{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:02:19Z","timestamp":1790370139061,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.bios.2022.114854","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T03:49:26Z","timestamp":1666928966000},"page":"114854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Accurate diagnosis of prostate cancer with CRISPR-based nucleic acid test strip by simultaneously identifying PCA3 and KLK3 genes"],"prefix":"10.1016","volume":"220","author":[{"given":"Wenzhe","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanlin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0723-5529","authenticated-orcid":false,"given":"Hongxing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bios.2022.114854_bib1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.euf.2018.01.010","volume":"5","author":"Ankerst","year":"2019","journal-title":"Eur. Urol. Focus"},{"issue":"23","key":"10.1016\/j.bios.2022.114854_bib2","first-page":"5975","volume":"59","author":"Bussemakers","year":"1999","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.bios.2022.114854_bib3","first-page":"1051","volume":"104","author":"Carlsson","year":"2020","journal-title":"Med. Clin."},{"issue":"8","key":"10.1016\/j.bios.2022.114854_bib4","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","volume":"19","author":"Chandrashekar","year":"2017","journal-title":"Neoplasia"},{"issue":"3","key":"10.1016\/j.bios.2022.114854_bib5","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1039\/C5LC01388G","volume":"16","author":"Choi","year":"2016","journal-title":"Lab Chip"},{"issue":"4","key":"10.1016\/j.bios.2022.114854_bib6","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.juro.2007.11.038","volume":"179","author":"Deras","year":"2008","journal-title":"J. Urol."},{"issue":"2","key":"10.1016\/j.bios.2022.114854_bib7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1586\/erm.10.122","volume":"11","author":"Durand","year":"2011","journal-title":"Expert Rev. Mol. Diagn."},{"issue":"4","key":"10.1016\/j.bios.2022.114854_bib8","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/clinchem\/hvab002","volume":"67","author":"Ferraro","year":"2021","journal-title":"Clin. Chem."},{"issue":"33","key":"10.1016\/j.bios.2022.114854_bib9","doi-asserted-by":"crossref","first-page":"15530","DOI":"10.1039\/C9NR04864B","volume":"11","author":"Fu","year":"2019","journal-title":"Nanoscale"},{"issue":"1","key":"10.1016\/j.bios.2022.114854_bib10","first-page":"191","volume":"95","author":"Gjertson","year":"2011","journal-title":"Med. Clin."},{"issue":"35","key":"10.1016\/j.bios.2022.114854_bib11","doi-asserted-by":"crossref","first-page":"11899","DOI":"10.1021\/acs.analchem.1c02533","volume":"93","author":"Gong","year":"2021","journal-title":"Anal. Chem."},{"issue":"6","key":"10.1016\/j.bios.2022.114854_bib12","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1373\/clinchem.2005.063289","volume":"52","author":"Groskopf","year":"2006","journal-title":"Clin. Chem."},{"issue":"6","key":"10.1016\/j.bios.2022.114854_bib13","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41551-019-0371-x","volume":"3","author":"Hajian","year":"2019","journal-title":"Nat. Biomed. Eng."},{"issue":"5","key":"10.1016\/j.bios.2022.114854_bib14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrurol.2009.40","volume":"6","author":"Hessels","year":"2009","journal-title":"Nat. Rev. Urol."},{"issue":"3","key":"10.1016\/j.bios.2022.114854_bib15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.biotechadv.2016.02.008","volume":"34","author":"Hu","year":"2016","journal-title":"Biotechnol. Adv."},{"issue":"26","key":"10.1016\/j.bios.2022.114854_bib16","volume":"119","author":"Hu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bios.2022.114854_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113770","volume":"197","author":"Hussain","year":"2022","journal-title":"Biosens. Bioelectron."},{"issue":"7","key":"10.1016\/j.bios.2022.114854_bib18","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41551-021-00760-7","volume":"5","author":"Kaminski","year":"2021","journal-title":"Nat. Biomed. Eng."},{"issue":"8","key":"10.1016\/j.bios.2022.114854_bib19","doi-asserted-by":"crossref","first-page":"8362","DOI":"10.1021\/acsnano.8b03698","volume":"12","author":"Koo","year":"2018","journal-title":"ACS Nano"},{"issue":"45","key":"10.1016\/j.bios.2022.114854_bib20","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1002\/smll.201602161","volume":"12","author":"Koo","year":"2016","journal-title":"Small"},{"issue":"3","key":"10.1016\/j.bios.2022.114854_bib21","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1158\/0008-5472.CAN-07-3224","volume":"68","author":"Laxman","year":"2008","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bios.2022.114854_bib22","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.eururo.2012.11.014","volume":"65","author":"Leyten","year":"2014","journal-title":"Eur. Urol."},{"issue":"24","key":"10.1016\/j.bios.2022.114854_bib23","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1001\/jama.2017.7248","volume":"317","author":"Litwin","year":"2017","journal-title":"JAMA"},{"issue":"33","key":"10.1016\/j.bios.2022.114854_bib24","doi-asserted-by":"crossref","first-page":"36851","DOI":"10.1021\/acsami.0c08064","volume":"12","author":"Mao","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"3","key":"10.1016\/j.bios.2022.114854_bib25","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.urology.2006.12.014","volume":"69","author":"Marks","year":"2007","journal-title":"Urology"},{"issue":"8","key":"10.1016\/j.bios.2022.114854_bib26","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrurol.2012.130","volume":"9","author":"Murphy","year":"2012","journal-title":"Nat. Rev. Urol."},{"issue":"14\u201315","key":"10.1016\/j.bios.2022.114854_bib27","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.clinbiochem.2008.06.013","volume":"41","author":"Neves","year":"2008","journal-title":"Clin. Biochem."