{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:46:45Z","timestamp":1778593605807,"version":"3.51.4"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Guangzhou Associated & Service Center of Scientific Instrument","award":["201201"],"award-info":[{"award-number":["201201"]}]},{"name":"the Natural Science Foundation of Guangdong Province","award":["S2011010005208"],"award-info":[{"award-number":["S2011010005208"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["51272152\/E0208"],"award-info":[{"award-number":["51272152\/E0208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.bios.2013.05.013","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T16:56:54Z","timestamp":1368637014000},"page":"139-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["A novel probe density controllable electrochemiluminescence biosensor for ultra-sensitive detection of Hg2+ based on DNA hybridization optimization with gold nanoparticles array patterned self-assembly platform"],"prefix":"10.1016","volume":"49","author":[{"given":"Wenhua","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunsheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaowen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fushen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanguang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2013.05.013_bib1","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.1021\/ac0505270","volume":"77","author":"Ahn","year":"2005","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bios.2012.06.038","volume":"39","author":"Bang","year":"2013","journal-title":"Biosensors and Bioelectronics"},{"key":"10.1016\/j.bios.2013.05.013_bib3","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1016\/j.bios.2006.09.028","volume":"22","author":"Berganza","year":"2007","journal-title":"Biosensors and Bioelectronics"},{"key":"10.1016\/j.bios.2013.05.013_bib4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0167-7799(02)01942-X","volume":"20","author":"Broude","year":"2002","journal-title":"Trends Biotechnology"},{"key":"10.1016\/j.bios.2013.05.013_bib5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2144\/02321dd04","volume":"32","author":"Bruno","year":"2002","journal-title":"Biotechniques"},{"key":"10.1016\/j.bios.2013.05.013_bib6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bioelechem.2004.04.009","volume":"66","author":"Calvo-Munoz","year":"2005","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0165-9936(04)00104-9","volume":"23","author":"Campas","year":"2004","journal-title":"Trends in Analytical Chemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib8","doi-asserted-by":"crossref","first-page":"7572","DOI":"10.1021\/ja060162g","volume":"128","author":"Cao","year":"2006","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/j.bios.2013.05.013_bib9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bios.2011.09.018","volume":"30","author":"Chang","year":"2011","journal-title":"Biosensors and Bioelectronics"},{"key":"10.1016\/j.bios.2013.05.013_bib10","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.electacta.2006.05.036","volume":"52","author":"Chang","year":"2006","journal-title":"Electrochimica Acta"},{"key":"10.1016\/j.bios.2013.05.013_bib11","doi-asserted-by":"crossref","first-page":"7932","DOI":"10.1021\/ja042482a","volume":"127","author":"Du","year":"2005","journal-title":"Journal of the American Chemical Society."},{"key":"10.1016\/j.bios.2013.05.013_bib12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1023\/A:1024573701073","volume":"25","author":"Eisler","year":"2003","journal-title":"Environmental Geochemistry and Health"},{"key":"10.1016\/j.bios.2013.05.013_bib13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.aca.2008.08.041","volume":"628","author":"Fang","year":"2008","journal-title":"Analytica Chimica Acta"},{"key":"10.1016\/j.bios.2013.05.013_bib14","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0022-0728(99)00154-0","volume":"466","author":"Finot","year":"1999","journal-title":"Journal of Electroanalytical Chemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/abio.1999.4344","volume":"276","author":"Henry","year":"1999","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib16","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.elecom.2009.01.009","volume":"11","author":"Huang","year":"2009","journal-title":"Electrochemistry Communications"},{"key":"10.1016\/j.bios.2013.05.013_bib17","doi-asserted-by":"crossref","first-page":"11653","DOI":"10.1021\/jp070524m","volume":"111","author":"Ito","year":"2007","journal-title":"Journal of Physical Chemistry C"},{"key":"10.1016\/j.bios.2013.05.013_bib18","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.bios.2006.04.011","volume":"22","author":"Jin","year":"2006","journal-title":"Biosensors and Bioelectronics"},{"key":"10.1016\/j.bios.2013.05.013_bib19","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/0013-4686(90)80004-8","volume":"35","author":"Juttner","year":"1990","journal-title":"Electrochimica Acta"},{"key":"10.1016\/j.bios.2013.05.013_bib20","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1021\/nn2009485","volume":"5","author":"Law","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2013.05.013_bib21","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1002\/anie.200705991","volume":"47","author":"Li","year":"2008","journal-title":"Angewandte Chemie International Edition"},{"key":"10.1016\/j.bios.2013.05.013_bib22","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.bios.2010.07.098","volume":"26","author":"Li","year":"2010","journal-title":"Biosensors and Bioelectronics"},{"key":"10.1016\/j.bios.2013.05.013_bib23","doi-asserted-by":"crossref","first-page":"7583","DOI":"10.1021\/ac301990f","volume":"84","author":"Li","year":"2012","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib24","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.talanta.2007.01.062","volume":"72","author":"Li","year":"2007","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2013.05.013_bib25","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.bios.2010.06.044","volume":"26","author":"Li","year":"2010","journal-title":"Biosensors and Bioelectronics"},{"key":"10.1016\/j.bios.2013.05.013_bib26","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.elecom.2008.06.027","volume":"10","author":"Li","year":"2008","journal-title":"Electrochemistry Communications"},{"key":"10.1016\/j.bios.2013.05.013_bib27","doi-asserted-by":"crossref","first-page":"5724","DOI":"10.1021\/ac900527f","volume":"81","author":"Liu","year":"2009","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib28","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1021\/ac0495236","volume":"76","author":"Miao","year":"2004","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib29","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1002\/anie.200454172","volume":"43","author":"Ono","year":"2004","journal-title":"Angewandte Chemie International Edition"},{"key":"10.1016\/j.bios.2013.05.013_bib30","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.bios.2010.06.067","volume":"26","author":"Parab","year":"2010","journal-title":"Biosensors and Bioelectronics"},{"key":"10.1016\/j.bios.2013.05.013_bib31","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.1067003","volume":"295","author":"Park","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bios.2013.05.013_bib32","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.1021\/ja0036256","volume":"123","author":"Patolsky","year":"2001","journal-title":"Journal of the American Chemical Society."