{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:35:12Z","timestamp":1789655712505,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2015203231"],"award-info":[{"award-number":["H2015203231"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hebei Education Department of China","award":["QN2014004"],"award-info":[{"award-number":["QN2014004"]}]},{"name":"Key Research and Development Program of Qin Huang Dao","award":["201602A110"],"award-info":[{"award-number":["201602A110"]}]},{"name":"Doctoral Fund of Yanshan University"},{"name":"Hebei Province Key Research and Development Projects","award":["17272402D"],"award-info":[{"award-number":["17272402D"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.bios.2018.09.076","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T20:16:38Z","timestamp":1537560998000},"page":"261-268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"special_numbering":"C","title":["Aptamer-DNA concatamer-quantum dots based electrochemical biosensing strategy for green and ultrasensitive detection of tumor cells via mercury-free anodic stripping voltammetry"],"prefix":"10.1016","volume":"126","author":[{"given":"Yue","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengquan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunling","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jidong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bios.2018.09.076_bib1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.talanta.2006.05.090","article-title":"Voltammetric characterisation of silicon-based microelectrode arrays and their application to mercury-free stripping voltammetry of copper ions","volume":"71","author":"Berduque","year":"2007","journal-title":"Talanta"},{"issue":"44","key":"10.1016\/j.bios.2018.09.076_bib2","doi-asserted-by":"crossref","first-page":"12116","DOI":"10.1039\/c1cc15695k","article-title":"A simple and ultrasensitive electrochemical DNA biosensor based on DNA concatamers","volume":"47","author":"Chen","year":"2011","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bios.2018.09.076_bib3","first-page":"353","article-title":"Detection of heavy metals released at the sediment\/water interface by combining anodic stripping voltammetry (ASV) and scanning electrochemical microscopy (SECM) measurements","volume":"107","author":"Daniele","year":"2003","journal-title":"J. De. Phys."},{"issue":"1","key":"10.1016\/j.bios.2018.09.076_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0039-9140(03)00062-6","article-title":"Voltammetry determination of trace manganese with pretreatment glassy carbon electrode by linear sweep voltammetry","volume":"60","author":"Di","year":"2003","journal-title":"Talanta"},{"issue":"3","key":"10.1016\/j.bios.2018.09.076_bib5","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1021\/nn500606a","article-title":"Mechanism of Graphene Oxide Formation","volume":"8","author":"Dimiev","year":"2014","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.bios.2018.09.076_bib6","first-page":"205","article-title":"Mercury film electrodes: developments, trends and potentialities for electroanalysis","volume":"128","author":"Economou","year":"2003","journal-title":"Analyst"},{"key":"10.1016\/j.bios.2018.09.076_bib7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.snb.2015.03.020","article-title":"Application of Au cage\/Ru(bpy)(3)(2+) nanostructures for the electrochemiluminescence detection of K562 cancer cells based on aptamer","volume":"214","author":"Ge","year":"2015","journal-title":"Sens. Actuators B-Chem."},{"issue":"40","key":"10.1016\/j.bios.2018.09.076_bib8","doi-asserted-by":"crossref","first-page":"7602","DOI":"10.1002\/anie.200800169","article-title":"Semiconductor quantum dots for bioanalysis","volume":"47","author":"Gill","year":"2008","journal-title":"Angew. Chem. Int. Ed."},{"issue":"3","key":"10.1016\/j.bios.2018.09.076_bib9","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.3390\/s80314000","article-title":"Electrochemical biosensors - sensor principles and architectures","volume":"8","author":"Grieshaber","year":"2008","journal-title":"Sensors"},{"key":"10.1016\/j.bios.2018.09.076_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.snb.2018.05.019","article-title":"Leukemia biomarker detection by using photoconductive response of CNT electrode: analysis of sensing mechanism based on charge transfer induced Fermi level fluctuation","volume":"270","author":"Gulati","year":"2018","journal-title":"Sens. Actuators B Chem."},{"issue":"3","key":"10.1016\/j.bios.2018.09.076_bib11","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.trac.2004.11.014","article-title":"Determination of trace metals by underpotential deposition\u2013stripping voltammetry at solid electrodes","volume":"24","author":"Herzog","year":"2005","journal-title":"TrAC Trends Anal. Chem."},{"issue":"7","key":"10.1016\/j.bios.2018.09.076_bib12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0165-9936(03)00703-9","article-title":"Screen-printed electrochemical sensors for monitoring metal pollutants","volume":"22","author":"Honeychurch","year":"2003","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.bios.2018.09.076_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bios.2013.08.006","article-title":"A novel quantum dot nanocluster as versatile probe for electrochemiluminescence and electrochemical assays of DNA and cancer cells","volume":"52","author":"Jie","year":"2014","journal-title":"Biosens. Bioelectron."