{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:18:04Z","timestamp":1792653484823,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.bios.2021.113015","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T11:45:18Z","timestamp":1611143118000},"page":"113015","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":149,"special_numbering":"C","title":["Entropy-driven amplified electrochemiluminescence biosensor for RdRp gene of SARS-CoV-2 detection with self-assembled DNA tetrahedron scaffolds"],"prefix":"10.1016","volume":"178","author":[{"given":"Zhenqiang","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuedi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7021-5395","authenticated-orcid":false,"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bios.2021.113015_bib1","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1021\/acsinfecdis.0c00236","volume":"6","author":"Ahidjo","year":"2020","journal-title":"ACS Infect. Dis."},{"issue":"5","key":"10.1016\/j.bios.2021.113015_bib2","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1021\/acsnano.0c03930","volume":"14","author":"Brownlee","year":"2020","journal-title":"ACS Nano"},{"issue":"20","key":"10.1016\/j.bios.2021.113015_bib3","doi-asserted-by":"crossref","first-page":"13813","DOI":"10.1021\/acs.analchem.0c02288","volume":"92","author":"Cazares","year":"2020","journal-title":"Anal. Chem."},{"issue":"4","key":"10.1016\/j.bios.2021.113015_bib4","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1021\/acsami.8b20144","volume":"11","author":"Chen","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bios.2021.113015_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2214\/AJR.20.23233","volume":"215","author":"Cheng","year":"2020","journal-title":"Am. J. Roentgenol."},{"issue":"10","key":"10.1016\/j.bios.2021.113015_bib6","doi-asserted-by":"crossref","first-page":"12522","DOI":"10.1021\/acsnano.0c07197","volume":"14","author":"Chung","year":"2020","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.bios.2021.113015_bib7","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045","volume":"25","author":"Corman","year":"2020","journal-title":"Euro Surveill."},{"issue":"24","key":"10.1016\/j.bios.2021.113015_bib8","doi-asserted-by":"crossref","first-page":"15688","DOI":"10.1021\/acs.analchem.0c04679","volume":"92","author":"Costa dos Santos Junior","year":"2020","journal-title":"Anal. Chem."},{"issue":"20","key":"10.1016\/j.bios.2021.113015_bib9","doi-asserted-by":"crossref","first-page":"17637","DOI":"10.1021\/acsami.7b04553","volume":"9","author":"Feng","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bios.2021.113015_bib10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bios.2016.11.060","volume":"90","author":"Feng","year":"2017","journal-title":"Biosens. Bioelectron."},{"issue":"15","key":"10.1016\/j.bios.2021.113015_bib11","doi-asserted-by":"crossref","first-page":"10196","DOI":"10.1021\/acs.analchem.0c02060","volume":"92","author":"Feng","year":"2020","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.bios.2021.113015_bib12","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1021\/acsnano.6b05737","volume":"11","author":"Jasinski","year":"2017","journal-title":"ACS Nano"},{"issue":"49","key":"10.1016\/j.bios.2021.113015_bib13","doi-asserted-by":"crossref","first-page":"17715","DOI":"10.1021\/jacs.7b10038","volume":"139","author":"Kabza","year":"2017","journal-title":"J. Am. Chem. Soc."},{"issue":"8","key":"10.1016\/j.bios.2021.113015_bib14","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.1021\/acsnano.6b02060","volume":"10","author":"Kim","year":"2016","journal-title":"ACS Nano"},{"issue":"5","key":"10.1016\/j.bios.2021.113015_bib15","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1021\/ac500251t","volume":"86","author":"Lin","year":"2014","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.bios.2021.113015_bib16","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1021\/cr030183i","volume":"109","author":"Liu","year":"2009","journal-title":"Chem. Rev."},{"issue":"32","key":"10.1016\/j.bios.2021.113015_bib17","doi-asserted-by":"crossref","first-page":"13148","DOI":"10.1021\/ja302447r","volume":"134","author":"Lu","year":"2012","journal-title":"J. Am. Chem. Soc."},{"issue":"10224","key":"10.1016\/j.bios.2021.113015_bib18","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.bios.2021.113015_bib19","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1021\/acs.analchem.9b01617","volume":"91","author":"Ma","year":"2019","journal-title":"Anal. Chem."},{"issue":"6","key":"10.1016\/j.bios.2021.113015_bib20","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1021\/nn5015962","volume":"8","author":"Meng","year":"2014","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.bios.2021.113015_bib21","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1021\/acs.bioconjchem.5b00064","volume":"26","author":"Miao","year":"2015","journal-title":"Bioconjugate Chem."