{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:56:53Z","timestamp":1791579413552,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.bios.2021.113568","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T13:44:01Z","timestamp":1629207841000},"page":"113568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Multiplexed electrokinetic sensor for detection and therapy monitoring of extracellular vesicles from liquid biopsies of non-small-cell lung cancer patients"],"prefix":"10.1016","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5077-3218","authenticated-orcid":false,"given":"Sara","family":"Cavallaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"H\u00e5\u00e5g","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth S.","family":"Sahu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenca","family":"Berisha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-5270","authenticated-orcid":false,"given":"Vitaliy O.","family":"Kaminskyy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8343-6226","authenticated-orcid":false,"given":"Simon","family":"Ekman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Lewensohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Linnros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4552-3561","authenticated-orcid":false,"given":"Kristina","family":"Viktorsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6235-2891","authenticated-orcid":false,"given":"Apurba","family":"Dev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2021.113568_bib1","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1634\/theoncologist.2018-0112","article-title":"Role of targeted therapy and immune checkpoint blockers in advanced non\u2010small cell lung cancer: a review","volume":"24","author":"Abdel Karim","year":"2019","journal-title":"Oncol."},{"key":"10.1016\/j.bios.2021.113568_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cis.2009.09.004","article-title":"Streaming potential studies of colloid, polyelectrolyte and protein deposition","volume":"153","author":"Adamczyk","year":"2010","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.bios.2021.113568_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800160","article-title":"Unique protein profiles of extracellular vesicles as diagnostic biomarkers for early and advanced non-small cell lung cancer","volume":"19","author":"An","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.bios.2021.113568_bib4","doi-asserted-by":"crossref","first-page":"8179","DOI":"10.1007\/s11033-020-05869-7","article-title":"Liquid biopsy approaches for pleural effusion in lung cancer patients","volume":"47","author":"Baburaj","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bios.2021.113568_bib5","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1039\/D0NA00948B","article-title":"Comparison and optimization of nanoscale extracellular vesicle imaging by scanning electron microscopy for accurate size-based profiling and morphological analysis","volume":"3","author":"Cavallaro","year":"2021","journal-title":"Nanoscale Adv."},{"key":"10.1016\/j.bios.2021.113568_bib6","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1021\/acssensors.9b00418","article-title":"Label-free surface protein profiling of extracellular vesicles by an electrokinetic sensor","volume":"4","author":"Cavallaro","year":"2019","journal-title":"ACS Sens."},{"key":"10.1016\/j.bios.2021.113568_bib7","doi-asserted-by":"crossref","first-page":"111749","DOI":"10.1016\/j.bios.2019.111749","article-title":"Simultaneous multiplexed detection of exosomal microRNAs and surface proteins for prostate cancer diagnosis","volume":"146","author":"Cho","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113568_bib8","doi-asserted-by":"crossref","first-page":"58771","DOI":"10.18632\/oncotarget.17680","article-title":"Multiple receptor tyrosine kinase activation related to ALK inhibitor resistance in lung cancer cells with ALK rearrangement","volume":"8","author":"Choi","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bios.2021.113568_bib9","doi-asserted-by":"crossref","first-page":"e155","DOI":"10.1016\/j.jtho.2017.04.023","article-title":"Circulating tumor DNA identifies EGFR coamplification as a mechanism of resistance to crizotinib in a patient with advanced MET-amplified lung adenocarcinoma","volume":"12","author":"Dagogo-Jack","year":"2017","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.bios.2021.113568_bib10","doi-asserted-by":"crossref","first-page":"100060","DOI":"10.1016\/j.esmoop.2021.100060","article-title":"How to use liquid biopsies to treat patients with cancer","volume":"6","author":"De Mattos-Arruda","year":"2021","journal-title":"ESMO Open"},{"key":"10.1016\/j.bios.2021.113568_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bios.2016.03.060","article-title":"Electrokinetic effect for molecular recognition: a label-free approach for real-time biosensing","volume":"82","author":"Dev","year":"2016","journal-title":"Biosens. Bioelectron."