{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:43:29Z","timestamp":1792529009199,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.bios.2022.114094","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T11:45:14Z","timestamp":1645098314000},"page":"114094","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"special_numbering":"C","title":["Plasmon color-preserved gold nanoparticle clusters for high sensitivity detection of SARS-CoV-2 based on lateral flow immunoassay"],"prefix":"10.1016","volume":"205","author":[{"given":"Hyun-Kyung","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0725-9739","authenticated-orcid":false,"given":"Kihyeun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0626-1346","authenticated-orcid":false,"given":"Hyungsoon","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Maher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Gon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bios.2022.114094_bib1","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.jsps.2020.09.014","article-title":"Middle East Respiratory Syndrome (MERS) and novel coronavirus disease-2019 (COVID-19): from causes to preventions in Saudi Arabia","volume":"28","author":"Alyami","year":"2020","journal-title":"Saudi Pharmaceut. J."},{"issue":"9","key":"10.1016\/j.bios.2022.114094_bib2","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.1021\/acs.jpcc.1c01071","article-title":"Insight on the coupling of plasmonic nanoparticles from near-field spectra determined via discrete dipole approximations","volume":"125","author":"Barr","year":"2021","journal-title":"J Phys Chem C Nanomater Interfaces"},{"issue":"10223","key":"10.1016\/j.bios.2022.114094_bib3","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0140-6736(20)30154-9","article-title":"A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster","volume":"395","author":"Chan","year":"2020","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.bios.2022.114094_bib4","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.7150\/thno.42364","article-title":"Self-assembled colloidal gold superparticles to enhance the sensitivity of lateral flow immunoassays with sandwich format","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.bios.2022.114094_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmi.2020.09.057","article-title":"Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection","volume":"27","author":"Diao","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"issue":"16","key":"10.1016\/j.bios.2022.114094_bib6","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1007\/s00216-021-03421-5","article-title":"Strip modification and alternative architectures for signal amplification in nanoparticle-based lateral flow assays","volume":"413","author":"Diaz-Gonzalez","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"issue":"3","key":"10.1016\/j.bios.2022.114094_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1473-3099(13)70250-0","article-title":"Diagnostic point-of-care tests in resource-limited settings","volume":"14","author":"Drain","year":"2014","journal-title":"Lancet Infect. Dis."},{"issue":"16","key":"10.1016\/j.bios.2022.114094_bib8","doi-asserted-by":"crossref","first-page":"11305","DOI":"10.1021\/acs.analchem.0c01975","article-title":"SARS-CoV-2 coronavirus nucleocapsid antigen-detecting half-strip lateral flow assay toward the development of point of care tests using commercially available reagents","volume":"92","author":"Grant","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2022.114094_bib9","doi-asserted-by":"crossref","first-page":"n823","DOI":"10.1136\/bmj.n823","article-title":"Covid-19: lateral flow tests are better at identifying people with symptoms, finds Cochrane review","volume":"372","author":"Griffin","year":"2021","journal-title":"BMJ"},{"issue":"22","key":"10.1016\/j.bios.2022.114094_bib10","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1039\/c3lc50672j","article-title":"Oligonucleotide-linked gold nanoparticle aggregates for enhanced sensitivity in lateral flow assays","volume":"13","author":"Hu","year":"2013","journal-title":"Lab Chip"},{"issue":"8","key":"10.1016\/j.bios.2022.114094_bib11","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1021\/acsanm.9b00956","article-title":"Quantifying the numbers of gold nanoparticles in the test zone of lateral flow immunoassay strips","volume":"2","author":"Khlebtsov","year":"2019","journal-title":"ACS Appl. Nano Mater."},{"issue":"1","key":"10.1016\/j.bios.2022.114094_bib12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1042\/EBC20150012","article-title":"Lateral flow assays","volume":"60","author":"Koczula","year":"2016","journal-title":"Essays Biochem."