},{"issue":"8","key":"10.1016\/j.bios.2018.09.076_bib14","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1093\/clinchem\/48.8.1296","article-title":"Proteomics and bioinformatics approaches for identification of serum biomarkers to detect breast cancer","volume":"48","author":"Li","year":"2002","journal-title":"Clin. Chem."},{"issue":"4","key":"10.1016\/j.bios.2018.09.076_bib15","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1039\/B916304B","article-title":"Electrochemical analysis of two analytes based on a dual-functional aptamer DNA sequence","volume":"46","author":"Li","year":"2010","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bios.2018.09.076_bib16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.talanta.2016.03.039","article-title":"Self-assembly of novel fluorescent quantum dot-cerasome hybrid for bioelectrochemistry","volume":"154","author":"Liu","year":"2016","journal-title":"Talanta"},{"issue":"23","key":"10.1016\/j.bios.2018.09.076_bib17","doi-asserted-by":"crossref","first-page":"7126","DOI":"10.1021\/ac049107l","article-title":"Electrochemical coding for multiplexed immunoassays of proteins","volume":"76","author":"Liu","year":"2004","journal-title":"Anal. Chem."},{"issue":"6","key":"10.1016\/j.bios.2018.09.076_bib18","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1021\/ac303789x","article-title":"Supersandwich cytosensor for selective and ultrasensitive detection of cancer cells using aptamer-DNA concatamer-quantum dots probes","volume":"85","author":"Liu","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2018.09.076_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.electacta.2012.10.071","article-title":"Nanopore array derived from l-cysteine oxide\/gold hybrids: enhanced sensing platform for hydroquinone and catechol determination","volume":"88","author":"Liu","year":"2013","journal-title":"Electrochim. Acta"},{"issue":"19","key":"10.1016\/j.bios.2018.09.076_bib20","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1200\/JCO.2013.49.2678","article-title":"Fertility preservation for patients with cancer: american society of clinical oncology clinical practice guideline update","volume":"31","author":"Loren","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bios.2018.09.076_bib21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nnano.2008.373","article-title":"One-step DNA-programmed growth of luminescent and biofunctionalized nanocrystals","volume":"4","author":"Ma","year":"2008","journal-title":"Nat. Nanotechnol."},{"issue":"5906","key":"10.1016\/j.bios.2018.09.076_bib22","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1126\/science.1164266","article-title":"Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia","volume":"322","author":"Mullighan","year":"2008","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.bios.2018.09.076_bib23","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1056\/NEJMoa0808253","article-title":"Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia","volume":"360","author":"Mullighan","year":"2009","journal-title":"New Engl. J. Med."},{"issue":"7","key":"10.1016\/j.bios.2018.09.076_bib24","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.bios.2009.11.022","article-title":"Selective collection and detection of leukemia cells on a magnet-quartz crystal microbalance system using aptamer-conjugated magnetic beads","volume":"25","author":"Pan","year":"2010","journal-title":"Biosens. Bioelectron."},{"issue":"10","key":"10.1016\/j.bios.2018.09.076_bib25","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/cyto.a.21125","article-title":"Cell labeling approaches for fluorescence-based In vivo flow cytometry","volume":"79A","author":"Pitsillides","year":"2011","journal-title":"Cytom. Part A"},{"issue":"3","key":"10.1016\/j.bios.2018.09.076_bib26","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1021\/ac802092j","article-title":"Enrichment of cancer cells using aptamers immobilized on a microfluidic channel","volume":"81","author":"Phillips","year":"2009","journal-title":"Anal. Chem."},{"issue":"6","key":"10.1016\/j.bios.2018.09.076_bib27","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/smll.200500530","article-title":"Facile one-pot synthesis of luminescent, water-soluble, and biocompatible glutathione-coated CdTe nanocrystals","volume":"2","author":"Qian","year":"2006","journal-title":"Small"},{"key":"10.1016\/j.bios.2018.09.076_bib28","doi-asserted-by":"crossref","first-page":"9462","DOI":"10.1021\/ac202171x","article-title":"Electrochemical biosensors employing an internal electrode attachment site and achieving reversible, high gain detection of specific nucleic acid sequences","volume":"83","author":"Rowe","year":"2011","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.bios.2018.09.076_bib29","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1021\/cr2001178","article-title":"Gold nanoparticles in chemical and biological sensing","volume":"112","author":"Saha","year":"2012","journal-title":"Chem. Rev."},{"issue":"10","key":"10.1016\/j.bios.2018.09.076_bib30","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/elan.200900571","article-title":"Graphene based electrochemical sensors and biosensors: a review","volume":"22","author":"Shao","year":"2010","journal-title":"Electroanalysis"},{"issue":"3","key":"10.1016\/j.bios.2018.09.076_bib31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s13562-012-0162-x","article-title":"Electrochemical determination of indole butyric acid by differential pulse voltammetry on hanging mercury drops electrode","volume":"22","author":"Shen","year":"2013","journal-title":"J. Plant Biochem. Biotechnol."