{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:20:08Z","timestamp":1792750808347,"version":"4.5.0"},"reference-count":124,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.bios.2021.113789","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T00:12:41Z","timestamp":1636848761000},"page":"113789","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Current progress in aptamer-based sensing tools for ultra-low level monitoring of Alzheimer's disease biomarkers"],"prefix":"10.1016","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-7938","authenticated-orcid":false,"given":"Javad","family":"Zamanian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Khoshbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Abnous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9836-2189","authenticated-orcid":false,"given":"Seyed Mohammad","family":"Taghdisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Hosseinzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor Mohammd","family":"Danesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2021.113789_bib1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.bios.2017.03.028","article-title":"A new amplified \u03c0-shape electrochemical aptasensor for ultrasensitive detection of aflatoxin B1","volume":"94","author":"Abnous","year":"2017","journal-title":"Biosens. Bioelectron."},{"issue":"4","key":"10.1016\/j.bios.2021.113789_bib2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00604-017-2113-7","article-title":"Amperometric aptasensor for ochratoxin A based on the use of a gold electrode modified with aptamer, complementary DNA, SWCNTs and the redox marker Methylene Blue","volume":"184","author":"Abnous","year":"2017","journal-title":"Microchimica Acta"},{"key":"10.1016\/j.bios.2021.113789_bib3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bios.2015.11.028","article-title":"A novel colorimetric sandwich aptasensor based on an indirect competitive enzyme-free method for ultrasensitive detection of chloramphenicol","volume":"78","author":"Abnous","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113789_bib4","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/14737159.2021.1920397","article-title":"Aptamer-based sensing of breast cancer biomarkers: a comprehensive review of analytical figures of merit","author":"Ahirwar","year":"2021","journal-title":"Expert Rev. Mol. Diagn."},{"issue":"2","key":"10.1016\/j.bios.2021.113789_bib5","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jalz.2013.02.003","article-title":"Alzheimer's disease facts and figures","volume":"9","author":"Association","year":"2013","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.bios.2021.113789_bib6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.talanta.2014.11.020","article-title":"Sensing and inhibition of amyloid-\u03b2 based on the simple luminescent aptamer\u2013ruthenium complex system","volume":"134","author":"Babu","year":"2015","journal-title":"Talanta"},{"issue":"12","key":"10.1016\/j.bios.2021.113789_bib7","doi-asserted-by":"crossref","first-page":"1900193","DOI":"10.1002\/adbi.201900193","article-title":"Cell\u2010SELEX, an effective way to the discovery of biomarkers and unexpected molecular events","volume":"3","author":"Bing","year":"2019","journal-title":"Advanced Biosystems"},{"issue":"3","key":"10.1016\/j.bios.2021.113789_bib8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrneurol.2010.4","article-title":"Cerebrospinal fluid and plasma biomarkers in Alzheimer disease","volume":"6","author":"Blennow","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bios.2021.113789_bib9","doi-asserted-by":"crossref","first-page":"120644","DOI":"10.1016\/j.talanta.2019.120644","article-title":"Applications of biosensors in Alzheimer's disease diagnosis","volume":"210","author":"Brazaca","year":"2020","journal-title":"Talanta"},{"issue":"3","key":"10.1016\/j.bios.2021.113789_bib10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jalz.2007.04.381","article-title":"Forecasting the global burden of Alzheimer's disease","volume":"3","author":"Brookmeyer","year":"2007","journal-title":"Alzheimer's Dementia"},{"issue":"4","key":"10.1016\/j.bios.2021.113789_bib11","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1021\/cr030063a","article-title":"Chemistry and properties of nanocrystals of different shapes","volume":"105","author":"Burda","year":"2005","journal-title":"Chem. Rev."},{"issue":"10","key":"10.1016\/j.bios.2021.113789_bib12","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.7150\/thno.29232","article-title":"Highly sensitive quantification of Alzheimer's disease biomarkers by aptamer-assisted amplification","volume":"9","author":"Chan","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.bios.2021.113789_bib13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jconrel.2018.01.002","article-title":"Gold nanoparticle should understand protein corona for being a clinical nanomaterial","volume":"272","author":"Charbgoo","year":"2018","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bios.2021.113789_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.trac.2016.08.008","article-title":"Nanoparticles application in high sensitive aptasensor design","volume":"85","author":"Charbgoo","year":"2016","journal-title":"Trac. Trends Anal. Chem."