},{"issue":"1\u20139","key":"10.1016\/j.bios.2021.113568_bib12","article-title":"Rapid inertial solution exchange for enrichment and flow cytometric detection of microvesicles","volume":"9","author":"Dudani","year":"2015","journal-title":"Biomicrofluidics"},{"key":"10.1016\/j.bios.2021.113568_bib13","doi-asserted-by":"crossref","first-page":"112066","DOI":"10.1016\/j.bios.2020.112066","article-title":"High-sensitive and multiplex biosensing assay of NSCLC-derived exosomes via different recognition sites based on SPRi array","volume":"154","author":"Fan","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113568_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/adbi.201900305","article-title":"Modeling EV kinetics for use in early cancer detection","volume":"4","author":"Ferguson","year":"2020","journal-title":"Adv. Biosyst."},{"key":"10.1016\/j.bios.2021.113568_bib15","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1158\/1078-0432.CCR-15-3101","article-title":"EGFR mutations and ALK rearrangements are associated with low response rates to PD-1 pathway blockade in non-small cell lung cancer: a retrospective analysis","volume":"22","author":"Gainor","year":"2016","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.bios.2021.113568_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ph13120474","article-title":"The emerging therapeutic landscape of alk inhibitors in non-small cell lung cancer","volume":"13","author":"Gristina","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bios.2021.113568_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.610923","article-title":"Concurrent genetic alterations and other biomarkers predict treatment efficacy of EGFR-TKIs in EGFR-mutant non-small cell lung cancer: a review","volume":"10","author":"Guo","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bios.2021.113568_bib18","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.cell.2020.07.009","article-title":"Extracellular vesicle and particle biomarkers define multiple human cancers","volume":"182","author":"Hoshino","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bios.2021.113568_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.lungcan.2018.07.018","article-title":"Exosomal RNA-profiling of pleural effusions identifies adenocarcinoma patients through elevated miR-200 and LCN2 expression","volume":"124","author":"Hydbring","year":"2018","journal-title":"Lung Canc."},{"key":"10.1016\/j.bios.2021.113568_bib20","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1021\/acsnano.5b07584","article-title":"Integrated magneto-electrochemical sensor for exosome analysis","volume":"10","author":"Jeong","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2021.113568_bib21","first-page":"699","volume":"1","author":"Kang","year":"2021"},{"key":"10.1016\/j.bios.2021.113568_bib22","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1039\/C4LC00136B","article-title":"Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes","volume":"14","author":"Kanwar","year":"2014","journal-title":"Lab Chip"},{"key":"10.1016\/j.bios.2021.113568_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s12276-019-0295-2","article-title":"Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer","volume":"51","author":"Kim","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bios.2021.113568_bib24","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.4143\/crt.2018.486","article-title":"Alterations in PD-L1 expression associated with acquisition of resistance to ALK inhibitors in ALK-rearranged lung cancer","volume":"51","author":"Kim","year":"2019","journal-title":"Cancer Res. Treat"},{"key":"10.1016\/j.bios.2021.113568_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/elps.200305754","article-title":"Zeta potential of microfluidic substrates: 1. Theory, experimental techniques, and effects on separations","volume":"25","author":"Kirby","year":"2004","journal-title":"Electrophoresis"},{"key":"10.1016\/j.bios.2021.113568_bib26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0956-5663(99)00008-1","article-title":"Protein detection with a novel ISFET-based zeta potential analyzer","volume":"14","author":"Koch","year":"1999","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113568_bib27","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3390\/cancers13040804","article-title":"Targeted therapy in advanced and metastatic non-small cell lung cancer. An update on treatment of the most important actionable oncogenic driver alterations","volume":"13","author":"K\u00f6nig","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bios.2021.113568_bib28","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/annonc\/mdx765","article-title":"Improved EGFR mutation detection using combined exosomal RNA and circulating tumor DNA in NSCLC patient plasma","volume":"29","author":"Krug","year":"2018","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bios.2021.113568_bib29","doi-asserted-by":"crossref","first-page":"103225","DOI":"10.1016\/j.critrevonc.2021.103225","article-title":"Moving beyond epidermal growth factor receptor resistance in metastatic non-small cell lung cancer - a drug development perspective","volume":"159","author":"Lai-Kwon","year":"2021","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.bios.2021.113568_bib30","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.21037\/jtd.2019.08.30","article-title":"Mechanisms of resistance to osimertinib","volume":"12","author":"Lazzari","year":"2020","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.bios.2021.113568_bib31","first-page":"1","article-title":"Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis","volume":"20","author":"Li","year":"2021","journal-title":"Mol. Canc."