},{"key":"10.1016\/j.bios.2018.09.076_bib32","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature03128","article-title":"Identification of human brain tumour initiating cells","volume":"432","author":"Singh","year":"2004","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.bios.2018.09.076_bib33","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1373\/49.9.1458","article-title":"Numeric definition of the clinical performance of the nested reverse transcription-PCR for detection of hematogenous epithelial cells and correction for specific mRNA of non-target cell origin as evaluated for prostate cancer cells","volume":"49","author":"Schamhart","year":"2003","journal-title":"Clin. Chem."},{"issue":"6","key":"10.1016\/j.bios.2018.09.076_bib34","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00216-005-0069-7","article-title":"Voltammetric analysis using a self-renewable non-mercury electrode","volume":"383","author":"Surmann","year":"2005","journal-title":"Anal. Bioanal. Chem."},{"issue":"8","key":"10.1016\/j.bios.2018.09.076_bib35","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1039\/C4AN02129K","article-title":"Label-free and highly sensitive electrochemiluminescence biosensing using quantum dots\/carbon nanotubes in ionic liquid","volume":"140","author":"Tu","year":"2015","journal-title":"Analyst"},{"issue":"14","key":"10.1016\/j.bios.2018.09.076_bib36","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1021\/ac000108x","article-title":"Bismuth-coated carbon electrodes for anodic stripping voltammetry","volume":"72","author":"Wang","year":"2000","journal-title":"Anal. Chem."},{"issue":"Supplement C","key":"10.1016\/j.bios.2018.09.076_bib37","first-page":"1","article-title":"Ultrasensitive electrochemical detection of tumor cells based on multiple layer CdS quantum dots-functionalized polystyrene microspheres and graphene oxide \u2013 polyaniline composite","volume":"100","author":"Wang","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2018.09.076_bib38","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.snb.2018.05.162","article-title":"A ratiometric magnesium sensor using DNAzyme-templated CdTe quantum dots and Cy5","volume":"272","author":"Wang","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.bios.2018.09.076_bib39","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.optmat.2017.06.023","article-title":"Facile synthesis and properties of CdSe quantum dots in a novel two-phase liquid\/liquid system","volume":"72","author":"Wang","year":"2017","journal-title":"Opt. Mater."},{"key":"10.1016\/j.bios.2018.09.076_bib40","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bios.2018.02.049","article-title":"Problems analysis and new fabrication strategies of mediated electrochemical biosensors for wastewater toxicity assessment","volume":"108","author":"Yang","year":"2018","journal-title":"Biosens. Bioelectron."},{"issue":"3","key":"10.1016\/j.bios.2018.09.076_bib41","article-title":"Experimental determination of the extinction coefficient of CdTe, CdSe and CdS nanocrystals (vol 15, pg 2854, 2003)","volume":"16","author":"Yu","year":"2004","journal-title":"Chem. Mater."},{"issue":"31","key":"10.1016\/j.bios.2018.09.076_bib42","doi-asserted-by":"crossref","first-page":"10171","DOI":"10.1021\/ja061787h","article-title":"Manipulation of aqueous growth of CdTe nanocrystals to fabricate colloidally stable one-dimensional nanostructures","volume":"128","author":"Zhang","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bios.2018.09.076_bib43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bios.2017.04.005","article-title":"CdS:Mn quantum dot-functionalized g-C3N4 nanohybrids as signal-generation tags for photoelectrochemical immunoassay of prostate specific antigen coupling DNAzyme concatamer with enzymatic biocatalytic precipitation","volume":"95","author":"Zhang","year":"2017","journal-title":"Biosens. Bioelectron."},{"issue":"12","key":"10.1016\/j.bios.2018.09.076_bib44","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1021\/acsami.6b01010","article-title":"Simultaneous detection of tumor cell apoptosis regulators Bcl-2 and bax through a dual-signal-marked electrochemical immunosensor","volume":"8","author":"Zhou","year":"2016","journal-title":"Acs Appl. Mater. Interfaces"},{"key":"10.1016\/j.bios.2018.09.076_bib45","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.foodchem.2015.07.042","article-title":"Simultaneously determination of trace Cd2+ and Pb2+ based on l-cysteine\/graphene modified glassy carbon electrode","volume":"192","author":"Zhou","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.bios.2018.09.076_bib46","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1021\/ja110094g","article-title":"Bioresponsive controlled release using mesoporous silica nanoparticles capped with aptamer-based molecular gate","volume":"133","author":"Zhu","year":"2011","journal-title":"J. Am. Chem. Soc."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566318307723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566318307723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:53:55Z","timestamp":1760662435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566318307723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":46,"alternative-id":["S0956566318307723"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2018.09.076","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aptamer-DNA concatamer-quantum dots based electrochemical biosensing strategy for green and ultrasensitive detection of tumor cells via mercury-free anodic stripping voltammetry","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2018.09.076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}