},{"key":"10.1016\/j.bios.2013.05.013_bib33","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1093\/nar\/29.24.5163","volume":"29","author":"Peterson","year":"2001","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.bios.2013.05.013_bib34","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1021\/j100250a018","volume":"89","author":"Shimdzu","year":"1985","journal-title":"Journal of Physical Chemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib35","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1016\/j.bios.2011.03.001","volume":"26","author":"Soreta","year":"2011","journal-title":"Biosensors and Bioelectronics"},{"key":"10.1016\/j.bios.2013.05.013_bib36","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1021\/ja00424a057","volume":"98","author":"Sprintschnik","year":"1976","journal-title":"Journal of the American Chemical Society."},{"key":"10.1016\/j.bios.2013.05.013_bib37","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1021\/ac035175g","volume":"76","author":"Su","year":"2004","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib38","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1021\/ic50190a006","volume":"17","author":"Sullivan","year":"1978","journal-title":"Inorganic Chemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib39","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1021\/ac9029289","volume":"82","author":"Sun","year":"2010","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib40","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1021\/ja065552h","volume":"129","author":"Tanaka","year":"2007","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/j.bios.2013.05.013_bib41","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0006-3495(95)80193-1","volume":"68","author":"Terpetschnig","year":"1995","journal-title":"Biophysical Journal"},{"key":"10.1016\/j.bios.2013.05.013_bib42","doi-asserted-by":"crossref","first-page":"5719","DOI":"10.1039\/c002727h","volume":"46","author":"Tian","year":"2010","journal-title":"Chemical Communications"},{"key":"10.1016\/j.bios.2013.05.013_bib43","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1021\/la8033148","volume":"25","author":"Tokuhisa","year":"2009","journal-title":"Langmuir"},{"key":"10.1016\/j.bios.2013.05.013_bib44","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1126\/science.290.5495.1315","volume":"290","author":"Turner","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bios.2013.05.013_bib45","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/nbt0396-303","volume":"14","author":"Tyagi","year":"1996","journal-title":"Nature Biotechnology"},{"key":"10.1016\/j.bios.2013.05.013_bib46","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.aca.2006.05.080","volume":"575","author":"Wang","year":"2006","journal-title":"Analytica Chimica Acta"},{"key":"10.1016\/j.bios.2013.05.013_bib47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.envpol.2004.01.010","volume":"131","author":"Wang","year":"2004","journal-title":"Environmental Pollution"},{"key":"10.1016\/j.bios.2013.05.013_bib48","doi-asserted-by":"crossref","first-page":"7661","DOI":"10.1016\/j.electacta.2008.05.020","volume":"53","author":"Wang","year":"2008","journal-title":"Electrochimica Acta"},{"key":"10.1016\/j.bios.2013.05.013_bib49","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1016\/j.bios.2009.04.019","volume":"24","author":"Wang","year":"2009","journal-title":"Biosensors and Bioelectronics"},{"key":"10.1016\/j.bios.2013.05.013_bib50","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1021\/la702345p","volume":"24","author":"Wang","year":"2008","journal-title":"Langmuir"},{"key":"10.1016\/j.bios.2013.05.013_bib51","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1021\/ac00062a019","volume":"65","author":"Yamaguchi","year":"1993","journal-title":"Analytical Chemistry."},{"key":"10.1016\/j.bios.2013.05.013_bib52","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1016\/j.bios.2009.04.016","volume":"24","author":"Yao","year":"2009","journal-title":"Biosensors and Bioelectronics"},{"key":"10.1016\/j.bios.2013.05.013_bib53","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1006\/abio.1995.1341","volume":"228","author":"Yguerabide","year":"1995","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib54","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1021\/ac701995g","volume":"80","author":"Zhang","year":"2008","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib55","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.aca.2011.11.003","volume":"713","author":"Zhou","year":"2012","journal-title":"Analytica Chimica Acta"},{"key":"10.1016\/j.bios.2013.05.013_bib56","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1021\/ac0713306","volume":"80","author":"Zhu","year":"2008","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.bios.2013.05.013_bib57","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1016\/j.bios.2009.04.027","volume":"24","author":"Zhu","year":"2009","journal-title":"Biosensors and Bioelectronics"},{"key":"10.1016\/j.bios.2013.05.013_bib58","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1039\/b926319e","volume":"46","author":"Zhu","year":"2010","journal-title":"Chemical Communications"},{"key":"10.1016\/j.bios.2013.05.013_bib59","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bios.2012.07.015","volume":"39","author":"Zhuang","year":"2013","journal-title":"Biosensors and Bioelectronics"}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566313003370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566313003370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T23:59:08Z","timestamp":1760659148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566313003370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":59,"alternative-id":["S0956566313003370"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2013.05.013","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel probe density controllable electrochemiluminescence biosensor for ultra-sensitive detection of Hg2+ based on DNA hybridization optimization with gold nanoparticles array patterned self-assembly platform","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2013.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}