"Biomass Bioenergy"},{"key":"10.1016\/j.biortech.2023.130123_b0080","doi-asserted-by":"crossref","first-page":"8184","DOI":"10.1021\/acssuschemeng.0c00907","article-title":"Methanol-based chain elongation with acetate to n-butyrate and isobutyrate at varying selectivities dependent on pH","volume":"8","author":"De Leeuw","year":"2020","journal-title":"ACS Sustain. Chem. Eng."},{"key":"10.1016\/j.biortech.2023.130123_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138814","article-title":"Evaluation of the feed composition for an effective medium chain carboxylic acid production in an open culture fermentation","volume":"728","author":"Duber","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biortech.2023.130123_b0090","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1021\/acssuschemeng.1c05869","article-title":"Lactate and ethanol chain elongation in the presence of lactose: insight into product selectivity and microbiome composition","volume":"10","author":"Duber","year":"2022","journal-title":"ACS Sustain. Chem. Eng."},{"key":"10.1016\/j.biortech.2023.130123_b0095","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1128\/jb.72.5.681-689.1956","article-title":"Properties of a fatty acid forming organism isolated from the rumen of sheep","volume":"72","author":"Elsden","year":"1956","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.biortech.2023.130123_b0100","first-page":"26","article-title":"Acid whey: Is the waste product an untapped goldmine?","volume":"95","author":"Erickson","year":"2017","journal-title":"Chem. Eng. News"},{"key":"10.1016\/j.biortech.2023.130123_b0105","doi-asserted-by":"crossref","first-page":"10442","DOI":"10.1002\/er.5673","article-title":"Improved dark fermentation of cane molasses in mesophilic and thermophilic anaerobic fluidized bed reactors by selecting operational conditions","volume":"44","author":"Ferreira","year":"2020","journal-title":"Int. J. Energy Res."},{"key":"10.1016\/j.biortech.2023.130123_b0110","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.695306","article-title":"Diverse profile of fermentation byproducts from thin stillage","volume":"9","author":"Fortney","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.biortech.2023.130123_b0115","doi-asserted-by":"crossref","first-page":"7669","DOI":"10.1021\/es5017075","article-title":"Bioaugmentation as a solution to increase methane production from an ammonia-rich substrate","volume":"48","author":"Fotidis","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.biortech.2023.130123_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2019.121574","article-title":"Fruity flavors from waste: A novel process to upgrade crude glycerol to ethyl valerate","volume":"289","author":"Ganigu\u00e9","year":"2019","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2023.130123_b0125","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1128\/aem.42.1.12-19.1981","article-title":"Features of rumen and sewage sludge strains of Eubacterium limosum, a methanol- and H2-CO2-utilizing species","volume":"42","author":"Genthner","year":"1981","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.biortech.2023.130123_b0130","first-page":"119","article-title":"Bioaugmentation and its application in wastewater treatment: A review","volume":"140","author":"Herrero","year":"2015","journal-title":"Chemosphere, Wastewater-Energy Nexus: towards Sustainable Wastewater Reclamation"},{"key":"10.1016\/j.biortech.2023.130123_b0135","doi-asserted-by":"crossref","first-page":"11980","DOI":"10.1038\/s41598-021-91386-x","article-title":"Propionic acid produced by Cutibacterium acnes fermentation ameliorates ultraviolet B-induced melanin synthesis","volume":"11","author":"Kao","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biortech.2023.130123_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2021.126211","article-title":"Metabolic cascade of complex organic wastes to medium-chain carboxylic acids: A review on the state-of-the-art multi-omics analysis for anaerobic chain elongation pathways","volume":"344","author":"Kim","year":"2022","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2023.130123_b0145","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.3390\/molecules26237096","article-title":"Imaging flow cytometry to study biofilm-associated microbial aggregates","volume":"26","author":"Konieczny","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.biortech.2023.130123_b0150","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.watres.2016.02.018","article-title":"Conversion of L-lactate into n-caproate by a continuously fed reactor microbiome","volume":"93","author":"Kucek","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.biortech.2023.130123_b0155","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.watres.2017.02.023","article-title":"Thermodynamic and physiological study of caproate and 1,3-propanediol co-production through glycerol fermentation and fatty acids chain elongation","volume":"114","author":"Leng","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.biortech.2023.130123_b0160","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.watres.2018.10.063","article-title":"Shaping microbial consortia in coupling glycerol fermentation and carboxylate chain elongation for Co-production of 1,3-propanediol and caproate: Pathways and mechanisms","volume":"148","author":"Leng","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.biortech.2023.130123_b0165","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.3390\/microorganisms8121970","article-title":"Three novel clostridia isolates produce n-caproate and iso-butyrate from lactate: comparative genomics of chain-elongating bacteria","volume":"8","author":"Liu","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.biortech.2023.130123_b0170","doi-asserted-by":"crossref","first-page":"134","DOI":"10.20546\/ijcmas.2016.508.016","article-title":"Whey and its utilization","volume":"5","author":"Macwan","year":"2016","journal-title":"Int. J. Curr. Microbiol. App. Sci."