},{"key":"10.1016\/j.bios.2021.113789_bib15","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1021\/acssensors.1c00596","article-title":"Sensitive detection of SARS-CoV-2 using a SERS-based aptasensor","author":"Chen","year":"2021","journal-title":"ACS Sens."},{"key":"10.1016\/j.bios.2021.113789_bib16","doi-asserted-by":"crossref","first-page":"112496","DOI":"10.1016\/j.bios.2020.112496","article-title":"SERS imaging-based aptasensor for ultrasensitive and reproducible detection of influenza virus A","volume":"167","author":"Chen","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113789_bib17","doi-asserted-by":"crossref","first-page":"120930","DOI":"10.1016\/j.talanta.2020.120930","article-title":"A facile biosensor for A\u03b240O based on fluorescence quenching of prussian blue nanoparticles","volume":"216","author":"Chen","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2021.113789_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2020.03.017","article-title":"A sensitive homogenous aptasensor based on tetraferrocene labeling for thrombin detection","volume":"1111","author":"Cheng","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bios.2021.113789_bib19","doi-asserted-by":"crossref","first-page":"121818","DOI":"10.1016\/j.talanta.2020.121818","article-title":"Aptamer selection and aptasensor construction for bone density biomarkers","volume":"224","author":"Chinnappan","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2021.113789_bib20","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.bios.2014.09.087","article-title":"Surface-enhanced Raman scattering aptasensor for ultrasensitive trace analysis of bisphenol A","volume":"64","author":"Chung","year":"2015","journal-title":"Biosens. Bioelectron."},{"issue":"12","key":"10.1016\/j.bios.2021.113789_bib21","doi-asserted-by":"crossref","first-page":"16973","DOI":"10.1021\/acsnano.0c06078","article-title":"Photomodulating carbon dots for spatiotemporal suppression of Alzheimer's \u03b2-amyloid aggregation","volume":"14","author":"Chung","year":"2020","journal-title":"ACS Nano"},{"issue":"23","key":"10.1016\/j.bios.2021.113789_bib22","doi-asserted-by":"crossref","first-page":"13170","DOI":"10.1073\/pnas.93.23.13170","article-title":"Evidence that the 42-and 40-amino acid forms of amyloid \u03b2 protein are generated from the \u03b2-amyloid precursor protein by different protease activities","volume":"93","author":"Citron","year":"1996","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.bios.2021.113789_bib23","doi-asserted-by":"crossref","first-page":"122219","DOI":"10.1016\/j.talanta.2021.122219","article-title":"2D titanium carbide nanosheets based fluorescent aptasensor for sensitive detection of thrombin","volume":"228","author":"Cui","year":"2021","journal-title":"Talanta"},{"issue":"4","key":"10.1016\/j.bios.2021.113789_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00604-020-4217-8","article-title":"An electrochemical aptasensor for amyloid-\u03b2 oligomer based on double-stranded DNA as \u201cconductive spring.\u201d","volume":"187","author":"Deng","year":"2020","journal-title":"Microchimica Acta"},{"issue":"3","key":"10.1016\/j.bios.2021.113789_bib25","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1021\/acs.analchem.7b03468","article-title":"Light-up nonthiolated aptasensor for low-mass, soluble amyloid-\u03b240 oligomers at high salt concentrations","volume":"90","author":"Deng","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2021.113789_bib26","doi-asserted-by":"crossref","first-page":"112872","DOI":"10.1016\/j.bios.2020.112872","article-title":"Impedimetric aptamer-based glycan PSA score for discrimination of prostate cancer from other prostate diseases","volume":"175","author":"D\u00edaz-Fern\u00e1ndez","year":"2021","journal-title":"Biosens. Bioelectron."},{"issue":"3","key":"10.1016\/j.bios.2021.113789_bib27","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1021\/acssensors.6b00772","article-title":"Rational design of a stimuli-responsive polymer electrode interface coupled with in vivo microdialysis for measurement of sialic acid in live mouse brain in Alzheimer's Disease","volume":"2","author":"Ding","year":"2017","journal-title":"ACS Sens."},{"issue":"9","key":"10.1016\/j.bios.2021.113789_bib28","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1021\/acs.analchem.0c05276","article-title":"Engineering allosteric ribozymes to detect thiamine pyrophosphate in whole blood","volume":"93","author":"Du","year":"2021","journal-title":"Anal. Chem."},{"issue":"22","key":"10.1016\/j.bios.2021.113789_bib29","doi-asserted-by":"crossref","first-page":"15162","DOI":"10.1021\/acs.analchem.0c03643","article-title":"Polyvalent biotinylated aptamer scaffold for rapid and sensitive detection of tau proteins","volume":"92","author":"Duan","year":"2020","journal-title":"Anal. Chem."