{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:55:20Z","timestamp":1790902520132,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["B17018"],"award-info":[{"award-number":["B17018"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402032"],"award-info":[{"award-number":["32402032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011496"],"award-info":[{"award-number":["2024A1515011496"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M751730"],"award-info":[{"award-number":["2024M751730"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011620","name":"Center for Life Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioresource Technology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.biortech.2026.135573","type":"journal-article","created":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T14:04:17Z","timestamp":1786284257000},"page":"135573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Multi-omics framework reveals molecular determinants of small peptide trileucine enhancing ethanol stress tolerance in industrial yeast"],"prefix":"10.1016","volume":"462","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-5658","authenticated-orcid":false,"given":"Xiaofan","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biortech.2026.135573_b0005","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1126\/science.1131969","article-title":"Engineering yeast transcription machinery for improved ethanol tolerance and production","volume":"314","author":"Alper","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.biortech.2026.135573_b0010","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1038\/s41467-025-60189-3","article-title":"Machine learning reveals genes impacting oxidative stress resistance across yeasts","volume":"16","author":"Aranguiz","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biortech.2026.135573_b0015","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.febslet.2014.11.024","article-title":"The transcription factor Rap1p is required for tolerance to cell-wall perturbing agents and for cell-wall maintenance in Saccharomyces cerevisiae","volume":"589","author":"Azad","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.biortech.2026.135573_b0020","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41467-020-14525-4","article-title":"FMN reduces Amyloid-\u03b2 toxicity in yeast by regulating redox status and cellular metabolism","volume":"11","author":"Chen","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biortech.2026.135573_b0025","doi-asserted-by":"crossref","first-page":"31311","DOI":"10.1038\/srep31311","article-title":"Protective Effects of arginine on Saccharomyces cerevisiae against ethanol stress","volume":"6","author":"Cheng","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biortech.2026.135573_b0030","doi-asserted-by":"crossref","first-page":"7483","DOI":"10.1007\/s00253-020-10768-9","article-title":"Assessment of ethanol tolerance of Kluyveromyces marxianus CCT 7735 selected by adaptive laboratory evolution","volume":"104","author":"da Silveira","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biortech.2026.135573_b0035","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.cell.2016.09.031","article-title":"L-Arginine modulates T cell metabolism and enhances survival and anti-tumor activity","volume":"167","author":"Geiger","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.biortech.2026.135573_b0040","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1038\/s41598-018-26128-7","article-title":"Pdr18 is involved in yeast response to acetic acid stress counteracting the decrease of plasma membrane ergosterol content and order","volume":"8","author":"Godinho","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biortech.2026.135573_b0045","first-page":"1","article-title":"Metabolo-transcriptomics analyses reveal alfalfa adaptation to combined saline-alkali and low-temperature stress in the field","author":"Guo","year":"2025","journal-title":"Plant Biotechnol. J."},{"key":"10.1016\/j.biortech.2026.135573_b0050","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1074\/jbc.275.5.3037","article-title":"Enkephalins are transported by a novel eukaryotic peptide uptake system","volume":"275","author":"Hauser","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biortech.2026.135573_b0055","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1038\/ncomms3502","article-title":"Analysing the substrate multispecificity of a proton-coupled oligopeptide transporter using a dipeptide library","volume":"4","author":"Ito","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biortech.2026.135573_b0060","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12934-025-02663-7","article-title":"Response mechanism of ethanol-tolerant Saccharomyces cerevisiae strain ES-42 to increased ethanol during continuous ethanol fermentation","volume":"24","author":"Ji","year":"2025","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.biortech.2026.135573_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2021.111387","article-title":"Metabonomic analysis reveals enhanced growth and ethanol production of brewer\u2019s yeast by wheat gluten hydrolysates and potassium supplementation","volume":"145","author":"Jin","year":"2021","journal-title":"LWT"},{"key":"10.1016\/j.biortech.2026.135573_b0070","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13068-020-01798-6","article-title":"Exogenous l-proline improved rhodosporidium toruloides lipid production on crude glycerol","volume":"13","author":"Kamal","year":"2020","journal-title":"Biotechnol. Biofuels"},{"key":"10.1016\/j.biortech.2026.135573_b0075","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1016\/j.bmcl.2008.05.046","article-title":"Design of a fluorescence polarization assay platform for the study of human Hsp70","volume":"18","author":"Kang","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.biortech.2026.135573_b0080","doi-asserted-by":"crossref","DOI":"10.3389\/ffunb.2022.827704","article-title":"Burden imposed by heterologous protein production in two major industrial yeast cell factories: identifying sources and mitigation strategies","volume":"3","author":"Kastberg","year":"2022","journal-title":"Front. Fungal Biol."