{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:49:20Z","timestamp":1791020960757,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012900","name":"Qingdao Agricultural University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.bios.2019.111395","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T11:17:17Z","timestamp":1559733437000},"page":"111395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Label-free and immobilization-free photoelectrochemical biosensing strategy using methylene blue in homogeneous solution as signal probe for facile DNA methyltransferase activity assay"],"prefix":"10.1016","volume":"141","author":[{"given":"Ting","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2019.111395_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0168-9525(89)90054-1","volume":"5","author":"Barras","year":"1989","journal-title":"Trends Genet."},{"issue":"15","key":"10.1016\/j.bios.2019.111395_bib2","doi-asserted-by":"crossref","first-page":"6394","DOI":"10.1073\/pnas.88.15.6394","volume":"88","author":"Bergerat","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"5","key":"10.1016\/j.bios.2019.111395_bib3","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1128\/jb.174.5.1682-1685.1992","volume":"174","author":"Boye","year":"1992","journal-title":"J. Bacteriol."},{"issue":"8","key":"10.1016\/j.bios.2019.111395_bib4","doi-asserted-by":"crossref","first-page":"6887","DOI":"10.1021\/acsami.7b17813","volume":"10","author":"Chen","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"17","key":"10.1016\/j.bios.2019.111395_bib5","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/(SICI)1521-4109(199911)11:17<1259::AID-ELAN1259>3.0.CO;2-B","volume":"11","author":"Cooper","year":"1999","journal-title":"Electroanalysis"},{"issue":"14","key":"10.1016\/j.bios.2019.111395_bib6","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1021\/ac980123q","volume":"70","author":"Cooper","year":"1998","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2019.111395_bib7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0076-6879(94)36030-8","volume":"236","author":"Elsinghorst","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bios.2019.111395_bib8","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bios.2015.09.041","volume":"77","author":"Ge","year":"2016","journal-title":"Biosens. Bioelectron."},{"issue":"4","key":"10.1016\/j.bios.2019.111395_bib9","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1021\/acs.analchem.5b03844","volume":"88","author":"Ge","year":"2016","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.bios.2019.111395_bib10","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1039\/C5SC03336E","volume":"7","author":"Hao","year":"2016","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bios.2019.111395_bib11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bios.2018.08.071","volume":"121","author":"Hong","year":"2018","journal-title":"Biosens. Bioelectron."},{"issue":"22","key":"10.1016\/j.bios.2019.111395_bib12","doi-asserted-by":"crossref","first-page":"11368","DOI":"10.1021\/acs.analchem.5b02790","volume":"87","author":"Hou","year":"2015","journal-title":"Anal. Chem."},{"issue":"15","key":"10.1016\/j.bios.2019.111395_bib13","doi-asserted-by":"crossref","first-page":"9591","DOI":"10.1021\/acs.analchem.8b02523","volume":"90","author":"Hou","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2019.111395_bib14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bios.2015.08.063","volume":"75","author":"Hou","year":"2016","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.bios.2019.111395_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0378-4347(94)00327-0","volume":"661","author":"Lennard","year":"1994","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"issue":"0","key":"10.1016\/j.bios.2019.111395_bib16","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.bios.2015.03.060","volume":"70","author":"Li","year":"2015","journal-title":"Biosens. Bioelectron."},{"issue":"21","key":"10.1016\/j.bios.2019.111395_bib17","doi-asserted-by":"crossref","first-page":"11803","DOI":"10.1021\/acs.analchem.7b03451","volume":"89","author":"Lin","year":"2017","journal-title":"Anal. Chem."},{"issue":"10","key":"10.1016\/j.bios.2019.111395_bib18","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1021\/acs.analchem.7b00942","volume":"89","author":"Lin","year":"2017","journal-title":"Anal. Chem."},{"issue":"7","key":"10.1016\/j.bios.2019.111395_bib19","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1021\/acs.analchem.5b00355","volume":"87","author":"Liu","year":"2015","journal-title":"Anal. Chem."},{"issue":"6","key":"10.1016\/j.bios.2019.111395_bib20","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1021\/ac802317k","volume":"81","author":"Lubin","year":"2009","journal-title":"Anal. Chem."},{"issue":"44","key":"10.1016\/j.bios.2019.111395_bib21","doi-asserted-by":"crossref","first-page":"16632","DOI":"10.1021\/ja4085918","volume":"135","author":"Muren","year":"2013","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.bios.2019.111395_bib22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jphotochem.2010.11.020","volume":"218","author":"Ortiz","year":"2011","journal-title":"J. Photochem. Photobiol., A"},{"issue":"6","key":"10.1016\/j.bios.2019.111395_bib23","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1039\/C2CS35266D","volume":"42","author":"Osterloh","year":"2013","journal-title":"Chem. Soc. Rev."