},{"issue":"4","key":"10.1016\/j.bios.2021.113789_bib30","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1021\/acs.analchem.9b04938","article-title":"Highly enhanced electrochemiluminescence luminophore generated by zeolitic imidazole framework-8-linked porphyrin and its application for thrombin detection","volume":"92","author":"Fang","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2021.113789_bib31","doi-asserted-by":"crossref","first-page":"112607","DOI":"10.1016\/j.bios.2020.112607","article-title":"Fluorescent aptasensor based on G-quadruplex-assisted structural transformation for the detection of biomarker lipocalin 1","volume":"169","author":"Gao","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113789_bib32","doi-asserted-by":"crossref","first-page":"111484","DOI":"10.1016\/j.bios.2019.111484","article-title":"Application of various optical and electrochemical aptasensors for detection of human prostate specific antigen: a review","volume":"142","author":"Ghorbani","year":"2019","journal-title":"Biosens. Bioelectron."},{"issue":"8","key":"10.1016\/j.bios.2021.113789_bib33","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1021\/am5010909","article-title":"Fluorogenic resveratrol-confined graphene oxide for economic and rapid detection of Alzheimer's disease","volume":"6","author":"He","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.bios.2021.113789_bib34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF02080933","article-title":"Alterations of thiamine phosphorylation and of thiamine-dependent enzymes in Alzheimer's disease","volume":"11","author":"H\u00e9roux","year":"1996","journal-title":"Metab. Brain Dis."},{"issue":"2","key":"10.1016\/j.bios.2021.113789_bib35","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.3390\/s120201181","article-title":"Applications of aptasensors in clinical diagnostics","volume":"12","author":"Hong","year":"2012","journal-title":"Sensors"},{"issue":"14","key":"10.1016\/j.bios.2021.113789_bib36","doi-asserted-by":"crossref","first-page":"10114","DOI":"10.1021\/acs.analchem.0c02117","article-title":"Highly sensitive and selective photoelectrochemical aptasensor for cancer biomarker CA125 based on AuNPs\/GaN Schottky junction","volume":"92","author":"Hu","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2021.113789_bib37","series-title":"J. Guo. Aptamer-Based Lateral Flow Assay On-Site Biosensors","first-page":"113279","author":"Huang","year":"2021"},{"key":"10.1016\/j.bios.2021.113789_bib38","doi-asserted-by":"crossref","first-page":"113666","DOI":"10.1016\/j.jpba.2020.113666","article-title":"An enzyme linked aptamer photoelectrochemical biosensor for Tau-381 protein using AuNPs\/MoSe2 as sensing material","volume":"192","author":"Hun","year":"2021","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.bios.2021.113789_bib39","doi-asserted-by":"crossref","first-page":"107701","DOI":"10.1016\/j.bioelechem.2020.107701","article-title":"Ultra-sensitive and selective electrochemical biosensor with aptamer recognition surface based on polymer quantum dots and C60\/MWCNTs-polyethylenimine nanocomposites for analysis of thrombin protein","volume":"138","author":"Jamei","year":"2021","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.bios.2021.113789_bib40","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.talanta.2017.04.021","article-title":"Detection of A\u03b2 oligomers based on magnetic-field-assisted separation of aptamer-functionalized Fe3O4 magnetic nanoparticles and BaYF5: Yb, Er nanoparticles as upconversion fluorescence labels","volume":"170","author":"Jiang","year":"2017","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2021.113789_bib41","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bios.2017.09.017","article-title":"Electrochemiluminescence resonance energy transfer system between GNRs and Ru (bpy) 32+: application in magnetic aptasensor for \u03b2-amyloid","volume":"100","author":"Ke","year":"2018","journal-title":"Biosens. Bioelectron."},{"issue":"23","key":"10.1016\/j.bios.2021.113789_bib42","doi-asserted-by":"crossref","first-page":"19440","DOI":"10.1074\/jbc.M112.346072","article-title":"Trans-cellular propagation of Tau aggregation by fibrillar species","volume":"287","author":"Kfoury","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bios.2021.113789_bib43","series-title":"Recent Advances in Computational Methods for Biosensor Design","author":"Khoshbin","year":"2020"},{"key":"10.1016\/j.bios.2021.113789_bib44","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.aca.2019.04.049","article-title":"A simple paper-based aptasensor for ultrasensitive detection of lead (II) ion","volume":"1071","author":"Khoshbin","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bios.2021.113789_bib45","doi-asserted-by":"crossref","first-page":"113689","DOI":"10.1016\/j.ab.2020.113689","article-title":"A low-cost paper-based aptasensor for simultaneous trace-level monitoring of mercury (II) and silver (I) ions","volume":"597","author":"Khoshbin","year":"2020","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bios.2021.113789_bib46","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bios.2018.05.051","article-title":"Simultaneous detection and determination of mercury (II) and lead (II) ions through the achievement of novel functional nucleic acid-based biosensors","volume":"116","author":"Khoshbin","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113789_bib47","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.bios.2018.09.060","article-title":"Aptasensors as the future of antibiotics test kits-a case study of the aptamer application in the chloramphenicol detection","volume":"122","author":"Khoshbin","year":"2018","journal-title":"Biosens. Bioelectron."