{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:11:20Z","timestamp":1773180680912,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosensors and Bioelectronics"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.bios.2022.114910","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T07:42:26Z","timestamp":1668152546000},"page":"114910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Multifunctional AuNPs@HRP@FeMOF immune scaffold with a fully automated saliva analyzer for oral cancer screening"],"prefix":"10.1016","volume":"222","author":[{"given":"Xinyi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianyou","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liubing","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoru","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6474-2722","authenticated-orcid":false,"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bios.2022.114910_bib1","unstructured":"Alt, K., Carraro, F., Jap, E., Linares-Moreau, M., Ricc\u00f2, R., Righetto, M., Bogar, M., Amenitsch, H., Hashad, R.A., Doonan, C., Hagemeyer, C.E., Falcaro, P., Self-Assembly of Oriented Antibody-Decorated Metal\u2013Organic Framework Nanocrystals for Active-Targeting Applications. Advanced Materials n\/a(n\/a), 2106607."},{"issue":"4","key":"10.1016\/j.bios.2022.114910_bib2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4103\/IJPM.IJPM_140_16","article-title":"Role of salivary biomarkers in early detection of oral squamous cell carcinoma","volume":"60","author":"Awasthi","year":"2017","journal-title":"Indian J. Pathol. Microbiol."},{"issue":"2","key":"10.1016\/j.bios.2022.114910_bib3","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1021\/acsami.0c14946","article-title":"Label-free electrochemical immunosensor for ultrasensitive detection of carbohydrate antigen 125 based on antibody-immobilized biocompatible MOF-808\/CNT","volume":"13","author":"Biswas","year":"2021","journal-title":"Acs Appl. Mater. Inter."},{"key":"10.1016\/j.bios.2022.114910_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.sab.2020.105797","article-title":"Detection of three tumor biomarkers in human lung cancer serum using single particle inductively coupled plasma mass spectrometry combined with magnetic immunoassay","volume":"166","author":"Cao","year":"2020","journal-title":"Spectrochim. Acta B Atom Spectrosc."},{"issue":"1","key":"10.1016\/j.bios.2022.114910_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2001-1326-3-3","article-title":"A review of research on salivary biomarkers for oral cancer detection","volume":"3","author":"Cheng","year":"2014","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bios.2022.114910_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2019.01476","article-title":"Salivary biomarkers for oral squamous cell carcinoma diagnosis and follow-up: current status and perspectives","volume":"10","author":"Cristaldi","year":"2019","journal-title":"Front. Physiol."},{"issue":"26","key":"10.1016\/j.bios.2022.114910_bib7","doi-asserted-by":"crossref","first-page":"10181","DOI":"10.1039\/c3ra23443f","article-title":"Synthesis of amine-tagged metal\u2013organic frameworks isostructural to MIL-101(Cr)","volume":"3","author":"Ferreira","year":"2013","journal-title":"RSC Adv."},{"key":"10.1016\/j.bios.2022.114910_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.aca.2016.12.016","article-title":"Highly sensitive detection of multiple tumor markers for lung cancer using gold nanoparticle probes and microarrays","volume":"958","author":"Gao","year":"2017","journal-title":"Anal. Chim. Acta"},{"issue":"2","key":"10.1016\/j.bios.2022.114910_bib9","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1158\/1078-0432.CCR-13-1101","article-title":"Prognostic relevance of circulating tumor cells in blood and disseminated tumor cells in bone marrow of patients with squamous cell carcinoma of the oral cavity","volume":"20","author":"Gr\u00f6be","year":"2014","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.bios.2022.114910_bib10","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1021\/acs.analchem.5b03926","article-title":"Multiplexed activity of perAuxidase: DNA-capped AuNPs act as adjustable peroxidase","volume":"88","author":"Hizir","year":"2016","journal-title":"Anal. Chem."},{"issue":"6","key":"10.1016\/j.bios.2022.114910_bib11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0964-1955(96)00017-6","article-title":"Serum levels of CYFRA 21-1 in nasopharyngeal carcinoma and its possible role in monitoring of therapy","volume":"32","author":"Ho","year":"1996","journal-title":"Eur. J. Cancer B Oral Oncol."},{"issue":"46","key":"10.1016\/j.bios.2022.114910_bib12","doi-asserted-by":"crossref","first-page":"15225","DOI":"10.1021\/acs.analchem.1c03521","article-title":"Construction of an integrated device of a self-powered biosensor and matching capacitor based on graphdiyne and multiple signal amplification: ultrasensitive method for MicroRNA detection","volume":"93","author":"Hou","year":"2021","journal-title":"Anal. Chem."