},{"issue":"8","key":"10.1016\/j.bios.2022.114094_bib13","doi-asserted-by":"crossref","first-page":"e452","DOI":"10.1016\/S2468-2667(20)30157-2","article-title":"Impact of delays on effectiveness of contact tracing strategies for COVID-19: a modelling study","volume":"5","author":"Kretzschmar","year":"2020","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.bios.2022.114094_bib14","series-title":"Delta Variant Triggers New Phase in the Pandemic","author":"Kupferschmidt","year":"2021"},{"issue":"52","key":"10.1016\/j.bios.2022.114094_bib15","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/nass\/nrn344","article-title":"Single-molecule accommodation of streptavidin in nanometer-scale wells formed in DNA nanostructures","author":"Kuzuya","year":"2008","journal-title":"Nucleic Acids Symp. Ser."},{"issue":"3","key":"10.1016\/j.bios.2022.114094_bib16","doi-asserted-by":"crossref","first-page":"105924","DOI":"10.1016\/j.ijantimicag.2020.105924","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges","volume":"55","author":"Lai","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"31","key":"10.1016\/j.bios.2022.114094_bib17","doi-asserted-by":"crossref","first-page":"26178","DOI":"10.1039\/C6RA03695C","article-title":"Effect of different-sized spherical gold nanoparticles grown layer by layer on the sensitivity of an immunochromatographic assay","volume":"6","author":"Li","year":"2016","journal-title":"RSC Adv."},{"issue":"8","key":"10.1016\/j.bios.2022.114094_bib18","doi-asserted-by":"crossref","first-page":"6940","DOI":"10.3168\/jds.2019-17934","article-title":"Integrated gold superparticles into lateral flow immunoassays for the rapid and sensitive detection of Escherichia coli O157:H7 in milk","volume":"103","author":"Li","year":"2020","journal-title":"J. Dairy Sci."},{"issue":"1","key":"10.1016\/j.bios.2022.114094_bib19","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1039\/C5AY02810H","article-title":"Colorimetric sensing of atrazine in rice samples using cysteamine functionalized gold nanoparticles after solid phase extraction","volume":"8","author":"Liu","year":"2016","journal-title":"Anal. Methods"},{"issue":"1","key":"10.1016\/j.bios.2022.114094_bib20","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nprot.2006.38","article-title":"Preparation of aptamer-linked gold nanoparticle purple aggregates for colorimetric sensing of analytes","volume":"1","author":"Liu","year":"2006","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.bios.2022.114094_bib21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1039\/C3AY41711E","article-title":"One-step highly sensitive detection of melamine using gold nanoparticle-based dynamic light scattering","volume":"6","author":"Ma","year":"2014","journal-title":"Anal. Methods"},{"key":"10.1016\/j.bios.2022.114094_bib22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3389\/fmed.2020.00225","article-title":"Development and potential usefulness of the COVID-19 Ag respi-strip diagnostic assay in a pandemic context","volume":"7","author":"Mertens","year":"2020","journal-title":"Front. Med."},{"issue":"3","key":"10.1016\/j.bios.2022.114094_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1109\/JPHOT.2018.2825435","article-title":"Probing the plasmon coupling, quantum yield, and effects of tip geometry of gold nanoparticle using analytical models and FDTD simulation","volume":"10","author":"Mohsin","year":"2018","journal-title":"IEEE Photonics J."},{"key":"10.1016\/j.bios.2022.114094_bib24","doi-asserted-by":"crossref","first-page":"n1596","DOI":"10.1136\/bmj.n1596","article-title":"Covid-19: cases of delta variant rise by 79%, but rate of growth slows","volume":"373","author":"O'Dowd","year":"2021","journal-title":"BMJ"},{"issue":"12","key":"10.1016\/j.bios.2022.114094_bib25","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1038\/s41596-020-0357-x","article-title":"Tutorial: design and fabrication of nanoparticle-based lateral-flow immunoassays","volume":"15","author":"Parolo","year":"2020","journal-title":"Nat. Protoc."},{"issue":"7297","key":"10.1016\/j.bios.2022.114094_bib26","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1136\/bmj.322.7297.1285","article-title":"Point of care testing","volume":"322","author":"Price","year":"2001","journal-title":"BMJ"},{"issue":"8","key":"10.1016\/j.bios.2022.114094_bib27","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ni.2621","article-title":"Matching cellular dimensions with molecular sizes","volume":"14","author":"Reth","year":"2013","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.bios.2022.114094_bib28","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jscs.2014.09.001","article-title":"Designs, formats and applications of lateral flow assay: a literature review","volume":"19","author":"Sajid","year":"2015","journal-title":"J. Saudi Chem. Soc."