},{"issue":"15","key":"10.1016\/j.bios.2021.113789_bib48","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1039\/D0CS00107D","article-title":"Chemical sensing platforms for detecting trace-level Alzheimer's core biomarkers","volume":"49","author":"Kim","year":"2020","journal-title":"Chem. Soc. Rev."},{"issue":"18","key":"10.1016\/j.bios.2021.113789_bib49","doi-asserted-by":"crossref","first-page":"20882","DOI":"10.1021\/acsami.0c03709","article-title":"Aptamer-functionalized three-dimensional carbon nanowebs for ultrasensitive and free-standing PDGF biosensor","volume":"12","author":"Kim","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bios.2021.113789_bib50","doi-asserted-by":"crossref","first-page":"113341","DOI":"10.1016\/j.bios.2021.113341","article-title":"Bio-inspired Ag nanovilli-based sandwich-type SERS aptasensor for ultrasensitive and selective detection of 25-hydroxy vitamin D3","volume":"188","author":"Kim","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113789_bib51","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bios.2015.06.040","article-title":"Aptamer-based nanobiosensors","volume":"76","author":"Kim","year":"2016","journal-title":"Biosens. Bioelectron."},{"issue":"15","key":"10.1016\/j.bios.2021.113789_bib52","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1039\/C2CP43155F","article-title":"SERS-based immunoassay of tumor marker VEGF using DNA aptamers and silica-encapsulated hollow gold nanospheres","volume":"15","author":"Ko","year":"2013","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.bios.2021.113789_bib53","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ijbiomac.2020.10.063","article-title":"Efficient immobilization of aptamers on the layered double hydroxide nanohybrids for the electrochemical proteins detection","volume":"166","author":"Konari","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bios.2021.113789_bib54","doi-asserted-by":"crossref","first-page":"112053","DOI":"10.1016\/j.bios.2020.112053","article-title":"Amyloid-beta peptide detection via aptamer-functionalized nanowire sensors exploiting single-trap phenomena","volume":"154","author":"Kutovyi","year":"2020","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.bios.2021.113789_bib55","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1146\/annurev.neuro.24.1.1121","article-title":"Neurodegenerative tauopathies","volume":"24","author":"Lee","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.bios.2021.113789_bib56","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1586\/epr.11.37","article-title":"Neurochemical dementia diagnostics in Alzheimer's disease: where are we now and where are we going?","volume":"8","author":"Lewczuk","year":"2011","journal-title":"Expet Rev. Proteonomics"},{"key":"10.1016\/j.bios.2021.113789_bib57","doi-asserted-by":"crossref","first-page":"112520","DOI":"10.1016\/j.bios.2020.112520","article-title":"Facile fluorescent aptasensor using aggregation-induced emission luminogens for exosomal proteins profiling towards liquid biopsy","volume":"168","author":"Li","year":"2020","journal-title":"Biosens. Bioelectron."},{"issue":"13","key":"10.1016\/j.bios.2021.113789_bib58","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1002\/adma.201104864","article-title":"Using graphene oxide high near\u2010infrared absorbance for photothermal treatment of Alzheimer's disease","volume":"24","author":"Li","year":"2012","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bios.2021.113789_bib59","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.aca.2013.08.023","article-title":"Cyclically amplified fluorescent detection of theophylline and thiamine pyrophosphate by coupling self-cleaving RNA ribozyme with endonuclease","volume":"797","author":"Li","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bios.2021.113789_bib60","doi-asserted-by":"crossref","first-page":"122058","DOI":"10.1016\/j.talanta.2020.122058","article-title":"Proximity hybridization triggered hybridization chain reaction for label-free electrochemical homogeneous aptasensors","volume":"226","author":"Liao","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2021.113789_bib61","doi-asserted-by":"crossref","first-page":"114604","DOI":"10.1016\/j.jelechem.2020.114604","article-title":"Signal-on and label-free electrochemical detection of amyloid \u03b2 oligomers based on dual amplification induced hemin\/G-quadruplex formation","volume":"878","author":"Liao","year":"2020","journal-title":"J. Electroanal. Chem."