},{"key":"10.1016\/j.bios.2021.113568_bib32","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.snb.2017.12.130","article-title":"A microfluidic streaming potential analyzer for label-free DNA detection","volume":"259","author":"Li","year":"2018","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.bios.2021.113568_bib33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.lungcan.2021.03.004","article-title":"Relationship between PD-L1 expression and outcome in EGFR-mutant lung cancer patients treated with EGFR tyrosine kinase inhibitors","volume":"155","author":"Liu","year":"2021","journal-title":"Lung Canc."},{"issue":"1\u20133","key":"10.1016\/j.bios.2021.113568_bib34","article-title":"Electrical detection of DNA immobilization and hybridization by streaming current measurements in microchannels","author":"Martins","year":"2011","journal-title":"Appl. Phys. Lett."},{"key":"10.1016\/j.bios.2021.113568_bib35","doi-asserted-by":"crossref","first-page":"787","DOI":"10.21037\/tlcr.2020.04.03","article-title":"Emergence of a HER2-amplified clone during disease progression in an ALK-rearranged NSCLC patient treated with ALK-inhibitors: a case report","volume":"9","author":"Minari","year":"2020","journal-title":"Transl. Lung Cancer Res."},{"key":"10.1016\/j.bios.2021.113568_bib36","doi-asserted-by":"crossref","first-page":"129452","DOI":"10.1016\/j.snb.2021.129452","article-title":"Utilization of chromogenic enzyme substrates for signal amplification in multiplexed detection of biomolecules using surface mass spectrometry","volume":"332","author":"Na","year":"2021","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.bios.2021.113568_bib37","first-page":"225","article-title":"Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain","volume":"2","author":"Pao","year":"2005","journal-title":"PLoS Med."},{"key":"10.1016\/j.bios.2021.113568_bib38","article-title":"Extracellular vesicles in non-small-cell lung cancer: functional role and involvement in resistance to targeted treatment and immunotherapy","volume":"12","author":"Pasini","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.bios.2021.113568_bib39","first-page":"179","article-title":"Micro- to nano- Biosensors and actuators integrated for responsive delivery of countermeasures","volume":"1","author":"Peteu","year":"2010","journal-title":"Proc. Int. Semicond. Conf. CAS"},{"key":"10.1016\/j.bios.2021.113568_bib40","doi-asserted-by":"crossref","first-page":"iv192","DOI":"10.1093\/annonc\/mdy275","article-title":"Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"29","author":"Planchard","year":"2018","journal-title":"Ann. Oncol."},{"issue":"2\u201318","key":"10.1016\/j.bios.2021.113568_bib41","article-title":"Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours.pdf","volume":"8","author":"Ricklefs","year":"2019","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.bios.2021.113568_bib42","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.jtho.2018.05.030","article-title":"Liquid biopsy for advanced non-small cell lung cancer (NSCLC): a statement paper from the iaslc","volume":"13","author":"Rolfo","year":"2018","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.bios.2021.113568_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112005","article-title":"Influence of molecular size and zeta potential in electrokinetic biosensing","volume":"152","author":"Sahu","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113568_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112917","article-title":"Electrokinetic sandwich assay and DNA mediated charge amplification for enhanced sensitivity and specificity","volume":"176","author":"Sahu","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113568_bib45","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.molonc.2016.10.003","article-title":"Exosomal proteins as prognostic biomarkers in non-small cell lung cancer","volume":"10","author":"Sandfeld-Paulsen","year":"2016","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.bios.2021.113568_bib46","doi-asserted-by":"crossref","first-page":"S882","DOI":"10.21037\/jtd.2018.03.81","article-title":"Liquid biopsy for lung cancer early