},{"issue":"1","key":"10.1016\/j.bios.2022.114854_bib28","volume":"11","author":"Nguyen","year":"2020","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.bios.2022.114854_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0040204","volume":"4","author":"Piepenburg","year":"2006","journal-title":"PLoS Biol."},{"issue":"47","key":"10.1016\/j.bios.2022.114854_bib30","doi-asserted-by":"crossref","first-page":"24823","DOI":"10.1002\/anie.202108827","volume":"60","author":"Qi","year":"2021","journal-title":"Angew. Chem., Int. Ed. Engl."},{"issue":"8","key":"10.1016\/j.bios.2022.114854_bib31","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1021\/jacs.7b13047","volume":"140","author":"Raper","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bios.2022.114854_bib32","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nbt.3481","volume":"34","author":"Richardson","year":"2016","journal-title":"Nat. Biotechnol."},{"issue":"3","key":"10.1016\/j.bios.2022.114854_bib33","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.juro.2011.10.133","volume":"187","author":"Salagierski","year":"2012","journal-title":"J. Urol."},{"key":"10.1016\/j.bios.2022.114854_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113520","volume":"192","author":"S\u00e1nchez-Salcedo","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2022.114854_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2020.128659","volume":"322","author":"Shi","year":"2020","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.bios.2022.114854_bib36","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bios.2019.03.065","volume":"137","author":"Singh","year":"2019","journal-title":"Biosens. Bioelectron."},{"issue":"50","key":"10.1016\/j.bios.2022.114854_bib37","doi-asserted-by":"crossref","first-page":"46645","DOI":"10.1021\/acsami.9b19180","volume":"11","author":"Soares","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"7490","key":"10.1016\/j.bios.2022.114854_bib38","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature13011","volume":"507","author":"Sternberg","year":"2014","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bios.2022.114854_bib39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"CA","volume":"71","author":"Sung","year":"2021","journal-title":"Cancer J. Clin."},{"issue":"12","key":"10.1016\/j.bios.2022.114854_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202115907","volume":"61","author":"Tang","year":"2022","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"10.1016\/j.bios.2022.114854_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113701","volume":"196","author":"Tian","year":"2022","journal-title":"Biosens. Bioelectron."},{"issue":"1\u20132","key":"10.1016\/j.bios.2022.114854_bib42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.clinbiochem.2007.10.009","volume":"41","author":"V\u00e4\u00e4n\u00e4nen","year":"2008","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.bios.2022.114854_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112445","volume":"166","author":"van Dongen","year":"2020","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.bios.2022.114854_bib44","volume":"15","author":"Wang","year":"2019","journal-title":"Small"},{"issue":"21","key":"10.1016\/j.bios.2022.114854_bib45","doi-asserted-by":"crossref","first-page":"12698","DOI":"10.1021\/acs.analchem.8b02959","volume":"90","author":"Wang","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bios.2022.114854_bib46","volume":"354","author":"Wang","year":"2022","journal-title":"Sensor. Actuator. B Chem."},{"issue":"2","key":"10.1016\/j.bios.2022.114854_bib47","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1021\/acsnano.0c00022","volume":"14","author":"Wang","year":"2020","journal-title":"ACS Nano"},{"issue":"16","key":"10.1016\/j.bios.2022.114854_bib48","doi-asserted-by":"crossref","first-page":"16ra8","DOI":"10.1126\/scitranslmed.3000513","volume":"2","author":"Wu","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bios.2022.114854_bib49","volume":"157","author":"Wu","year":"2020","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.bios.2022.114854_bib50","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41421-020-0175-x","volume":"6","author":"Xia","year":"2020","journal-title":"Cell Discov"},{"issue":"10","key":"10.1016\/j.bios.2022.114854_bib51","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1002\/anie.202014506","volume":"60","author":"Xiong","year":"2021","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"10.1016\/j.bios.2022.114854_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113797","volume":"197","author":"Yan","year":"2022","journal-title":"Biosens. Bioelectron."},{"issue":"8","key":"10.1016\/j.bios.2022.114854_bib53","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1021\/acs.analchem.1c00013","volume":"93","author":"Zhang","year":"2021","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.bios.2022.114854_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-02088-w","volume":"9","author":"Zhou","year":"2018","journal-title":"Nat. Commun."}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566322008946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566322008946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T01:35:45Z","timestamp":1760664945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566322008946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":54,"alternative-id":["S0956566322008946"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2022.114854","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Accurate diagnosis of prostate cancer with CRISPR-based nucleic acid test strip by simultaneously identifying PCA3 and KLK3 genes","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2022.114854","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114854"}}