},{"key":"10.1016\/j.bios.2021.113789_bib62","doi-asserted-by":"crossref","first-page":"107447","DOI":"10.1016\/j.bioelechem.2019.107447","article-title":"Electrochemical detection of specific interactions between apolipoprotein E isoforms and DNA sequences related to Alzheimer's disease","volume":"133","author":"Lima","year":"2020","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.bios.2021.113789_bib63","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.aca.2018.07.029","article-title":"Non-SELEX isolation of DNA aptamers for the homogeneous-phase fluorescence anisotropy sensing of tau Proteins","volume":"1038","author":"Lisi","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bios.2021.113789_bib64","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.snb.2017.05.106","article-title":"Two-in-one polydopamine nanospheres for fluorescent determination of beta-amyloid oligomers and inhibition of beta-amyloid aggregation","volume":"251","author":"Liu","year":"2017","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.bios.2021.113789_bib65","doi-asserted-by":"crossref","first-page":"122360","DOI":"10.1016\/j.talanta.2021.122360","article-title":"An electrochemical aptasensor based on AuPt alloy nanoparticles for ultrasensitive detection of amyloid-\u03b2 oligomers","volume":"231","author":"Liu","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.bios.2021.113789_bib66","series-title":"Femtomolar Detection of Thrombin in Serum and Cerebrospinal Fluid via Direct Electrocatalysis of Oxygen Reduction by the Covalent G4-Hemin-Aptamer Complex","author":"Malecka","year":"2021"},{"issue":"5","key":"10.1016\/j.bios.2021.113789_bib67","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/ana.410390508","article-title":"Brain protein and \u03b1\u2010ketoglutarate dehydrogenase complex activity in alzheimer\u2010s disease","volume":"39","author":"Mastrogiacomo","year":"1996","journal-title":"Ann. Neurol.: Official Journal of the American Neurological Association and the Child Neurology Society"},{"issue":"1","key":"10.1016\/j.bios.2021.113789_bib68","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1001\/archneur.57.1.100","article-title":"Plasma and cerebrospinal fluid levels of amyloid \u03b2 proteins 1-40 and 1-42 in Alzheimer disease","volume":"57","author":"Mehta","year":"2000","journal-title":"Arch. Neurol."},{"issue":"8","key":"10.1016\/j.bios.2021.113789_bib69","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/j.bbamem.2007.03.015","article-title":"Fluorescence as a method to reveal structures and membrane-interactions of amyloidogenic proteins","volume":"1768","author":"Munishkina","year":"2007","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.bios.2021.113789_bib70","doi-asserted-by":"crossref","first-page":"112018","DOI":"10.1016\/j.bios.2020.112018","article-title":"Aptamers in nanostructure-based electrochemical biosensors for cardiac biomarkers and cancer biomarkers: a review","volume":"152","author":"Negahdary","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113789_bib71","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.talanta.2019.01.109","article-title":"An ultrasensitive electrochemical aptasensor for early diagnosis of Alzheimer's disease, using a fern leaves-like gold nanostructure","volume":"198","author":"Negahdary","year":"2019","journal-title":"Talanta"},{"issue":"3","key":"10.1016\/j.bios.2021.113789_bib72","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3390\/bios6030028","article-title":"Aptasensors based on whispering gallery mode resonators","volume":"6","author":"Nunzi Conti","year":"2016","journal-title":"Biosensors"},{"key":"10.1016\/j.bios.2021.113789_bib73","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ijbiomac.2018.05.084","article-title":"Diagnosing human blood clotting deficiency","volume":"116","author":"Ong","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.bios.2021.113789_bib74","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1039\/D0AN00239A","article-title":"Competitive aptasensor for the ultrasensitive multiplexed detection of cancer biomarkers by fluorescent nanoparticle counting","volume":"145","author":"Pei","year":"2020","journal-title":"Analyst"},{"issue":"1","key":"10.1016\/j.bios.2021.113789_bib75","doi-asserted-by":"crossref","first-page":"e0243902","DOI":"10.1371\/journal.pone.0243902","article-title":"Aptamarker prediction of brain amyloid-\u03b2 status in cognitively normal individuals at risk for Alzheimer's disease","volume":"16","author":"Penner","year":"2021","journal-title":"PLoS One"},{"issue":"48","key":"10.1016\/j.bios.2021.113789_bib76","doi-asserted-by":"crossref","first-page":"eabd5575","DOI":"10.1126\/sciadv.abd5575","article-title":"Single-cell peripheral immunoprofiling of Alzheimer's and Parkinson's diseases","volume":"6","author":"Phongpreecha","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bios.2021.113789_bib77","doi-asserted-by":"crossref","first-page":"116069","DOI":"10.1016\/j.trac.2020.116069","article-title":"Highly sensitive and specific detection of small molecules using advanced aptasensors based on split aptamers: a review","author":"Qi","year":"2020","journal-title":"Trac. Trends Anal. Chem."