},{"key":"10.1016\/j.biortech.2023.130123_b0175","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1128\/aem.55.6.1570-1573.1989","article-title":"Metabolism and some characteristics of ruminal strains of Megasphaera elsdenii","volume":"55","author":"Marounek","year":"1989","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.biortech.2023.130123_b0180","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1128\/aem.58.5.1435-1439.1992","article-title":"Reciprocal isomerization of butyrate and isobutyrate by the strictly anaerobic bacterium strain WoG13 and methanogenic isobutyrate degradation by a defined triculture","volume":"58","author":"Matthies","year":"1992","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.biortech.2023.130123_b0185","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.biortech.2015.02.100","article-title":"Bioaugmentation with an anaerobic fungus in a two-stage process for biohydrogen and biogas production using corn silage and cattail","volume":"185","author":"Nkemka","year":"2015","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2023.130123_b0190","series-title":"OECD-FAO Agricultural Outlook 2017\u20132026","author":"Oecd","year":"2017"},{"key":"10.1016\/j.biortech.2023.130123_b0195","doi-asserted-by":"crossref","first-page":"8389","DOI":"10.1039\/D0GC02700F","article-title":"Production of isobutyric acid from methanol by Clostridium luticellarii","volume":"22","author":"Petrognani","year":"2020","journal-title":"Green Chem."},{"key":"10.1016\/j.biortech.2023.130123_b0200","doi-asserted-by":"crossref","first-page":"8564","DOI":"10.1128\/AEM.02443-12","article-title":"Lactate and acrylate metabolism by Megasphaera elsdenii under batch and steady-state conditions","volume":"78","author":"Prabhu","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.biortech.2023.130123_b0205","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/(SICI)1097-4660(199707)69:3<383::AID-JCTB723>3.0.CO;2-H","article-title":"Production of hexanoic acid by free and immobilised cells of Megasphaera elsdenii: influence of in-situ product removal using ion exchange resin","volume":"69","author":"Roddick","year":"1997","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"10.1016\/j.biortech.2023.130123_b0210","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1128\/JB.01217-10","article-title":"Complete genome sequence of a carbon monoxide-utilizing acetogen, Eubacterium limosum KIST612","volume":"193","author":"Roh","year":"2011","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.biortech.2023.130123_b0215","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.copbio.2014.01.003","article-title":"Chain elongation in anaerobic reactor microbiomes to recover resources from waste","volume":"27","author":"Spirito","year":"2014","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.biortech.2023.130123_b0220","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/bit.21857","article-title":"Glycerol fermentation by (open) mixed cultures: A chemostat study","volume":"100","author":"Temudo","year":"2008","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.biortech.2023.130123_b0225","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1007\/s13762-019-02562-6","article-title":"Anaerobic production of valeric acid from crude glycerol via chain elongation","volume":"17","author":"Veras","year":"2020","journal-title":"Int. J. Environ. Sci. Technol."},{"key":"10.1016\/j.biortech.2023.130123_b0230","doi-asserted-by":"crossref","DOI":"10.1021\/acs.est.9b07651","article-title":"Enrichment versus bioaugmentation\u2014Microbiological production of caproate from mixed carbon sources by mixed bacterial culture and Clostridium kluyveri","author":"Zagrodnik","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.biortech.2023.130123_b0235","article-title":"The synthesis of n-caproate from lactate: a new efficient process for medium-chain carboxylates production","volume":"5","author":"Zhu","year":"2015","journal-title":"Sci. Rep."}],"container-title":["Bioresource Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960852423015511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960852423015511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:10:58Z","timestamp":1760764258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960852423015511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":47,"alternative-id":["S0960852423015511"],"URL":"https:\/\/doi.org\/10.1016\/j.biortech.2023.130123","relation":{},"ISSN":["0960-8524"],"issn-type":[{"value":"0960-8524","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous medium chain carboxylic acids and 1,3-propanediol production in a bioaugmented lactate-based chain elongation induced with glycerol","name":"articletitle","label":"Article Title"},{"value":"Bioresource Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biortech.2023.130123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"130123"}}