{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:06:58Z","timestamp":1790208418458,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22278314"],"award-info":[{"award-number":["22278314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32501130"],"award-info":[{"award-number":["32501130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioresource Technology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.biortech.2026.135499","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:19:27Z","timestamp":1784906367000},"page":"135499","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Rational design of IsPETase variant toward efficient poly(ethylene terephthalate) ambient degradation"],"prefix":"10.1016","volume":"461","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4104-6657","authenticated-orcid":false,"given":"Jiaxing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1192-5442","authenticated-orcid":false,"given":"Wei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengping","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengfan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biortech.2026.135499_b0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"issue":"8","key":"10.1016\/j.biortech.2026.135499_b0010","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41929-022-00821-3","article-title":"Directed evolution of an efficient and thermostable PET depolymerase","volume":"5","author":"Bell","year":"2022","journal-title":"Nat. Catal."},{"issue":"3","key":"10.1016\/j.biortech.2026.135499_b0015","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1021\/acscatal.0c05126","article-title":"Computational redesign of a PETase for plastic biodegradation under ambient condition by the GRAPE strategy","volume":"11","author":"Cui","year":"2021","journal-title":"ACS Catal."},{"issue":"1","key":"10.1016\/j.biortech.2026.135499_b0020","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/s41467-024-45662-9","article-title":"Computational redesign of a hydrolase for nearly complete PET depolymerization at industrially relevant high-solids loading","volume":"15","author":"Cui","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biortech.2026.135499_b0025","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jbiotec.2021.05.006","article-title":"Enhancing PET hydrolytic enzyme activity by fusion of the cellulose\u2013binding domain of cellobiohydrolase I from Trichoderma reesei","volume":"334","author":"Dai","year":"2021","journal-title":"J. Biotechnol."},{"issue":"19","key":"10.1016\/j.biortech.2026.135499_b0030","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1063\/1.470117","article-title":"A smooth particle mesh Ewald method","volume":"103","author":"Essmann","year":"1995","journal-title":"J. Chem. Phys."},{"issue":"3","key":"10.1016\/j.biortech.2026.135499_b0035","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1039\/D1GC03885K","article-title":"Efficient glycolysis of PET catalyzed by a metal-free phosphazene base: the important role of EG\u2212","volume":"24","author":"Fan","year":"2022","journal-title":"Green Chem."},{"issue":"35","key":"10.1016\/j.biortech.2026.135499_b0040","doi-asserted-by":"crossref","first-page":"19243","DOI":"10.1021\/jacs.3c04427","article-title":"Insights into the enhancement of the poly(ethylene terephthalate) degradation by FAST-PETase from computational modeling","volume":"145","author":"Garc\u00eda-Meseguer","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"5","key":"10.1016\/j.biortech.2026.135499_b0045","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1021\/acs.jctc.7b00118","article-title":"A Robust and accurate tight-binding quantum chemical method for structures, vibrational frequencies, and noncovalent interactions of large molecular systems parametrized for all spd-block elements (Z = 1\u201386)","volume":"13","author":"Grimme","year":"2017","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.biortech.2026.135499_b0050","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.synbio.2025.10.001","article-title":"Synergistic engineering PETase reveals loop-region mutations for enhanced catalytic activity and thermal stability","volume":"11","author":"Han","year":"2026","journal-title":"Synth. Syst. Biotechnol."},{"issue":"12","key":"10.1016\/j.biortech.2026.135499_b0055","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1021\/ma200949p","article-title":"Enzymatic surface hydrolysis of PET: effect of structural diversity on kinetic properties of cutinases from thermobifida","volume":"44","author":"Herrero Acero","year":"2011","journal-title":"Macromolecules"},{"issue":"14","key":"10.1016\/j.biortech.2026.135499_b0060","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1021\/acs.jcim.3c00519","article-title":"DSDP: a blind docking strategy accelerated by GPUs","volume":"63","author":"Huang","year":"2023","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"10.1016\/j.biortech.2026.135499_b0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."},{"issue":"6223","key":"10.1016\/j.biortech.2026.135499_b0070","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1260352","article-title":"Plastic waste inputs from land into the ocean","volume":"347","author":"Jambeck","year":"2015","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.biortech.2026.135499_b0075","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41467-018-02881-1","article-title":"Structural insight into molecular mechanism of poly(ethylene terephthalate) degradation","volume":"9","author":"Joo","year":"2018","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.biortech.2026.135499_b0080","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","article-title":"Comparison of simple potential functions for simulating liquid water","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J. Chem. Phys."