},{"issue":"6","key":"10.1016\/j.bios.2021.113015_bib22","doi-asserted-by":"crossref","first-page":"7617","DOI":"10.1021\/acsnano.0c03822","volume":"14","author":"Moitra","year":"2020","journal-title":"ACS Nano"},{"issue":"42","key":"10.1016\/j.bios.2021.113015_bib23","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1002\/adma.201002767","volume":"22","author":"Pei","year":"2010","journal-title":"Adv. Mater."},{"issue":"5","key":"10.1016\/j.bios.2021.113015_bib24","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.1021\/acsnano.0c02439","volume":"14","author":"Qiu","year":"2020","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.bios.2021.113015_bib25","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1021\/nn4038223","volume":"8","author":"Sadowski","year":"2014","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.bios.2021.113015_bib26","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1021\/acsnano.0c02823","volume":"14","author":"Seo","year":"2020","journal-title":"ACS Nano"},{"issue":"44","key":"10.1016\/j.bios.2021.113015_bib27","doi-asserted-by":"crossref","first-page":"17705","DOI":"10.1021\/ja2060116","volume":"133","author":"Shen","year":"2011","journal-title":"J. Am. Chem. Soc."},{"issue":"43","key":"10.1016\/j.bios.2021.113015_bib28","doi-asserted-by":"crossref","first-page":"13804","DOI":"10.1021\/jacs.5b08144","volume":"137","author":"Shi","year":"2015","journal-title":"J. Am. Chem. Soc."},{"issue":"9","key":"10.1016\/j.bios.2021.113015_bib29","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1021\/nl102184c","volume":"10","author":"Shi","year":"2010","journal-title":"Nano Lett."},{"key":"10.1016\/j.bios.2021.113015_bib30","doi-asserted-by":"crossref","first-page":"112356","DOI":"10.1016\/j.bios.2020.112356","volume":"165","author":"Tian","year":"2020","journal-title":"Biosens. Bioelectron."},{"issue":"4","key":"10.1016\/j.bios.2021.113015_bib31","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1021\/acsnano.0c02624","volume":"14","author":"Udugama","year":"2020","journal-title":"ACS Nano"},{"issue":"48","key":"10.1016\/j.bios.2021.113015_bib32","doi-asserted-by":"crossref","first-page":"14085","DOI":"10.1021\/bi0203987","volume":"41","author":"Vijayanathan","year":"2002","journal-title":"Biochemistry"},{"issue":"19","key":"10.1016\/j.bios.2021.113015_bib33","doi-asserted-by":"crossref","first-page":"7418","DOI":"10.1021\/ac201491p","volume":"83","author":"Wen","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2021.113015_bib34","doi-asserted-by":"crossref","first-page":"200343","DOI":"10.1148\/radiol.2020200343","volume":"296","author":"Xie","year":"2020","journal-title":"Radiology"},{"issue":"14","key":"10.1016\/j.bios.2021.113015_bib35","doi-asserted-by":"crossref","first-page":"9699","DOI":"10.1021\/acs.analchem.0c01032","volume":"92","author":"Xue","year":"2020","journal-title":"Anal. Chem."},{"issue":"20","key":"10.1016\/j.bios.2021.113015_bib36","doi-asserted-by":"crossref","first-page":"14139","DOI":"10.1021\/acs.analchem.0c03202","volume":"92","author":"Yu","year":"2020","journal-title":"Anal. Chem."},{"issue":"29","key":"10.1016\/j.bios.2021.113015_bib37","doi-asserted-by":"crossref","first-page":"11998","DOI":"10.1021\/ja305969c","volume":"134","author":"Zhang","year":"2012","journal-title":"J. Am. Chem. Soc."},{"issue":"43","key":"10.1016\/j.bios.2021.113015_bib38","doi-asserted-by":"crossref","first-page":"17189","DOI":"10.1021\/jacs.9b07521","volume":"141","author":"Zhang","year":"2019","journal-title":"J. Am. Chem. Soc."},{"issue":"5853","key":"10.1016\/j.bios.2021.113015_bib39","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1126\/science.1148532","volume":"318","author":"Zhang","year":"2007","journal-title":"Science"},{"issue":"32","key":"10.1016\/j.bios.2021.113015_bib40","doi-asserted-by":"crossref","first-page":"11198","DOI":"10.1021\/ja505101a","volume":"136","author":"Zhang","year":"2014","journal-title":"J. Am. Chem. Soc."},{"issue":"20","key":"10.1016\/j.bios.2021.113015_bib41","doi-asserted-by":"crossref","first-page":"11892","DOI":"10.1021\/acs.analchem.8b01966","volume":"90","author":"Zhang","year":"2018","journal-title":"Anal. Chem."},{"issue":"7798","key":"10.1016\/j.bios.2021.113015_bib42","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566321000518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566321000518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T01:15:56Z","timestamp":1760663756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566321000518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":42,"alternative-id":["S0956566321000518"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2021.113015","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Entropy-driven amplified electrochemiluminescence biosensor for RdRp gene of SARS-CoV-2 detection with self-assembled DNA tetrahedron scaffolds","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2021.113015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113015"}}