{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:49:22Z","timestamp":1791323362710,"version":"4.3.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004027","name":"Postdoctoral Foundation of Heilongjiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioresource Technology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.biortech.2026.135220","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:09:48Z","timestamp":1782774588000},"page":"135220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Interpretable machine learning for optimization of ultrasound-assisted polysaccharide extraction using natural deep eutectic solvents: From yield enhancement to structural and antioxidant activity validation"],"prefix":"10.1016","volume":"459","author":[{"given":"Shulu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruichen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinze","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiting","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biortech.2026.135220_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122003","article-title":"Insights into the molecular mechanisms, structure-activity relationships and application prospects of polysaccharides by regulating Nrf2-mediated antioxidant response","volume":"333","author":"Chen","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biortech.2026.135220_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132391","article-title":"The relationship between polysaccharide structure and its antioxidant activity needs to be systematically elucidated","volume":"270","author":"Chen","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biortech.2026.135220_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2024.129143","article-title":"Application of a novel deep eutectic solvent as an eco-friendly medium for green extraction of cadmium from herbal medicines","volume":"354","author":"Dong","year":"2025","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.biortech.2026.135220_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.engappai.2023.107829","article-title":"Global and local interpretability techniques of supervised machine learning black box models for numerical medical data","volume":"131","author":"Hakkoum","year":"2024","journal-title":"Eng. Appl. Artif. Intel."},{"key":"10.1016\/j.biortech.2026.135220_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117521","article-title":"Deep eutectic solvents as extraction media for food-derived biomacromolecules","volume":"171","author":"He","year":"2024","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.biortech.2026.135220_b0030","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.ijbiomac.2018.10.096","article-title":"Anti-oxidation and anti-aging activity of polysaccharide from Malus micromalus Makino fruit wine","volume":"121","author":"Hui","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biortech.2026.135220_b0035","doi-asserted-by":"crossref","unstructured":"Jiang, S., Wang, Q., Wang, Z., Borjigin, G., Sun, J., Zhao, Y., Li, Q., Shi, X., faizan ali shah, S., Wang, X., Gan, C., Wu, Y., Song, X., Li, Q., Yang, C. 2024. Ultrasound-assisted polysaccharide extraction from Fritillaria ussuriensis Maxim. and its structural characterization, antioxidant and immunological activity. Ultrasonics Sonochemistry, 103, 106800.","DOI":"10.1016\/j.ultsonch.2024.106800"},{"issue":"11","key":"10.1016\/j.biortech.2026.135220_b0040","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.1021\/jf900269r","article-title":"Purification of a water extract of chinese sweet tea plant (Rubus suavissimus S. Lee) by alcohol precipitation","volume":"57","author":"Koh","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biortech.2026.135220_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.120481","article-title":"A novel Stauntonia leucantha fruits arabinogalactan: isolation and structural characterization","volume":"303","author":"Li","year":"2023","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.biortech.2026.135220_b0050","doi-asserted-by":"crossref","DOI":"10.1111\/1541-4337.70104","article-title":"Recent advances in pressurized hot water extraction\/modification of polysaccharides: structure, physicochemical properties, bioactivities, and applications","volume":"24","author":"Li","year":"2025","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.biortech.2026.135220_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135575","article-title":"Sustainable protein\/polysaccharide aerogel for the simultaneous and efficient removal of multiple organic contaminants: insights from DFT calculations and phenomenological mass\u2013transfer modeling","volume":"479","author":"Li","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.biortech.2026.135220_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122417","article-title":"Structural characterisation and anti-colon cancer activity of an arabinogalactan RSA-1 from Raphani semen","volume":"342","author":"Li","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biortech.2026.135220_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130263","article-title":"Polysaccharides extraction from Ganoderma lucidum using a ternary deep eutectic solvents of choline chloride\/guaiacol\/lactic acid","volume":"263","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biortech.2026.135220_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.142575","article-title":"One-pot production of 5-methylfurfural (5-MF) and enhanced dewaterability of waste activated sludge by hydrothermal treatment with natural deep eutectic solvents (NADES): experimental and theoretical studies","volume":"464","author":"Liu","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.biortech.2026.135220_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.124581","article-title":"Evaluation of I-optimal and Box\u2013Behnken designs for green extraction of pectins using NADES from carrot pomace","volume":"373","author":"Mazurek-Ho\u0142ys","year":"2026","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biortech.2026.135220_b0080","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cpc.2017.12.002","article-title":"PAREMD: a parallel program for the evaluation of momentum space properties of atoms and molecules","volume":"224","author":"Meena","year":"2018","journal-title":"Comput. Phys. Commun."