},{"issue":"11","key":"10.1016\/j.bios.2019.111395_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/s7112671","volume":"7","author":"Pan","year":"2007","journal-title":"Sensors"},{"issue":"24","key":"10.1016\/j.bios.2019.111395_bib25","doi-asserted-by":"crossref","first-page":"13252","DOI":"10.1021\/acs.analchem.7b03278","volume":"89","author":"Rauf","year":"2017","journal-title":"Anal. Chem."},{"issue":"8","key":"10.1016\/j.bios.2019.111395_bib26","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg1655","volume":"6","author":"Robertson","year":"2005","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.bios.2019.111395_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35049533","volume":"1","author":"Robertson","year":"2000","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bios.2019.111395_bib28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.bios.2014.09.044","volume":"64","author":"Shen","year":"2015","journal-title":"Biosens. Bioelectron."},{"issue":"16","key":"10.1016\/j.bios.2019.111395_bib29","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1039\/C4CC07688E","volume":"51","author":"Su","year":"2015","journal-title":"Chem. Commun."},{"issue":"5","key":"10.1016\/j.bios.2019.111395_bib30","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1039\/C7SC04975G","volume":"9","author":"Sun","year":"2018","journal-title":"Chem. Sci."},{"issue":"18","key":"10.1016\/j.bios.2019.111395_bib31","doi-asserted-by":"crossref","first-page":"9204","DOI":"10.1021\/acs.analchem.5b01470","volume":"87","author":"Tan","year":"2015","journal-title":"Anal. Chem."},{"issue":"7237","key":"10.1016\/j.bios.2019.111395_bib32","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0140-6736(62)92030-5","volume":"279","author":"Trafford","year":"1962","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.bios.2019.111395_bib33","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/74487","volume":"18","author":"van Steensel","year":"2000","journal-title":"Nat. Biotechnol."},{"issue":"7","key":"10.1016\/j.bios.2019.111395_bib34","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1021\/ac500101t","volume":"86","author":"Wei","year":"2014","journal-title":"Anal. Chem."},{"issue":"14","key":"10.1016\/j.bios.2019.111395_bib35","doi-asserted-by":"crossref","first-page":"6908","DOI":"10.1021\/ac401346x","volume":"85","author":"Wu","year":"2013","journal-title":"Anal. Chem."},{"issue":"12","key":"10.1016\/j.bios.2019.111395_bib36","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.1021\/ac301033w","volume":"84","author":"Xuan","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2019.111395_bib37","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bios.2014.11.015","volume":"66","author":"Yang","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2019.111395_bib38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bios.2013.07.040","volume":"51","author":"Yin","year":"2014","journal-title":"Biosens. Bioelectron."},{"issue":"19","key":"10.1016\/j.bios.2019.111395_bib39","doi-asserted-by":"crossref","first-page":"9489","DOI":"10.1021\/ac502540m","volume":"86","author":"Zhang","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2019.111395_bib40","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.bios.2018.07.001","volume":"117","author":"Zhang","year":"2018","journal-title":"Biosens. Bioelectron."},{"issue":"12","key":"10.1016\/j.bios.2019.111395_bib41","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1039\/C5CC09147K","volume":"52","author":"Zhao","year":"2016","journal-title":"Chem. Commun."},{"issue":"15","key":"10.1016\/j.bios.2019.111395_bib42","doi-asserted-by":"crossref","first-page":"7421","DOI":"10.1021\/cr500100j","volume":"114","author":"Zhao","year":"2014","journal-title":"Chem. Rev."},{"issue":"3","key":"10.1016\/j.bios.2019.111395_bib43","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1039\/C4CS00228H","volume":"44","author":"Zhao","year":"2015","journal-title":"Chem. Soc. Rev."},{"issue":"1","key":"10.1016\/j.bios.2019.111395_bib44","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1021\/acs.analchem.7b04672","volume":"90","author":"Zhao","year":"2018","journal-title":"Anal. Chem."},{"issue":"46","key":"10.1016\/j.bios.2019.111395_bib45","doi-asserted-by":"crossref","first-page":"40087","DOI":"10.1021\/acsami.7b13551","volume":"9","author":"Zhou","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566319304749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566319304749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T01:00:08Z","timestamp":1760662808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566319304749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":45,"alternative-id":["S0956566319304749"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2019.111395","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Label-free and immobilization-free photoelectrochemical biosensing strategy using methylene blue in homogeneous solution as signal probe for facile DNA methyltransferase activity assay","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2019.111395","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111395"}}