detection","volume":"10","author":"Santarpia","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.bios.2021.113568_bib47","doi-asserted-by":"crossref","first-page":"112721","DOI":"10.1016\/j.bios.2020.112721","article-title":"An origami electrical biosensor for multiplexed analyte detection in body fluids","volume":"171","author":"Shen","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113568_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep30460","article-title":"Real time and label free profiling of clinically relevant exosomes","volume":"6","author":"Sina","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bios.2021.113568_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers13040922","article-title":"Detection of tumor\u2010associated membrane receptors on extracellular vesicles from non\u2010small cell lung cancer patients via immuno\u2010pcr","volume":"13","author":"Stiller","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bios.2021.113568_bib50","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1080\/14737140.2017.1355243","article-title":"Overcoming resistance to EGFR tyrosine kinase inhibitors in lung cancer, focusing on non-T790M mechanisms","volume":"17","author":"Suda","year":"2017","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.bios.2021.113568_bib51","first-page":"1","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","author":"Sung","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.bios.2021.113568_bib52","doi-asserted-by":"crossref","first-page":"471","DOI":"10.7150\/ijbs.39123","article-title":"Exploration of serum exosomal LncRNA TBILA and AGAP2-AS1 as promising biomarkers for diagnosis of non-small cell lung cancer","volume":"16","author":"Tao","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bios.2021.113568_bib53","doi-asserted-by":"crossref","first-page":"11125","DOI":"10.1021\/ac502082b","article-title":"Detecting exosomes specifically: a multiplexed device based on alternating current electrohydrodynamic induced nanoshearing","volume":"86","author":"Vaidyanathan","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2021.113568_bib54","first-page":"11","article-title":"Cancer diagnosis: from tumor to liquid biopsy and beyond","volume":"19","author":"Vaidyanathan","year":"2019","journal-title":"Lab Chip"},{"key":"10.1016\/j.bios.2021.113568_bib55","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1093\/annonc\/mdy458","article-title":"Nanoscale extracellular vesicle-derived DNA is superior to circulating cell-free DNA for mutation detection in early-stage non-small-cell lung cancer","volume":"29","author":"Wan","year":"2018","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bios.2021.113568_bib56","doi-asserted-by":"crossref","first-page":"101047","DOI":"10.1016\/j.tranon.2021.101047","article-title":"The role of exosomal PD-L1 in tumor immunotherapy","volume":"14","author":"Wang","year":"2021","journal-title":"Transl. Oncol"},{"key":"10.1016\/j.bios.2021.113568_bib57","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41571-018-0036-9","article-title":"Extracellular vesicles in cancer \u2014 implications for future improvements in cancer care","volume":"15","author":"Xu","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bios.2021.113568_bib58","doi-asserted-by":"crossref","first-page":"113591","DOI":"10.1016\/j.ab.2020.113591","article-title":"Development of a lateral flow aptamer assay strip for facile identification of theranostic exosomes isolated from human lung carcinoma cells","volume":"594","author":"Yu","year":"2020","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bios.2021.113568_bib59","doi-asserted-by":"crossref","first-page":"113134","DOI":"10.1016\/j.bios.2021.113134","article-title":"Multiplex quantitative detection of SARS-CoV-2 specific IgG and IgM antibodies based on DNA-assisted nanopore sensing","volume":"181","author":"Zhang","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113568_bib60","first-page":"1","article-title":"Discovery and validation of extracellular vesicle-associated miRNAs as noninvasive detection biomarkers for early-stage non-small-cell lung cancer","author":"Zhong","year":"2020","journal-title":"Mol. Oncol."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566321006059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566321006059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T01:25:32Z","timestamp":1760664332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566321006059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":60,"alternative-id":["S0956566321006059"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2021.113568","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.04.08.438994","asserted-by":"object"}]},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiplexed electrokinetic sensor for detection and therapy monitoring of extracellular vesicles from liquid biopsies of non-small-cell lung cancer patients","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2021.113568","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113568"}}