},{"issue":"7","key":"10.1016\/j.biortech.2026.135499_b0085","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1021\/acscatal.7b00838","article-title":"An inverse Michaelis\u2013Menten approach for interfacial enzyme kinetics","volume":"7","author":"Kari","year":"2017","journal-title":"ACS Catal."},{"issue":"12","key":"10.1016\/j.biortech.2026.135499_b0090","doi-asserted-by":"crossref","first-page":"11966","DOI":"10.1021\/acscatal.8b03547","article-title":"Sabatier principle for interfacial (heterogeneous) enzyme catalysis","volume":"8","author":"Kari","year":"2018","journal-title":"ACS Catal."},{"issue":"19","key":"10.1016\/j.biortech.2026.135499_b0095","doi-asserted-by":"crossref","DOI":"10.1063\/5.0007045","article-title":"CP2K: an electronic structure and molecular dynamics software package - Quickstep: efficient and accurate electronic structure calculations","volume":"152","author":"K\u00fchne","year":"2020","journal-title":"J. Chem. Phys."},{"issue":"6510","key":"10.1016\/j.biortech.2026.135499_b0100","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1126\/science.aba9475","article-title":"Evaluating scenarios toward zero plastic pollution","volume":"369","author":"Lau","year":"2020","journal-title":"Science"},{"issue":"23","key":"10.1016\/j.biortech.2026.135499_b0105","doi-asserted-by":"crossref","first-page":"8899","DOI":"10.1039\/D2GC02588D","article-title":"Expanding plastics recycling technologies: chemical aspects, technology status and challenges","volume":"24","author":"Li","year":"2022","journal-title":"Green Chem."},{"key":"10.1016\/j.biortech.2026.135499_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2026.141130","article-title":"Rationality-informed protein evolution enables enhancement of PET hydrolase activity","volume":"503","author":"Lin","year":"2026","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.biortech.2026.135499_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124131","article-title":"Polyethylene terephthalate (PET)-degrading bacteria in the pelagic deep-sea sediments of the Pacific Ocean","volume":"352","author":"Liu","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.biortech.2026.135499_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136389","article-title":"Structure-guided discovery and rational design of a new poly(ethylene terephthalate) hydrolase from AlphaFold protein structure database","volume":"480","author":"Liu","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.biortech.2026.135499_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154947","article-title":"Enhancement of the degradation capacity of IsPETase for PET plastic degradation by protein engineering","volume":"834","author":"Liu","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"43","key":"10.1016\/j.biortech.2026.135499_b0130","doi-asserted-by":"crossref","first-page":"E10049","DOI":"10.1073\/pnas.1807473115","article-title":"Entropic contribution to enhanced thermal stability in the thermostable P450 CYP119","volume":"115","author":"Liu","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"7907","key":"10.1016\/j.biortech.2026.135499_b0135","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41586-022-04599-z","article-title":"Machine learning-aided engineering of hydrolases for PET depolymerization","volume":"604","author":"Lu","year":"2022","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.biortech.2026.135499_b0140","article-title":"A comprehensive electron wavefunction analysis toolbox for chemists","volume":"161","author":"Lu","year":"2024","journal-title":"Multiwfn. J. Chem. Phys."},{"key":"10.1016\/j.biortech.2026.135499_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2025.108788","article-title":"From traditional to AI-driven: the evolution of intelligent enzyme engineering for biocatalysis","volume":"87","author":"Lv","year":"2026","journal-title":"Biotechnol. Adv."},{"issue":"8","key":"10.1016\/j.biortech.2026.135499_b0150","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J. Chem. Theory Comput."},{"issue":"10","key":"10.1016\/j.biortech.2026.135499_b0155","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1002\/jcc.21787","article-title":"MDAnalysis: a toolkit for the analysis of molecular dynamics simulations","volume":"32","author":"Michaud-Agrawal","year":"2011","journal-title":"J. Comput. Chem."},{"issue":"14","key":"10.1016\/j.biortech.2026.135499_b0160","doi-asserted-by":"crossref","first-page":"8550","DOI":"10.1021\/acscatal.1c01204","article-title":"Positive charge introduction on the surface of thermostabilized PET hydrolase facilitates PET binding and degradation","volume":"11","author":"Nakamura","year":"2021","journal-title":"ACS Catal."},{"key":"10.1016\/j.biortech.2026.135499_b0165","doi-asserted-by":"crossref","unstructured":"Protenix, T., Zhang, Y., Gong, C., Zhang, H., Ma, W., Liu, Z., Chen, X., Guan, J., Wang, L., Xiao, W., 2026. Protenix-v1: Toward High-Accuracy Open-Source Biomolecular Structure Prediction. bioRxiv, 2026.02.05.703733. https:\/\/doi.org\/10.64898\/2026.02.05.703733.","DOI":"10.64898\/2026.02.05.703733"},{"issue":"1","key":"10.1016\/j.biortech.2026.135499_b0170","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s42004-020-0291-4","article-title":"Non-bonded force field model with advanced restrained electrostatic potential charges (RESP2)","volume":"3","author":"Schauperl","year":"2020","journal-title":"Commun. Chem."},{"issue":"14","key":"10.1016\/j.biortech.2026.135499_b0175","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202218390","article-title":"Complete depolymerization of PET wastes by an evolved PET hydrolase from directed evolution","volume":"62","author":"Shi","year":"2023","journal-title":"Angew. Chem."},{"issue":"10","key":"10.1016\/j.biortech.2026.135499_b0180","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/biot.201000391","article-title":"Engineered thermobifida fusca cutinase with increased activity on polyester substrates","volume":"6","author":"Silva","year":"2011","journal-title":"Biotechnol. J."