},{"key":"10.1016\/j.biortech.2026.135220_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.123155","article-title":"An arabinogalactan from Lycium barbarum mitigated DSS caused intestinal injury via inhibiting mucosal damage and regulating the gut microbiota disorder","volume":"352","author":"Mou","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biortech.2026.135220_b0090","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ins.2017.12.059","article-title":"A Pearson\u2019s correlation coefficient based decision tree and its parallel implementation","volume":"435","author":"Mu","year":"2018","journal-title":"Inf. Sci."},{"key":"10.1016\/j.biortech.2026.135220_b0095","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1016\/j.ijbiomac.2021.05.213","article-title":"Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide","volume":"183","author":"Nai","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biortech.2026.135220_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2023.115001","article-title":"Non-destructive detection of polysaccharides and moisture in Ganoderma lucidum using near-infrared spectroscopy and machine learning algorithm","volume":"184","author":"Ni","year":"2023","journal-title":"LWT"},{"key":"10.1016\/j.biortech.2026.135220_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.152657","article-title":"Process strategies for recovery of sugars, lipids, and lignin from oilcane bagasse using natural deep eutectic solvents (NADES)","volume":"493","author":"Raj","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.biortech.2026.135220_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2021.117624","article-title":"Density functional theory investigation into the interaction of deep eutectic solvents with amino acids","volume":"343","author":"Shakourian-Fard","year":"2021","journal-title":"J. Mol. Liq."},{"issue":"2","key":"10.1016\/j.biortech.2026.135220_b0115","doi-asserted-by":"crossref","first-page":"141","DOI":"10.31545\/intagr\/117501","article-title":"Optimization of acid assisted extraction process of foxtail millet polysaccharides and its antioxidant activity","volume":"34","author":"Shi","year":"2020","journal-title":"Int. Agrophys."},{"key":"10.1016\/j.biortech.2026.135220_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2023.122063","article-title":"Extraction of Lycium barbarum polysaccharides using temperature-switchable deep eutectic solvents: a sustainable methodology for recycling and reuse of the extractant","volume":"383","author":"Tang","year":"2023","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.biortech.2026.135220_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.104499","article-title":"Characterization and in vitro digestion of alkali-extracted polysaccharides from Grifola frondosa and its impacts on human gut microbiota","volume":"60","author":"Tian","year":"2024","journal-title":"Food Biosci."},{"key":"10.1016\/j.biortech.2026.135220_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2023.105460","article-title":"Determination of polysaccharide content in shiitake mushroom beverage by NIR spectroscopy combined with machine learning: a comparative analysis","volume":"122","author":"Wang","year":"2023","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.biortech.2026.135220_b0135","article-title":"Development and optimization of green extraction of polyphenols in Michelia alba using natural deep eutectic solvents (NADES) and evaluation of bioactivity","volume":"37","author":"Wang","year":"2024","journal-title":"Sustain. Chem. Pharm."},{"key":"10.1016\/j.biortech.2026.135220_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127955","article-title":"Effect of monosaccharide composition and proportion on the bioactivity of polysaccharides: a review","volume":"254","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biortech.2026.135220_b0145","article-title":"Efficient extraction of pectic polysaccharides from thinned unripe kiwifruits by deep eutectic solvent-based methods: chemical structures and bioactivities","volume":"21","author":"Wu","year":"2024","journal-title":"Food Chem.: X"},{"key":"10.1016\/j.biortech.2026.135220_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122199","article-title":"Deep eutectic solvents as sustainable extraction media for extraction of polysaccharides from natural sources: status, challenges and prospects","volume":"338","author":"Yahaya","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biortech.2026.135220_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.123388","article-title":"Alkali-extracted rhamnogalactoarabinan from Chaetomorpha linum: characterisation and anti-type 2 diabetic effect","volume":"356","author":"Yang","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biortech.2026.135220_b0160","first-page":"9","article-title":"Effects of monosaccharide composition on quantitative analysis of total sugar content by phenol-sulfuric acid method","author":"Yue","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.biortech.2026.135220_b0165","doi-asserted-by":"crossref","unstructured":"Zhang, J., Liang, Z., Zhang, K., Tang, X., Wang, L., Gu, X., Savelkoul, H.F.J., Li, J. 2025. Ultrasound-Assisted Extraction, Characterization, and Antioxidant Activities of the Polysaccharides from Fermented Astragalus membranaceus. in: Molecules, Vol. 30, pp. 1159.","DOI":"10.3390\/molecules30051159"},{"key":"10.1016\/j.biortech.2026.135220_b0170","first-page":"11","article-title":"A Review of the Pharmacological Action of Astragalus Polysaccharide","author":"Zheng","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biortech.2026.135220_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2026.147769","article-title":"Enhanced and sustainable extraction of acetic acid from wastewater using a novel ternary deep eutectic solvent","volume":"545","author":"Zhou","year":"2026","journal-title":"J. Clean. Prod."}],"container-title":["Bioresource Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960852426013027?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960852426013027?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:57:58Z","timestamp":1787122678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960852426013027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":35,"alternative-id":["S0960852426013027"],"URL":"https:\/\/doi.org\/10.1016\/j.biortech.2026.135220","relation":{},"ISSN":["0960-8524"],"issn-type":[{"value":"0960-8524","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interpretable machine learning for optimization of ultrasound-assisted polysaccharide extraction using natural deep eutectic solvents: From yield enhancement to structural and antioxidant activity validation","name":"articletitle","label":"Article Title"},{"value":"Bioresource Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biortech.2026.135220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"135220"}}