},{"key":"10.1016\/j.bios.2021.113789_bib78","doi-asserted-by":"crossref","first-page":"111438","DOI":"10.1016\/j.bios.2019.111438","article-title":"A label-free and signal-on electrochemiluminescence strategy for sensitive amyloid-beta assay","volume":"141","author":"Qin","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113789_bib79","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.2147\/IJN.S302396","article-title":"Alzheimer's disease determination by a dual probe on gold nanourchins and nanohorn hybrids","volume":"16","author":"Qiu","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bios.2021.113789_bib80","doi-asserted-by":"crossref","first-page":"113116","DOI":"10.1016\/j.bios.2021.113116","article-title":"Gold nanostructured laser-scribed graphene: a new electrochemical biosensing platform for potential point-of-care testing of disease biomarkers","volume":"180","author":"Rauf","year":"2021","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"10.1016\/j.bios.2021.113789_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00604-019-4092-3","article-title":"An aptamer based fluorometric assay for amyloid-\u03b2 oligomers using a metal-organic framework of type Ru@ MIL-101 (Al) and enzyme-assisted recycling","volume":"187","author":"Ren","year":"2020","journal-title":"Microchimica Acta"},{"issue":"9","key":"10.1016\/j.bios.2021.113789_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00604-020-04518-x","article-title":"A label-free reusable aptasensor for Alzheimer's disease","volume":"187","author":"Ren","year":"2020","journal-title":"Microchimica Acta"},{"issue":"21","key":"10.1016\/j.bios.2021.113789_bib83","doi-asserted-by":"crossref","first-page":"12488","DOI":"10.1109\/JSEN.2020.3000583","article-title":"Graphene field effect transistor biosensors based on aptamer for amyloid-\u03b2 detection","volume":"20","author":"Salehirozveh","year":"2020","journal-title":"IEEE Sensor. J."},{"key":"10.1016\/j.bios.2021.113789_bib84","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.celrep.2014.02.031","article-title":"Detection of misfolded Abeta oligomers for sensitive biochemical diagnosis of Alzheimer's disease","volume":"7","author":"Salvadores","year":"2014","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.bios.2021.113789_bib85","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3390\/s20030914","article-title":"FRET-based aptasensor for the selective and sensitive detection of lysozyme","volume":"20","author":"Sapkota","year":"2020","journal-title":"Sensors"},{"issue":"9","key":"10.1016\/j.bios.2021.113789_bib86","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1016\/j.bios.2011.02.031","article-title":"Optical detection systems using immobilized aptamers","volume":"26","author":"Sassolas","year":"2011","journal-title":"Biosens. Bioelectron."},{"issue":"15","key":"10.1016\/j.bios.2021.113789_bib87","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1039\/C8AN00527C","article-title":"A novel electrochemical aptamer\u2013antibody sandwich assay for the detection of tau-381 in human serum","volume":"143","author":"Shui","year":"2018","journal-title":"Analyst"},{"key":"10.1016\/j.bios.2021.113789_bib88","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.biochi.2017.12.015","article-title":"Biosensors for Alzheimer's disease biomarker detection: a review","volume":"147","author":"Shui","year":"2018","journal-title":"Biochimie"},{"key":"10.1016\/j.bios.2021.113789_bib89","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bios.2019.04.050","article-title":"Highly sensitive aptasensor based on interferometric reflectance spectroscopy for the determination of amyloid \u03b2 as an Alzheimer's disease biomarkers using nanoporous anodic alumina","volume":"137","author":"Tabrizi","year":"2019","journal-title":"Biosens. Bioelectron."},{"issue":"3","key":"10.1016\/j.bios.2021.113789_bib90","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3390\/bios9030084","article-title":"Development of a label-free electrochemical aptasensor for the detection of Tau381 and its preliminary application in AD and non-AD patients' sera","volume":"9","author":"Tao","year":"2019","journal-title":"Biosensors"},{"issue":"11","key":"10.1016\/j.bios.2021.113789_bib91","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1016\/j.bios.2008.11.010","article-title":"Aptasensors for detection of microbial and viral pathogens","volume":"24","author":"Torres-Chavolla","year":"2009","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"10.1016\/j.bios.2021.113789_bib92","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jneumeth.2008.09.002","article-title":"Characterisation of two antibodies to oligomeric A\u03b2 and their use in ELISAs on human brain tissue homogenates","volume":"176","author":"van Helmond","year":"2009","journal-title":"J. Neurosci. Methods"},{"issue":"3","key":"10.1016\/j.bios.2021.113789_bib93","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1474-4422(10)70325-2","article-title":"Apolipoprotein E in Alzheimer's disease and other neurological disorders","volume":"10","author":"Verghese","year":"2011","journal-title":"Lancet Neurol."},{"issue":"12","key":"10.1016\/j.bios.2021.113789_bib94","doi-asserted-by":"crossref","first-page":"14765","DOI":"10.1021\/acsomega.9b01264","article-title":"Signal enhancement of silicon nanowire field-effect transistor immunosensors by RNA aptamer","volume":"4","author":"Vu","year":"2019","journal-title":"ACS Omega"},{"issue":"8","key":"10.1016\/j.bios.2021.113789_bib95","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.bios.2009.11.012","article-title":"Nanomaterial-assisted aptamers for optical sensing","volume":"25","author":"Wang","year":"2010","journal-title":"Biosens. Bioelectron."