},{"issue":"4","key":"10.1016\/j.biortech.2026.135499_b0185","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1021\/acscatal.9b00568","article-title":"Rational protein engineering of thermo-stable PETase from ideonella sakaiensis for highly efficient PET degradation","volume":"9","author":"Son","year":"2019","journal-title":"ACS Catal."},{"key":"10.1016\/j.biortech.2026.135499_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.enzmictec.2020.109656","article-title":"Structural bioinformatics-based protein engineering of thermo-stable PETase from Ideonella sakaiensis","volume":"141","author":"Son","year":"2020","journal-title":"Enzyme Microb. Technol."},{"issue":"5","key":"10.1016\/j.biortech.2026.135499_b0195","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1128\/AEM.06725-11","article-title":"Isolation of a novel cutinase homolog with polyethylene terephthalate-degrading activity from leaf-branch compost by using a metagenomic approach","volume":"78","author":"Sulaiman","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.biortech.2026.135499_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bej.2025.109708","article-title":"Energy-guided accumulated mutation strategy achieves a highly efficient polyethylene terephthalate-degrading enzyme","volume":"219","author":"Wang","year":"2025","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.biortech.2026.135499_b0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-environ-102016-060700","article-title":"Plastic as a persistent marine pollutant","volume":"42","author":"Worm","year":"2017","journal-title":"Annu. Rev. Env. Resour."},{"key":"10.1016\/j.biortech.2026.135499_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.enzmictec.2020.109715","article-title":"Secretory expression in Bacillus subtilis and biochemical characterization of a highly thermostable polyethylene terephthalate hydrolase from bacterium HR29","volume":"143","author":"Xi","year":"2021","journal-title":"Enzyme Microb. Technol."},{"key":"10.1016\/j.biortech.2026.135499_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2022.128026","article-title":"Enhancement of the polyethylene terephthalate and mono-(2-hydroxyethyl) terephthalate degradation activity of Ideonella sakaiensis PETase by an electrostatic interaction-based strategy","volume":"364","author":"Yin","year":"2022","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2026.135499_b0220","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1039\/D3GC03663D","article-title":"Efficient polyethylene terephthalate biodegradation by an engineered Ideonella sakaiensis PETase with a fixed substrate-binding W156 residue","volume":"26","author":"Yin","year":"2024","journal-title":"Green Chem."},{"key":"10.1016\/j.biortech.2026.135499_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134448","article-title":"Toxic effects of fragmented polyethylene terephthalate particles on the marine rotifer Brachionus koreanus: based on ingestion and egestion assay, in vivo toxicity test, and multi-omics analysis","volume":"472","author":"Yoo","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"6278","key":"10.1016\/j.biortech.2026.135499_b0230","first-page":"1196","article-title":"A bacterium that degrades and assimilates poly(ethylene terephthalate)","volume":"351","author":"Yoshida","year":"2016","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.biortech.2026.135499_b0235","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3390\/molecules31101683","article-title":"s_mmpbsa: a lite and cross-platform MM-PBSA program","volume":"31","author":"Zhang","year":"2026","journal-title":"Molecules"},{"key":"10.1016\/j.biortech.2026.135499_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131295","article-title":"Enantioselectivity and origin of enhanced efficiency in polyethylene terephthalate hydrolases catalyzed depolymerization","volume":"452","author":"Zheng","year":"2023","journal-title":"J. Hazard. Mater."},{"issue":"5","key":"10.1016\/j.biortech.2026.135499_b0245","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1021\/acscatal.4c00400","article-title":"Dynamic docking-assisted engineering of hydrolases for efficient PET depolymerization","volume":"14","author":"Zheng","year":"2024","journal-title":"ACS Catal."},{"key":"10.1016\/j.biortech.2026.135499_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2024.131461","article-title":"High terephthalic acid purity: effective polyethylene terephthalate degradation process based on pH regulation with dual-function hydrolase","volume":"413","author":"Zhou","year":"2024","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biortech.2026.135499_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2024.131759","article-title":"Simple enzymatic depolymerization process based on rapid ball milling pretreatment for high-crystalline polyethylene terephthalate fibers","volume":"416","author":"Zhou","year":"2025","journal-title":"Bioresour. Technol."}],"container-title":["Bioresource Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960852426015816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960852426015816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:55:46Z","timestamp":1790207746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960852426015816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":51,"alternative-id":["S0960852426015816"],"URL":"https:\/\/doi.org\/10.1016\/j.biortech.2026.135499","relation":{},"ISSN":["0960-8524"],"issn-type":[{"value":"0960-8524","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rational design of IsPETase variant toward efficient poly(ethylene terephthalate) ambient degradation","name":"articletitle","label":"Article Title"},{"value":"Bioresource Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biortech.2026.135499","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"135499"}}