},{"issue":"6","key":"10.1016\/j.bios.2022.114910_bib13","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.1021\/acsnano.7b00905","article-title":"Surface-enhanced Raman scattering active gold nanoparticles with enzyme-mimicking activities for measuring glucose and lactate in living tissues","volume":"11","author":"Hu","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.bios.2022.114910_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110671","article-title":"Non-invasive bioassay of Cytokeratin Fragment 21.1 (Cyfra 21.1) protein in human saliva samples using immunoreaction method: an efficient platform for early-stage diagnosis of oral cancer based on biomedicine","volume":"131","author":"Jafari","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bios.2022.114910_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.elecom.2020.106881","article-title":"Recent advances in lithium-based batteries using metal organic frameworks as electrode materials","volume":"122","author":"Jiang","year":"2021","journal-title":"Electrochem. Commun."},{"key":"10.1016\/j.bios.2022.114910_bib16","article-title":"Porphyrin-based framework materials for energy conversion","volume":"1","author":"Jiawei","year":"2022","journal-title":"Nano Res. Energy"},{"issue":"5","key":"10.1016\/j.bios.2022.114910_bib17","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/1535370216681550","article-title":"Saliva diagnostics \u2013 Current views and directions","volume":"242","author":"Kaczor-Urbanowicz","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.bios.2022.114910_bib18","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bios.2015.11.084","article-title":"Nanostructured zirconia decorated reduced graphene oxide based efficient biosensing platform for non-invasive oral cancer detection","volume":"78","author":"Kumar","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2022.114910_bib19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.envint.2019.01.033","article-title":"Novel sensing platform based on gold nanoparticle-aptamer and Fe-metal-organic framework for multiple antibiotic detection and signal amplification","volume":"125","author":"Li","year":"2019","journal-title":"Environ. Int."},{"issue":"30","key":"10.1016\/j.bios.2022.114910_bib20","doi-asserted-by":"crossref","first-page":"18198","DOI":"10.1039\/D1RA02116H","article-title":"Probing protein dissociation from gold nanoparticles and the influence of temperature from the protein corona formation mechanism","volume":"11","author":"Li","year":"2021","journal-title":"RSC Adv."},{"issue":"12","key":"10.1016\/j.bios.2022.114910_bib21","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00604-018-3081-2","article-title":"Dual-aptamer-based voltammetric biosensor for the Mycobacterium tuberculosis antigen MPT64 by using a gold electrode modified with a peroxidase loaded composite consisting of gold nanoparticles and a Zr(IV)\/terephthalate metal-organic framework","volume":"185","author":"Li","year":"2018","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.bios.2022.114910_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.131396","article-title":"Carbon dots confined in N-doped carbon as peroxidase-like nanozyme for detection of gastric cancer relevant D-amino acids","volume":"428","author":"Li","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bios.2022.114910_bib23","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bios.2016.01.084","article-title":"Bead-based microarray immunoassay for lung cancer biomarkers using quantum dots as labels","volume":"80","author":"Liu","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.bios.2022.114910_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01510","article-title":"An overview on current non-invasive diagnostic devices in oral oncology","volume":"9","author":"Mascitti","year":"2018","journal-title":"Front. Physiol."},{"issue":"12","key":"10.1016\/j.bios.2022.114910_bib25","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1039\/D1QI00345C","article-title":"A Ni-MOF nanosheet array for efficient oxygen evolution electrocatalysis in alkaline media","volume":"8","author":"Meng","year":"2021","journal-title":"Inorg. Chem. Front."},{"issue":"1","key":"10.1016\/j.bios.2022.114910_bib26","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/odi.12216","article-title":"Salivary and serum level of CYFRA 21-1 in oral precancer and oral squamous cell carcinoma","volume":"21","author":"Rajkumar","year":"2015","journal-title":"Oral Dis."