},{"issue":"9","key":"10.1016\/j.bios.2021.113789_bib96","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1021\/nn9006303","article-title":"Nucleic acid conjugated nanomaterials for enhanced molecular recognition","volume":"3","author":"Wang","year":"2009","journal-title":"ACS Nano"},{"issue":"20","key":"10.1016\/j.bios.2021.113789_bib97","doi-asserted-by":"crossref","first-page":"12968","DOI":"10.1021\/acsami.6b00021","article-title":"Ceria doped zinc oxide nanoflowers enhanced luminol-based electrochemiluminescence immunosensor for amyloid-\u03b2 detection","volume":"8","author":"Wang","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"14","key":"10.1016\/j.bios.2021.113789_bib98","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1007\/s00216-021-03319-2","article-title":"An excellent electrochemical aptasensor for amyloid-\u03b2 oligomers based on a triple-helix aptamer switch via target-triggered signal transduction DNA displacement events","volume":"413","author":"Wang","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"issue":"2","key":"10.1016\/j.bios.2021.113789_bib99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00604-021-04704-5","article-title":"Switchable electrochemical aptasensor for amyloid-\u03b2 oligomers detection based on triple helix switch coupling with AuNPs@ CuMOF labeled signaling displaced-probe","volume":"188","author":"Wang","year":"2021","journal-title":"Microchimica Acta"},{"issue":"40","key":"10.1016\/j.bios.2021.113789_bib100","doi-asserted-by":"crossref","first-page":"36299","DOI":"10.1021\/acsami.9b09492","article-title":"Design and biosensing of a ratiometric electrochemiluminescence resonance energy transfer aptasensor between a g-C3N4 nanosheet and Ru@ MOF for amyloid-\u03b2 protein","volume":"11","author":"Wang","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.bios.2021.113789_bib101","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1001\/archneurol.2008.565","article-title":"A specific enzyme-linked immunosorbent assay for measuring \u03b2-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease","volume":"66","author":"Xia","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bios.2021.113789_bib102","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.aca.2020.08.007","article-title":"Fe-MOFs as signal probes coupling with DNA tetrahedral nanostructures for construction of ratiometric electrochemical aptasensor","volume":"1135","author":"Xie","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bios.2021.113789_bib103","doi-asserted-by":"crossref","first-page":"107522","DOI":"10.1016\/j.bioelechem.2020.107522","article-title":"Highly sensitive host-guest mode homogenous electrochemical thrombin signal amplification aptasensor based on tetraferrocene label","volume":"134","author":"Xu","year":"2020","journal-title":"Bioelectrochemistry"},{"issue":"3","key":"10.1016\/j.bios.2021.113789_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00604-020-4111-4","article-title":"An electrochemical thrombin aptasensor based on the use of graphite-like C 3 N 4 modified with silver nanoparticles","volume":"187","author":"Xu","year":"2020","journal-title":"Microchimica Acta"},{"issue":"3","key":"10.1016\/j.bios.2021.113789_bib105","doi-asserted-by":"crossref","first-page":"1906273","DOI":"10.1002\/smll.201906273","article-title":"The regulatory functionality of exosomes derived from hUMSCs in 3D culture for Alzheimer's disease therapy","volume":"16","author":"Yang","year":"2020","journal-title":"Small"},{"issue":"28","key":"10.1016\/j.bios.2021.113789_bib106","doi-asserted-by":"crossref","first-page":"31270","DOI":"10.1021\/acsami.0c09179","article-title":"Colorimetric urinalysis for on-site detection of metabolic biomarkers","volume":"12","author":"Yeasmin","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.bios.2021.113789_bib107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00604-021-04710-7","article-title":"Determination of \u03b2-amyloid oligomer using electrochemiluminescent aptasensor with signal enhancement by AuNP\/MOF nanocomposite","volume":"188","author":"Yin","year":"2021","journal-title":"Microchimica Acta"},{"key":"10.1016\/j.bios.2021.113789_bib108","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bios.2013.03.003","article-title":"Highly sensitive detection of thrombin using SERS-based magnetic aptasensors","volume":"47","author":"Yoon","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113789_bib109","doi-asserted-by":"crossref","first-page":"114017","DOI":"10.1016\/j.jelechem.2020.114017","article-title":"A novel electrochemical biosensor with molecularly imprinted polymers and aptamer-based sandwich assay for determining amyloid-\u03b2 oligomer","volume":"862","author":"You","year":"2020","journal-title":"J. Electroanal. Chem."},{"key":"10.1016\/j.bios.2021.113789_bib110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bios.2019.01.015","article-title":"Aptasensors as a new sensing technology developed for the detection of MUC1 mucin: a review","volume":"130","author":"Yousefi","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113789_bib111","doi-asserted-by":"crossref","first-page":"111726","DOI":"10.1016\/j.bios.2019.111726","article-title":"Rapid and reagentless detection of thrombin in clinic samples via microfluidic aptasensors with multiple target-binding sites","volume":"146","author":"Yu","year":"2019","journal-title":"Biosens. Bioelectron."