},{"issue":"3","key":"10.1016\/j.bios.2022.114094_bib29","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1021\/acsomega.8b03593","article-title":"Signal-enhanced lateral flow immunoassay with dual gold nanoparticle conjugates for the detection of hepatitis B surface antigen","volume":"4","author":"Shen","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.bios.2022.114094_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2021.116200","article-title":"Enhancing the analytical performance of paper lateral flow assays: from chemistry to engineering","volume":"136","author":"Shirshahi","year":"2021","journal-title":"Trac. Trends Anal. Chem."},{"issue":"5","key":"10.1016\/j.bios.2022.114094_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/nano11051142","article-title":"Visual and optical absorbance detection of melamine in milk by melamine-induced aggregation of gold nanoparticles","volume":"11","author":"Siddiquee","year":"2021","journal-title":"Nanomaterials"},{"issue":"10","key":"10.1016\/j.bios.2022.114094_bib32","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1021\/jp807904s","article-title":"On the use of plasmonic nanoparticle pairs as a plasmon ruler: the dependence of the near-field dipole plasmon coupling on nanoparticle size and shape","volume":"113","author":"Tabor","year":"2009","journal-title":"J. Phys. Chem."},{"issue":"11","key":"10.1016\/j.bios.2022.114094_bib33","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.tibtech.2015.09.001","article-title":"Emerging technologies for next-generation point-of-care testing","volume":"33","author":"Vashist","year":"2015","journal-title":"Trends Biotechnol."},{"issue":"3","key":"10.1016\/j.bios.2022.114094_bib34","doi-asserted-by":"crossref","DOI":"10.5101\/nbe.v8i3.p172-183","article-title":"The application of lateral flow immunoassay in point of care testing: a review","volume":"8","author":"Wang","year":"2016","journal-title":"Nano Biomed. Eng."},{"issue":"5","key":"10.1016\/j.bios.2022.114094_bib35","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s00216-008-2572-0","article-title":"Point-of-care testing of proteins","volume":"393","author":"Warsinke","year":"2009","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.bios.2022.114094_bib39","doi-asserted-by":"crossref","first-page":"553837","DOI":"10.3389\/fcimb.2020.553837","article-title":"Foundation and clinical evaluation of a new method for detecting SARS-CoV-2 antigen by fluorescent microsphere immunochromatography","volume":"10","author":"Zhang","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.bios.2022.114094_bib40","doi-asserted-by":"crossref","first-page":"112370","DOI":"10.1016\/j.bios.2020.112370","article-title":"Antibody-gold nanoparticle bioconjugates for biosensors: synthesis, characterization and selected applications","volume":"165","author":"Zhang","year":"2020","journal-title":"Biosens. Bioelectron."},{"issue":"9393","key":"10.1016\/j.bios.2022.114094_bib41","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0140-6736(03)14630-2","article-title":"Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003","volume":"362","author":"Zhong","year":"2003","journal-title":"Lancet"},{"issue":"19","key":"10.1016\/j.bios.2022.114094_bib42","doi-asserted-by":"crossref","first-page":"10575","DOI":"10.1021\/acs.chemrev.5b00100","article-title":"Gold nanoparticles for in vitro diagnostics","volume":"115","author":"Zhou","year":"2015","journal-title":"Chem. Rev."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566322001348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566322001348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T01:28:13Z","timestamp":1760664493000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566322001348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":39,"alternative-id":["S0956566322001348"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2022.114094","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasmon color-preserved gold nanoparticle clusters for high sensitivity detection of SARS-CoV-2 based on lateral flow immunoassay","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2022.114094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114094"}}