},{"issue":"4","key":"10.1016\/j.bios.2022.114910_bib27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/proteomes4040041","article-title":"Advances of salivary proteomics in oral squamous cell carcinoma (OSCC) detection: an update","volume":"4","author":"Sannam Khan","year":"2016","journal-title":"Proteomes"},{"key":"10.1016\/j.bios.2022.114910_bib28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.aca.2018.04.025","article-title":"Fluorescence-based immunosensor using three-dimensional CNT network structure for sensitive and reproducible detection of oral squamous cell carcinoma biomarker","volume":"1027","author":"Song","year":"2018","journal-title":"Anal. Chim. Acta"},{"issue":"28","key":"10.1016\/j.bios.2022.114910_bib29","doi-asserted-by":"crossref","first-page":"16167","DOI":"10.1073\/pnas.2001395117","article-title":"Oral squamous cell carcinoma diagnosed from saliva metabolic profiling","volume":"117","author":"Song","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"72","key":"10.1016\/j.bios.2022.114910_bib30","doi-asserted-by":"crossref","first-page":"38048","DOI":"10.1039\/C4RA05402D","article-title":"Epoxidation of styrene over Fe(Cr)-MIL-101 metal\u2013organic frameworks","volume":"4","author":"Sun","year":"2014","journal-title":"RSC Adv."},{"issue":"5","key":"10.1016\/j.bios.2022.114910_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/admt.202001048","article-title":"An investigation into the intrinsic peroxidase-like activity of Fe-MOFs and Fe-MOFs\/Polymer composites","volume":"6","author":"Thakur","year":"2021","journal-title":"Adv. Mater. Technol."},{"key":"10.1016\/j.bios.2022.114910_bib32","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.bios.2016.10.020","article-title":"L-cysteine capped lanthanum hydroxide nanostructures for non-invasive detection of oral cancer biomarker","volume":"89","author":"Tiwari","year":"2017","journal-title":"Biosens. Bioelectron."},{"issue":"30","key":"10.1016\/j.bios.2022.114910_bib33","doi-asserted-by":"crossref","first-page":"25113","DOI":"10.1021\/acsami.8b07225","article-title":"Integrated antibody with catalytic metal\u2013organic framework for colorimetric immunoassay","volume":"10","author":"Wang","year":"2018","journal-title":"Acs Appl. Mater. Inter."},{"issue":"14","key":"10.1016\/j.bios.2022.114910_bib34","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1039\/D1AN00466B","article-title":"Synthesis and modification of carbon dots for advanced biosensing application","volume":"146","author":"Wang","year":"2021","journal-title":"Analyst"},{"issue":"7","key":"10.1016\/j.bios.2022.114910_bib35","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1039\/C9TB02574J","article-title":"A high-energy sandwich-type self-powered biosensor based on DNA bioconjugates and a nitrogen doped ultra-thin carbon shell","volume":"8","author":"Wang","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bios.2022.114910_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.nanoen.2019.104310","article-title":"Boosting performance of self-powered biosensing device with high-energy enzyme biofuel cells and cruciform DNA","volume":"68","author":"Wang","year":"2020","journal-title":"Nano Energy"},{"key":"10.1016\/j.bios.2022.114910_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2020.128933","article-title":"Significantly improving the performance of self-powered biosensor by effectively combining with high-energy enzyme biofuel cells, N-doped graphene, and ultrathin hollow carbon shell","volume":"327","author":"Xu","year":"2021","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.bios.2022.114910_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2021.130399","article-title":"An immune-scaffold relying biosensor for simultaneous detection of nitrofurazone and furazolidone","volume":"345","author":"Yin","year":"2021","journal-title":"Sensor. Actuator. B Chem."},{"issue":"8","key":"10.1016\/j.bios.2022.114910_bib39","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/cnma.202100153","article-title":"Co-MOF nanosheet arrays for efficient alkaline oxygen evolution electrocatalysis","volume":"7","author":"Yu","year":"2021","journal-title":"ChemNanoMat"},{"key":"10.1016\/j.bios.2022.114910_bib40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bioelechem.2017.11.003","article-title":"A sandwich-type electrochemical immunoassay for ultrasensitive detection of non-small cell lung cancer biomarker CYFRA21-1","volume":"120","author":"Zeng","year":"2018","journal-title":"Bioelectrochemistry"}],"container-title":["Biosensors and Bioelectronics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566322009502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0956566322009502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T01:45:22Z","timestamp":1760665522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0956566322009502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":40,"alternative-id":["S0956566322009502"],"URL":"https:\/\/doi.org\/10.1016\/j.bios.2022.114910","relation":{},"ISSN":["0956-5663"],"issn-type":[{"value":"0956-5663","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multifunctional AuNPs@HRP@FeMOF immune scaffold with a fully automated saliva analyzer for oral cancer screening","name":"articletitle","label":"Article Title"},{"value":"Biosensors and Bioelectronics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bios.2022.114910","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114910"}}