},{"issue":"19","key":"10.1016\/j.bios.2021.113789_bib112","doi-asserted-by":"crossref","first-page":"7242","DOI":"10.1021\/acs.analchem.1c00415","article-title":"\u201cDual signal-on\u201d split-type Aptasensor for TNF-\u03b1: integrating MQDs\/ZIF-8@ ZnO NR arrays with MB-liposome-mediated signal amplification","volume":"93","author":"Zhang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2021.113789_bib113","doi-asserted-by":"crossref","first-page":"137096","DOI":"10.1016\/j.electacta.2020.137096","article-title":"g-C3N4-heme bound to amyloid \u03b2 peptides: in-situ generation of the secondary co-reactant for dual-enhanced electrochemiluminescence assay of amyloid \u03b2 detection","volume":"361","author":"Zhang","year":"2020","journal-title":"Electrochim. Acta"},{"key":"10.1016\/j.bios.2021.113789_bib114","doi-asserted-by":"crossref","first-page":"111846","DOI":"10.1016\/j.bios.2019.111846","article-title":"Electrochemical sandwich-type thrombin aptasensor based on dual signal amplification strategy of silver nanowires and hollow Au\u2013CeO2","volume":"150","author":"Zhang","year":"2020","journal-title":"Biosens. Bioelectron."},{"issue":"8","key":"10.1016\/j.bios.2021.113789_bib115","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1021\/acssensors.9b00974","article-title":"Robust and universal SERS sensing platform for multiplexed detection of Alzheimer's disease core biomarkers using PAapt-AuNPs conjugates","volume":"4","author":"Zhang","year":"2019","journal-title":"ACS Sens."},{"key":"10.1016\/j.bios.2021.113789_bib116","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.snb.2019.03.049","article-title":"Monitoring amyloid-\u03b2 proteins aggregation based on label-free aptasensor","volume":"288","author":"Zhang","year":"2019","journal-title":"Sensor. Actuator. B Chem."},{"issue":"31","key":"10.1016\/j.bios.2021.113789_bib117","doi-asserted-by":"crossref","first-page":"16501","DOI":"10.1039\/D0NR03421E","article-title":"Electrochemical dual-aptamer biosensors based on nanostructured multielectrode arrays for the detection of neuronal biomarkers","volume":"12","author":"Zhang","year":"2020","journal-title":"Nanoscale"},{"issue":"11","key":"10.1016\/j.bios.2021.113789_bib118","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1021\/acssensors.9b01630","article-title":"Amperometric aptasensor for amyloid-\u03b2 oligomer detection by optimized stem-loop structures with an adjustable detection range","volume":"4","author":"Zhang","year":"2019","journal-title":"ACS Sens."},{"key":"10.1016\/j.bios.2021.113789_bib119","doi-asserted-by":"crossref","first-page":"112942","DOI":"10.1016\/j.jim.2020.112942","article-title":"Graphene oxide-gold nanoparticle-aptamer complexed probe for detecting amyloid beta oligomer by ELISA-based immunoassay","volume":"489","author":"Zhao","year":"2021","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.bios.2021.113789_bib120","doi-asserted-by":"crossref","first-page":"111840","DOI":"10.1016\/j.bios.2019.111840","article-title":"A simple aptasensor for A\u03b240 oligomers based on tunable mismatched base pairs of dsDNA and graphene oxide","volume":"149","author":"Zhao","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2021.113789_bib121","series-title":"Photoelectrochemical Aptasensing for Thrombin Based on Exonuclease III-Assisted Recycling Signal Amplification and Nanoceria Enzymatic Strategy","first-page":"122577","author":"Zhou","year":"2021"},{"issue":"36","key":"10.1016\/j.bios.2021.113789_bib122","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1039\/C8AY00736E","article-title":"A sensitive aptasensor for the detection of \u03b2-amyloid oligomers based on metal\u2013organic frameworks as electrochemical signal probes","volume":"10","author":"Zhou","year":"2018","journal-title":"Anal. Methods"},{"issue":"5","key":"10.1016\/j.bios.2021.113789_bib123","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00216-019-02350-8","article-title":"A dip-and-read optical aptasensor for detection of tau protein","volume":"412","author":"Ziu","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"issue":"8","key":"10.1016\/j.bios.2021.113789_bib124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00604-020-04380-x","article-title":"Photoelectrochemical aptasensor for thrombin based on Au-rGO-CuS as signal amplification elements","volume":"187","author":"Zou","year":"2020","journal-title":"Microchimica Acta"}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566321008265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566321008265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T01:27:51Z","timestamp":1760664471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566321008265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":124,"alternative-id":["S0956566321008265"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2021.113789","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Current progress in aptamer-based sensing tools for ultra-low level monitoring of Alzheimer's disease biomarkers","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2021.113789","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113789"}}