},{"key":"10.1016\/j.biortech.2026.135573_b0085","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s10529-012-1088-z","article-title":"Soy peptides enhance yeast cell growth at low temperatures","volume":"35","author":"Kitagawa","year":"2013","journal-title":"Biotechnol. Lett"},{"key":"10.1016\/j.biortech.2026.135573_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121226","article-title":"Impact of uranium exposure on marine yeast, Yarrowia lipolytica: insights into the yeast strategies to withstand uranium stress","volume":"381","author":"Kolhe","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.biortech.2026.135573_b0095","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.cels.2019.10.006","article-title":"Critical roles of the pentose phosphate pathway and GLN3 in isobutanol-specific tolerance in yeast","volume":"9","author":"Kuroda","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.biortech.2026.135573_b0100","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1126\/science.1257859","article-title":"Engineering alcohol tolerance in yeast","volume":"346","author":"Lam","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.biortech.2026.135573_b0105","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf7613","article-title":"Engineered yeast tolerance enables efficient production from toxified lignocellulosic feedstocks","volume":"7","author":"Lam","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.biortech.2026.135573_b0110","doi-asserted-by":"crossref","first-page":"53879","DOI":"10.1021\/acsami.0c18919","article-title":"Collagen peptide provides saccharomyces cerevisiae with robust stress tolerance for enhanced bioethanol production","volume":"12","author":"Li","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biortech.2026.135573_b0115","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/yea.3137","article-title":"New mechanisms that regulate Saccharomyces cerevisiae short peptide transporter achieve balanced intracellular amino acid concentrations","volume":"33","author":"Melnykov","year":"2016","journal-title":"Yeast"},{"key":"10.1016\/j.biortech.2026.135573_b0120","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1038\/s41467-025-57911-6","article-title":"Transcriptional heterogeneity shapes stress-adaptive responses in yeast","volume":"16","author":"Nadal-Ribelles","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biortech.2026.135573_b0125","doi-asserted-by":"crossref","first-page":"12652","DOI":"10.1038\/s41598-021-92069-3","article-title":"Yeast adaptive response to acetic acid stress involves structural alterations and increased stiffness of the cell wall","volume":"11","author":"Ribeiro","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biortech.2026.135573_b0130","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fpls.2020.00050","article-title":"Arabidopsis mitochondrial voltage-dependent anion channels are involved in maintaining reactive oxygen species homeostasis, oxidative and salt stress tolerance in yeast","volume":"11","author":"Sanyal","year":"2020","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.biortech.2026.135573_b0135","doi-asserted-by":"crossref","DOI":"10.1126\/science.aag1550","article-title":"A transcription factor hierarchy defines an environmental stress response network","volume":"354","author":"Song","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.biortech.2026.135573_b0140","doi-asserted-by":"crossref","first-page":"5544","DOI":"10.1038\/s41467-025-60501-1","article-title":"Unraveling the regulatory network of barley grain metabolism through the integrative analysis of multiomics and mQTL","volume":"16","author":"Song","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biortech.2026.135573_b0145","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/s41467-025-56472-y","article-title":"Advances in lignocellulosic feedstocks for bioenergy and bioproducts","volume":"16","author":"Sulis","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biortech.2026.135573_b0150","doi-asserted-by":"crossref","first-page":"12136","DOI":"10.1080\/10408398.2022.2098688","article-title":"Food yeasts: occurrence, functions, and stress tolerance in the brewing of fermented foods","volume":"63","author":"Wang","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.biortech.2026.135573_b0155","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1263\/jbb.99.383","article-title":"Effect of amino acids on peptide transport in sake yeast","volume":"99","author":"Yamada","year":"2005","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.biortech.2026.135573_b0160","doi-asserted-by":"crossref","first-page":"6713","DOI":"10.1126\/science.adn3747","article-title":"Climate change exacerbates the environmental impacts of agriculture","volume":"385","author":"Yang","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.biortech.2026.135573_b0165","doi-asserted-by":"crossref","first-page":"e01620","DOI":"10.1128\/AEM.01620-19","article-title":"Membrane fluidity of saccharomyces cerevisiae from huangjiu (chinese rice wine) is variably regulated by OLE1 to offset the disruptive effect of ethanol","volume":"85","author":"Yang","year":"2019","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.biortech.2026.135573_b0170","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1007\/s00253-014-5589-7","article-title":"Two non-exclusive strategies employed to protect Torulopsis glabrata against hyperosmotic stress","volume":"98","author":"Yu","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biortech.2026.135573_b0175","doi-asserted-by":"crossref","first-page":"e02911","DOI":"10.1128\/AEM.02911-19","article-title":"Enhancement of sphingolipid synthesis improves osmotic tolerance of saccharomyces cerevisiae","volume":"86","author":"Zhu","year":"2020","journal-title":"Appl. Environ. Microbiol."}],"container-title":["Bioresource Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096085242601655X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096085242601655X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:23:49Z","timestamp":1790900629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096085242601655X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":35,"alternative-id":["S096085242601655X"],"URL":"https:\/\/doi.org\/10.1016\/j.biortech.2026.135573","relation":{},"ISSN":["0960-8524"],"issn-type":[{"value":"0960-8524","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omics framework reveals molecular determinants of small peptide trileucine enhancing ethanol stress tolerance in industrial yeast","name":"articletitle","label":"Article Title"},{"value":"Bioresource Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biortech.2026.135573","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"135573"}}